Yini i-Silodosin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Silodosin iyimithi kadokotela eyenzelwe ngqo ukusiza amadoda anendlala yesinye elukhuni ukuba aphefumule kalula uma kuziwa ekuphumeni komchamo. Le mithi emnene kodwa esebenzayo ingeyeqembu elibizwa ngokuthi ama-alpha-blockers, asebenza ngokukhulula imisipha ethile endlaleni yakho yesinye nasezintanyeni zesinye ukuze kuthuthukiswe ukugeleza komchamo.

Uma ubulokhu ulwa nokuvakashela njalo endlini yangasese, ukuphuma komchamo okubuthakathaka, noma lowo muzwa odidayo wokungayikhiphi ngokuphelele isinye sakho, i-silodosin ingase ibe yisikhululo obusilindele. Udokotela wakho unquma le mithi uma indlala yakho yesinye isikhule yaba nkulu ngokwanele ukucindezela i-urethra yakho, okwenza ukuphuma komchamo kube nzima futhi kungakhululeki.

Yini i-Silodosin?

I-Silodosin iyimithi eqondiwe esiza ngqo amadoda ukubhekana nezimpawu zomchamo ezibangelwa yi-benign prostatic hyperplasia (BPH), okuyigama elingokwelashwa elisho indlala yesinye elukhuni. Ngokungafani neminye imithi ethinta umzimba wakho wonke, i-silodosin isebenza ikakhulukazi kuma-receptor athile endlaleni yakho yesinye nasendaweni yesinye.

Le mithi ithathwa njengeqinile ngokulinganisela futhi ekhethekile kakhulu, okusho ukuthi igxila emiphumeleni yayo ikakhulukazi lapho uyidinga kakhulu. Le mithi yakhiwe ngqo ukunciphisa imiphumela emibi ngenkathi ikhulisa ukukhululeka kulezo zimpawu zomchamo ezididayo ezingathinta kakhulu impilo yakho yansuku zonke.

Indlala yakho yesinye ikhula ngokwemvelo njengoba ukhula, futhi kumadoda amaningi, lokhu kukhula kungabangela ukuthi le gland icindezele i-urethra yakho njengokucindezela ipayipi lengadi. I-Silodosin isiza ukukhulula lezi zindawo eziqinile, ivumela umchamo ukuthi ugeleze ngokukhululeka futhi kunciphise ukucindezeleka esinyeni sakho.

Isetshenziselwani i-Silodosin?

ISilodosin ngokuyinhloko sinqunyelwe ukwelapha izimpawu zomchamo ezihambisana ne-benign prostatic hyperplasia (BPH) emadodeni. Lesi simo sithinta izigidi zamadoda, ikakhulukazi labo abaneminyaka engaphezu kwengama-50, futhi singenza imisebenzi elula njengokulala ebusuku noma ukuphuma endlini kube yinselelo.

Umuthi ubhekana nezimpawu ezithile ezingathinta kakhulu izinga lempilo yakho. Ungase uzithole uvuka izikhathi eziningi ebusuku ukuze uchame, uhlangabezana nomfula womchamo obuthakathaka noma ophazamisekile, noma uzizwe sengathi awukwazi ukukhipha ngokuphelele isinye sakho ngisho nangemva kokuchama.

Amanye amadoda nawo ahlangabezana nemizwa ephuthumayo yokudinga ukuchama, ubunzima bokuqala ukuchama, noma umuzwa wokuthi isinye sawo sisagcwele ngisho nangemva kokusebenzisa indlu yangasese. ISilodosin sisiza ukudambisa lezi zimpawu ngokuvumela umchamo wakho ukuthi ugeleze ngokwemvelo nangokugcwele.

Isebenza Kanjani I-Silodosin?

ISilodosin isebenza ngokuvimba ama-alpha-1A receptors athile atholakala ikakhulukazi ku-prostate yakho, intamo yesinye, kanye ne-urethra. Cabanga ngalezi zithako njengamashintshi amancane, lapho esetshenzisiwe, abangela imisipha kulezi zindawo ukuthi iqine futhi idale ukumelana nokugeleza komchamo.

Ngokuvimba lezi zithako, i-silodosin ivimbela imisipha ukuthi ingaqinisi kakhulu, okwenza indlela yomchamo iphumule futhi yande. Lokhu kuphumula kwenza kube lula kakhulu ukuthi umchamo uphume esinyeni sakho futhi udlule ku-urethra yakho ngaphandle kokucindezeleka nokucindezela okungenzeka ukuthi uke wahlangabezana nakho ngaphambili.

Umuthi usebenza kahle ikakhulukazi ngoba ukhethekile kakhulu kuma-alpha-1A receptors agxilwe kakhulu ezicutshini ze-prostate. Le ndlela eqondiwe isho ukuthi uthola usizo lapho uludinga kakhulu ngenkathi unciphisa imiphumela kwezinye izingxenye zomzimba wakho, njengomfutho wegazi lakho noma izinga lokushaya kwenhliziyo.

Kufanele Ngiyithathe Kanjani I-Silodosin?

I-Silodosin kufanele ithathwe ngendlela eqondile udokotela wakho ayiyalayo, ngokuvamile kanye ngosuku ngokudla. Ukuyithatha nokudla kusiza umzimba wakho ukuba umunce imithi ngempumelelo futhi kunganciphisa ithuba lokuthi isisu singakhathazeki noma isiyezi.

Umthamo ojwayelekile wokuqala uvame ukuba ngu-8 mg kanye ngosuku, nakuba udokotela wakho angase alungise lokhu ngokusekelwe ezidingweni zakho ezithile nokuthi uyithatha kahle kangakanani imithi. Kubalulekile ukuthatha i-silodosin cishe ngesikhathi esifanayo nsuku zonke ukuze kugcinwe amazinga aqhubekayo ohlelweni lwakho.

Kufanele ugwinye ikhaphule ngokuphelele ngenkomishi yamanzi egcwele futhi ugweme ukuyichoboza noma ukuyivula. Uma unezinkinga zezinso, udokotela wakho angase akuyalele umthamo ophansi ongu-4 mg ngosuku, njengoba umzimba wakho ungase ukwazi ukucubungula imithi kancane.

Zama ukusungula umkhuba ngokuthatha i-silodosin ngokudla okufanayo nsuku zonke, kungakhathaliseki ukuthi lokho kungukudla kwasekuseni, kwasemini, noma kwakusihlwa. Lokhu kuqhubeka kusiza umzimba wakho ukuba ugcine amazinga aqhubekayo emithini futhi kungathuthukisa ukusebenza kwayo ekuphatheni izimpawu zakho.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Silodosin?

I-Silodosin ngokuvamile iyindlela yokwelapha yesikhathi eside ozoqhubeka uyithatha uma nje isiza izimpawu zakho futhi uyithatha kahle. Amadoda amaningi adinga ukuthatha le mithi unomphela ngoba i-BPH yisimo esiqhubekayo esingathuthuki ngokwazo.

Ungase uqale ukuqaphela ukuthuthuka okuthile ezimpawini zakho zomchamo phakathi nezinsuku zokuqala kuya emavikini okuqala ukwelashwa, nakuba kungathatha inyanga ukuzwa izinzuzo eziphelele. Udokotela wakho cishe uzohlela ama-aphoyintimenti okulandelayo ukuze aqaphele ukuthi imithi isebenza kahle kangakanani kuwe.

Ubude bokwelashwa buxhomeke ezintweni eziningana, okuhlanganisa ukuthi izimpawu zakho zinzima kangakanani, ukuthi usabela kahle kangakanani emithini, nokuthi ngabe uhlangabezana nanoma yimaphi imiphumela emibi enezinkinga. Amanye amadoda athatha i-silodosin iminyaka ngaphandle kwezinkinga, kanti amanye angase adinge ukushintshela kwezinye izindlela zokwelapha.

Udkt. wakho uzohlola njalo ukuthi i-silodosin iyaqhubeka yini iyona ekufanele. Uma izimpawu zakho zishintsha kakhulu noma uma uba nemiphumela emibi ethinta izinga lempilo yakho, bangase balungise umthamo wakho noma batusa ezinye izindlela zokwelapha.

Yini Imiphumela Emibi ye-Silodosin?

Njengayo yonke imithi, i-silodosin ingabangela imiphumela emibi, nakuba amadoda amaningi eyibekezelela kahle. Umphumela ovamile kakhulu ukuchitheka kwesidoda emuva, okusho ukuthi isidoda sigeleza emuva singene esinyeni esikhundleni sokuphuma ngesitho sangasese sowesilisa ngesikhathi sokuzithokozisa.

Nakuba ukuchitheka kwesidoda emuva kungase kuzwakale kukhathaza, ngokuvamile akulimazi futhi kuyashintsheka uma uyeka ukuthatha umuthi. Usazoqhubeka nokuzwa umuzwa wokuzithokozisa, kodwa ungase uqaphele isidoda esincane noma esingekho ngesikhathi sokuchitheka kwesidoda, okungase kumangaze kodwa akuyona ingozi.

Nansi imiphumela emibi evamile ongase uyithole, ukhumbula ukuthi eminingi imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Ukuchitheka kwesidoda emuva (okuvamile kakhulu, okuthinta kufika ku-90% wamadoda)
• Isiyezi noma ukukhathala, ikakhulukazi uma usukuma ngokushesha
• Ikhanda elibuhlungu
• Ukuphuma kwamakhemikhali noma ukuminyana kwamakhala
• Ukuqunjelwa
• Ubuthakathaka noma ukukhathala

Le miphumela emibi ngokuvamile iyalawuleka futhi ivame ukungabonakali ngokuqhubeka kwesikhathi njengoba umzimba wakho uzivumela emuthini.

Imiphumela emibi engavamile kodwa ebucayi ingenzeka, nakuba ithinta iphesenti elincane lamadoda athatha i-silodosin. Kubalulekile ukwazi lezi zinto ezingenzeka ukuze ukwazi ukufuna usizo lwezokwelapha uma kudingeka:

• Isiyezi esikhulu noma ukuquleka
• Ukuphendula komzimba ngaphandle kokubekezelela okuhlanganisa ukuqubuka, ukuluma, noma ubunzima bokuphefumula
• Ukuvuka okulukhuni noma okubuhlungu okuhlala ngaphezu kwamahora angu-4
• Ukushaya kwenhliziyo okungajwayelekile noma ubuhlungu besifuba
• Ukuvuvukala kobuso, izindebe, ulimi, noma umphimbo

Uma uhlangabezana nanoma yimaphi alawa maphuzu abucayi, xhumana nodokotela wakho ngokushesha noma funa ukwelashwa okuphuthumayo uma izimpawu zinzima.

Ubani Ongafanele Athathe I-Silodosin?

I-Silodosin ayifanele wonke umuntu, futhi udokotela wakho uzocabangela umlando wakho wezokwelapha ngokucophelela ngaphambi kokuyinika. Lo muthi wenzelwe ngqo amadoda ane-BPH futhi akufanele neze uthathwe abesifazane noma izingane.

Uma unezifo ezinzima zezinso, udokotela wakho cishe ngeke anikeze i-silodosin noma ayisebenzise ngokucophelela okukhulu. Umuthi ucubungulwa ngezinso zakho, futhi izinkinga ezinzima zezinso zingabangela amazinga ayingozi ukuthi akheke emzimbeni wakho.

Abantu abanezimo ezithile zezokwelapha badinga ukucatshangelwa okukhethekile ngaphambi kokuqala i-silodosin, njengoba umuthi ungase uqhubekisele phambili izimpawu zabo noma uhlangane nokwelashwa kwabo okukhona:

• Isifo esinzima sezinso (ukuhlanjululwa kwe-creatinine okungaphansi kuka-30 mL/min)
• Isifo esinzima sesibindi
• Umlando wokucindezelwa kwegazi eliphansi noma izikhathi zokuquleka
• Ukuhlinzwa kwamehlo okuhleliwe noma i-glaucoma
• Ukungezwani ne-silodosin noma imithi efanayo

Udokotela wakho uzobuye abuke wonke imithi yakho yamanje ukuze ahlole ukuthi kungenzeka yini ukuthi ihlangane, ikakhulukazi neminye imithi yokucindezela igazi noma imithi ethinta ama-enzyme esibindi.

Uma uhlelelwe ukuhlinzwa kwamehlo, ikakhulukazi ukususwa kwamehlo, qiniseka ukuthi utshela udokotela ohlinzayo ukuthi uthatha i-silodosin. Umuthi ungabangela isimo esibizwa nge-floppy iris syndrome ngesikhathi sokuhlinzwa, okudingeka ukuthi udokotela ohlinzayo akwazi ngaphambi kwesikhathi ukuze athathe izinyathelo ezifanele.

Amagama Omkhiqizo we-Silodosin

I-Silodosin itholakala kakhulu ngaphansi kwegama lomkhiqizo elithi Rapaflo e-United States. Leli yigama lomkhiqizo lokuqala lapho umuthi waqala ukuthengiswa futhi usaqhubeka ukunikezwa odokotela.

Izinhlobo ezivamile ze-silodosin nazo ziyatholakala, eziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efana neyegama lomkhiqizo. Ikhemisi lakho lingase lithathe indawo yohlobo olujwayelekile ngaphandle uma udokotela wakho ecela ngokuqondile igama lomkhiqizo.

Noma ngabe uthola i-Rapaflo noma i-silodosin ejwayelekile, umuthi kufanele usebenze ngendlela efanayo emzimbeni wakho. Umehluko omkhulu uvame ukuba yizindleko, ngezinhlobo ezivamile ezivame ukuba ngentengo ephansi ngenkathi zigcina izinga elifanayo nezindinganiso zokusebenza.

Ezinye izindlela ze-Silodosin

Uma i-silodosin ingasebenzi kahle kuwe noma idala imiphumela engathandeki, imithi eminingi ehlukile ingasiza ekuphatheni izimpawu ze-BPH. Ezinye izivimbeli ze-alpha ezifana ne-tamsulosin (Flomax), i-alfuzosin (Uroxatral), kanye ne-doxazosin (Cardura) zisebenza ngendlela efanayo kodwa zingase zibe nemiphumela ehlukile.

Udokotela wakho angase futhi acabangele izithiyo ze-5-alpha reductase ezifana ne-finasteride (Proscar) noma i-dutasteride (Avodart), esebenza ngendlela ehlukile ngokunciphisa ngempela i-prostate ngokuhamba kwesikhathi kunokumane iphumulele imisipha. Le mithi ingasiza ikakhulukazi uma une-prostate ekhulisiwe kakhulu.

Kwabanye abesilisa, ukwelashwa okuhlanganisiwe kusetshenziswa kokubili isivimbeli se-alpha kanye nesithiyo se-5-alpha reductase kunikeza ukukhululeka okungcono kwezimpawu kunanoma yimuphi umuthi wodwa. Udokotela wakho angasiza ekunqumeni ukuthi iyiphi indlela engasebenza kangcono esimweni sakho esithile.

Ukwelashwa okungekona okwemithi nakho kuyatholakala, okuhlanganisa izinqubo ezingahlaseli kakhulu kanye nezinketho zokuhlinzwa kwabesilisa abanezimpawu ezinzima ezingasabeli kahle emithini noma abangathandi ukuyithatha isikhathi eside.

Ingabe i-Silodosin ingcono kune-Tamsulosin?

Kokubili i-silodosin kanye ne-tamsulosin ziyizivimbeli ze-alpha ezisebenzayo zokwelapha izimpawu ze-BPH, kodwa zomehluko obalulekile ongase wenze enye ifaneleke kakhulu kuwe kunenye. I-Silodosin ikhetha kakhulu ama-alpha-1A receptors ku-prostate, okungasho imiphumela embalwa ekucindezelekeni kwegazi.

Ukuhwebelana okukhulu ukuthi i-silodosin ibangela ukuchithwa kwesidoda emuva cishe kuma-90% amadoda, uma kuqhathaniswa nama-35% nge-tamsulosin. Kodwa-ke, i-silodosin ingase ingabangeli isiyezi noma izinguquko zomfutho wegazi, okungaba kubalulekile uma usumdala noma unezifo zenhliziyo.

I-Tamsulosin isitholakala isikhathi eside futhi ivame ukungabizi, ikakhulukazi ngesimo esivamile. Itholakala futhi nasezinhlobonhlobo zokwakheka, okuhlanganisa amaphilisi akhishwa kanye ngosuku okuthile amadoda akuthola kulula.

Udokotela wakho uzocabangela izinto ezinjengezinye izimo zakho zempilo, imithi yamanje, nezintandokazi zomuntu siqu lapho enquma phakathi kwalezi zinketho. Zombili le mithi ivamise ukusebenza, ngakho ukukhetha kuvame ukwehla emiphumeleni emibi ozizwa ukhululekile ukuyilawula.

Imibuzo Evame Ukubuzwa Mayelana ne-Silodosin

Ingabe i-Silodosin iphephile ezigulini zenhliziyo?

I-Silodosin ngokuvamile ithathwa njengephephile emadodeni anezifo zenhliziyo uma iqhathaniswa namanye ama-alpha-blockers ngoba mancane amathuba okuthi abangele ukwehla okukhulu komfutho wegazi. Kodwa-ke, kufanele uxoxe ngesimo senhliziyo yakho nodokotela wakho ngaphambi kokuqala ukwelashwa.

Ukukhetha komuthi kuma-receptors e-prostate kusho ukuthi unethonya elincane enhliziyweni nasemithanjeni yegazi kubantu abaningi. Noma kunjalo, udokotela wakho uzofuna ukukuqapha, ikakhulukazi uma uqala ukuthatha i-silodosin, ukuqinisekisa ukuthi ayihlangani nemithi yakho yenhliziyo noma yenza izimo ezikhona zibe zimbi.

Ngingenzani uma ngiphuthelwa ngengozi ngisebenzisa i-Silodosin eningi kakhulu?

Uma ngengozi uthatha i-silodosin eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma ukulawulwa ngokushesha, ikakhulukazi uma uthathe okuningi kakhulu kunomthamo wakho ovamile. Ukuthatha i-silodosin eningi kakhulu kungabangela isiyezi esikhulu, ukuquleka, noma ukwehla okuyingozi komfutho wegazi.

Ungazami ukuzelapha ngokweqile ngokuthatha eminye imithi noma ukulala uwedwa. Kunalokho, funa usizo lwezokwelapha ngokushesha, ikakhulukazi uma uzizwa unesiyezi, ubuthakathaka, noma sengathi ungaquleka. Kubalulekile ukuba nomuntu ohamba naye ngenkathi uthola usizo lwezokwelapha uma izimpawu zakho ziba zimbi.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Silodosin?

Uma weqa umthamo we-silodosin, yithathe ngokushesha lapho ukhumbula, okungcono ngokudla. Kodwa-ke, uma sekuseduze isikhathi somthamo wakho olandelayo, weqa umthamo owuqegile bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuqegile, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi efana nesiyezi noma umfutho wegazi ophansi. Uma uvame ukukhohlwa imithamo, cabanga ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Ngingayeka Nini Ukuthatha I-Silodosin?

Kufanele uyeke kuphela ukuthatha i-silodosin ngaphansi kwesiqondiso sikadokotela wakho, njengoba ukuyeka imithi cishe kuzobangela ukuthi izimpawu zakho ze-BPH zibuye. Ngokungafani neminye imithi ongayeka ngokuphazima kweso, ngokuvamile kuphephile ukuyeka i-silodosin ngokuzumayo, nakuba izimpawu zakho zingase zibuye phakathi nezinsuku kuya emavikini.

Udokotela wakho angase ancome ukuyeka i-silodosin uma uhlangabezana nemiphumela emibi ekhathazayo, uma izimpawu zakho zithuthuke kakhulu, noma uma ushintshela ekwelashweni okuhlukile. Bazokusiza ukuthi uthuthukise uhlelo lokuphatha izimpawu zakho uma unquma ukuyeka imithi.

Ngingayithatha I-Silodosin Ngeminye Imithi?

I-Silodosin ingasebenzisana neminye imithi eminingi, ngakho-ke kubalulekile ukutshela udokotela wakho ngakho konke okuthathayo, okuhlanganisa imithi etholakala ngaphandle kwe-oda kanye nezithasiselo. Eminye imithi ingakhuphula amazinga e-silodosin egazini lakho, okungenzeka ukuthi ibangele imiphumela emibi eyengeziwe.

Izinto eziqinile ze-CYP3A4 ezifana ne-ketoconazole, i-clarithromycin, kanye neminye imithi ye-HIV ingakwazi ukukhuphula kakhulu amazinga e-silodosin futhi kufanele igwenywe ngokujwayelekile. Udokotela wakho uzobuyekeza yonke imithi yakho ukuze athole noma yikuphi ukuxhumana okungase kube khona futhi kungase kudingeke ukuthi alungise imithamo noma isikhathi sokuthi uthatha nini imithi ehlukene.