Tacrine (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Mayelana naleli khambi
ITacrine isetshenziswa ekwelapheni izimpawu zesifo se-Alzheimer esilula kuya kwesiphakathi. ITacrine ngeke iliphelelise isifo se-Alzheimer, futhi ngeke ilise isifo ekukhuleni. Kodwa-ke, iTacrine ingathuthukisa ikhono lokucabanga kwabanye abantu abanesifo se-Alzheimer. Esifoneni se-Alzheimer, izinguquko eziningi zekhemikhali zenzeka ebuchosheni. Esinye sezinguquko zokuqala nezinkulu kunazo zonke yilokho okungekho umthunywa wekhemikhali obizwa ngokuthi i-acetylcholine (ACh). I-ACh iyasiza ubuchopho ukuba usebenze kahle. ITacrine iyancipha ukubhidlika kwe-ACh, ngakho ingakha futhi ibe nomphumela omkhulu. Kodwa-ke, njengoba isifo se-Alzheimer siqhubeka sibe sibi, kuzoba ne-ACh encane kakhulu, ngakho iTacrine ingase ingasebenzi kahle. ITacrine ingabangela izinkinga zesibindi. Ngesikhathi uthatha leli yomethamo, kufanele ube nezivivinyo zegazi njalo ukuze ubone ukuthi leli yomethamo liyithinta yini isibindi sakho. Lolu yomethamo lwalutholakala kuphela ngesikripthi sedokotela wakho. ITacrine (Cognex®) yasuswa emakethe yase-US ngoMeyi 2012.
Ngaphambi kokusebenzisa leli khambi
Ekwahluleni kokusebenzisa imithi, izingozi zokuthatha imithi kufanele ziqhathaniswe nezinzuzo ezizoletha. Lo ngumqululo owenzayo wena nodokotela wakho. Kule mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqondile noma olukhulu lokungezwani nale mithi noma eminye imithi. Tshela futhi ochwepheshe bakho bezempilo uma uneminye imihlobo yokungezwani, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenaso iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo kule mithi zenziwe kuphela kubantu abadala, futhi alukho ulwazi oluqondile oluqhathanisa ukusetshenziswa kwe-tacrine kubantwana nokuyisebenzisa kwezinye izigaba zezinyanga. Izifundo ze-tacrine zenziwe kuphela kubantu abaneminyaka ephakathi nabadala. Ulwazi ngemiphumela ye-tacrine luqokiwe kulaba ziguli. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthatha le mithi, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma yimiphi imithi ehlongozwayo ngezansi. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yimiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ashintshe ezinye izidakamizwa ozithathayo. Ukusebenzisa le mithi nanoma yimiphi imithi elandelayo ngokuvamile ayinconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili izidakamizwa. Ukusebenzisa le mithi nanoma yimiphi imithi elandelayo kungabangela ukwanda kengozi yezinye izingozi ezibekiwe, kodwa ukusebenzisa kokubili izidakamizwa kungaba ukwelashwa okuhle kuwe. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili izidakamizwa. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi noma eduze kwesikhathi sokudla ukudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshaba ngezinye izidakamizwa kungabangela ukuhlangana. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile ayinconywa, kodwa kungaphephekile kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli leyeza kuphela njengoba kunqunyiwe udokotela wakho. Ungathathi okuningi noma okuncane, futhi ungalithathi ngokukhulu noma ngokuncane njengoba kunqunyiwe udokotela wakho. Ukuthatha okuningi kungase kukhulise amathuba ezingozi ezihambisana naleli leyeza, kuyilapho ukuthatha okuncane kungase kungalungisi isimo sakho. I-Tacrine ithathelwa kangcono isisu singenalutho (ihora elilodwa ngaphambi noma amahora amabili ngemva kokudla). Noma kunjalo, uma leli leyeza likuthukuthelisa isisu, udokotela wakho angase afune ukuthi ulithathe nokudla. Kubonakala sengathi i-Tacrine isebenza kangcono uma ithathelwa ngezikhathi ezilinganiselwe, ngokuvamile izikhathi ezine ngosuku. Inani leli leyeza lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esembolekweni. Ulwazi olulandelayo luhlanganisa kuphela amanani ajwayelekile aleli leyeza. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani leyeza olithathayo lixhomeke emandleni leyeza. Futhi, inani lemithamo olithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwemithamo, nobude besikhathi olithatha leli leyeza kuya ngesimo sezokwelapha osilithatha ngaso. Uma uphuthelwa umthamo waleli leyeza, uthathe ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi somthamo wakho olandelayo, susa umthamo ophuthelwe bese ubuyela esimweni sakho esivamile sokudla. Ungawandisi imithamo. Gcina leli leyeza esitsheni esivaliwe ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungalwi. Gcina ungafinyeleleki ezinganeni. Ungagcini leyeza eliphelile noma leyeza elingasadingeki.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.