Tacrolimus (indlela ye-intravenous)
Imikhiqizo etholakalayo
Prograf
Mayelana naleli khambi
Isikhubekiso seTacrolimus sisetshenziswa ndawonye nezinye izidakamizwa ukuvimbela umzimba ekulahlekweni komthamo oshintshiwe (isib. ikidini, isibindi, inhliziyo, noma uphuphu). Lolu lwemi lwezokwelapha lungasetshenziswa ne-steroids, azathioprine, noma i-mycophenolate mofetil. ITacrolimus iyingxenye yeqembu lemithi ebizwa ngokuthi yi-immunosuppressive agents. Uma isiguli samukela ukuhlinzwa komthamo, amangqamuzana amhlophe egazi azozama ukususa (ukulahla) umthamo oshintshiwe. ITacrolimus isebenza ngokucindezela uhlelo lokulwa nezifo ukuvimbela amangqamuzana amhlophe egazi ekuzameni ukususa umthamo oshintshiwe. ITacrolimus iyilwemi elikhulu kakhulu. Lingabangela imiphumela emibi engaba nzima kakhulu, njengoba kungenzeka kube nezingqinamba zezinkidini. Kungase futhi kunciphisa ikhono lomzimba lokulwa nokutheleleka. Wena nodokotela wakho kufanele nixoxe ngezinzuzo zalolu lwemi kanye nezingozi zokusebenzisa. Lolu lwemi kufanele lunikezwe kuphela yi- noma ngaphansi kokunakekelwa okuqondile kodokotela. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma ukhetha ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokusebenzisa imithi nezinzuzo ezizolethwa yiyo. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma iyiphi impendulo engaqondakali noma ebangelwa uketshezi kule mithi noma kwezinye izidakamizwa. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zoketshezi, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantwana ezingalimi ukusetshenziswa kokudubula i-tacrolimus kubantwana abane-liver, ikidini, inhliziyo, noma ukutshalwa kwezitho. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalimi ukusetshenziswa kokudubula i-tacrolimus kubantu abadala. Kodwa-ke, abantu abadala banesibopho esikhulu sokuba nezinkinga zezinkukhu, isibindi, noma inhliziyo, okungadinga ukuqapha nokulungiswa komthamo kwabaguli abamukela ukudubula i-tacrolimus. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo izidakamizwa ezimbili ezahlukene zingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma wamukele le mithi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlongozwayo ngezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ukushintsha ezinye izidakamizwa ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile ayinconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili izidakamizwa ziyalelwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uzosebenzisa kangaki enye noma zombili izidakamizwa. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo kungabangela ukwanda kengozi yezinye izingozi ezibuhlungu, kodwa ukusebenzisa kokubili izidakamizwa kungaba ukwelashwa okuhle kuwe. Uma kokubili izidakamizwa ziyalelwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uzosebenzisa kangaki enye noma zombili izidakamizwa. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi noma eduze kwesikhathi sokudla ukudla noma ukudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungabangela ukusebenzisana. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile ayinconywa, kodwa kungase kungakhuphuki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uzosebenzisa kangaki le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Umshula wesibeletho noma omunye ochwepheshe bezempilo oqeqeshwe uzohlinzeka ngale miyekezo esibhedlela. Inikezwa ngenhlanzi ebekwe kwenye yezinsizi zakho. Imithi kufanele ihlukaniswe kancane, ngakho-ke i-IV yakho kufanele ihlale isikhathi esingamaminithi angu-30. Uzokwamukela le miyekezo izinsuku ezimbalwa kuphela. Khona-ke udokotela wakho uzokushintshela ekutholeni i-tacrolimus ngomlomo (ngomlomo). Le miyekezo iza ne-insert yolwazi lwabaguli nemiyalelo yabaguli. Funda futhi ulandele imiyalelo ngokucophelela. Buza udokotela wakho uma unemibuzo. Akufanele udle i-grapefruit noma uphuze ijusi le-grapefruit ngenkathi uthola le miyekezo. I-grapefruit nejusi le-grapefruit kuzokwandisa inani lemiyekezo emzimbeni.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.