Yini i-Tafasitamab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Tafasitamab yindlela yokwelapha umdlavuza eqondiswe ngqo ezinhlotsheni ezithile zomdlavuza wegazi. Lo muthi ungowodwa ohlwini lwemithi ebizwa ngokuthi ama-monoclonal antibodies, asebenza njengemishini eqondisiwe ukuthola nokuhlasela amaseli omdlavuza kuyilapho eshiya amaseli anempilo kakhulu.

Uma wena noma othile omkhathalelayo enikezwe i-tafasitamab, cishe unemibuzo eminingi mayelana nokuthi yini ongayilindela. Lo muthi umelele intuthuko ebalulekile ekwelapheni imidlazva ethile yegazi, futhi ukuqonda ukuthi isebenza kanjani kungakusiza uzizwe ulungele uhambo lwakho lokwelashwa.

Yini i-Tafasitamab?

I-Tafasitamab iyi-antibody eyenziwe e-laboratory eqondiswe kuphrotheni ethile etholakala kumaseli athile omdlavuza. Cabanga ngayo njengokhiye okhethekile ovuleka kuphela emakhiyini atholakala kumaseli omdlavuza, okusiza amasosha akho omzimba ukuthi aqaphele futhi abhubhise la maseli ayingozi ngempumelelo.

Umuthi unikezwa nge-IV infusion, okusho ukuthi ulethwa ngqo emgudwini wakho wegazi ngomthambo. Lokhu kuvumela umuthi ukuthi uhambe emzimbeni wakho wonke ukuze ufinyelele kumaseli omdlavuza noma ngabe angase acashe kuphi.

I-Tafasitamab yaziwa nangegama layo lomkhiqizo elithi Monjuvi. Igama eliphelele lamakhemikhali lifaka phakathi

Umuthi wenzelwe abantu abadala abamaseli abo omdlavuza ahlolwa ukuthi aneprotein ebizwa nge-CD19. Ithimba lakho lezokwelapha lizokwenza izivivinyo ezithile ukuqinisekisa ukuthi i-tafasitamab iyindlela efanele yohlobo lwakho oluthile lwe-lymphoma.

Isebenza Kanjani I-Tafasitamab?

I-Tafasitamab isebenza ngokunamathela ku-protein ebizwa nge-CD19 ehlala ngaphezulu kwamaseli athile omdlavuza. Uma inamathiselwe, ithumela amasignali ohlelweni lwakho lomzimba lokuzivikela ukuthi lihlaselwe futhi libhubhise la maseli.

Lo muthi uthathwa njengokwelashwa komdlavuza okuphakathi nendawo. Inamandla ngokwanele ukuthi iqondise ngempumelelo amaseli omdlavuza kodwa ngokuvamile ibangela imiphumela emibi embalwa kunezidakamizwa zokwelapha ngamakhemikhali zendabuko.

Ukwelashwa kusebenza ngezindlela ezimbili eziyinhloko. Okokuqala, ivimba ngokuqondile amasignali asiza amaseli omdlavuza ukuthi asinde futhi ande. Okwesibili, iqasha amaseli akho emvelo okuzivikela emzimbeni ukuthi ajoyine impi yokulwa nomdlavuza.

Kufanele Ngiyithathe Kanjani I-Tafasitamab?

I-Tafasitamab inikezwa kuphela nge-IV infusion endaweni yezokwelapha, ngakho ngeke uthathe lo muthi ekhaya. Ithimba lakho lezempilo lizosingatha konke ukulungiselela nokuphatha kwakho.

Ngaphambi kwe-infusion ngayinye, ngokuvamile uzothola imithi yangaphambi kokwelashwa ukusiza ukuvimbela ukusabela komzimba. Lokhu kungabandakanya ama-antihistamine, izinciphisi zomkhuhlane, noma ama-steroid. Ithimba lakho lezokwelapha lizokuqapha eduze ngesikhathi nangemva kwe-infusion ngayinye.

Akudingeki ukuthi ulandele noma yimiphi imikhawulo ekhethekile yokudla nge-tafasitamab. Nokho, kubalulekile ukuhlala unamanzi kahle ngaphambi nangemva kokwelashwa kwakho. Ithimba lakho lezempilo lingase linikeze imihlahlandlela ethile mayelana nokudla nokuphuza ezinsukwini zokwelashwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Tafasitamab?

Inkambo yokwelashwa ejwayelekile nge-tafasitamab ihlala cishe izinyanga eziyi-12, nakuba lokhu kungahluka ngokuya ngokuthi usabela kahle kangakanani emuthini. Uhlelo lwakho lokwelashwa cishe luzobandakanya ama-infusion njalo emavikini ambalwa ngalesi sikhathi.

Udktela wakho uzohlola njalo inqubekela phambili yakho ngokusebenzisa ukuhlolwa kwegazi kanye nokuskena ngemifanekiso. Lokhu kuhlolwa kusiza ukuthola ukuthi ngabe ukwelashwa kusebenza kahle yini nokuthi ngabe kudingeka yini ukulungiswa.

Isinqumo sokuqhubeka noma ukuyeka ukwelashwa sincike ezintweni eziningana, okuhlanganisa ukuthi umdlavuza uphendula kanjani, yiziphi izimo ezingezinhle ozitholayo, kanye nempilo yakho yonke. Ithimba lakho lezokwelapha lizosebenza eduze nawe ukwenza lezi zinqumo.

Yiziphi Izimo Ezingezinhle Zokwelashwa Nge-Tafasitamab?

Njengazo zonke izindlela zokwelapha umdlavuza, i-tafasitamab ingabangela izimo ezingezinhle, yize abantu abaningi beyibekezelela kahle. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzilungiselele futhi wazi ukuthi ungaxhumana nini nethimba lakho lezempilo.

Izimo ezingezinhle ezivamile ongase uzithole zihlanganisa ukukhathala, okungahluka ekukhathaleni okuncane kuya ekukhathaleni okukhulu. Abantu abaningi baphawula nezinguquko ekubalweni kwegazi labo, okuzohlolwa ithimba lakho lezokwelapha ngokucophelela ngokusebenzisa ukuhlolwa kwegazi okujwayelekile.

Nawa amanye amaphutha avame ukubikwa:

• Ukukhathala nobuthakathaka
• Ukubalwa kwamangqamuzana amhlophe egazi okuphansi (ukwandisa ingozi yokutheleleka)
• Ukubalwa kwamangqamuzana abomvu egazi okuphansi (i-anemia)
• Ukubalwa kwamaphlatelethi okuphansi (okuthinta ukujiya kwegazi)
• Ukuqunjelwa
• Ukuncipha kwesifiso sokudla
• Ukukhwehlela
• Umkhuhlane

Lezi zimo ezingezinhle zivame ukulawuleka ngosizo olufanele lwezokwelapha nokuqapha. Ithimba lakho lezempilo linolwazi lokusiza iziguli ngalezi zinselelo.

Abanye abantu bangase bathole izimo ezingezinhle ezingathi sína kodwa ezingavamile. Lezi zidinga ukunakekelwa kwezokwelapha ngokushesha futhi zihlanganisa ukutheleleka okukhulu, ukopha okukhulu, noma ukusabela okukhulu komzimba ngesikhathi sokufakwa.

Izimo ezingezinhle ezingavamile kodwa ezingathi sína zingahlanganisa:

• Izifo ezinzima ngenxa yesistimu yokuzivikela ebuthakathaka
• I-Tumor lysis syndrome (ukuwohloka okusheshayo kwamaseli omdlavuza)
• Ukuphendula okukhulu komzimba
• I-Progressive multifocal leukoencephalopathy (ukutheleleka kobuchopho okungavamile)
• Ukuvuselelwa kwe-Hepatitis B kubantu abake bahlangabezana nayo

Ithimba lakho lezokwelapha lizobheka ngokucophelela lezi zinkinga ezingavamile futhi lithathe izinyathelo zokuzivimbela uma kungenzeka. Unganqikazi ukubika noma yiziphi izimpawu ezingavamile, kungakhathaliseki ukuthi zincane kangakanani.

Ubani Ongafanele Athathe I-Tafasitamab?

I-Tafasitamab ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi iphephile yini kuwe. Abantu abanezimo ezithile zezokwelapha noma izimo zempilo bangase badinge ukugwema lo muthi noma badinge ukuqashwa okukhethekile.

Akufanele uthole i-tafasitamab uma uke waba nokuphendula okukhulu komzimba kulo muthi noma kunoma iyiphi ingxenye yawo esikhathini esidlule. Udokotela wakho uzophinda aqaphele uma unomlando wokuphendula okukhulu komzimba kwamanye ama-monoclonal antibodies.

Ithimba lakho lezokwelapha lizobheka ngokukhethekile uma unezinye zalezi zimo:

• Ukutheleleka okusebenzayo, ikakhulukazi izifo ezinzima zamagciwane, amagciwane, noma isikhunta
• Umlando wokutheleleka nge-hepatitis B
• Isistimu yokuzivikela ebuthakathaka kakhulu
• Ukukhulelwa noma izinhlelo zokukhulelwa
• Ukuncelisa
• Izidingo zomgomo ophilayo

Uma ukhulelwe noma uhlela ukukhulelwa, lo muthi ungalimaza ingane yakho esakhula. Ithimba lakho lezempilo lizoxoxa ngezindlela zokuvimbela zokuphepha nezinketho zokuhlela umndeni nawe.

Igama Lomkhiqizo Le-Tafasitamab

I-Tafasitamab ithengiswa ngaphansi kwegama lomkhiqizo elithi Monjuvi e-United States. Leli gama lomkhiqizo yilokho ozokubona ngokuvamile emashedyulini akho okwelashwa kanye nemibhalo yomshuwalense.

Umuthi ukhiqizwa yi-MorphoSys futhi uthengiswa ngokubambisana ne-Incyte Corporation. Uma nixoxa ngomuthi wakho nezinkampani zomshuwalense noma abanye abahlinzeki bezempilo, womabili amagama (tafasitamab kanye ne-Monjuvi) abhekisela emuthini ofanayo.

Ezinye Izindlela Zokwelapha i-Tafasitamab

Kunezinketho eziningi zokwelapha i-diffuse large B-cell lymphoma, nakuba ukukhetha okungcono kuncike esimweni sakho esithile. Udokotela wakho uzocabangela izinto ezinjengempilo yakho yonke, ukwelashwa kwangaphambilini, nokuthi umdlavuza wakho usabela kanjani.

Ukwelashwa okuhlukile kungabandakanya izinhlanganisela zokwelapha ngamakhemikhali zendabuko njenge-R-CHOP noma ukwelashwa okusha okuqondiwe. Ukwelashwa kwe-CAR T-cell kumelela enye inketho ethuthukisiwe kwabanye abantu, nakuba idinga izikhungo zezokwelapha ezikhethekile.

Abanye abantu bangazuza ezivivinyweni zomtholampilo ezihlola ukwelashwa okusha okuyisampula. Udokotela wakho we-oncologist angakusiza ukuthi uqonde ukuthi ngabe yiziphi izifundo zocwaningo ezingase zifanele isimo sakho.

Ingabe i-Tafasitamab Ingcono Kune-Rituximab?

I-Tafasitamab ne-rituximab yomibili imithi yokulwa ngamangqamuzana esetshenziselwa ukwelapha imidlavuza yegazi, kodwa isebenza ngezindlela ezehlukile futhi isetshenziswa ezimweni ezehlukene. Ukuqhathanisa akuhlali kuqondile ngoba ngokuvamile zisetshenziswa ezigabeni ezihlukene zokwelashwa.

I-Rituximab itholakala isikhathi eside futhi ngokuvamile isetshenziswa njengengxenye yezinhlanganisela zokwelapha zomugqa wokuqala. I-Tafasitamab ngokuvamile igcinelwe izimo lapho umdlavuza ubuyile noma ungasabelanga kahle ekwelashweni kokuqala.

Udokotela wakho uzokhetha umuthi ofanele kakhulu ngokusekelwe ohlotsheni lwakho oluthile lwe-lymphoma, umlando wakho wokwelashwa, nempilo yakho yonke. Yomibili imithi ifakazelwe ukuthi iyasebenza ekusetshenzisweni kwayo okuhlosiwe, futhi ukukhetha

ITafasitamab ngokuvamile ingasetshenziswa ngokuphepha kubantu abanezifo zenhliziyo, kodwa udokotela wakho wenhliziyo kanye nodokotela we-oncologist kuzodingeka basebenzisane ukuze bakuqaphele ngokucophelela. Umuthi awuqondisi ngqo ezicutshini zenhliziyo, kodwa ukwelashwa komdlavuza ngezinye izikhathi kungathinta impilo yenhliziyo nemithambo yegazi.

Ithimba lakho lezokwelapha cishe lizokwenza izivivinyo zomsebenzi wenhliziyo ngaphambi kokuqala ukwelashwa futhi likuqaphele kuyo yonke inkambo yokwelashwa. Uma unezinkinga ezinkulu zenhliziyo, bangase balungise isimiso sakho sokwelashwa noma banikeze izinyathelo ezengeziwe zokuvikela inhliziyo.

Kufanele ngenzeni uma ngiphuthelwa ngephutha ukufakwa kweTafasitamab?

Njengoba i-tafasitamab inikezwa endaweni yezokwelapha, ukuphuthelwa umthamo kuvame ukwenzeka ngenxa yezingxabano zeshejuli noma izinkinga zempilo. Xhumana nethimba lakho lezempilo ngokushesha uma udinga ukuphuthelwa noma ukuhlehlisa i-aphoyintimenti.

Ithimba lakho lezokwelapha lizokusiza ukuthi uhlehlise kabusha ngokushesha nje lapho kuphephile ukwenza kanjalo. Bangase balungise isimiso sakho sokwelashwa kancane, kodwa kubalulekile ukuthi ungagxumi imithamo ngaphandle kwesiqondiso sezokwelapha, njengoba lokhu kungathinta ukuthi ukwelashwa kwakho kusebenza kahle kangakanani.

Ngingayeka nini ukuthatha i-Tafasitamab?

Isinqumo sokuyeka i-tafasitamab sincike ekutheni umdlavuza wakho usabela kahle kangakanani ekwelashweni nokuthi yiziphi imiphumela emibi oyitholayo. Abantu abaningi baqeda cishe izinyanga eziyi-12 zokwelashwa, kodwa lokhu kungahluka.

Udokotela wakho uzosebenzisa ukuskena okuvamile nokuhlolwa kwegazi ukuze aqaphele inqubekela phambili yakho. Uma umdlavuza unyamalala noma ungatholakali, ungaqeda inkambo yokwelashwa ehleliwe. Uma imiphumela emibi ebalulekile ithuthuka, udokotela wakho angase ancome ukuyeka ngaphambi kwesikhathi futhi ashintshele kwenye indlela.

Ngingakwazi yini ukuthola imithi yokugoma ngenkathi ngithatha i-Tafasitamab?

Kufanele ugweme imithi yokugoma ephilayo ngenkathi uthola i-tafasitamab ngoba umuthi uthinta amasosha akho omzimba. Kodwa-ke, imithi yokugoma engasebenzi (njengomjovo womkhuhlane) ngokuvamile iphephile futhi ivame ukunconywa.

Iqembu lakho lezempilo lizohlinzeka ngesiqondiso esiqondile mayelana nemithi yokugomela ephephile ngesikhathi sokwelashwa kwakho. Bangase batusa ukuthola imithi yokugomela ethile ngaphambi kokuqala i-tafasitamab noma ukulinda kuze kube ngemva kokuqeda ukwelashwa kwakho.

Ingabe i-Tafasitamab Izothinta Ikhono Lami Lokusebenza Noma Ukushayela?

Abantu abaningi bangaqhubeka nokusebenza nokushayela ngenkathi bethola i-tafasitamab, nakuba kungase kudingeke ukuthi wenze izinguquko ezithile. Ukukhathala kuwumphumela ovamile ongase uthinte amazinga akho wamandla nokugxila.

Hlela ukuba nokuguquguquka okuthile esimisweni sakho, ikakhulukazi ezinsukwini zokwelashwa nangosuku olulandelayo ngemva kokufakwa. Abanye abantu bazizwa bekhathele usuku noma ezimbili ngemva kokwelashwa ngakunye, kanti abanye bagcina amazinga abo ajwayelekile wamandla phakathi nenkambo yokwelashwa.