Talazoparib (indaba yokumunca)
Imikhiqizo etholakalayo
Talzenna
Mayelana naleli khambi
ITalazoparib isetshenziswa ekwelapheni lomdlavuza webele oqine kakhulu onga-HER2, ophambili noma osakazekile (umdlavuza osakazekile) onomgudu we-BRCA owohlokayo noma ocindezelwe. Udokotela wakho uzosebenzisa izivivinyo ukuhlola lo mgudu ngaphambi kokuthi uthole le mishini. ITalazoparib isetshenziswa futhi kanye ne-enzalutamide ekwelapheni lomdlavuza we-prostate osakazekile ongapheli amandla, (umdlavuza we-prostate onqabile ukwelashwa ngezindlela zokwelapha noma zokuthunga eziphansi i-testosterone futhi usakazekile ezingxenyeni zomzimba) ngezinye i-genes ezingezona eziwumndeni noma ezitholiwe ebizwa ngokuthi yi-homologous recombination repair (HRR genes). Udokotela wakho uzosebenzisa izivivinyo ukuhlola lo mgudu ngaphambi kokuthi uthole le mishini. Lolu lwemi lapho lutholakala kuphela ngesikripthi sodokotela wakho. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekucatshangeni kokusebenzisa imithi, okuyingozi kokusebenzisa imithi kumele kuqhathaniswe nezinzuzo ezizokwenzeka. Lo ngumqulu ozowenza wena nodokotela wakho. Kule mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nokuthile okungavamile noma ukuqabuka okungavamile kule mithi noma kwezinye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubudlelwano bokuphila nokuthinta kwe-talazoparib kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingawumisa ukusetshenziswa kwe-talazoparib kubantu abadala. Noma kunjalo, abantu abadala banesizotha kakhulu ekuthinteni kwale mithi kunabantu abadala abasebancane. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokusebenzisa le mithi ngesikhathi sokuncelisa. Nakuba ezinye imithi akumele isetshenziswe ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha kungadingeka. Uma uthatha le mithi, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma yimiphi imithi ehlwini elingezansi. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yimiphi imithi elandelayo ngokuvamile akusikholisi, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Ezinye imithi akumele isetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshaba nanoma yimiphi imithi kungabangela ukuhlangana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Imithi ebizwa ngokuthi i-anticancer inamandla kakhulu futhi ingaba nemiphumela eminingi emibi. Ngaphambi kokuthola le mithi, qiniseka ukuthi uyayiqonda yonke imingcele nezinzuzo. Kubalulekile ukusebenzisana eduze nodokotela wakho phakathi nokwelashwa kwakho. Thatha le mithi ngokuqondile njengoba udokotela wakho ekutshele. Ungayithathi ngaphezulu, ungayithathi kaningi, futhi ungayithathi isikhathi eside kunalokho udokotela wakho akuyalile. Ukwenza kanjalo kungandisa amathuba emiphumela emibi. Le mithi iza nephephapheshe eliqukethe ulwazi lwabaguli. Funda futhi ulandele lezi zinkomba ngokucophelela. Buza udokotela wakho uma unemibuzo. Ngokuphathelene nomdlavuza wesibindisi: Kufanele uthole nokwelashwa kwe-gonadotropin-releasing hormone (GnRH) analog noma ube nokuhlinzwa kokunciphisa i-testosterone emzimbeni wakho (ukusika ngokuhlinzwa) phakathi kokwelashwa ngale mithi. Ungayithatha le mithi ngokudla noma ngaphandle kokudla. Gwinya ikhaphsuli yonke. Ungayivuli, ungayiqhekeza, ungayaphula, noma ungayichithe. Inani lemithi lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela amanani aphakathi ale mithi. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani lemithi oyithatha lixhomeke emandleni emithi. Futhi, inani lemithi oyithatha nsuku zonke, isikhathi esivunyelwe phakathi kwemithi, nobude besikhathi oyithatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi. Uma uphuthelwa yidosi yale mithi, tshela le dosi oyiphothile bese ubuyela esimweni sakho sokuthatha imithi. Ungawandisi amanani. Uma uhlanza ngemuva kokuthatha i-dose, ungayithathi i-dose eyengeziwe. Gcina imithi esitsheni esivalekile ekamelweni lokushisa, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungayivumeli ukuba iqhube. Gcina ingafinyeleleki kubantwana. Ungagcini imithi esele iphelile noma imithi engasadingeki. Buza ochwepheshe bezempilo ukuthi kufanele uyilahla kanjani noma iyiphi imithi ongayisebenzisi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.