Yini i-Talimogene Laherparepvec: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Talimogene laherparepvec iyindlela yokwelapha umdlavuza eshintsha umhlaba esebenzisa igciwane le-herpes elishintshiwe ukulwa ne-melanoma. Le ndlela yokwelapha entsha isebenza ngokuthelela amaseli omdlavuza futhi isize amasosha akho omzimba ukuba aqaphele futhi awabhubhise ngempumelelo.

Ungase uzizwe ukhungathekile ngokuqonda ngale ndlela yokwelapha, futhi lokho kuqondakala ngokuphelele. Ake sihambe kukho konke okudingeka ukwazi ngale mithi ngamagama acacile, alula ukuze uzizwe uqiniseka kakhulu ngohambo lwakho lokwelashwa.

Yini i-Talimogene Laherparepvec?

I-Talimogene laherparepvec iyindlela yokwelapha ngegciwane le-oncolytic, okusho ukuthi iyindlela yokwelapha esebenzisa amagciwane ukulwa nomdlavuza. Le mithi iqukethe igciwane le-herpes simplex elishintshiwe elakhiwe ukuba liphephe ekwelapheni umdlavuza.

Igciwane elikule mithi lihlukile ku-herpes obangela izilonda ebandayo. Ososayensi baye balishintsha ngokucophelela ukuze likwazi ukukhula ngaphakathi kwamaseli omdlavuza kuphela, hhayi amaseli anempilo. Lapho igciwane lithelela amaseli e-melanoma, libangela ukuba awohloke futhi likhiphe izinto eziqwashisa amasosha akho omzimba ukuba ahlasele umdlavuza.

Le ndlela yokwelapha imelela indlela entsha yokunakekelwa komdlavuza ebizwa ngokuthi i-immunotherapy. Esikhundleni sokusebenzisa amakhemikhali noma imisebe ukuze kubulale amaseli omdlavuza ngokuqondile, isebenza ngohlelo lwakho lokuzivikela lomzimba lwemvelo ukulwa nalesi sifo.

Isetshenziselwani i-Talimogene Laherparepvec?

Le mithi ivunyelwe ngokuqondile ukwelapha i-melanoma esabalale kuma-lymph nodes akho noma ezinye izingxenye zesikhumba sakho kodwa engakafinyeleli ezithweni zakho zangaphakathi. Udokotela wakho uzokuncoma kuphela le ndlela yokwelapha uma i-melanoma yakho ingakhishwa ngokuphelele ngokuhlinzwa.

Ukwelashwa kusebenza kahle kakhulu lapho umdlavuza usagxile ezindaweni ezingajovwa ngokuqondile. Udokotela wakho we-oncologist uzohlola ngokucophelela ukuthi uhlobo lwakho oluthile nesigaba se-melanoma kukwenza yini ukuba ube ngumuntu ofanelekayo ngale ndlela yokwelapha.

Ngesinye isikhathi odokotela bangase bacabange ngale ndlela yokwelapha ezinye izinhlobo zomdlavuza emithwalweni yezokwelapha, kodwa i-melanoma isahlala iyona esetshenziswa kakhulu. Ithimba lakho lezokwelapha lizoxoxa ukuthi lokhu kuyahambisana yini nesimo sakho esithile.

Isebenza Kanjani I-Talimogene Laherparepvec?

Lo muthi usebenza ngenqubo yezinyathelo ezimbili ehluke kakhulu ekwelashweni komdlavuza okujwayelekile. Okokuqala, igciwane elishintshiwe linamathisela emangqamuzaneni akho e-melanoma futhi libangele ukuthi ahlukane, okubhubhisa ngokuqondile amanye amaseli omdlavuza.

Isinyathelo sesibili yilapho amandla angempela elele khona. Njengoba amaseli omdlavuza ewohloka, akhipha izingcezu zawo kanye nezinto ezisebenza njengama-alamu ohlelweni lwakho lomzimba lokuzivikela. Lokhu kusiza izivikelo zomzimba wakho zemvelo ukuthi zibone amaseli omdlavuza njengokusongela okudingeka ukuba kuwohlwe.

Cabanga ngakho njengokufundisa uhlelo lwakho lomzimba lokuzivikela ukuthi lube yiqhawe elingcono lomdlavuza. Ukwelashwa empeleni kwenza umdlavuza wakho ube yindawo yokuqeqesha lapho amaseli akho omzimba wokuzivikela afunda khona ukubona nokubhubhisa amaseli e-melanoma emzimbeni wakho wonke.

Lokhu kuthathwa njengokwelashwa okuhloswe ngakho ngoba kufuna ngqo amaseli omdlavuza kuyilapho kushiya amaseli akho anempilo ewedwa. Igciwane elishintshiwe alikwazi ukuzala ngaphakathi kwamaseli ajwayelekile, anempilo, okwenza liphephe kakhulu kunokusebenzisa igciwane elivamile.

Kufanele Ngiyithathe Kanjani I-Talimogene Laherparepvec?

Lo muthi unikezwa njengomjovo ngqo ezilondeni zakho ze-melanoma, hhayi njengepilisi noma nge-IV. Udokotela wakho uzosebenzisa inaliti encane ukujova umuthi ngqo ezindaweni zomdlavuza ezingafinyelelwa ngokuphepha.

Uzothola ukwelashwa kwakho kokuqala ehhovisi likadokotela wakho noma esikhungweni sokwelapha. Inqubo yokujova ngokwayo ivame ukuthatha imizuzu embalwa nje, yize kungase kudingeke uhlale ukuze ubukwe ngemva kwalokho ukuze uqiniseke ukuthi uzizwa kahle.

Ithimba lakho lezempilo lizohlanza indawo yokujova ngokucophelela ngaphambi kokwelashwa ngakunye. Akudingeki ukuthi wenze lutho olukhethekile ukulungiselela, njengokuzila ukudla noma ukuthatha eminye imithi ngaphambi kwesikhathi. Vele ugqoke izingubo ezikhululekile ezivumela ukufinyelela kalula ezindaweni ezelashwayo.

Ngemva kokujova, udokotela wakho uzomboza indawo ezelashwayo ngobhandishi noma ukugqoka. Uzothola imiyalelo ethile mayelana nokugcina indawo ihlanzekile futhi yomile izinsuku ezimbalwa ezilandelayo.

Kufanele Ngithathe Isikhathi Esingakanani I-Talimogene Laherparepvec?

Uhlelo lokwelashwa ngokuvamile luqala ngokujova kokuqala, kulandelwe ukujova kwesibili emavikini amathathu kamuva. Ngemva kwalokho, ngokuvamile uzothola imijovo njalo emavikini amabili kuze kube izinyanga eziyisithu, nakuba lokhu kungahluka ngokuya ngendlela ozabela ngayo.

Udokotela wakho uzoqapha intuthuko yakho ngokucophelela ngesikhathi sokwelashwa. Bazobheka ukuthi amathumba akho asabela kanjani nokuthi uziqeda kahle kangakanani imijovo. Abanye abantu bangase badinge ukwelashwa izinyanga eziyisithu, kanti abanye bangase baqede ngaphambi kwesikhathi.

Inani eliphelele lemijovo ozolidinga lincike ezintweni eziningana. Lokhu kuhlanganisa usayizi nenani lamathumba akho, indlela asabela ngayo ekwelashweni, nokuthi ngabe uhlangabezana nanoma yimaphi imiphumela emibi edinga ukulungiswa kohlelo lwakho.

Ithimba lakho lezokwelapha lizohlola njalo ukuthi ngabe ukuqhubeka nokwelashwa kuyakuzuzisa yini. Bazolinganisela izinzuzo ezingaba khona ngokumelene nanoma yimiphumela emibi ongase uhlangabezane nayo.

Yiziphi Imiphumela Emibi ye-Talimogene Laherparepvec?

Abantu abaningi bahlangabezana nemiphumela emibi ethile ngalokhu kwelashwa, kodwa ngokuvamile iyaphathwa futhi yesikhashana. Imiphumela emibi evame kakhulu yenzeka endaweni yokujova futhi ihlanganisa ubuhlungu, ukuvuvukala, nobubomvu lapho kuthathwe khona imithi.

Nansi imiphumela emibi ongase uhlangabezane nayo, futhi kubalulekile ukwazi ukuthi ukuba nalezi zindlela zokuphendula ngokuvamile kusho ukuthi ukwelashwa kuyasebenza njengoba kuhloswe:

• Ukukhathala okungahlala izinsuku eziningana ngemuva komjovo ngamunye
• Ukuqhaqhazela nomkhuhlane, ikakhulukazi emahoreni angama-24 okuqala
• Isicanucanu noma ukuzizwa ungaphilile ngokujwayelekile
• Ikhanda elivame ukusabela kahle emithini yokwelapha ubuhlungu etholakala ngaphandle kwemvume kadokotela
• Ukulimala kwemisipha okufana nezimpawu zomkhuhlane
• Ukusabela endaweni yokujova njengokulimala noma ukuzwela

Lezi zimpawu ngokuvamile zithuthuka ezinsukwini ezimbalwa futhi zivame ukuba ngaphansi uma ukwelashwa okulandelayo njengoba umzimba wakho ujwayela imithi.

Abanye abantu bangase babe nemiphumela emibi kakhulu edinga ukunakekelwa kwezempilo ngokushesha. Xhumana nethimba lakho lezempilo ngokushesha uma uba nezimpawu ezinzima ezinjengomkhuhlane, izimpawu zokutheleleka endaweni yokujova, noma yiziphi izimpawu ezingavamile ezikukhathazayo.

Ngokuvamile, abanye abantu bangase babe nokusabela komzimba okuthinta ezinye izingxenye zomzimba wabo. Udokotela wakho uzokuhlola ngokucophelela nganoma yiziphi izimpawu zalokhu futhi uzokwazi ukuthi angayiphatha kanjani uma kwenzeka.

Ubani Ongafanele Athole I-Talimogene Laherparepvec?

Lokhu kwelashwa akulungelwe wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukutusa. Abantu abanezinhlelo zokuzivikela ezibuthakathaka ngokuvamile abakwazi ukuthola lokhu kwelashwa ngokuphepha.

Akufanele uthole lo muthi uma ukhulelwe noma uncelisa, njengoba imiphumela ezinganeni ezisakhulayo ingaziwa ngokugcwele. Udokotela wakho uzoxoxa ngezindlela zokulawula inzalo ezisebenzayo uma uneminyaka yokuzala.

Abantu abanezifo ezisebenzayo, ikakhulukazi izifo ze-herpes, bangase badinge ukulinda kuze kube yilapho lezi zinto zicacile ngaphambi kokuqala ukwelashwa. Uhlelo lwakho lokuzivikela emzimbeni ludinga ukuba luqine ngokwanele ukuze luphathe ukwelashwa ngempumelelo.

Labo abathatha imithi ecindezela kakhulu uhlelo lokuzivikela emzimbeni kungenzeka bangabi ngabantu abafanelekayo. Lokhu kuhlanganisa abantu abaye bathola ukufakelwa kwezitho noma abathatha imithamo ephezulu yama-steroids kwezinye izimo.

Udktora wakho uzobheka nokuthi i-melanoma yakho isisabalale yini ezingxenyeni zangaphakathi zomzimba, njengoba lokhu kwelashwa kusebenza kahle kakhulu lapho amathumba engajovwa ngqo.

Igama Lomkhiqizo le-Talimogene Laherparepvec

Lo muthi uthengiswa ngaphansi kwegama lomkhiqizo elithi Imlygic. Ungase ulubone leli gama emabhodleleni akho kadokotela, emaphepheni omshwalense, noma emadokhumentini okuhlela ukwelashwa.

I-Imlygic yigama lomkhiqizo elilodwa kuphela lalo muthi njengamanje. Njengoba lokhu kuyindlela ekhethekile yokwelapha umdlavuza, itholakala kuphela ngezikhungo ezithile zezempilo ezinolwazi ngalolu hlobo lokwelapha.

Ithimba lakho le-oncology lizosingatha uku-oda nokuphatha i-Imlygic, ngakho ngeke kudingeke ukuthi uyilande ekhemisi elivamile njengeminye imithi.

Ezinye Izindlela Zokwelapha ze-Talimogene Laherparepvec

Kukhona ezinye izindlela zokwelapha i-melanoma, nakuba ngalinye lisebenza ngendlela ehlukile futhi lingase lifanele izimo ezihlukene. Udokotela wakho we-oncologist uzobheka icala lakho elithile lapho exoxa ngezindlela ezingenye.

Eminye imithi yokwelapha ngomzimba efana ne-pembrolizumab noma i-nivolumab isebenza ngokuvimba amaprotheni avimbela amasosha akho omzimba ekuhlaseleni amaseli omdlavuza. Lezi zinikezwa ngokufakwa kwe-IV kunokuthi kujovwe ngqo emathunjini.

Ukwelashwa kwendabuko njengokuhlinzwa, ukwelashwa ngemisebe, noma i-chemotherapy kungase kube izinketho kuye ngendawo nesigaba se-melanoma yakho. Abanye abantu bathola inhlanganisela yokwelashwa okuhlukene ukuze bathole imiphumela engcono kakhulu.

Imithi yokwelapha eqondiwe evimba amaprotheni athile kumaseli omdlavuza imele enye indlela. Lezi ngokuvamile amaphilisi athathwa nsuku zonke futhi asebenza kahle kuma-melanomas anezinguquko ezithile zofuzo.

Ithimba lakho lezempilo lizochaza ukuthi yiziphi ezinye izindlela ezingase zisebenze kangcono esimweni sakho esithile futhi zikusize uqonde izinzuzo nobubi benketho ngayinye.

Ingabe i-Talimogene Laherparepvec Ingcono Kunezinye Izindlela Zokwelapha i-Melanoma?

Le nyango inikeza izinzuzo eziyingqayizivele ezigulini ezithile, kodwa ukuthi "ingcono" kuncike esimweni sakho ngasinye. Ngokungafani nokwelashwa okuhlelekile okuthinta umzimba wakho wonke, le therapy iqondisa ngqo izimila ngenkathi kungenzeka idale izimpendulo ezibanzi zokuzivikela komzimba.

Kubantu abane-melanoma engajovwa ngqo, lokhu kwelashwa kungase kubangele imiphumela emibi embalwa kunezinye izindlela zokwelapha umzimba. Imiphumela emibi ivame ukuba yendawo futhi ilawuleke kalula uma iqhathaniswa nokwelashwa okuthinta uhlelo lwakho lonke.

Nokho, lokhu kwelashwa kusebenza kuphela ku-melanoma engakaze isakazekele ezingxenyeni zangaphakathi. Ezinye izindlela zokwelapha umzimba noma ukwelashwa okuqondiwe kungase kufaneleke uma umdlavuza wakho usakazeke kakhulu.

Ukwelashwa okungcono kakhulu kuwe kuncike ezintweni eziningi ezihlanganisa isigaba somdlavuza wakho, indawo, izici zofuzo, nempilo yakho yonke. Udokotela wakho we-oncologist uzokusiza ukuthi ulinganise lezi zinto ukuze wenze isinqumo esingcono kakhulu esimweni sakho esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Talimogene Laherparepvec

Ingabe i-Talimogene Laherparepvec iphephile kubantu abanesifo sikashukela?

Ukuba nesifo sikashukela akukuvimbeli ngokuzenzakalelayo ukuthi uthole lokhu kwelashwa, kodwa udokotela wakho uzodinga ukukuqapha eduze. Abantu abanesifo sikashukela bangase babe nengozi ephezulu yokutheleleka noma ukuphola kancane ezindaweni zokujova.

Ithimba lakho lezempilo lizosebenza nawe ukuze ligcine amazinga kashukela egazini lakho elawulwa kahle ngesikhathi sokwelashwa. Ukuphathwa okuhle kwesifo sikashukela kungasiza ekunciphiseni ingozi yakho yezinkinga futhi kuthuthukise ikhono lomzimba wakho lokuphola ngemva kokujova.

Ngingenzani uma ngithinta ngengozi indawo yokujova?

Uma ngengozi uthinta indawo ewelashwe, geza izandla zakho kahle ngensipho namanzi ngokushesha. Umuthi uqukethe igciwane eliguquliwe, ngakho ukuhlanzeka okuhle kusiza ukuvimbela noma iyiphi ingozi engokwemvelo yokusabalalisa kwabanye.

Gwema ukuthinta indawo yokujova ngokungadingekile futhi uyigcine imbozwe ngendwangu yokugqoka eqhutshwa ithimba lakho lezempilo. Uma ibhandishi likhishwa noma limanzi, xhumana nesikhungo sakho sokwelapha ukuze uthole isiqondiso sokuthi ungahlanzeka kanjani kahle futhi umboze kabusha le ndawo.

Kufanele Ngenzeni Uma Niphuthelwa Ukujova Okuhleliwe?

Xhumana nethimba lakho lezempilo ngokushesha ngangokunokwenzeka uma uphuthelwa ukwelashwa okuhleliwe. Bazokusiza ukuthi uhlele kabusha futhi banqume ukuthi ngabe kukhona yini ukulungiswa ohlelweni lwakho lokwelapha okudingekayo.

Ungazami ukwenza izidakamizwa eziphuthelwe ngokuhlela ukwelashwa eduze. Udokotela wakho udinga ukugcina isikhala esifanele phakathi kokujova ukuze ukwelashwa kusebenze ngempumelelo nangokuphepha.

Ngingayeka nini ukuthatha i-Talimogene Laherparepvec?

Udokotela wakho uzonquma ukuthi ungaleka nini ukwelashwa ngokususelwa ekutheni amatumo akho aphendula kanjani nokuthi uzibekezelela kahle kangakanani ukujova. Abantu abaningi bathola ukwelashwa izinyanga eziyisithupha, kepha lokhu kungahluka.

Ungayeka ngaphambi kwesikhathi uma amatumo akho enyamalala ngokuphelele noma uma uhlangabezana nemiphumela emibi eyenza ukuqhubeka nokwelashwa kungaphephile. Ithimba lakho lezempilo lizobheka intuthuko yakho ngokucophelela futhi lixoxe nganoma yiziphi izinguquko ohlelweni lwakho lokwelapha nawe.

Ngingahamba yini ngesikhathi sokwelashwa?

Ngokuvamile ungaqhubeka nokuhamba phakathi kokwelashwa, kepha kubalulekile ukuhlela ngokucophelela ngeshejuli yakho yokujova. Qiniseka ukuthi uzobuya ngesikhathi sokuqokwa kwakho okulandelayo nokuthi unokufinyelela ekunakekelweni kwezempilo uma uba nanoma yiziphi izimpawu ezikhathazayo ngenkathi ungekho.

Yazisa ithimba lakho lezempilo nganoma yiziphi izinhlelo zokuhamba, ikakhulukazi uma uya endaweni engenza kube nzima ukuthola ukunakekelwa kwezempilo ngokushesha. Bangakunikeza isiqondiso sokuthi yini okufanele uyibheke nokuthi ungayiphatha kanjani imiphumela emibi engase yenzeke ngenkathi ungekho.