Yini i-Tapinarof: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Tapinarof iyikhambi elisha elisetshenziswa ngaphandle elisiza ukwelapha i-psoriasis ye-plaque ngokusebenza ngendlela ehlukile kunezindlela zokwelapha zendabuko. Liyi-cream oyigcoba ngqo ezindaweni zesikhumba ezithintekile, futhi ingeyeqembu lemithi ebizwa ngokuthi ama-aryl hydrocarbon receptor agonists. Le mithi inikeza ithemba kubantu abafuna enye indlela kuma-cream e-steroid noma abangazange baphumelele ngezinye izindlela zokwelapha i-psoriasis.

Yini i-Tapinarof?

I-Tapinarof iyi-cream esetshenziswa ngaphandle engeyona i-steroidal eyenzelwe ngqo ukwelapha i-psoriasis ye-plaque kubantu abadala. Ngokungafani nama-cream e-steroid anganciphisa isikhumba sakho ngokuhamba kwesikhathi, i-tapinarof isebenza ngendlela ehluke ngokuphelele engathwali izingozi ezifanayo zesikhathi eside.

Lo muthi wagunyazwa yi-FDA ngo-2022, okwenza kube enye yezinketho ezintsha ezitholakalayo zokwelapha i-psoriasis. Itholakala emuthini wemvelo otholakala emabhaktheriya, kodwa inguqulo esetshenziswa emithini yenziwa emalebhu ukuqinisekisa ukuhlanzeka nokusebenza kahle.

Uzothola i-tapinarof itholakala njenge-cream engu-1% eza ngamashubhu osayizi abahlukene. I-cream inokubukeka okubushelelezi, okumhlophe futhi isakazeka kalula esikhumbeni sakho ngaphandle kokushiya insali enamafutha.

Yini i-Tapinarof Esizwa Ngayo?

I-Tapinarof isetshenziswa ikakhulukazi ukwelapha i-psoriasis ye-plaque, okuyindlela ejwayelekile ye-psoriasis ethinta izigidi zabantu emhlabeni jikelele. I-Plaque psoriasis idala izindawo eziphakanyisiwe, ezibomvu ezimbozwe ngamakala esiliva angavela noma yikuphi emzimbeni wakho.

Lo muthi usebenza kahle kakhulu ku-psoriasis ye-plaque elula kuya kwemaphakathi. Udokotela wakho angase ancome i-tapinarof uma unezindawo ze-psoriasis ezindaweni ezinjengamathanga akho, amadolo, isikhumba sekhanda, noma ezinye izingxenye zomzimba ezingazange zithuthuke kahle kwezinye izindlela zokwelapha.

Abanye odokotela baphinda banikeze i-tapinarof uma iziguli zifuna ukugwema ukusebenzisa ama-steroid isikhathi eside. Njengoba ingeyona i-steroid, ungayisebenzisa isikhathi eside ngaphandle kokukhathazeka ngokuncipha kwesikhumba noma eminye imiphumela emibi ehlobene nama-steroid.

Isebenza Kanjani I-Tapinarof?

I-Tapinarof isebenza ngokuvula into ebizwa ngokuthi i-aryl hydrocarbon receptor emangqamuzaneni esikhumba sakho. Le receptor isebenza njengokushintsha okusiza ukulawula ukuvuvukala futhi ikhuthaze ukukhula okujwayelekile kwamangqamuzana esikhumba.

Lapho i-psoriasis ivutha, amangqamuzana esikhumba sakho azala ngokushesha kakhulu futhi akhe amachashazi aqinile, anesikali. I-Tapinarof isiza ukunciphisa lokhu kukhula kwamaselula okusheshayo ngenkathi kunciphisa ukuvuvukala okubangela ububomvu nokucasuka.

Umuthi uthathwa njengomuthi oqinile ngokulinganisela kodwa othambile kunezindlela eziningi zokwelapha i-psoriasis ezinqunyiwe. Ngokuvamile kuthatha amasonto amaningana ukukhombisa imiphumela yawo egcwele, ngakho ukubekezela kubalulekile lapho uqala le mithi.

Kufanele Ngiyithathe Kanjani I-Tapinarof?

Gcobisa ukhilimu we-tapinarof kanye ngosuku ezindaweni ezithintekile zesikhumba sakho, okungcono ngesikhathi esifanayo nsuku zonke. Akudingeki ukuthi uyithathe nokudla noma amanzi ngoba igcotshwa ngqo esikhumbeni sakho.

Nansi indlela yokusebenzisa i-tapinarof ngendlela efanele:

1. Geza izandla zakho kahle ngaphambi kokugcoba ukhilimu
2. Hlanza indawo yesikhumba ethintekile ngobumnene bese uyomisa
3. Gcobisa ungqimba oluncane lukakhilimu ukuze umboze amachashazi e-psoriasis ngokuphelele
4. Gcobisa ukhilimu ngobumnene kuze kube yilapho unyamalala esikhumbeni sakho
5. Geza izandla zakho futhi ngemva kokugcoba ngaphandle uma welapha izandla zakho

Ungagcobisa i-tapinarof kufika ku-20% wendawo yomzimba wakho. Ungasebenzisi ukhilimu omningi kunokunconyiwe, ngoba lokhu ngeke kukwenze kusebenze ngokushesha futhi kungase kwandise ingozi yakho yemiphumela emibi.

Ukhilimu usebenza kahle uma ugcotshwa esikhumbeni esihlanzekile, esomile. Akudingeki ukuthi ugweme ukudla ukudla okuthile noma uthathe noma yiziphi izinyathelo zokuphepha ezikhethekile ngokudla ngoba i-tapinarof igcotshwa ngqo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Tapinarof?

Abantu abaningi basebenzisa i-tapinarof izinyanga eziningana ukuze babone ukuthuthuka okukhulu ezimpawini zabo ze-psoriasis. Izifundo zomtholampilo zakhombisa ukuthi iziguli eziningi zathola izinzuzo eziphawulekayo ngemuva kwamasonto angu-12 okusetshenziswa nsuku zonke.

Udkt wakho cishe uzoncoma ukusebenzisa i-tapinarof okungenani izinyanga ezi-3 kuya kwezi-6 ukuyinika isikhathi sokusebenza ngempumelelo. Abanye abantu bangase badinge ukuyisebenzisa isikhathi eside, kuye ngokuthi isikhumba sabo sisabela kanjani ekwelashweni.

Ngokungafani nama-steroid creams adinga ukuphumula ukuze avimbele imiphumela emibi, i-tapinarof ingasetshenziswa ngokuqhubekayo isikhathi eside. Udkt wakho uzoqapha inqubekela phambili yakho futhi angase alungise uhlelo lwakho lokwelashwa ngokusekelwe ekutheni isikhumba sakho sithuthuka kangakanani.

Yini Imiphumela Eceleni Ye-Tapinarof?

Abantu abaningi bayayibekezelela kahle i-tapinarof, kodwa njenganoma imuphi umuthi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathí sina ayivamile ngalesi sithako esisetshenziswa ngaphandle.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa:

• Ukuvuvukala kwesikhumba noma ububomvu endaweni yokusebenzisa
• Ukuluma noma ukusha lapho kuqala ukusetshenziswa
• Isikhumba esomile ezindaweni eziphathwayo
• Ukushaya okuncane okuvame ukuthuthuka ngokuhamba kwesikhathi
• I-Folliculitis (amaqhubu amancane azungeze ama-follicles ezinwele)

Le miphumela emibi ngokuvamile imnene futhi ivame ukuthuthuka njengoba isikhumba sakho sijwayela umuthi. Abantu abaningi bathola ukuthi noma yikuphi ukuvuvukala kokuqala kuyancipha ngemuva kwamasonto ambalwa okuqala ukusetshenziswa.

Imiphumela emibi engavamile kodwa engathi sína ingahlanganisa ukusabela okukhulu komzimba. Uma uthola ukuqubuka okusabalale kabanzi, ubunzima bokuphefumula, noma ukuvuvukala kobuso bakho, izindebe, noma umphimbo, funa usizo lwezokwelapha ngokushesha.

Abanye abantu bangase bathuthukise i-contact dermatitis, ebangela ukuvuvukala kwesikhumba okukhulu kunokujwayelekile. Lokhu akuvamile kodwa kudinga ukuyeka umuthi futhi uthintane nodkt wakho ukuze uthole ezinye izindlela zokwelashwa.

Ubani Ongafanele Athathwe I-Tapinarof?

I-Tapinarof ayifaneleki kuwo wonke umuntu, nakuba abantu abadala abaningi abane-psoriasis ye-plaque bengayisebenzisa ngokuphepha. Kufanele ukugweme lo muthi uma unokungezwani komzimba ne-tapinarof noma yiziphi izithako ezikukhilimu.

Izingane ezingaphansi kweminyaka engu-18 ubudala akufanele zisebenzise i-tapinarof njengoba izifundo zingakawuqinisekisi ukuphepha nokusebenza kwayo ezigulini ze-pediatric. Abesifazane abakhulelwe kufanele baxoxe ngezingozi nezinzuzo nodokotela wabo ngaphambi kokusebenzisa lo muthi.

Abantu abanezimo ezithile zesikhumba ezenza bazwele kakhulu emithini esetshenziswa esikhumbeni kungenzeka badinge ukugwema i-tapinarof. Udokotela wakho angasiza ekutholeni ukuthi lo muthi ulungele isimo sakho esithile.

Amagama Omkhiqizo we-Tapinarof

I-Tapinarof ithengiswa ngaphansi kwegama lomkhiqizo elithi Vtama e-United States. Leli okwamanje yilo kuphela igama lomkhiqizo elitholakalayo lalo muthi, njengoba liselisha emakethe.

I-Vtama iqukethe i-1% ye-tapinarof njengesithako esisebenzayo. Lo khilimu uza ngamashubhu angu-30-gram kanye nama-60-gram, kuye ngokuthi udinga ukwelapha indawo yesikhumba engakanani.

Izinhlobo ze-generic ze-tapinarof azikatholakali okwamanje njengoba lo muthi usavikelwe ngamalungelo obunikazi. Lokhu kusho ukuthi i-Vtama iyona kuphela inketho yakho yokuthola ukwelashwa kwe-tapinarof njengamanje.

Ezinye Izindlela Zokwelapha i-Tapinarof

Eminye imithi eminingi esetshenziswa esikhumbeni ingelapha i-psoriasis ye-plaque uma i-tapinarof ingasebenzi kuwe noma ingafaneleki. Lezi ezinye izindlela zokwelapha zisebenza ngezindlela ezihlukene futhi zingaba izinketho ezingcono kuye ngezidingo zakho ezithile.

Ama-corticosteroids asetshenziswa esikhumbeni ahlala eyimithi evame ukunqunywa kakhulu yokwelapha i-psoriasis. Lokhu kufaka phakathi imithi efana ne-clobetasol, i-betamethasone, ne-triamcinolone, ehlisa ukuvuvukala ngokushesha kodwa idinga ukuqashwa ngokucophelela ekusetshenzisweni kwesikhathi eside.

Ama-analogs e-Vitamin D afana ne-calcipotriene (Dovonex) anikeza enye inketho engeyona i-steroid. Le mithi isiza ukujwayela ukukhula kwamaseli esikhumba futhi ingasetshenziswa isikhathi eside ngaphandle kwezingozi ezihambisana nama-steroids.

Ezinye izindlela ezintsha zihlanganisa i-roflumilast (Zoryve), elinye elingelona i-steroid elithuthukiswayo elisebenza ngokuvimbela i-enzyme ebizwa nge-PDE4. Lo muthi wagunyazwa cishe ngesikhathi esifanayo ne-tapinarof futhi unikeza izinzuzo ezifanayo.

Ingabe i-Tapinarof Ingcono Kune-Clobetasol?

I-Tapinarof ne-clobetasol zisebenza ngendlela ehlukile futhi zinezinzuzo ezihlukene kuye ngesimo sakho. I-Clobetasol iyi-steroid enamandla kakhulu ethuthukiswayo esebenza ngokushesha kodwa inezingozi eziningi zesikhathi eside.

I-Clobetasol ngokuvamile ibonisa imiphumela phakathi kwezinsuku kuya emavikini, kuyilapho i-tapinarof ingathatha amasonto amaningana kuya ezinyangeni ukuze isebenze ngokugcwele. Kodwa-ke, i-clobetasol ingabangela ukuncipha kwesikhumba, izimpawu zokwelula, neminye imiphumela engemihle ngokusebenzisa isikhathi eside.

I-Tapinarof inikeza inzuzo yokuphepha ekusetshenzisweni kwesikhathi eside ngaphandle kokukhathazeka okuhambisana nama-steroid anamandla. Ivame ukubhekwa njengcono ekwelapheni ukugcinwa uma i-psoriasis yakho isilawulwa.

Udokotela wakho angase ancome ukuqala nge-clobetasol ukuze uthole ukukhululeka okusheshayo, bese ushintshela ku-tapinarof ukuze ulawule isikhathi eside. Le ndlela ihlanganisa isenzo esisheshayo sama-steroid kanye nephrofayili yokuphepha ye-tapinarof.

Imibuzo Evame Ukubuzwa Nge-Tapinarof

Ingabe i-Tapinarof Iphephile Ku-Diabetes?

Yebo, i-tapinarof ngokuvamile iphephile kubantu abanesifo sikashukela ngoba isetshenziswa ngaphandle futhi ayithinti ngokuphawulekayo amazinga kashukela egazini. Umuthi usebenza endaweni esikhumbeni sakho futhi awuphazamisi imithi yesifo sikashukela noma i-insulin.

Kodwa-ke, abantu abanesifo sikashukela kufanele baqaphele isikhumba sabo ngokucophelela lapho besebenzisa noma yimuphi umuthi omusha othuthukiswayo. Isifo sikashukela singanciphisa ukuphulukiswa kwamanxeba futhi sandise ingozi yokutheleleka, ngakho-ke bika noma yiziphi izinguquko ezingavamile zesikhumba kudokotela wakho ngokushesha.

Ngingenzani Uma Ngisebenzisa I-Tapinarof Engaphezu Kakhulu Ngengozi?

Ukusebenzisa i-tapinarof eningi kakhulu ngezikhathi ezithile akuyona ingozi, kodwa ngeke kwenze umuthi usebenze kangcono. Vele usule noma iyiphi ikhremu engaphezulu bese uqhubeka nomkhuba wakho ojwayelekile wokusebenzisa ngosuku olulandelayo.

Uma usebenzisa ukhilimu omningi njalo, ungenza ukuthi isikhumba sakho sicasuke kakhulu kunokujwayelekile. Nciphisa inani olisebenzisayo bese usebenzisa ungqimba oluncane kuphela oluhlanganisa izindawo ezithintekile ngokuphelele.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Tapinarof?

Uma ukhohlwa ukusebenzisa i-tapinarof, yisebenzise ngokushesha nje lapho ukhumbula ngalo lolo suku. Ungasebenzisi ukhilimu owengeziwe ngosuku olulandelayo ukuze ulungise umthamo ophuthelwe.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kukulimaze, kodwa ukuyisebenzisa nsuku zonke njalo kukunikeza imiphumela engcono kakhulu. Cabangela ukusetha isikhumbuzi sansuku zonke ocingweni lwakho ukukusiza ukuthi ukhumbule isikhathi sakho sokusebenzisa.

Ngingayeka nini ukuthatha i-Tapinarof?

Ungayeka ukusebenzisa i-tapinarof uma udokotela wakho enquma ukuthi i-psoriasis yakho ilawulwa kahle noma uma uba nemiphumela emibi edlula izinzuzo. Ungayeki ngokuzumayo ngaphandle kokubonisana nodokotela wakho kuqala.

Abanye abantu bangase badinge ukusebenzisa i-tapinarof isikhathi eside ukuze bagcine isikhumba esicacile, kanti abanye bangase bashintshele ekwelashweni okuhlukile kokugcina. Udokotela wakho uzokusiza ukuthi uthuthukise isu elingcono kakhulu lesikhathi eside lokuphatha i-psoriasis yakho.

Ngingayisebenzisa i-Tapinarof nezinye izindlela zokwelapha i-Psoriasis?

I-Tapinarof ingahlanganiswa kaningi nezinye izindlela zokwelapha i-psoriasis, kodwa kufanele uhlale uhlola nodokotela wakho kuqala. Ezinye izinhlanganisela zisebenza kahle ndawonye, ​​kanti ezinye zingase zikhuphule ingozi yakho yokucasuka kwesikhumba.

Udokotela wakho angase ancome ukusebenzisa i-tapinarof kanye nezinto ezithambisa isikhumba, izinto zokuhlanza ezithambile, noma ngisho neminye imithi yendawo. Bazokusiza ukuthi udale uhlelo lokwelapha olubanzi olwandisa izinzuzo ngenkathi kuncishiswa imiphumela emibi.