Yini i-Tavaborole: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Tavaborole iyikhambi elingaphandle elilwa nesikhunta eliphatha izifo zesikhunta sezipikili, ikakhulukazi i-onychomycosis. Isebenza ngendlela ehlukile kwezinye izindlela zokwelapha isikhunta ngokuvimba i-enzyme ethile edingwa isikhunta ukuze siphile futhi sikhule. Lo muthi kadokotela uza njengesixazululo esicacile osigcoba ngqo ezinzweni ezinomkhuhlane kanye ngosuku izinsuku ezingafika kuma-48.

Yini i-Tavaborole?

I-Tavaborole yisixazululo esinconywe ngudokotela esilwa nesikhunta esenzelwe izifo zesikhunta sezipikili. Ingaphansi kohlobo oluyingqayizivele lwemithi elwa nesikhunta ebizwa ngokuthi ama-inhibitors asekelwe ku-boron, okwenza ihluke ekwelashweni okujwayelekile kokulwa nesikhunta.

Umuthi uqondise izifo zesikhunta ezingeni leselula ngokuphazamisa ukukhiqizwa kwamaprotheni ezingxenyeni zesikhunta. Le ndlela isiza ukususa ukutheleleka ngenkathi ivumela izicubu zezipikili ezinempilo ukuthi zikhule emuva ngokuhamba kwesikhathi.

I-Tavaborole intsha uma iqhathaniswa nezinye izindlela zokwelapha isikhunta, njengoba yavunywa yi-FDA ngonyaka ka-2014. Inikeza enye indlela kubantu abangazange basabele kahle ekwelashweni okungaphandle kokulwa nesikhunta noma abangathandi ukuthatha imithi yomlomo elwa nesikhunta.

Isetshenziselwani i-Tavaborole?

I-Tavaborole iphatha i-onychomycosis, eyaziwa ngokuthi isikhunta sezipikili noma ukutheleleka ngesikhunta sezipikili. Lesi simo senza izipikili zibe zinkulu, zibe nemibala, zibe buthaka, futhi ngezinye izikhathi zibe buhlungu.

Umuthi usebenza kahle kakhulu ekuthelelekeni ngesikhunta sezipikili esingathí sina kuya esimaphakathi esingakaze sisabalale emgqeni wezipikili (indawo lapho ukukhula kwezipikili kuqala khona). Isebenza ikakhulukazi lapho ukutheleleka kuthinta ngaphansi kuka-50% wendawo yesipikili.

Udokotela wakho angase ancome i-tavaborole uma unezifo zesikhunta sezipikili eziphindaphindayo noma uma ezinye izindlela zokwelapha ezingaphandle zingasebenzi ngempumelelo. Kubuye kucatshangelwe uma imithi yomlomo elwa nesikhunta ingafaneleki ngenxa yokuxhumana okungase kube khona kwemithi noma izinkinga zesibindi.

Isebenza Kanjani i-Tavaborole?

ITavaborole isebenza ngokuvimba i-enzyme ebizwa ngokuthi i-leucyl-tRNA synthetase, okuyinto amaseli e-fungal ayidingayo ukuze enze amaprotheni abalulekile ukuze asinde. Lena indlela yokulwa nesikhunta enamandla aphakathi nendawo eqondiswe ngqo kumaseli e-fungal ngaphandle kokuthinta kakhulu amaseli omuntu.

Umuthi ungena ngaphakathi kwepuleti lesipikili ukuze ufinyelele endaweni yokutheleleka ngaphansi kwesipikili. Uma uselapho, uphazamisa ikhono lesikhunta lokuzala nokuzigcina, kancane kancane ususa ukutheleleka ezinyangeni ezimbalwa.

Ngokungafani namanye ama-antifungals aqinile ohlelweni, i-tavaborole isebenza endaweni yokufaka isicelo. Le ndlela eqondiwe isho imiphumela emincane emzimbeni wakho wonke ngenkathi isahlinzeka ngemithi ephumelelayo endaweni enegciwane.

Kufanele Ngiyithathe Kanjani I-Tavaborole?

Faka i-tavaborole kanye ngosuku ezinzwaneni ezihlanzekile, ezomile, okungcono ngesikhathi esifanayo nsuku zonke. Akudingeki ukuthi uyithathe nokudla noma ubisi ngoba ifakwa ngaphandle kunokuba igwinywe.

Ngaphambi kokufaka, geza izandla nezinyawo zakho kahle ngensipho namanzi, bese womisa ngokuphelele. Faka ungqimba oluncane lwesisombululo kuyo yonke indawo yesipikili, okuhlanganisa umbhede wesipikili nangaphansi kwethiphu yesipikili uma kungenzeka.

Vumela umuthi ukuthi wome ngokuphelele ngaphambi kokufaka amasokisi noma izicathulo, okuthatha imizuzu engaba ngu-2-3. Gwema ukugeza indawo ephathwayo okungenani amahora angu-6 ngemva kokufaka ukuze kuvunyelwe ukumuncwa okufanele.

Ungadla ngokujwayelekile ngoba le yimithi yendawo, kodwa gwema ukuthola isisombululo esikhumbeni esinempilo esizungeze isipikili ngangokunokwenzeka. Uma uthola okuthile esikhumbeni esizungezile, ngokuvamile akulimazi kodwa kungase kubangele ukucasuka okuncane.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Tavaborole?

Abantu abaningi badinga ukusebenzisa i-tavaborole amasonto angu-48 (cishe unyaka owodwa) ukuze babone imiphumela ephelele. Lesi sikhathi sokwelashwa esandisiwe siyadingeka ngoba izipikili zezinzwane zikhula kancane kakhulu, futhi kuthatha isikhathi ukuthi isipikili esinempilo sithathe izindawo ezinamagciwane.

Ungase uqale ukubona ngcono ukubukeka kwezipikili ngemuva kwamasonto angama-24, kodwa kubalulekile ukuqhubeka nokwelashwa isikhathi esinqunyiwe esiphelele. Ukuyeka ngaphambi kwesikhathi kuvame ukuholela ekubuyeni kokutheleleka ngoba isikhunta singase sibe khona ezicutshini zezipikili ezibukeka zilungile.

Udokotela wakho uzoqapha ukuqhubeka kwakho ngesikhathi sokwelashwa futhi angase alungise ubude besikhathi ngokuya ngendlela izipikili zakho ezisabela ngayo. Abanye abantu abanezifo ezinzima bangase badinge ukwelashwa ngaphezu kwamasonto angama-48, kanti abanye abanezimo ezilula bangase babone ukucaca okuphelele ngokushesha.

Yini Imiphumela Eceleni ye-Tavaborole?

Abantu abaningi bayakubekezelela kahle i-tavaborole, nemiphumela emibi ngokuvamile ithambile futhi ikhawulelwe endaweni yokusebenzisa. Imiphumela emibi evame kakhulu ithinta isikhumba nezipikili lapho usebenzisa umuthi.

Nansi imiphumela emibi ongase uyithole, uqonda ukuthi iningi lingelesikhashana futhi liyalawuleka:

• Ukuvuvukala kwesikhumba noma ububomvu ngasezipikili eziphathwayo
• Ukusha okuncane noma umuzwa wokugwaza uma uqala ukusebenzisa
• Isikhumba esomile noma esikhuhlayo eduze nendawo yokusebenzisa
• Ukushintsha kombala kwezipikili okwesikhashana noma izinguquko ekuthungeni kwezipikili
• Ukuvuvukala okuncane kozwane noma izicubu ezizungezile

Lezi zimpendulo ngokuvamile ziyathuthuka njengoba isikhumba sakho sizivumela emuthini emasontweni ambalwa okuqala okwelashwa.

Imiphumela emibi engavamile kodwa ebucayi ingenzeka kwabanye abantu, nakuba lokhu kuthinta ngaphansi kuka-1% wabasebenzisi:

• Ukuphendula okukhulu komzimba okune-rash ebanzi noma ubunzima bokuphefumula
• Ukusha okuqhubekayo noma ubuhlungu obuqhubeka ngokuhamba kwesikhathi
• Izimpawu zokutheleleka kwamagciwane okwesibili (ukwanda kobubomvu, ukufudumala, ubomvu)
• Ukwahlukana kwezipikili embhedeni wezipikili (onycholysis)
• Ukuqhekeka kwesikhumba okukhulu noma ukuqhekeka

Uma uhlangabezana nanoma yiziphi izimpendulo ezinzima, xhumana nomhlinzeki wakho wezempilo ngokushesha ngoba lokhu kungase kudingeke ukuyeka umuthi noma ukwelashwa okwengeziwe.

Ubani Ongafanele Athathwe i-Tavaborole?

ITavaborole ayifanele wonke umuntu, futhi izimo ezithile zenza kungafaneleki noma zidinga izinyathelo zokuphepha ezikhethekile. Abantu abaziwa ukuthi banezinto ezibangela ukungezwani komzimba ku-tavaborole noma yiziphi izithako ezingasebenzi kufanele bagweme lo muthi.

Kufanele uxoxe ngezindlela ezingezinye nodokotela wakho uma unomonakalo omkhulu wezipikili noma izifo ezihilela ngaphezu kuka-50% wendawo yesipikili. Umuthi usebenza kahle ezifweni ezilula kuya kweziphakathi nendawo futhi kungenzeka ungasebenzi ezimweni ezithuthukisiwe.

Abantu abanezinhlelo zokuzivikela ezithintekile, njengalabo abanesifo sikashukela, i-HIV, noma abathatha imithi ecindezela amasosha omzimba, bangase badinge ukuqashwa eduze ngesikhathi sokwelashwa. Ngenkathi kungavunyelwe ukusetshenziswa, lezi zimo zingathinta ukuphulukiswa futhi zandise izingozi zokutheleleka.

Abesifazane abakhulelwe nabancelisayo kufanele basebenzise i-tavaborole kuphela uma izinzuzo zicacile ukwedlula izingozi ezingaba khona. Idatha elinganiselwe ikhona ekuphepheni kwayo ngesikhathi sokukhulelwa, ngakho udokotela wakho uzohlola ngokucophelela isimo sakho esithile.

Igama Lomkhiqizo we-Tavaborole

I-Tavaborole ithengiswa ngaphansi kwegama lomkhiqizo elithi Kerydin e-United States. Lolu njengamanje olukuphela komkhiqizo ovunyelwe yi-FDA oqukethe i-tavaborole njengesithako esisebenzayo.

I-Kerydin ikhiqizwa yi-Anacor Pharmaceuticals (manje eyingxenye ye-Pfizer) futhi iza njengesixazululo esingu-5% sendawo ebhokisini elinebhulashi lokusebenzisa. Ifomula yegama lomkhiqizo yilokho okuye kwafundwa ezivivinyweni zomtholampilo futhi kuvunyelwe ukwelapha isikhunta sezinzwane.

Izinhlobo ezivamile ze-tavaborole azikatholakali kabanzi, ngakho imiyalelo eminingi izogcwaliswa ngegama lomkhiqizo elithi Kerydin. Ukukhava kwakho komshuwalense kungahluka ngemithi yegama lomkhiqizo, ngakho hlola nomhlinzeki wakho mayelana nezinketho zokukhava.

Ezinye izindlela ze-Tavaborole

Kukhona ezinye izindlela zokwelashwa zesikhunta sezinzwane uma i-tavaborole ingafaneleki noma ingasebenzi kuwe. Lezi zinketho zihlanganisa ezinye izinto ezilwa nesikhunta zendawo, imithi yomlomo, kanye nokwelashwa kwenqubo.

Ezinye izindlela zokwelapha isikhunta zihlanganisa i-ciclopirox (Penlac), i-efinaconazole (Jublia), kanye ne-amorolfine (ayitholakali e-US). Lezi zisebenza ngezindlela ezihlukene futhi zingase zisebenze uma i-tavaborole ingasebenzi.

Imithi yomlomo yokulwa nesikhunta efana ne-terbinafine (Lamisil) noma i-itraconazole (Sporanox) iyizinketho ezinamandla zokwelapha izifo ezinzima. Kodwa-ke, zithwala izingozi eziphakeme zemiphumela emibi kanye nokusebenzisana kwemithi uma kuqhathaniswa nokwelashwa okusebenzayo.

Ukwelashwa okusha kufaka phakathi ukwelashwa nge-laser, ukwelashwa nge-photodynamic, kanye nokususwa kwezipikili ngokuhlinzwa ezimweni ezinzima. Udokotela wakho angasiza ekutholeni ukuthi iyiphi enye indlela engasebenza kahle kakhulu ngokusekelwe esifweni sakho esithile kanye nesimo sempilo.

Ingabe i-Tavaborole Ingcono Kune-Ciclopirox?

Kokubili i-tavaborole ne-ciclopirox ziyizinto ezisebenzayo zokulwa nesikhunta, kodwa zisebenza ngezindlela ezihlukene futhi zinezinzuzo ezihlukene. I-Tavaborole ingasebenza kahle kakhulu kwabanye abantu ngenxa yesenzo sayo esiyingqayizivele sokuvimba ama-enzyme.

Izifundo zomtholampilo zikhomba ukuthi i-tavaborole ifinyelela amazinga okuphulukisa aphelele cishe ngama-6-9% uma kuqhathaniswa nezinga le-ciclopirox elingu-5-8%. Ngenkathi le nhluka ibonakala incane, indlela entsha ye-tavaborole yokusebenza ingasebenza kangcono ezifweni ezingamelani nezinto zokulwa nesikhunta zendabuko.

I-Ciclopirox idinga ukusetshenziswa kwansuku zonke ngokususwa kwamasonto onke kusetshenziswa utshwala obuhlikihlayo, kanti i-tavaborole inohlelo olulula lokusebenzisa kanye ngosuku. Abanye abantu bakhetha uhlelo lokusebenza olulula lwe-tavaborole futhi abakhathazeki ngesikhathi eside sokwelashwa.

Ukukhetha phakathi kwale mithi kuvame ukuncika ohlotsheni lwakho oluthile lwesikhunta, izimpendulo zokwelashwa zangaphambilini, kanye nezintandokazi zomuntu siqu. Udokotela wakho angasiza ekutholeni ukuthi iyiphi inketho enikeza ithuba elingcono kakhulu lokuphumelela ecaleni lakho elithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Tavaborole

Ingabe i-Tavaborole Iphephile Ku-Diabetes?

ITavaborole ingasetshenziswa ngokuphepha ngabantu abaningi abanesifo sikashukela, kodwa idinga ukuqapha okucophelelayo nokunakekelwa kwezinyawo. Isifo sikashukela singanciphisa ukuphola futhi sandise izingozi zokutheleleka, ngakho udokotela wakho uzofuna ukulandela intuthuko yakho eduze.

Abantu abanesifo sikashukela kufanele bahlole izinyawo zabo nsuku zonke ukuze babone noma yiziphi izimpawu zokucasuka noma ukutheleleka kwesibili ngenkathi besebenzisa i-tavaborole. Ukulawulwa okuhle kukashukela egazini kusiza ukuthuthukisa ukuphola futhi kunciphisa ingozi yezinkinga ngesikhathi sokwelashwa.

Umhlinzeki wakho wezempilo angase ancome ukuhlolwa okuvame kakhulu ukuze aqinisekise ukuthi umuthi awubangeli ukucasuka okukhulu noma ukufihla izimpawu zezinye izinkinga zezinyawo ezivamile esifweni sikashukela.

Ngingenzani Uma Ngisebenzisa I-Tavaborole Engakanani Ngengozi?

Uma usebenzisa i-tavaborole eningi kakhulu, ungesabi – lokhu akuvamile ukubangela izinkinga ezinkulu njengoba kuyimithi esetshenziswa ngaphandle. Susa noma yiluphi uketshezi oluningi ngethishe elihlanzekile futhi gwema ukusebenzisa okwengeziwe kuze kube umthamo wakho olandelayo ohleliwe.

Ukusebenzisa okuningi ngeke kwenze umuthi usebenze ngokushesha futhi kungase kwandise ukucasuka kwesikhumba endaweni ephathwayo. Uma uzwa ukusha okwengeziwe, ububomvu, noma ukucasuka, ungafaka amanzi abandayo endaweni ngobumnene.

Qhubeka neshejuli yakho yokusebenzisa ejwayelekile ngosuku olulandelayo, usebenzisa kuphela inani elinconyiwe. Uma ukucasuka kuqhubeka noma kuba kubi kakhulu, xhumana nomhlinzeki wakho wezempilo ukuze uthole isiqondiso sokuthi ngabe uzoqhubeka yini nokwelashwa.

Ngingenzani Uma Ngiphuthelwa Umthamo We-Tavaborole?

Uma uphuthelwa umthamo, sebenzisa i-tavaborole ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi sokusebenzisa kwakho okulandelayo okuhleliwe. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke neshejuli yakho ejwayelekile.

Ungaphindi kabili imithamo ngokusebenzisa imithi eyengeziwe ukuze ubuyisele ukusetshenziswa okulahlekile. Lokhu ngeke kusheshise ukuphola futhi kungase kwandise ingozi yokucasuka kwesikhumba.

Zama ukusungula isimiso esiqhubekayo, mhlawumbe usebenzise imithi ngesikhathi esifanayo nsuku zonke, ukusiza ukukhumbula imithamo. Ukusetha isikhumbuzi sefoni kungasiza ngesikhathi sokwelashwa eside.

Ngingayeka nini ukuthatha i-Tavaborole?

Kufanele uqhubeke usebenzisa i-tavaborole isikhathi esiphelele esinqunyiwe, ngokuvamile amasonto angama-48, ngisho noma izipikili zakho ziqala ukubukeka zingcono ngaphambi kwesikhathi. Ukuyeka ngokushesha kuvame ukuholela ekubuyeni kwesifo ngoba isikhunta singahlala ethissheni lesipikili elibukeka linempilo.

Udokotela wakho uzohlola inqubekela phambili yakho ngesikhathi sokuvakasha okulandelayo futhi anqume ukuthi kuphephile nini ukuyeka ukwelashwa. Ukucaca okuphelele kwesipikili, lapho lonke isipikili sibukeka sinempilo futhi sijwayelekile, yilona phakathi ngaphambi kokuyeka.

Ngemuva kokuyeka i-tavaborole, qhubeka nokwenza inhlanzeko enhle yezinyawo nokunakekelwa kwezipikili ukuvimbela ukutheleleka kabusha. Udokotela wakho angase ancome ukuhlolwa ngezikhathi ezithile ukuqinisekisa ukuthi isifo asibuyi.

Ngingagqoka yini i-Nail Polish ngenkathi ngisebenzisa i-Tavaborole?

Ngokuvamile kungcono ukugwema i-nail polish ngenkathi usebenzisa i-tavaborole, njengoba ingaphazamisa ikhono lomuthi lokungena esipikilini futhi afinyelele ekuthelelekeni. I-Nail polish futhi yenza kube nzima ukuqapha inqubekela phambili yakho yokwelashwa.

Uma kufanele ugqoke i-nail polish ngezikhathi ezikhethekile, yisuse ngokuphelele ngaphambi kokusebenzisa kwakho okulandelayo kwe-tavaborole futhi ulinde okungenani amahora angama-24 ngemuva kokusebenzisa umuthi ngaphambi kokuphinda usebenzise i-polish.

Gxila empilweni yesipikili ngesikhathi sokwelashwa kunokubukeka - khumbula ukuthi izipikili ezinempilo, ezicacile ziyilona phakathi lokuhamba kwakho kokwelashwa kwamasonto angama-48.