Yini i-Telavancin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Telavancin iyisibulala-magciwane esinamandla esisetshenziswa odokotela ukwelapha izifo ezinzima ezibangelwa amagciwane lapho eminye imithi ingase ingasebenzi kahle. Ingaphansi kweqembu lezibulala-magciwane elibizwa ngokuthi ama-lipoglycopeptides, aklanyelwe ukulwa namagciwane aqinile asevele amelana nezindlela eziningi zokwelapha.

Lo muthi unikezwa ngaso sonke isikhathi nge-IV (intravenous) line ngqo emgudwini wakho wegazi esibhedlela noma emtholampilo. Ngeke nanini uthathe i-telavancin njengepilisi ekhaya ngoba idinga ukunikezwa ochwepheshe bezempilo abangakuqapha eduze.

Isetshenziselwani i-Telavancin?

I-Telavancin iphatha izinhlobo ezimbili eziyinhloko zezifo ezinzima ezibangelwa amagciwane ezingase zibe yingozi ekuphileni uma zingelashwa. Udokotela wakho uzomisa lo muthi kuphela uma ekholelwa ukuthi unesifo esibi esidinga ukwelashwa ngokushesha, okunamandla.

Isimo sokuqala esiphathwayo yizifo eziyinkimbinkimbi zesikhumba nezicubu ezithambile. Lezi yizifo ezijulile, ezinzima ezingaphezu kobuso besikhumba sakho futhi ezithinta izendlalelo ezingaphansi, okuhlanganisa imisipha namafutha. Cabanga ngezifo ezingase zenzeke ngemva kokuhlinzwa, amanxeba amakhulu, noma izilonda zonyawo ezinoshukela eziye zaba nenkinga enkulu.

Isimo sesibili yi-pneumonia etholakala esibhedlela, okuhlanganisa i-pneumonia ehambisana ne-ventilator. Lesi yisifo samaphaphu esenzeka ngenkathi usesibhedlela, ngokuvamile lapho amasosha akho omzimba esivele ebuthakathaka. Kuvamile ikakhulukazi ezigulini ezidinga imishini yokuphefumula (ama-ventilator) ukuzisiza ziphefumule.

I-Telavancin iqondise ngqo amagciwane e-gram-positive, okuhlanganisa ezinye izinhlobo ezinzima kakhulu njenge-MRSA (methicillin-resistant Staphylococcus aureus). Lawa amagciwane aye athuthukisa ukumelana nezibulala-magciwane eziningi ezivamile, okwenza kube nzima kakhulu ukuwelapha ngemithi ejwayelekile.

Isebenza Kanjani i-Telavancin?

I-Telavancin ithathwa njenge-antibiotic enamandla, esindayo esebenza ngezindlela ezimbili ezihlukene ukubulala amagciwane. Lesi senzo esiphindwe kabili senza ukuthi sisebenze ikakhulukazi ekulweni nezinhlobo zamagciwane ezingamelani ezingase zisinde kwezinye izindlela zokwelapha.

Okokuqala, iphazamisa udonga lweseli lamagciwane, okufana nokudiliza umgoqo ovikelayo ogcina amagciwane ephila. Ngaphandle kwalolu donga, amagciwane awakwazi ukugcina ukuma kwawo nesakhiwo sawo, okubangela ukuthi afe.

Okwesibili, i-telavancin iphazamisa ikhono lamagciwane lokwenza amaprotheni awadingayo ukuze aphile futhi azale. Ngokuvala lokhu kukhiqizwa kwamaprotheni, empeleni ivimbela amagciwane ukuthi angakhuli futhi asabalale emzimbeni wakho wonke.

Le ndlela yokuhlanganisa yingakho i-telavancin ingasebenza ngempumelelo ekulweni namagciwane afunde ukumelana namanye ama-antibiotics. Kodwa-ke, ngenxa yokuthi inamandla kangako, odokotela bayigcina ezifweni ezinzima lapho ezinye izindlela zokwelapha zingasebenzanga noma kungenzeka zingasebenzi.

Kufanele Ngiyithathe Kanjani I-Telavancin?

Ngeke uzithathele wena i-telavancin ngoba inikezwa kuphela ngomugqa we-IV ochwepheshe bezempilo abaqeqeshiwe esibhedlela noma emtholampilo. Umuthi uza njengempushana okudingeka ixutshwe ngamanzi ahlanzekile bese incishiswa ngokuqhubekayo ngaphambi kokuthi ifakwe kancane emgudwini wakho wegazi.

Ithimba lakho lezempilo lizokunika i-telavancin njalo emahoreni angama-24, futhi ukufakwa ngakunye kuthatha imizuzu engaba ngu-60 ukuze kuqedwe. Bazokuqapha eduze ngesikhathi nangemva kwesilinganiso ngasinye ukuze babheke noma yiziphi izindlela zokuphendula noma imiphumela emibi.

Akudingeki ukhathazeke ngokuthatha lo muthi nokudla ngoba uqondiswa ngqo emgudwini wakho wegazi. Kodwa-ke, kubalulekile ukuhlala unamanzi kahle ngesikhathi sokwelashwa, ngakho-ke ithimba lakho lezokwelapha lizokukhuthaza ukuthi uphuze uketshezi oluningi uma ukwazi ukukwenza.

Ngaphambi komthamo ngamunye, abahlinzeki bakho bezempilo bazohlola ukusebenza kwezinso zakho ngokuhlolwa kwegazi. Lokhu kungenxa yokuthi i-telavancin ingathinta izinso zakho, futhi badinga ukuqinisekisa ukuthi umzimba wakho uyayicubungula imithi ngokuphepha.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Telavancin?

Ubude bokwelashwa kwakho nge-telavancin buxhomeke ohlotsheni nobukhulu bokutheleleka kwakho, kanye nokuthi usabela ngokushesha kangakanani emuthini. Abantu abaningi bathola ukwelashwa izinsuku eziyi-7 kuya kweziyi-14, nakuba abanye bengase badinge izifundo ezinde.

Ngezifo eziyinkimbinkimbi zesikhumba nezicubu ezithambile, ukwelashwa kuvame ukuthatha izinsuku eziyi-7 kuya kweziyi-14. Udokotela wakho uzohlola ukuthi ukutheleleka kuphendula kahle kangakanani futhi angase alungise ubude ngokuya ngenqubekela phambili yakho.

Nge-pneumonia etholwe esibhedlela, ukwelashwa kuvame ukuqhubeka izinsuku eziyi-7 kuya kwezingama-21. Ukutheleleka emaphashini kuvame ukuthatha isikhathi eside ukuthi kususwe ngokuphelele, ikakhulukazi uma uke waba se-ventilator noma unezinye izinkinga zempilo.

Ithimba lakho lezokwelapha lizogada izimpawu zakho zokutheleleka ngokuhlolwa kwegazi nokuhlolwa komzimba ukuze linqume ukuthi kuphephile nini ukuyeka ukwelashwa. Ungalokothi ucabange ukuthi ungasusa ngaphambi kwesikhathi, ngisho noma uqala ukuzizwa ungcono, ngoba ukuyeka ama-antibiotics ngokushesha kungavumela ukutheleleka ukuthi kubuye kube namandla kunakuqala.

Yiziphi Imiphumela Eceleni Ye-Telavancin?

Njengawo wonke ama-antibiotics anamandla, i-telavancin ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ithimba lakho lezempilo lizokugada eduze nganoma yiziphi izindlela futhi lingasiza ekuphatheni noma yiziphi izimpawu ezingakhululekile ezingase zivele.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa isicanucanu, ukuhlanza, kanye nezinguquko endleleni okudla okunambitheka ngayo. Lezi zimpawu zokugaya ukudla zivame ukuba mnene futhi zivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini.

Nawa imiphumela emibi evame kakhulu iziguli ezinokuyibika:

• Ukugula nokuhlanza ngezikhathi ezithile
• Ukunambitheka kwensimbi noma okungajwayelekile emlonyeni wakho
• Ukuphuma isifo sohudo noma izinguquko ekuhambeni kwamathumbu
• Ukuqaqamba kwekhanda noma isiyezi
• Ububomvu noma ukucasuka endaweni ye-IV
• Ukuzizwa ukhathele noma ubuthakathaka

Lezi zimpawu ngokuvamile ziyalawuleka futhi ngokuvamile azidingi ukumisa umuthi. Ithimba lakho lezempilo lingase lincoma izindlela zokunciphisa le miphumela futhi likugcine ukhululekile ngesikhathi sokwelashwa.

Imiphumela emibi engathi sína idinga ukunakekelwa kwezempilo ngokushesha, nakuba ingavamile. Ithimba lakho lezokwelapha lizobheka izimpawu zezinkinga zezinso, ezingabandakanya izinguquko ekuchameni, ukuvuvukala emilenzeni yakho noma ezinyaweni, noma ukuzizwa ukhathele ngokungavamile.

Nawa amanye amaphutha amabi adinga ukunakekelwa kwezempilo ngokushesha:

• Izinkinga ezinzima zezinso (ukwehla kokuchama, ukuvuvukala, ukudideka)
• Ukuphendula okungathi sína komzimba (ukuqubuka, ubunzima bokuphefumula, ukuvuvukala kobuso noma umphimbo)
• Isifo sohudo esibi esingase sibonise ukutheleleka kwamathumbu okuyingozi
• Izinkinga zokuzwa noma ukukhala ezindlebeni
• Ukuphendula kwesikhumba okukhulu noma ukulimala okungajwayelekile

Njengoba uthola lo muthi endaweni yokunakekelwa kwezempilo, ithimba lakho lezokwelapha lizobona lezi zinkinga kusenesikhathi futhi lithathe isinyathelo esifanele. Baqeqeshwe ukubona lezi zimpawu zokuxwayisa futhi basabele ngokushesha ukuze bakugcine uphephile.

Ezinye izimpawu ezingavamile kodwa ezingathi sína zihlanganisa i-QT prolongation (inkinga yesigqi senhliziyo) kanye ne-red man syndrome (ukusabela okubangela ukukhanya nokuchitheka). Abahlinzeki bakho bezempilo bazobheka isigqi senhliziyo yakho futhi banikeze umuthi kancane ukuze banciphise lezi zingozi.

Ubani Ongafanele Athole I-Telavancin?

I-Telavancin ayiphephile kuwo wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwubhala. Bazocabangela impilo yakho yonke, eminye imithi oyithathayo, nanoma yiziphi izimo ezingenza lesi sibulala-magciwane sibe yingozi kuwe.

Abesifazane abakhulelwe akufanele bathole i-telavancin ngoba ingalimaza umntwana osakhula. Uma ungumuntu wesifazane oseminyakeni yokuzala, udokotela wakho cishe uzoqhuba ukuhlolwa kokukhulelwa ngaphambi kokuqala ukwelashwa futhi axoxe ngezindlela zokulawula inzalo ezithembekile.

Abantu abanezifo ezinzima zezinso kungenzeka bangabi ngabantu abafanelekayo be-telavancin ngoba umuthi ungalimaza ngokuqhubekayo ukusebenza kwezinso. Udokotela wakho uzohlola ukusebenza kwezinso zakho ngokuhlolwa kwegazi ngaphambi nangemva kokwelashwa ukuze aqinisekise ukuthi kuphephile kuwe.

Nawa amanye amakhambi angase enze i-telavancin ingakulungele:

• Ukukhulelwa noma ukuhlela ukukhulelwa
• Isifo esinzima sezinso noma ukuhluleka kwezinso
• Ukungezwani okwaziwayo ne-telavancin noma ama-antibiotics afanayo
• Izinkinga ezithile zokushaya kwenhliziyo
• Izinkinga ezinkulu zokuzwa

Udokotela wakho uzophinda aqaphele uma uthatha imithi engase ithinte ukushaya kwenhliziyo yakho noma ukusebenza kwezinso. Bazobukeza yonke imithi yakho futhi kungase kudingeke ukuthi balungise imithamo noma bakuqaphele eduze ngesikhathi sokwelashwa.

Uma unomlando wokuhuda okuhlobene nama-antibiotic noma izifo zamathumbu, ithimba lakho lezokwelapha lizokubheka ngokucophelela izimpawu zalezi zinkinga eziphindayo. Bangathatha izinyathelo zokuvimbela noma ukwelapha ngokushesha lezi zinkinga uma zivela.

Amagama Omkhiqizo we-Telavancin

I-Telavancin ithengiswa ngaphansi kwegama lomkhiqizo elithi Vibativ e-United States. Leli yigama lomkhiqizo elilodwa elitholakalayo njengamanje, njengoba izinhlobo ezivamile zingakatholakali kabanzi emazweni amaningi.

Uma ubona lo muthi ohlwini lwamafayela akho esibhedlela noma emaphepheni omshwalense, ungase uvele njengokuthi "telavancin" noma "Vibativ." Womabili la magama abhekisela emuthini ofanayo, ngakho-ke ungadideki uma ubona amagama ahlukene esetshenziswa emadokhumenti akho ezokwelapha.

Ngenxa yokuthi leli yi-antibiotic ekhethekile esetshenziswa kuphela ezindaweni zase-hospital, ngeke uyithole emakhemisi avamile. Ngokuvamile igcinwa kuphela ezibhedlela nakumaziko akhethekile okufakwa imithi lapho kwelashwa khona izifo ezinzima ezibangelwa amagciwane.

Ezinye izindlela zokwelapha i-Telavancin

Ezinye izinhlobo eziningi zama-antibiotics zingelapha izifo ezifanayo, nakuba udokotela wakho ekhetha i-telavancin ngezizathu ezithile ngokusekelwe esimweni sakho esithile. Ukukhetha kuncike ohlotsheni lwamagciwane abangela ukutheleleka kwakho, umlando wakho wezokwelapha, nokuthi ungawamukela kanjani imithi ehlukene.

I-Vancomycin cishe iyindlela efana kakhulu futhi ivame ukuba yinto yokuqala yokukhetha ezifweni ezibangelwa amagciwane ezinzima ezi-gram-positive. Kodwa-ke, amanye amagciwane aye athuthukisa ukumelana ne-vancomycin, yingakho i-telavancin ingase ithandwe ezimweni ezithile.

Ezinye izindlela ezingase zicatshangelwe udokotela wakho zihlanganisa i-linezolid, i-daptomycin, noma i-ceftaroline. Ngayinye yalezi zinhlobo zama-antibiotics inamandla ahlukene futhi ilungele izinhlobo ezahlukene zezifo noma izimo zesiguli.

Isinqumo phakathi kwalezi zindlela sincike ezintweni eziningana, okuhlanganisa amagciwane athile atholakala ekuthelelekeni kwakho, ukusebenza kwezinso zakho, eminye imithi oyithathayo, nokuthi ngabe wake wathola ukwelashwa ngama-antibiotic angasebenzi kahle.

Ingabe i-Telavancin ingcono kune-Vancomycin?

I-Telavancin ne-vancomycin zombili zama-antibiotics asebenzayo ezifweni ezibangelwa amagciwane ezinzima, kodwa zisebenza ngendlela ehlukile futhi zinezinzuzo ezihlukene. Akukho noyedwa othi “ungcono” kunomunye - ukukhetha kuncike esimweni sakho esithile.

I-Telavancin ingase ithandwe lapho amagciwane esethuthukise ukumelana ne-vancomycin noma lapho kudingeka i-antibiotic esebenza ngokushesha. Indlela yayo yokusebenza ephindwe kabili ingayenza isebenze kahle ezinhlotsheni ezithile zamagciwane amelana nayo.

I-Vancomycin, ngakolunye uhlangothi, isetshenziswe amashumi eminyaka futhi inerekhodi elide lokuphepha nokusebenza. Ivame ukuba yinto yokuqala yokukhetha ngoba odokotela banolwazi oluningi ngayo futhi bayayiqonda kahle imiphumela yayo.

Udokotela wakho uzokhetha phakathi kwale mithi ngokusekelwe emiphumeleni yamasiko ekhomba amagciwane athile abangela ukutheleleka kwakho futhi ahlolisise ukuthi yimaphi ama-antibiotics asebenza kahle kuwo. Lokhu kuhlolwa kwelabhorethri kusiza ukuqinisekisa ukuthi uthola ukwelashwa okufanele kakhulu ukutheleleka kwakho okuthile.

Imibuzo Evame Ukubuzwa Mayelana ne-Telavancin

Ingabe i-Telavancin iphephile ezigulini ezinokugula kwezinso?

I-Telavancin ingaba yingozi kubantu abanezifo zezinso ngoba ingase ibangele ukulimala okwengeziwe kwezinso. Udokotela wakho uzohlola ngokucophelela ukusebenza kwezinso zakho ngaphambi kokukuyalela le mithi futhi akuqaphele eduze ngesikhathi sokwelashwa.

Uma unezinkinga ezingatheni zezinso, udokotela wakho angase akuyalele i-telavancin kodwa cishe uzolungisa umthamo futhi aqaphele ukusebenza kwezinso zakho kaningi. Kodwa-ke, uma unezifo ezinzima zezinso noma ukwehluleka kwezinso, cishe bazokhetha i-antibiotic ehlukile ephephe kakhulu ezinso zakho.

Ngesikhathi sokwelashwa, ithimba lakho lezempilo lizohlola njalo amazinga egazi lakho ukuze liqinisekise ukuthi izinso zakho zicubungula imithi ngendlela efanele. Uma beqaphela noma yiziphi izimpawu zezinkinga zezinso, bangalungisa uhlelo lwakho lokwelashwa noma bashintshele kwenye i-antibiotic.

Ngingenzani Uma Ngithola I-Telavancin eningi ngengozi?

Njengoba i-telavancin inikezwa ochwepheshe bezempilo endaweni yezokwelapha elawulwayo, ukweqisa ngengozi akuvamile kakhulu. Imithi ilinganiswa ngokucophelela futhi inikezwa abasebenzi abaqeqeshiwe abalandela imithetho eqinile ukuze baqinisekise ukuthi uthola umthamo ofanele.

Uma ngandlela thize kunikezwe imithi eningi kakhulu, ithimba lakho lezokwelapha lingaqala ngokushesha ukunakekela okusekelayo ukusiza umzimba wakho ukuthi uqhubeke nomuthi owedlulele. Bangase bakhulise uketshezi lwakho lwe-IV, baqaphele ukusebenza kwezinso zakho ngokucophelela, futhi baqaphele noma yiziphi izimpawu zokwanda kwemiphumela emibi.

Into ebaluleke kakhulu okufanele uyikhumbule ukuthi usesimweni esiphephile lapho ochwepheshe bezokwelapha bekuqapha njalo. Uma kwenzeka noma yimaphi amaphutha emithi, azobanjwa ngokushesha futhi alungiswe ngokushesha ukuqinisekisa ukuphepha kwakho.

Kufanele Ngenzeni Uma Ngeqa Umthamo We-Telavancin?

Ukweqa umthamo we-telavancin akunakwenzeka ngoba uyawuthola esibhedlela noma emtholampilo lapho ochwepheshe bezempilo bephatha isimiso sakho semithi. Kodwa-ke, uma umthamo uhlehliswa nganoma yisiphi isizathu, ithimba lakho lezokwelapha lizolungisa isikhathi ngendlela efanele.

Abahlinzeki bakho bezempilo abasoze bavele beqe umthamo noma baphinde kabili ngomunye olandelayo. Kunalokho, bazonquma indlela engcono kakhulu yokukubuyisela esimisweni ngenkathi begcina ukusebenza komuthi ngokumelene nokutheleleka kwakho.

Uma ukhathazekile ngesimiso sakho sokulinganisa noma uqaphela ukuthi umthamo ubonakala usuvuliwe, unganqikazi ukubuza umhlengikazi wakho noma udokotela. Bangachaza noma yiziphi izinguquko esimisweni sakho futhi baqinisekise ukuthi uthola ukwelashwa okungcono kakhulu kokutheleleka kwakho.

Ngingayeka Nini Ukuthatha I-Telavancin?

Akufanele uyeke ukuthatha i-telavancin ngokwakho, ngisho noma uqala ukuzizwa ungcono kakhulu. Udokotela wakho uzonquma ukuthi kuphephile nini ukuyeka ngokusekelwe ezintweni eziningana, okuhlanganisa ukuthi ukutheleleka kwakho kuphendula kanjani nemiphumela yakho yokuhlolwa kwelabhorethri.

Ithimba lakho lezokwelapha lizokwazi ukuqhubeka kwakho ngokuhlolwa komzimba, ukuhlolwa kwegazi, futhi ngezinye izikhathi izifundo zokucabanga ukuze libone ukuthi ukutheleleka kulungiswa kahle kangakanani. Bazophinda baqaphele izimpawu zokuthi amagciwane ayaqina emuthini.

Ukunqamula ama-antibiotics ngaphambi kwesikhathi kungavumela ukuthi ukutheleleka kubuye kube namandla kunakuqala, okungenzeka kwenze kube nzima ukukwelapha. Udokotela wakho uzoqhubeka nokwelapha kuze kube yilapho beqiniseka ukuthi ukutheleleka kuqedwe ngokuphelele emzimbeni wakho.

Ngingashayela ngemva kokuthola i-Telavancin?

Akufanele ushayele ngokushesha ngemva kokuthola i-telavancin, ikakhulukazi ngesikhathi semithamo yokuqala lapho usalungela imithi. I-antibiotic ingabangela isiyezi, ukukhathala, noma eminye imiphumela engase yonakalise ikhono lakho lokushayela ngokuphepha.

Njengoba kungenzeka ukuthi uthola lo muthi ngenkathi usibhedlela noma ngesikhathi sokwelashwa kwangaphandle okwandisiwe kokutheleleka okukhulu, cishe awukwazi ukushayela. Abantu abaningi abathola i-telavancin badinga ukugxila ekuphumuleni nasekutholeni amandla esikhundleni sokubuyela emisebenzini ejwayelekile efana nokushayela.

Uma usuqedile ukwelashwa futhi udokotela wakho ekukhulule ukuthi uqhubeke nemisebenzi ejwayelekile, ungaxoxa ngokuthi kuphephile nini ukushayela futhi. Lesi sinqumo sizoxhomeka ekutheni uzizwa kanjani sekukonke nokuthi ngabe uthatha eminye imithi engase ithinte ukuqapha kwakho noma ukuxhumana kwakho.