Yini i-Tigecycline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Tigecycline iyisibulala-magciwane esinamandla esisetshenziswa odokotela ukwelapha izifo ezingamathambo ezinzima lapho ezinye izibulala-magciwane zingase zingasebenzi kahle. Lo muthi ungowodidi olusha lwezibulala-magciwane olubizwa ngokuthi ama-glycylcyclines, futhi ngaso sonke isikhathi unikezwa ngomugqa we-IV (intravenous) endaweni yasesibhedlela.

Uma udokotela wakho ekutusele i-tigecycline wena noma othandiweyo wakho, kungokwemvelo ngokuphelele ukufuna ukuqonda okwengeziwe ngalokhu kwelashwa. Ake sihambe ngakho konke okudingeka ukwazi ngalo muthi ngendlela ezizwa ilawuleka futhi icacile.

Yini i-Tigecycline?

I-Tigecycline iyisibulala-magciwane esibanzi esilwa nezinhlobo eziningi ezahlukene zamagciwane abangela izifo ezinzima. Cabanga ngayo njengethuluzi elikhethekile elifinyelelwa odokotela uma bedinga okuthile okuphumelela ikakhulukazi ekulweni nezifo ezingamathambo ezinzima.

Lo muthi usebenza ngendlela ehlukile kwezinye izibulala-magciwane eziningi, okwenza ube yigugu ekwelapheni izifo eziye zamelana nezinye izindlela zokwelapha. Yenziwa ngaphansi kwegama lomkhiqizo elithi Tygacil futhi itholakala kuphela ezibhedlela lapho abasebenzi bezokwelapha bengakuqapha eduze.

Umuthi uza njengempushana exutshwa ngamanzi ahlanzekile futhi unikezwe kancane ngomugqa wakho we-IV. Le ndlela yokulungiselela nokuletha ngokucophelela isiza ukuqinisekisa ukuthi uthola inani elifanele lomuthi ngokuphepha.

Isetshenziselwani i-Tigecycline?

Odokotela ngokuvamile banikeza i-tigecycline ngezifo ezingamathambo eziyinkimbinkimbi ezithinta isikhumba sakho, izicubu ezithambile, noma isisu. Lezi yizifo ezivame ukuba zibe zimbi futhi zingase zingasabeli kahle ezibulala-magciwane ezijwayelekile.

Ithimba lakho lezempilo lingase lituse lo muthi uma unesifo sesikhumba esibi esisabalale sijule ezicutshini zakho. Lokhu kungabandakanya izifo ezizungeze izindawo zokuhlinzwa, izifo zonyawo ezinoshukela, noma i-cellulitis engathuthukanga ngezinye izindlela zokwelapha.

I-Tigecycline iphinde isebenze kahle ezifweni eziyinkimbinkimbi ezingaphakathi esiswini, okuyizifo ezingathi sína ngaphakathi esiswini sakho. Lokhu kungase kwenzeke ngemva kokuhlinzwa, okuvela emathunjini aqhumuke, noma kwezinye izimo ezivumela amagciwane ukuthi asakazeke emgodini wakho wesisu.

Ngezinye izikhathi odokotela basebenzisa i-tigecycline ngoba i-pneumonia etholakala emphakathini, okuyisifo samaphaphu ongathola ngaphandle kwendawo yasesibhedlela. Kodwa-ke, lokhu kusetshenziswa akuvamile futhi kuvame ukugcinelwa izimo ezithile lapho ezinye izibulala-magciwane zingafaneleki.

Isebenza Kanjani I-Tigecycline?

I-Tigecycline isebenza ngokuvimbela amagciwane ekwenzeni amaprotheni abawadingayo ukuze asinde futhi azale. Kufana nokuphazamisa umugqa wokukhiqiza wemboni - ngaphandle kwala maprotheni abalulekile, amagciwane awasebenzi kahle futhi ekugcineni ayafa.

Lo muthi uthathwa njenge-antibiotic eqinile, ebanzi, okusho ukuthi ingalwa nezinhlobo eziningi zamagciwane ngesikhathi esisodwa. Isebenza ikakhulukazi ngamagciwane asekela ukumelana nezinye izibulala-magciwane, okuhlanganisa ezinye izinhlobo eziyinselele kakhulu.

Indlela i-tigecycline enamathela ngayo emagciwaneni yehlukile kancane kuma-antibiotics amadala emndenini wayo. Lo mahluko uyayisiza ukuthi isebenze ngamagciwane afunde ukumelana ne-tetracycline ne-doxycycline, okuyimithi ehlobene.

Kufanele Ngiyithathe Kanjani I-Tigecycline?

Uzothola i-tigecycline kuphela endaweni yasesibhedlela ngomugqa we-IV engalweni yakho noma esandleni sakho. Umuthi unikezwa kancane kancane ngemizuzu engama-30 kuya kwengama-60, ngokuvamile njalo emahoreni ayi-12, futhi akudingeki ukuthi wenze lutho olukhethekile ukulungiselela umthamo ngamunye.

Ngokungafani nama-antibiotics omlomo, akudingeki ukhathazeke ngokuthatha i-tigecycline nokudla noma esiswini esingenalutho njengoba iqondana ngqo emgudwini wakho wegazi. Abahlengikazi bakho bazosingatha konke ukulungiselela nokuphatha ngenkathi uphumula ngokunethezeka.

Umthamo ovamile wokuqala ungama-100 mg anikezwa nge-IV yakho, kulandelwe ama-50 mg njalo emahoreni ayi-12. Nokho, udokotela wakho angase alungise leli nani ngokusekelwe esimweni sakho esithile, ukusebenza kwezinso, nokuthi usabela kanjani emuthini.

Ithimba lakho lezempilo lizokuqapha eduze ngesikhathi sokufakwa komuthi ngamunye ukuze libheke noma yiziphi izinto ezenzekayo. Bazophinda futhi baqaphele ukuthi uzizwa kanjani sekukonke futhi bahlole umsebenzi wegazi lakho njalo ukuze baqinisekise ukuthi umuthi usebenza kahle.

Kufanele Ngithathe Isikhathi Esingakanani I-Tigecycline?

Abantu abaningi bathola i-tigecycline izinsuku eziyi-5 kuya kweziyi-14, kuye ngohlobo nobukhulu bokutheleleka kwabo. Udokotela wakho uzoqoka ubude obuqondile bokwelashwa ngokusekelwe ekutheni ukutheleleka kwakho kuphendula ngokushesha kangakanani nokuthi uzizwa kanjani sekukonke.

Ezifweni zesikhumba nezicubu ezithambile, ukwelashwa kuvame ukuthatha izinsuku eziyi-5 kuya kweziyi-14. Uma unokutheleleka kwesisu okuyinkimbinkimbi, ungase udinge umuthi izinsuku eziyi-5 kuya kweziyi-14 futhi, nakuba udokotela wakho ezolungisa lokhu ngokusekelwe esimweni sakho esithile.

Ithimba lakho lezempilo lizohlola njalo ukuthi i-antibiotic isebenza kahle kangakanani ngokuhlola izimpawu zakho, izinga lokushisa, nokuhlolwa kwegazi. Bazoqhubeka nokwelashwa kuze kube yilapho ukutheleleka kwakho kubonisa izimpawu ezicacile zokuthuthuka futhi uzinzile ngokwanele ukushintshela kuma-antibiotics omlomo noma ukuyeka ukwelashwa ngokuphelele.

Kubalulekile ukuqeda inkambo ephelele yokwelashwa ngisho noma uqala ukuzizwa ungcono. Ukuyeka ngaphambi kwesikhathi kungavumela ukutheleleka ukuthi kubuye kube namandla noma kuthuthukise ukumelana nomuthi.

Yiziphi Izimo Ezingezinhle Ze-Tigecycline?

Njengayo yonke imithi, i-tigecycline ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ivame ukulawuleka futhi ithimba lakho lezempilo lizokuqapha eduze nganoma yiziphi izinkathazo.

Nansi imiphumela emibi ongase uyithole, futhi khumbula ukuthi ithimba lakho lezokwelapha lilungele ukukusiza ukuthi ulawule noma yiziphi zalezi:

• Ukugula nokuhlanza (imiphumela eseceleni evame kakhulu)
• Ukuphuma isifo sohudo noma izitulo ezithambile
• Ukucabanga
• Isiyezi
• Ubuhlungu, ububomvu, noma ukuvuvukala endaweni yakho ye-IV
• Ushintsho ekunambithekeni kwakho
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile

Le miphumela eseceleni ejwayelekile ivamise ukuba mncane futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Abahlengikazi bakho bangahlinzeka ngemithi yokusiza ngesicanucanu futhi bazoqapha indawo yakho ye-IV ukuvimbela ukucasuka.

Kukhona neminye imiphumela eseceleni engathi sína edinga ukunakekelwa kwezokwelapha ngokushesha, nakuba lokhu kungavamile:

• Ukuphuma isifo sohudo esibi okungase kubonise ukutheleleka emathunjini okuyingozi
• Ukuphuma igazi okungajwayelekile noma ukulimala
• Izimpawu zezinkinga zesibindi njengokushintsha kombala wesikhumba noma amehlo abe phuzi
• Ukuphendula okukhulu komzimba okuhlanganisa nobunzima bokuphefumula noma ukuvuvukala
• Ushintsho kumgqigqo wenhliziyo yakho

Njengoba uzobe usesimweni sesibhedlela, ithimba lakho lezempilo lizobe liqaphela le miphumela engathi sína futhi lingaphendula ngokushesha uma kwenzeka. Lokhu kuqapha okuqhubekayo kungenye yezizathu zokuthi i-tigecycline inikezwe kuphela ezindaweni zezokwelapha ezilawulwayo.

Ubani Ongafanele Athole I-Tigecycline?

I-Tigecycline ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Okukhathaza kakhulu ukuqinisekisa ukuthi lo muthi uphephile futhi ufanele isimo sakho esithile.

Akufanele uthole i-tigecycline uma unokungezwani nayo noma kuma-antibiotics afanayo njenge-tetracycline noma i-minocycline. Udokotela wakho uzoza ngazo zonke izindlela oye waziphendula ngazo kuma-antibiotics ngaphambi kokuqala ukwelashwa.

Abesifazane abakhulelwe ngokuvamile kufanele bagweme i-tigecycline, ikakhulukazi ngesikhathi sesibili nesesithathu, njengoba ingathinta amathambo namazinyo omntwana osakhula. Uma uncelisa, udokotela wakho uzoxoxa ngokuthi izinzuzo zidlula yini izingozi, njengoba umuthi ungangena obisini lwebele.

Izingane ezingaphansi kweminyaka engu-18 ngokuvamile akufanele zithole i-tigecycline ngoba ingaphazamisa ukukhula kwamathambo namazinyo okuvamile. Kodwa-ke, ezimweni ezinzima kakhulu, odokotela bangase bacabange ukuyisebenzisa uma izinzuzo zicacisa ukuthi zidlula izingozi.

Abantu abanezifo zesibindi ezinzima bangase badinge ukulungiswa komthamo noma bangase bangabi ngabazongenela i-tigecycline. Udokotela wakho uzohlola ukusebenza kwesibindi sakho ngaphambi nangemva kokwelashwa ukuze aqinisekise ukuthi kuphephile kuwe.

Igama Lomkhiqizo le-Tigecycline

I-Tigecycline ithengiswa ngaphansi kwegama lomkhiqizo elithi Tygacil, elikhiqizwa yi-Pfizer. Leli yigama eliyinhloko lomkhiqizo ozolibona ezibhedlela nakumarekhodi akho ezokwelapha.

Ezinye izindawo zingase zibe nezinhlobo ze-tigecycline ezivamile ezitholakalayo, kodwa ezindaweni eziningi, i-Tygacil ihlala iyindlela eyinhloko esetshenziswa ezibhedlela. Usokhemisi wakho nethimba lezokunakekelwa kwezempilo bazohlala bazi kahle ukuthi iyiphi inguqulo oyitholayo.

Noma ngabe uthola igama lomkhiqizo noma inguqulo ejwayelekile, umuthi uqobo lwawo luyefana. Into ebaluleke kakhulu ukuthi uthola umthamo ofanele ngesikhathi esifanele endaweni ephephile yesibhedlela.

Ezinye izindlela ze-Tigecycline

Uma i-tigecycline ingakulungele, udokotela wakho unezinye izinketho eziningi zama-antibiotic ngokuya ngohlobo lwakho oluthile lokutheleleka. Ukukhethwa kwenye indlela kuncike ekutheni yiziphi amagciwane abangela ukutheleleka kwakho kanye nezimo zakho zezokwelapha.

Ezifweni eziyinkimbinkimbi zesikhumba nezicubu ezithambile, ezinye izindlela zingabandakanya i-vancomycin, i-linezolid, noma i-daptomycin. Lawa wonke ama-antibiotic aqinile anganikezwa nge-IV futhi asebenza kahle kumagciwane amelana nawo.

Ezifweni eziyinkimbinkimbi zesisu, udokotela wakho angase acabange ukuhlanganiswa kwama-antibiotic afana ne-piperacillin-tazobactam ene-metronidazole, noma ama-antibiotic e-carbapenem afana ne-meropenem noma i-imipenem. Lokhu kuhlanganiswa kungasebenza kahle kakhulu kumagciwane axubile avame ukutholakala ezifweni zesisu.

Enye indlela ethile udokotela wakho ayikhethayo izoncika emiphumeleni yamasiko abonisa ngqo ukuthi yiziphi amagciwane abangela ukutheleleka kwakho. Lokhu kuhlolwa kusiza ukuqinisekisa ukuthi uthola ukwelashwa okuphumelela kakhulu.

Ingabe i-Tigecycline ingcono kune-Vancomycin?

I-Tigecycline ne-vancomycin yomibili imithi elwa namagciwane enamandla, kodwa isebenza ngezindlela ezahlukene futhi ingcono ezinhlotsheni ezahlukene zokutheleleka. Esikhundleni sokuthi eyodwa ibe ngcono ngokujwayelekile, ngayinye inezimo ezithile lapho iyindlela ekhethwayo.

I-Tigecycline inohlu olubanzi lomsebenzi, okusho ukuthi ingalwa nezinhlobo eziningi zamagciwane kune-vancomycin. Lokhu kuyenza ibe usizo ikakhulukazi lapho odokotela bengaqiniseki ngqo ukuthi yimaphi amagciwane abangela ukutheleleka kwakho noma lapho izinhlobo eziningi zamagciwane zihilelekile.

I-Vancomycin ivame ukukhethwa ezinhlotsheni ezithile zokutheleleka ezingamelani, ikakhulukazi lezo ezibangelwa yi-MRSA (i-methicillin-resistant Staphylococcus aureus). Iphinde yasetshenziswa isikhathi eside futhi inerekhodi eliqinile lezimo ezithile.

Udokotela wakho uzokhetha phakathi kwale mithi ngokusekelwe ekuthelelekeni kwakho okuthile, umlando wakho wezokwelapha, nokuthi yimaphi amagciwane asolwa noma aqinisekisiwe esimweni sakho. Zombili ziyizibulali-magciwane eziphumelelayo uma zisetshenziswa ezimweni ezifanele.

Imibuzo Evame Ukubuzwa Mayelana ne-Tigecycline

Ingabe i-Tigecycline iphephile ezigulini ezinokuwohloka kwezinso?

I-Tigecycline ngokuvamile ingasetshenziswa ngokuphepha kubantu abanokuwohloka kwezinso, okuhlanganisa nalabo abase-dialysis. Ngokungafani neminye imithi eminingi elwa namagciwane, i-tigecycline ayidingi ukulungiswa komthamo ngokuya ngomsebenzi wezinso, okuyenza ibe yindlela ewusizo kubantu abanezinkinga zezinso.

Nokho, udokotela wakho usazoqapha ukusebenza kwezinso zakho ngesikhathi sokwelashwa ukuze aqinisekise ukuthi konke kuhlala kuzinzile. Bazophinda baqaphele noma yiziphi izimpawu zokuthi izinso zakho azikwazi ukusingatha kahle imithi, nakuba lokhu kungavamile.

Uma use-dialysis, usengathola i-tigecycline ngaphandle kokudinga ukuhlela imithamo ngesikhathi sokuhlolwa kwakho kwe-dialysis. Umuthi awususwa kakhulu yi-dialysis, ngakho-ke isimiso sakho sokuthatha imithi esivamile singaqhubeka.

Kufanele Ngenzeni Uma Ngithola I-Tigecycline Eningi Ngengozi?

Njengoba i-tigecycline inikezwa ochwepheshe bezokwelapha abaqeqeshiwe endaweni yasesibhedlela, ukweqisa ngengozi akuvamile. Abahlengikazi bakho balandela imithetho eqinile ukuqinisekisa ukuthi uthola ngqo inani elifanele lomuthi.

Uma unokukhathazeka ngomthamo wakho noma uqaphela noma yini engajwayelekile ngesikhathi sokufakwa komuthi, khuluma ngokushesha. Ithimba lakho lezempilo lihlala litholakala ukuze liphendule noma yimiphi imibuzo noma ukukhathazeka ngemithi yakho.

Esimeni esingajwayelekile sokweqisa, ithimba lakho lezokwelapha linganikeza ukunakekelwa okusekelayo futhi likuqaphe eduze. Akukho umuthi oqondile we-tigecycline, kodwa odokotela bangelapha noma yiziphi izimpawu ezingase zivele.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Tigecycline?

Ukweqa umthamo we-tigecycline akunakwenzeka njengoba uyithola esibhedlela lapho ithimba lakho lokunakekela liphatha isimiso sakho semithi. Kodwa-ke, uma umthamo uhlehliswa nganoma yisiphi isizathu, abahlengikazi bakho bazosebenza nodokotela wakho ukunquma isikhathi esingcono kakhulu somthamo wakho olandelayo.

Ithimba lakho lezempilo lingase lilungise isimiso sakho kancane ukuze kulungiswe noma yimiphi imithamo ephuthelwe noma ehlahliwe. Bazoqinisekisa ukuthi usathola inani eliphelele lomuthi owudingayo ngesikhathi sokwelashwa kwakho.

Into ebaluleke kakhulu ukugcina amazinga aqhubekayo e-antibiotic ohlelweni lwakho ukuze ulwe nokutheleleka kwakho ngempumelelo. Ithimba lakho lezokwelapha lizosingatha yonke imininingwane yesikhathi nokuhlela yakho.

Ngingayeka Nini Ukuthatha I-Tigecycline?

Akufanele uyeke ukuthatha i-tigecycline ngokwakho - lesi sinqumo sizohlala senziwa ithimba lakho lezempilo ngokusekelwe ekutheni ukutheleleka kwakho kuphendula kahle kangakanani emithini. Bazobheka intuthuko yakho ngokuhlolwa komzimba, ukuthuthuka kwezimpawu, kanye nokuhlolwa kwegazi.

Udkt wakho ngokuvamile uzoqhubeka nokukunika i-tigecycline kuze kube yilapho ukutheleleka kwakho kubonisa izimpawu ezicacile zokuthuthuka futhi uzinzile ngokwanele ukushintshela kuma-antibiotics omlomo noma ukuyeka ukwelashwa ngama-antibiotics ngokuphelele. Lokhu kuvame ukwenzeka lapho umkhuhlane wakho usunyamalele, inani lakho lamaseli egazi elimhlophe selibuyele esimweni esijwayelekile, futhi izimpawu zakho zithuthuke kakhulu.

Ngezinye izikhathi ungase ushintshele kuma-antibiotics omlomo ukuze uqedele ukwelashwa kwakho ekhaya, kanti ngezinye izikhathi ungase ungadingi noma yimaphi ama-antibiotics engeziwe uma i-tigecycline isiqediwe. Ithimba lakho lezempilo lizochaza uhlelo olungcono kakhulu esimweni sakho esithile.

Ngingadla Ukudla Okujwayelekile Ngenkathi Ngithatha I-Tigecycline?

Yebo, ungadla ngokujwayelekile ngenkathi uthola i-tigecycline ngoba inikezwa nge-IV kunokuba ngomlomo. Umuthi ungena ngqo emsingeni wakho wegazi, ngakho ukudla ngeke kuphazamise ukuthi usebenza kahle kangakanani.

Nokho, uma uzwa isicanucanu (okuyisiphumela esivamile), ungase ukuthole kuwusizo ukudla ukudla okuncane, okuvame kakhulu noma unamathele ekudleni okungenambitheki kuze kube yilapho isicanucanu sidlula. Ithimba lakho lezempilo lingakunikeza imithi elwa nesicanucanu uma kudingeka.

Ukuhlala unomsoco ngempela kusiza umzimba wakho ukuthi ulwe nokutheleleka ngempumelelo enkulu, ngakho ukudla njalo uma uzizwa ukwazi ukukwenza kuyazuzisa. Uma unezithiyo ezithile zokudla noma ukukhathazeka, xoxa ngakho nethimba lakho lezempilo elingakunikeza isiqondiso esiqondene nawe.