Yini i-Trientine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Trientine iyimithi ekhethekile esiza ukususa ithusi eliningi emzimbeni wakho uma liqongelela emazingeni ayingozi. Isetshenziswa ikakhulu ukwelapha isifo sikaWilson, isimo esingavamile sezakhi zofuzo lapho ithusi liqongelela esibindini sakho, ebuchosheni, nakwezinye izitho ngoba umzimba wakho awukwazi ukuliqeda ngokwemvelo.

Le mithi isebenza njengomsizi oqaphile, ibopha ithusi elengeziwe ohlelweni lwakho futhi isize izinso zakho ukuthi zilikhiphe ngomchamo. Ngenkathi kungase kuzwakale kuyinkimbinkimbi, i-trientine ibilokhu isiza ngokuphepha abantu ukuthi balawule ukugcwala kwethusi amashumi eminyaka, inikeza iziguli indlela ethembekile yokuvikela izitho zabo ekulimaleni okuhlobene nethusi.

Yini i-Trientine?

I-Trientine iyisithunywa se-chelating, okusho ukuthi isebenza njengozibuthe wama-molecular okhanga futhi obophela ithusi emzimbeni wakho. Igama eliphelele lemithi lithi triethylene tetramine dihydrochloride, kodwa odokotela neziguli bayibiza ngokuthi i-trientine ukuze kube lula.

Le mithi yomlomo iza ngesimo se-capsule futhi ingeyeqembu elikhethekile lemithi eyenzelwe ngqo ukubulawa yinsimbi noma izimo zokugcwala. Ngokungafani nemithi eminingi ejwayelekile, i-trientine inomsebenzi ogxile kakhulu - iqondise ithusi ngqo futhi isiza umzimba wakho ukuthi uliqede eliningi ngezinso zakho.

Le mithi ivunyelwe yi-FDA futhi inerekhodi elide lokuphepha uma isetshenziswa ngendlela efanele ngaphansi kokuqondisa kwezokwelapha. Ithathwa njengokwelashwa okubalulekile kubantu abangakwazi ukuthatha i-penicillamine, okuyinye imithi esusa ithusi.

Isetshenziselwani i-Trientine?

I-Trientine ikakhulu inikezwa isifo sikaWilson, isimo sezakhi zofuzo esithinta cishe umuntu oyedwa kwabangu-30,000 emhlabeni jikelele. Esifweni sikaWilson, umzimba wakho awunayo iphrotheni ethile edingekayo ukuthutha ithusi ngaphandle kwesibindi sakho, okubangela ukuqongelela okuyingozi ezithweni zakho.

Umuthi uvame ukusetshenziswa uma iziguli zingakwazi ukubekezelela i-penicillamine, ukwelashwa kokuqala kwesifo sikaWilson. Abanye abantu bahlangabezana nokusabela komzimba noma imiphumela emibi evela ku-penicillamine, okwenza i-trientine ibe enye indlela ebalulekile.

Ezimweni ezingavamile, odokotela bangase banikeze i-trientine kwezinye izinhlobo zobuthi obunethusi noma izimo zokulayisha ngokweqile. Kodwa-ke, lezi zimo azivamile kakhulu futhi zingenzeka kuphela ngaphansi kwezimo ezithile zezokwelapha ngokugadwa ngokucophelela.

Isebenza Kanjani I-Trientine?

I-Trientine isebenza ngokwakha izibopho ezinamandla zamakhemikhali ngama-molecule ethusi egazini lakho nasezicutshini. Cabanga ngayo njengabasebenzi abakhethekile bokuhlanza abaqondise futhi babambe ithusi eliningi elingakwazi ukulisingatha umzimba wakho uwedwa.

Uma i-trientine isibophezele kuthusi, idala inhlanganisela ezinzileyo ezingakwazi ukuhlungwa kalula izinso zakho futhi ziqedwe ngomchamo. Le nqubo ithambile kodwa iyasebenza, inciphisa kancane amazinga ethusi ngokuhamba kwesikhathi kunokubangela izinguquko ezingazelelwe, ezimangalisayo.

Umuthi uthathwa njengomkhulu ngamandla awo okubopha ithusi. Unamandla ngokwanele ukususa ngempumelelo ithusi eliningi kodwa uthambile ngokwanele ukuthi ngeke ususe amanani amancane ethusi umzimba wakho owadingayo ngempela ukuze usebenze ngendlela efanele njengokwenza amaseli egazi abomvu nokugcina izicubu ezixhumayo ezinempilo.

Kufanele Ngiyithathe Kanjani I-Trientine?

Thatha amaphilisi e-trientine esiswini esingenalutho, okungenani ihora elilodwa ngaphambi kokudla noma amahora amabili ngemva kokudla. Ukudla kungaphazamisa ikhono lomuthi lokubopha nethusi, ngakho-ke isikhathi sibalulekile ukuze uthole imiphumela engcono kakhulu.

Gwinya amaphilisi wonke ngengilazi yamanzi egcwele. Ungawaqhekezi, uwachoboze, noma uwahlafune, ngoba lokhu kungathinta indlela umuthi ogxiliswa ngayo futhi ukhishwe emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinye izindlela.

Gwema ukuthatha i-trientine nobisi, ama-antacid, noma izithasiselo zensimbi, ngoba lokhu kunganciphisa ukusebenza kwayo. Hlukanisa lezi zinto okungenani ngamahora amabili ukusuka emthamo wakho we-trientine ukuvimbela noma yikuphi ukuphazamiseka ekumunceni.

Udkt wakho cishe uzoqala ngohlelo oluthile lokulinganisa, ngokuvamile ehlukanisa umthamo wakho wansuku zonke ube yimithamo emibili noma emithathu emincane usuku lonke. Lokhu kusiza ukugcina ukususwa kwethusi okungaguquki futhi kunciphisa ithuba lokucasuka kwesisu.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Trientine?

Abantu abaningi abanesifo sikaWilson badinga ukuthatha i-trientine impilo yabo yonke, njengoba isimo esingaphansi kwezakhi zofuzo singanyamalali. Umuthi ulawula amazinga ethusi kunokwelapha lesi sifo, ngakho ukuyeka ukwelashwa kungavumela ithusi ukuthi liphinde lakheke.

Udkt wakho uzoqapha amazinga akho ethusi ngokuhlolwa kwegazi nomchamo njalo ukuze aqinisekise ukuthi umuthi usebenza ngempumelelo. Lokhu kuhlolwa kusiza ukunquma ukuthi umthamo wakho udinga ukulungiswa yini futhi kuqinisekise ukuthi amazinga ethusi ahlala ebangeni eliphephile.

Ezinye iziguli zingase zidinge ukuphumula okwesikhashana ekwelashweni uma zithuthukisa imiphumela emibi noma zidinga ukuhlinzwa. Kodwa-ke, lezi zinqumo kufanele zenziwe ngaso sonke isikhathi ngesiqondiso sikadkt wakho, njengoba ukuyeka i-trientine ngaphandle kokuqondiswa kwezokwelapha kungaholela ekuqongeleleni kabusha ithusi eliyingozi.

Yini Imiphumela Emibi Ye-Trientine?

Imiphumela emibi evamile ye-trientine ngokuvamile imnene futhi iyaphathwa. Abantu abaningi abahlangabezani nezinkinga ezimbalwa ngalo muthi, ikakhulukazi uma kuqhathaniswa nokwelashwa okuhlukile okususwa ithusi.

Imiphumela emibi ebikwa kaningi ihlanganisa ukucasuka kwesisu, isicanucanu, kanye nohudo ngezikhathi ezithile. Lezi zimpawu zivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini, ngokuvamile phakathi namasonto ambalwa okuqala okwelashwa.

Nawa imiphumela emibi evame kakhulu ongase uyithole:

• Ukuqaqamba kwesisu noma ukuqaqamba okuncane
• Isicanucanu, ikakhulukazi uma uqala ukwelashwa
• Izitulo ezixekile noma isifo sohudo
• Ukunambitheka kwensimbi emlonyeni wakho
• Ukukhathazeka okuncane
• Ukulahlekelwa isifiso sokudla

Lezi zimpawu zivame ukuncipha njengoba umzimba wakho ujwayela umuthi, futhi ukuthatha i-trientine ngemali encane yokudla kungasiza ukunciphisa ukucasuka kwesisu.

Imiphumela emibi kakhulu ayivamile kodwa ingenzeka uma isetshenziswa isikhathi eside. Lokhu kudinga ukunakekelwa kwezempilo ngokushesha nokuqapha ngokucophelela ithimba lakho lezempilo.

Imiphumela emibi engavamile kodwa engathi sína ihlanganisa:

• Ukuntuleka kwegazi ngenxa yokubopha insimbi ngokweqile
• Ukuphendula kwesikhumba okukhulu noma ukuqubuka
• Ubuthakathaka bemisipha noma ubuhlungu bamalunga
• Ukulimala okungavamile noma ukuphuma kwegazi
• Ukuphendula okukhulu komzimba
• Izimpawu ezinjenge-Lupus ezinokuvuvukala kwamalunga

Udokotela wakho uzoqapha lezi zinkinga ngokuhlolwa kwegazi okuvamile nokuhlolwa komzimba. Ukutholwa kwasekuqaleni kuvumela ukulungiswa kokwelashwa okusheshayo uma kudingeka.

Ubani Ongafanele Athathwe I-Trientine?

Abantu abaziwa ukuthi banezinto ezithile ezingahambisani ne-trientine noma yiziphi izithako zayo kufanele bagweme lo muthi. Uma uke waba nokusabela komzimba okufana nalokhu okwenzeka kuma-ejenti afanayo e-chelating, xoxa lokhu ngokucophelela nodokotela wakho ngaphambi kokuqala ukwelashwa.

Abesifazane abakhulelwe badinga ukucatshangelwa okukhethekile, njengoba i-trientine ingawela umgoqo we-placental. Ngenkathi abanye besifazane abakhulelwe abanesifo sikaWilson bethatha i-trientine ngaphansi kokuqapha ngokucophelela, isinqumo sidinga ukulinganisa izingozi zokuqongelela ithusi elingelashwanga ngokumelene nemiphumela engaba khona kumntwana osakhulayo.

Omama abancelisa ngamabele kufanele futhi baqaphele, njengoba amanani amancane e-trientine engadlulela obisini. Udokotela wakho uzokusiza ukuthi ulinganise izinzuzo nezingozi zakho kanye nomntwana wakho.

Abantu abanezifo ezinzima zezinso bangase badinge ukulungiswa komthamo noma ezinye izindlela zokwelapha, njengoba i-trientine incike ekusebenzeni kwezinso ukuze iqede ithusi emzimbeni ngempumelelo.

Amagama Omkhiqizo we-Trientine

Igama elivamile lomkhiqizo we-trientine yi-Syprine, etholakala e-United States. Lo mkhiqizo ubelokhu uyindlela ejwayelekile iminyaka eminingi futhi usungulwe kahle ekwelapheni isifo sikaWilson.

Kwamanye amazwe, i-trientine ingase itholakale ngaphansi kwamanye amagama omkhiqizo noma njengamaphilisi ajwayelekile. Kodwa-ke, ngenxa yobunjalo obukhethekile baleli khambi, ngokuvamile litholakala kuphela ngemithi ekhethekile noma izinhlelo zezibhedlela.

Udokotela wakho uzochaza ukuthi iyiphi indlela engcono kakhulu ngesimo sakho, futhi kubalulekile ukunamathela kumkhiqizo ofanayo ngaphandle uma umhlinzeki wakho wezempilo encoma ukushintsha, njengoba izindlela ezihlukene zingase zibe nezici ezihlukile zokumuncwa.

Ezinye izindlela ze-Trientine

I-Penicillamine iyinye indlela ejwayelekile ye-trientine yokwelapha isifo sikaWilson. Ivame ukuba yikhambi lokuqala odokotela abalizama, kodwa ezinye iziguli azikwazi ukubekezelela imiphumela yayo emibi, engabandakanya izinkinga zesikhumba, izinkinga zezinso, noma ukucindezelwa komnkantsha wamathambo.

I-Zinc acetate noma i-zinc sulfate imele enye indlela yokwelapha. Esikhundleni sokususa ithusi njengoba i-trientine yenza, i-zinc isebenza ngokuvimba ukumuncwa kwethusi emathunjini akho, ivimbela ithusi elisha ukuthi lingangeni ohlelweni lwakho.

Iziguli ezingakwazi ukuthatha noma yimaphi alawa makhambi, odokotela bangase bacabange nge-ammonium tetrathiomolybdate, ukwelashwa okungokwesipiliyoni okusafundwa. Kodwa-ke, le nketho ngokuvamile igcinelwe amacala abucayi lapho ezinye izindlela zokwelapha ziye zahluleka.

Ezinye iziguli zisebenzisa ukwelashwa okuhlanganisiwe, zithatha i-zinc kanye ne-trientine noma i-penicillamine, kuye ngezidingo zazo ezithile nokuthi zithuthuka kangakanani ekwelashweni komuntu ngamunye.

Ingabe i-Trientine ingcono kune-Penicillamine?

Noma i-trientine noma i-penicillamine ayilona elithi "ngcono" ngokujwayelekile - ukukhetha kuncike ekuphenduleni kwakho komuntu ngamunye nokubekezelela imithi ngayinye. Zombili ziyasebenza ekususeni ithusi eliningi, kodwa zisebenza ngendlela ehlukile kancane futhi zinezinhlobo ezahlukene zemiphumela.

I-Penicillamine ivame ukuzanywa kuqala ngoba inesikhathi eside sokusetshenziswa kanye nedatha yocwaningo oluningi. Kodwa-ke, cishe ama-20-30% eziguli abakwazi ukubekezelela i-penicillamine ngenxa yemiphumela emibi efana nokuqubuka kwesikhumba, izinkinga zezinso, noma izifo zegazi.

I-Trientine ivame ukubangela imiphumela emibi embalwa kune-penicillamine, okuyenza ibe yindlela ekhethwayo ezigulini ezihlangabezana nezinkinga ngemithi yomugqa wokuqala. Abantu abaningi bathola ukuthi i-trientine kulula ukuyibekezelela esikhathini eside.

Udokotela wakho uzocabangela izinto ezinjengamazinga akho wamanje ethusi, noma yiziphi ezinye izimo zezempilo onazo, nokuthi usabela kanjani emithini lapho enquma ukuthi iyiphi imithi esebenza kangcono esimweni sakho esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Trientine

Ingabe i-Trientine iphephile ezigulini zenhliziyo?

Yebo, i-trientine ngokuvamile iphephile kubantu abanezifo zenhliziyo. Eqinisweni, ukunciphisa amazinga ethusi kungazuza inhliziyo yakho, njengoba ithusi eliningi lingaba nomthelela ezinkingeni zenhliziyo nemithambo yegazi ezigulini ze-Wilson's disease.

Kodwa-ke, udokotela wakho wenhliziyo nodokotela oqeda i-Wilson's disease yakho kufanele bahlele ukunakekelwa kwakho. Eminye imithi yenhliziyo ingase ihlangane ne-trientine, futhi isimo senhliziyo yakho singase sithinte izinqumo zokulinganisa.

Ukuqapha njalo kubaluleke nakakhulu uma unezimo zombili, njengoba ithimba lakho lezokwelapha lidinga ukuqinisekisa ukuthi ukususwa kwethusi akuphazamisi ukwelashwa kwenhliziyo yakho noma okuphambene nalokho.

Ngingenzani uma ngiphuthelwa ukuthatha i-Trientine eningi?

Uma ngabe uthatha i-trientine eningi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kakhulu kungase kukhiphe amaminerali abalulekile emzimbeni wakho noma kubangele ukuphazamiseka okukhulu kwesisu.

Ungazami ukuzenza uhlanze ngaphandle uma uqondiswe ngqo ochwepheshe bezokwelapha. Kunalokho, phuza amanzi amaningi futhi funa ukwelashwa ngokushesha ukuze unqume ukuthi ngabe kukhona yini ukwelashwa okudingekayo.

Gcina umkhondo wokuthi uthathe malini ngqo nokuthi nini, ngoba lolu lwazi luzosiza ochwepheshe bezokwelapha ukuthi banqume ukuthi yini okufanele yenziwe. Ukweqisa okuningi okungahlosiwe akubangeli izinkinga ezinkulu, kodwa ngaso sonke isikhathi kungcono ukuphepha.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Trientine?

Thatha umthamo owuqegile ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Uma usondela esikhathini somthamo wakho olandelayo, weqa umthamo owuqegile bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ukuze ulungise okukodwa okuqegiwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Kungcono ukweqa umthamo owodwa kunokubeka engcupheni yokuthatha okuningi ngesikhathi esisodwa.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi ukukusiza ukuthi uhlale emkhondweni. Ukuthatha imithamo ngokuqhubekayo kusiza ukugcina ukususwa kwethusi okuzinzile kanye nemiphumela engcono yokwelashwa.

Ngingayeka Nini Ukuthatha I-Trientine?

Kufanele uyeke kuphela ukuthatha i-trientine ngaphansi kokuqondisa okuqondile kukadokotela wakho. Abantu abaningi abanesifo sikaWilson badinga ukwelashwa impilo yonke ukuze bavimbele ukuqoqwa kwethusi okuyingozi ukuthi kubuye.

Udokotela wakho angase anciphise okwesikhashana noma amise umthamo wakho uma uba nemiphumela emibi, udinga ukuhlinzwa, noma uma amazinga akho ethusi eba phansi kakhulu. Kodwa-ke, lezi zinqumo zidinga ukuqapha ngokucophelela futhi ngokuvamile zihilela ukuhlolwa kwegazi njalo.

Abanye abantu abagulayo bangase bashintshe baye ekwelashweni kokulondoloza nge-zinc ngemuva kokuba amazinga abo e-copper ezinzile ngemithi ye-trientine. Lesi sinqumo sincike ekuphenduleni kwakho ngamunye kanye nokuhlola kukadokotela wakho ngezidingo zakho zesikhathi eside.

Ngingakwazi Ukuthatha Amavithamini Ngenkathi Ngithatha I-Trientine?

Yebo, ungathatha amavithamini amaningi ngenkathi uthatha i-trientine, kodwa isikhathi sibalulekile. Izithasiselo zensimbi kufanele zithathwe okungenani amahora amabili ngaphandle kwe-trientine ukuvimbela ukuphazamiseka ekubopheni kwe-copper.

Udokotela wakho angase empeleni ancome izithasiselo zamavithamini athile, ikakhulukazi uma ukuhlolwa kwegazi kukhombisa ukuntula. Abanye abantu abathatha i-trientine badinga izithasiselo zensimbi uma imithi ibopha insimbi kanye ne-copper.

Njalo yazisa udokotela wakho ngamavithamini noma izithasiselo ozithathayo, njengoba bengakunikeza isiqondiso ngesikhathi esifanele kanye nokulinganisa ukuqinisekisa ukuthi zombili izithasiselo zakho ne-trientine zisebenza ngempumelelo.