Yini i-Trihexyphenidyl: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Trihexyphenidyl iyimithi esiza ukulawula ukuqina kwemisipha nokuthuthumela, ikakhulukazi kubantu abanesifo i-Parkinson noma izinkinga zokunyakaza ezibangelwa imithi ethile yezifo zengqondo. Cabanga ngayo njengomsizi osebenza ebuchosheni bakho ukubuyisela ibhalansi lapho uhlelo lwakho lokulawula ukunyakaza luphazamiseka.

Le mithi ingeyeqembu elibizwa ngokuthi ama-anticholinergics, okusho ukuthi ivimba amasignali athile amakhemikhali ebuchosheni bakho angabangela ukunyakaza kwemisipha okungafuneki. Ngenkathi isineminyaka eminingi ikhona futhi isize abantu abaningi ukuthi babuyisele ukunyakaza okubushelelezi, kubalulekile ukuqonda ukuthi isebenza kanjani nokuthi yini ongayilindela.

Yini i-Trihexyphenidyl?

I-Trihexyphenidyl iyimithi yomlomo eza ngesimo samaphilisi futhi isebenza ngokuvimba i-acetylcholine, isithunywa samakhemikhali ebuchosheni bakho. Lapho i-acetylcholine iba namandla ngokweqile uma iqhathaniswa nelinye ikhemikhali lobuchopho elibizwa ngokuthi i-dopamine, ingabangela ukuqina kwemisipha, ukuthuthumela, nezinye izinkinga zokunyakaza.

Ngokuvimba amanye ala masignali e-acetylcholine, i-trihexyphenidyl isiza ukubuyisela imvelo yamakhemikhali elinganiselwe ebuchosheni bakho. Lokhu kubuyisela ibhalansi kuvumela imisipha yakho ukuthi iphumule futhi ukunyakaza kwakho kube bushelelezi futhi kulawulwe.

Le mithi itholakala ngamaphilisi akhishwa ngokushesha asebenza ngokushesha nama-capsules akhishwa isikhathi eside anikeza imiphumela ehlala isikhathi eside usuku lonke. Udokotela wakho uzokhetha ifomu elifanele ngokuya ngezidingo zakho ezithile kanye namaphethini ezimpawu.

Isetshenziselwani i-Trihexyphenidyl?

I-Trihexyphenidyl ngokuyinhloko iphatha izinkinga zokunyakaza ezenzeka lapho ibhalansi yamakhemikhali ebuchosheni bakho iphazamiseka. Ivame ukunqunywa kakhulu ngezimpawu zesifo i-Parkinson nezinkinga zokunyakaza ezibangelwa imithi.

Le mithi isiza ngezimo eziningana ezithile ezithinta ikhono lakho lokunyakaza ngokujwayelekile:

• Ukuthuthumela kwesifo sikaParkinson nokuqina kwemisipha
• I-parkinsonism ebangwa yimithi evela emithini ye-antipsychotic
• I-dystonia ebukhali (ukuqina kwemisipha okungazelelwe nokuncipha)
• I-tardive dyskinesia kwezinye izimo
• I-parkinsonism ngemva kwe-encephalitic

Abantu abaningi bakuthola kuwusizo ikakhulukazi ekunciphiseni ukuthuthumela okuthiwa yi- "pill-rolling" okuvame kakhulu esifweni sikaParkinson nokuqina kwemisipha okungenza imisebenzi yansuku zonke ibe yinselele. Kungasiza futhi ekuthuleni amathe nobunzima obuthile bokukhuluma obuhlobene nalezi zimo.

Ezimweni ezingavamile, odokotela bangase banikeze i-trihexyphenidyl kwezinye izifo zokunyakaza ezinjengesifo sikaWilson noma izinhlobo ezithile ze-dystonia, nakuba lezi zinto zivame kakhulu futhi zidinga ukugadwa kwezokwelapha okukhethekile.

Isebenza Kanjani I-Trihexyphenidyl?

I-Trihexyphenidyl isebenza ngokuvimba ama-receptors e-acetylcholine ebuchosheni bakho, ikakhulukazi ezindaweni ezilawula ukunyakaza. Le mithi ithathwa njengeqinile ngokulinganisela phakathi kokwelashwa kwezifo zokunyakaza, okusho ukuthi ingasebenza kahle kakhulu kodwa idinga ukuqapha ngokucophelela.

Ebuchosheni obunempilo, i-acetylcholine ne-dopamine zisebenza ndawonye njengabalingani bomdanso ukuze bahlele ukunyakaza okubushelelezi. Lapho amazinga e-dopamine ehla (njengasesifweni sikaParkinson) noma lapho imithi ethile ivimba i-dopamine, i-acetylcholine iba ebalulekile futhi ibangela izinkinga ezinjengokuthuthumela nokuqina.

Ngokunciphisa umsebenzi we-acetylcholine, i-trihexyphenidyl isiza ukubuyisela leli bhalansi elibucayi. Imithi ngokuvamile iqala ukusebenza kungakapheli ihora elingu-1-2 ngemva kokuyithatha, nemiphumela ihlala cishe amahora angu-6-12 kuye ngokuthi uthatha amafomu akhishwa ngokushesha noma akhishwa isikhathi eside.

Kubalulekile ukuqonda ukuthi i-trihexyphenidyl ayikwelaphi isimo esiyisisekelo kodwa ilawula izimpawu ngokuthuthukisa ibhalansi yamakhemikhali ebuchosheni bakho. Yingakho ukusetshenziswa kwansuku zonke okuqhubekayo kuvame ukudingeka ukuze kulondolozwe ukulawulwa kwezimpawu.

Kufanele Ngiyithathe Kanjani I-Trihexyphenidyl?

Thatha i-trihexyphenidyl ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile uqala ngomthamo ophansi okhuphuka kancane kancane ngokuhamba kwesikhathi. Abantu abaningi bayayithatha izikhathi ezi-3-4 ngosuku ngamaphilisi akhishwa ngokushesha noma izikhathi ezi-1-2 ngosuku ngamaphilisi akhishwa isikhathi eside.

Ungayithatha le mithi ngaphandle noma ngaphandle kokudla, kodwa ukuyithatha nokudla kungasiza ukunciphisa ukuphazamiseka kwesisu uma uhlangabezana nanoma yikuphi. Uma ukhetha ukuyithatha nokudla, zama ukungaguquguquki ngesikhathi sakho ukuze ugcine amazinga aqhubekayo ohlelweni lwakho.

Nawa amathiphu awusizo okuthatha i-trihexyphenidyl ngokuphepha:

• Yithathe ngezikhathi ezifanayo nsuku zonke ukuze ugcine ukulawulwa kwezimpawu okuqhubekayo
• Qala ngomthamo ophansi osebenzayo bese ukhuphuka kancane kancane njengoba uqondisiwe
• Ungachobozi noma uhlafune amaphilisi akhishwa isikhathi eside
• Gcina isimiso esiqhubekayo ukuze usize ukukhumbula imithamo yakho
• Hlala unamanzi kahle, njengoba imithi ingabangela umlomo owomile

Ungayeki ukuthatha i-trihexyphenidyl ngokuzumayo, njengoba lokhu kungabangela izimpawu zokuhoxisa kanye nokubuyela okuzumayo kwezinkinga zakho zokunyakaza. Njalo sebenzisana nodokotela wakho ukuze unciphise kancane kancane umthamo uma udinga ukuyeka imithi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Trihexyphenidyl?

Ubude bokwelashwa nge-trihexyphenidyl buhluka kakhulu kuye ngesimo sakho esiyisisekelo nokuphendula komuntu ngamunye. Abanye abantu bayayidinga izinyanga ezimbalwa, kanti abanye badinga ukwelashwa kwesikhathi eside iminyaka.

Ezinkingeni zokunyakaza ezibangelwa izidakamizwa, ungase udinge i-trihexyphenidyl okwesikhashana nje ngenkathi umzimba wakho uzivumela emithini yezifo zengqondo noma ngenkathi leyo mithamo ishintshwa. Ezimweni ezinjalo, ukwelashwa kungase kuthatha noma yikuphi kusukela emavikini ambalwa kuya ezinyangeni ezimbalwa.

Ngesifo sikaParkinson noma ezinye izinkinga zokunyakaza ezingapheli, i-trihexyphenidyl ivame ukuba ukwelashwa kwesikhathi eside ozoyithatha iminyaka. Udokotela wakho uzohlola njalo ukuthi ngabe izinzuzo zisaqhubeka yini ukwedlula noma yimaphi ama-side effects futhi angase alungise umthamo wakho noma acabange ezinye izindlela ngokuhamba kwesikhathi.

Abanye abantu bathola ukuthi umuthi awusebenzi kahle ngokuhamba kwesikhathi, okuyinto ebizwa ngokuthi ukubekezelela. Uma lokhu kwenzeka, udokotela wakho angase anciphise umthamo okwesikhashana, ashintshele komunye umuthi, noma angeze eminye imithi ohlelweni lwakho.

Yiziphi Izimo Ezingezinhle Zomuthi i-Trihexyphenidyl?

Njengayo yonke imithi, i-trihexyphenidyl ingabangela imiphumela engemihle, nakuba kungabona bonke abantu abayitholayo. Imiphumela engemihle evame kakhulu ihlobene nezakhiwo zayo ze-anticholinergic futhi ngokuvamile ithambile noma imaphakathi.

Imiphumela engemihle ejwayelekile abantu abaningi abangayilawula ihlanganisa:

• Umlomo owomile (ovamile kakhulu)
• Ukubona okungacacile noma ubunzima bokugxila
• Ukuqunjelwa
• Ukozela noma isiyezi
• Isicanucanu noma isisu esibuhlungu
• Ubunzima bokuchama
• Ukudideka noma izinkinga zenkumbulo, ikakhulukazi kubantu abadala

Iningi lale miphumela engemihle iyathuthuka njengoba umzimba wakho ujwayela umuthi noma ingalawulwa ngamasu alula njengokuhlala unamanzi, usebenzisa izinyembezi zokwenziwa, noma ukudla ukudla okunefayibha ephezulu.

Imiphumela engemihle engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Lokhu kuhlanganisa ukudideka okukhulu, ukucabanga okungamanga, ukushaya kwenhliziyo okusheshayo, ukuqunjelwa okukhulu, ukungakwazi ukuchama, noma izimpawu zokushaywa ukushisa (ngoba umuthi ungathinta ikhono lomzimba wakho lokulawula izinga lokushisa).

Imiphumela engemihle engavamile kodwa engaba yingozi ihlanganisa i-angle-closure glaucoma, ukusabela okukhulu komzimba, noma izinguquko ezinkulu ekushayeni kwenhliziyo. Uma uzwa ubuhlungu besifuba, ubunzima obukhulu bokuphefumula, noma izinguquko ezingazelelwe ekuboneni, funa usizo lwezempilo ngokushesha.

Ubani Ongafanele Athathe i-Trihexyphenidyl?

Abantu abathile kufanele bagweme i-trihexyphenidyl ngenxa yengozi eyengeziwe yezinkinga ezingathi sína. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-trihexyphenidyl uma une:

• I-glaucoma ye-narrow-angle
• I-colitis eqinile ye-ulcerative
• I-Myasthenia gravis
• Isifo esiqinile sezinso noma sesibindi
• Ukwanda kwendlala yesinye okubangela izinkinga zokuchama
• Ukungezwani okwaziwayo ne-trihexyphenidyl noma imithi efanayo

Ukuqapha okukhethekile kuyadingeka kubantu abadala, njengoba bezwela kakhulu emiphumeleni ye-anticholinergic efana nokudideka, izinkinga zenkumbulo, nokuwa. Abantu abanezimo zenhliziyo, i-glaucoma encane, noma ukukhula okuncane kwendlala yesinye bangase bakwazi ukuthatha umuthi kodwa badinga ukuqashwa okuseduze.

Uma ukhulelwe noma uncelisa, xoxa ngezingozi nezinzuzo nodokotela wakho, njengoba ukuphepha kwe-trihexyphenidyl ngesikhathi sokukhulelwa kungaqinisekiswanga ngokugcwele. Umuthi ungase udlulele obisini lwebele futhi ungase uthinte ingane encelisayo.

Amagama e-Brand ye-Trihexyphenidyl

I-Trihexyphenidyl itholakala ngaphansi kwamagama amaningi e-brand, nakuba inguqulo ejwayelekile ivame ukunqunywa. Igama le-brand elaziwa kakhulu yi-Artane, ebelitholakala amashumi eminyaka.

Amanye amagama e-brand afaka i-Apo-Trihex, i-Trihexane, kanye nezinhlobo ezihlukahlukene ezijwayelekile ezivela kubakhiqizi abahlukene. Zonke izinhlobo ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efanayo, nakuba abanye abantu bengase baqaphele umehluko omncane ngokushesha abamunca ngayo noma ukuthi bahlala isikhathi esingakanani.

Ikhemisi lakho lingase lithathele izinhlobo ezihlukene ezijwayelekile ngaphandle uma udokotela wakho ecacisa uhlobo oluthile. Uma uqaphela noma yiziphi izinguquko endleleni umuthi osebenza ngayo lapho ushintsha phakathi kwemikhiqizo, yazisa udokotela wakho ukuze benze noma yiziphi izinguquko ezidingekayo.

Ezinye izindlela ze-Trihexyphenidyl

Ezinye izindlela ze-trihexyphenidyl zikhona zokwelapha izifo zokunyakaza, ngasinye sinenzuzo yaso kanye nokucatshangelwa kwazo. Udokotela wakho angase aphakamise ezinye izindlela uma i-trihexyphenidyl ingasebenzi kahle kuwe noma ibangela imiphumela emibi.

Eminye imithi elwa ne-anticholinergic ihlanganisa i-benztropine (Cogentin) kanye ne-biperiden, esebenza ngendlela efanayo kodwa ingase ibe nemiphumela ehlukile. Abanye abantu bayayibekezelela kahle enye kunenye, ngakho ukushintshana phakathi kwazo kungaba usizo.

Ngokuqondile ngesifo sikaParkinson, ezinye izindlela zihlanganisa:

• I-Carbidopa-levodopa (iyindinganiso yegolide yokwelashwa kwesifo sikaParkinson)
• Ama-dopamine agonists afana ne-pramipexole noma i-ropinirole
• Ama-MAO-B inhibitors afana ne-rasagiline noma i-selegiline
• Ama-COMT inhibitors afana ne-entacapone
• I-Amantadine yokulawula ukuthuthumela

Ezinkingeni zokunyakaza ezibangelwa imithi, ezinye izindlela zingabandakanya ukunciphisa umthamo womuthi obangela le nkinga, ukushintshela kwenye imithi yezengqondo, noma ukusebenzisa ezinye izindlela zokwelapha izinkinga zokunyakaza njenge-tetrabenazine noma i-deutetrabenazine.

Ingabe i-Trihexyphenidyl Ingcono Kune-Benztropine?

Kokubili i-trihexyphenidyl ne-benztropine ziyimithi elwa ne-anticholinergic esebenzayo, kodwa zinezinye izinto ezibalulekile ezenza enye ibe ngcono kunenye kwabanye abantu. Ukukhetha phakathi kwazo kuncike ezimpawini zakho eziqondile, ukubekezelela imiphumela emibi, nezidingo zokuphila kwakho.

I-Trihexyphenidyl ivame ukucatshangwa ukuthi isebenza kahle ekulawuleni ukuthuthumela futhi ingase isebenze kangcono kubantu abanezimpawu ezibangelwa ukuthuthumela. Itholakala futhi nasezinhlotsheni ezikhishwe isikhathi eside, ezingaba lula kwabanye abantu abathanda ukuthatha imithi kaningi.

I-Benztropine, ngakolunye uhlangothi, ingase ibangele ukudideka okuncane nezinkinga zenkumbulo kubantu abadala futhi itholakala njengomjovo wokwelashwa okuphuthumayo kwezinkinga zokunyakaza eziqatha. Ivame futhi ukubangela umlomo owomile kancane kwabanye abantu.

Udokotela wakho uzocabangela izinto ezinjengobudala bakho, ezinye izimo zezokwelapha, eminye imithi oyithathayo, nezimpawu zakho eziqondile lapho ekhetha phakathi kwalezi zinketho. Abanye abantu bangase bazame zombili ukuze babone ukuthi iyiphi esebenza kangcono esimweni sabo esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Trihexyphenidyl

Umbuzo 1. Ingabe i-Trihexyphenidyl iphephile ezigulini zenhliziyo?

I-Trihexyphenidyl ingasetshenziswa kubantu abanezifo zenhliziyo, kodwa idinga ukuqashwa ngokucophelela nokulungiswa kwemithamo. Imithi ngezinye izikhathi ingabangela izinguquko esigqi senhliziyo noma ikhulise izinga lokushaya kwenhliziyo, ngakho udokotela wakho uzodinga ukulinganisa izinzuzo nezingozi ezingaba khona.

Uma unesifo senhliziyo, udokotela wakho cishe uzoqala ngomthamo ophansi futhi aqaphe ukusebenza kwenhliziyo yakho ngokucophelela. Bangase futhi bancomise ukuhlolwa okujwayelekile kwesigqi senhliziyo, ikakhulukazi lapho uqala imithi noma ukhulisa umthamo.

Abantu abanezimo zenhliziyo ezithile njengokwehluleka kwenhliziyo okukhulu noma ama-arrhythmias ayingozi bangase badinge ukugwema i-trihexyphenidyl ngokuphelele noma bayisebenzise ngaphansi kokuqashwa okuseduze kakhulu kwezokwelapha. Njalo yazisa udokotela wakho nganoma yiziphi izinkinga zenhliziyo ngaphambi kokuqala lo muthi.

Umbuzo 2. Kufanele ngenzeni uma ngiphuzile i-Trihexyphenidyl eningi ngengozi?

Uma ngengozi uthatha i-trihexyphenidyl eningi, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukweqisa kungabangela izimpawu ezinzima ezingase zingaveli ngokushesha.

Izimpawu zokweqisa i-trihexyphenidyl zihlanganisa ukudideka okukhulu, ukucabanga okungamanga, ukushaya kwenhliziyo okusheshayo, ubunzima bokuphefumula, umlomo owomile kakhulu, ukungakwazi ukuchama, umkhuhlane ophezulu, noma ukulahlekelwa ukwazi. Lezi zimpawu zidinga ukunakekelwa kwezimo eziphuthumayo zezokwelapha ngokushesha.

Ngenkathi ulindele usizo lwezokwelapha, hlala uzolile futhi ungazami ukuzihlanza ngaphandle uma uqondiswe ngqo ochwepheshe bezokwelapha. Gcina ibhodlela lemithi nawe ukuze ubonise abahlinzeki bezempilo ukuthi uthathe ini nokuthi uthathe kangakanani.

Ukuvimbela ukweqisa ngengozi, cabanga ukusebenzisa umhleli wamaphilisi, ukusetha ama-alamu ocingo, noma ukucela amalungu omndeni ukuthi akusize ukuthi ulandelele uhlelo lwakho lwemithi.

Umbuzo 3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Trihexyphenidyl?

Uma uphuthelwa umthamo we-trihexyphenidyl, yithathe ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi.

Uma uthatha amaphilisi akhishwe ngokushesha futhi sekudlule amahora angaphezu kwama-2-3 kusukela kumthamo wakho ophuthelwe, ungase ufune ukuwushaya indiva bese ulinda umthamo wakho olandelayo ovamile. Ngamaphilisi akhishwe isikhathi eside, iwindi lide, kodwa ungawuthathi umthamo ophuthelwe uma kungakapheli amahora angu-6 kusukela kumthamo wakho olandelayo ohleliwe.

Ukuphuthelwa imithamo ngezikhathi ezithile ngokuvamile ngeke kubangele izinkinga ezinkulu, kodwa ungase uqaphele ukubuyela okwesikhashana kwezimpawu zakho zokunyakaza. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukusiza ukugcina amazinga emithi aqhubekayo.

Q4. Ngingayeka nini ukuthatha i-Trihexyphenidyl?

Kufanele uyeke kuphela ukuthatha i-trihexyphenidyl ngaphansi kokuqondisa kukadokotela wakho, njengoba ukuyeka kungazelelwe kungabangela izimpawu zokuhoxiswa kanye nokubuyela ngokushesha kwezinkinga zakho zokunyakaza. Isinqumo sokuyeka sincike esimweni sakho esiyisisekelo nokuthi usabela kahle kangakanani ekwelashweni.

Ezimweni zesikhashana njengezifo zokunyakaza ezibangelwa izidakamizwa, ungase ukwazi ukuyeka i-trihexyphenidyl uma imbangela eyisisekelo isixazululiwe. Udokotela wakho ngokuvamile uzonciphisa umthamo kancane kancane phakathi namasonto amaningana ukuze avimbele izimpawu zokuhoxiswa.

Ezimweni ezingamahlalakhona njengesifo sikaParkinson, ukuyeka i-trihexyphenidyl kungase kucatshangelwe uma imiphumela emibi iba yinkinga noma uma okunye ukwelashwa kufakazela ukuthi kuphumelela kakhulu. Nokho, abantu abaningi baqhubeka beyithatha isikhathi eside njengengxenye yohlelo lwabo lokwelashwa olujwayelekile.

Izimpawu ezivamile zokuhoxiswa zihlanganisa ukukhathazeka, ukuqwasha, isicanucanu, kanye nokubuyela ngokushesha kwezimpawu zokunyakaza. Lezi zingancishiswa ngokunciphisa umthamo kancane kancane ngaphansi kokuqondisa kwezokwelapha kunokuyeka kungazelelwe.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Trihexyphenidyl?

Kungcono ukugwema utshwala noma ukulunciphisa kakhulu ngenkathi uthatha i-trihexyphenidyl, njengoba zombili lezi zinto zingabangela ukozela, ukudideka, nezinkinga zokuxhumana. Uma zihlanganisiwe, lezi zinto ezingahle zibe yingozi futhi zikhuphule ingozi yakho yokuwa noma izingozi.

Utshwala bungase futhi benze ngcono imiphumela eminingi ye-trihexyphenidyl, okuhlanganisa umlomo owomile, ukuqunjelwa, nobunzima bokuchama. Inhlanganisela ingase futhi yonakalise ukwahlulela kwakho nenkumbulo yakho ngaphezu kwento eyodwa.

Uma ukhetha ukuphuza utshwala ngezikhathi ezithile, qala ngezinto ezincane kakhulu ukuze ubone ukuthi umzimba wakho usabela kanjani, futhi ungalokothi uphuze bese ushayela noma usebenzise imishini. Njalo xoxa ngokusebenzisa utshwala nodokotela wakho, njengoba bengakunikeza iseluleko esiqondene nawe ngokusekelwe esimweni sakho esithile neminye imithi oyithathayo.