Yini i-Ubrogepant: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Ubrogepant iyimithi kadokotela eyenzelwe ngqo ukwelapha ikhanda elibuhlungu le-migraine uma liqala. Ingaphansi kwesigaba esisha semithi ye-migraine ebizwa ngokuthi ama-CGRP receptor antagonists, asebenza ngokuvimba izimpawu ezithile zobuhlungu ebuchosheni bakho ngesikhathi sokuhlaselwa yi-migraine.

Le mithi inikeza ithemba kubantu abangatholanga ukukhululeka ngemithi yendabuko ye-migraine. Ngokungafani neminye imithi ye-migraine endala, i-ubrogepant ayibangeli amakhanda abuhlungu futhi ingasetshenziswa kaningi uma kudingeka.

Yini i-Ubrogepant Esetshenziselwa Yona?

I-Ubrogepant iphatha ukuhlaselwa okukhulu kwe-migraine kubantu abadala, okusho ukuthi ithathwa uma usuvele unekhanda elibuhlungu le-migraine. Imithi isebenza ukumisa ubuhlungu be-migraine nezimpawu ezihambisana nazo njengokucasuka, ukuzwela ekukhanyeni, nokuzwela emsindweni.

Udokotela wakho angase akubhalele i-ubrogepant uma uhlangabezana nama-migraine aphakathi nendawo kuya kwabucayi aphazamisa imisebenzi yakho yansuku zonke. Ilusizo ikakhulukazi kubantu abangakwazi ukuthatha ama-triptans (elinye ikilasi lemithi ye-migraine) ngenxa yezimo zenhliziyo noma ezinye izinkinga zempilo.

Le mithi ayisetshenziselwa ukuvimbela ama-migraine ukuthi angabi khona. Kunalokho, yilokho odokotela abakubiza ngokuthi ukwelashwa okuthi "abortive" okuthathayo ekuqaleni kophawu lwe-migraine ukusiza ukuyimisa ezingomeni zayo.

Isebenza Kanjani i-Ubrogepant?

I-Ubrogepant ivimba ama-CGRP receptors ebuchosheni bakho, ahilelekile ezimpawini zobuhlungu be-migraine. I-CGRP imele i-calcitonin gene-related peptide, iphrotheni eba ngaphezu kwamandla ngesikhathi sokuhlaselwa yi-migraine futhi enegalelo ebuhlungwini obukhulu nezinye izimpawu.

Cabanga nge-CGRP njengokhiye ovula izindlela zobuhlungu ebuchosheni bakho ngesikhathi se-migraine. I-Ubrogepant isebenza njengembozo evikelayo ngaphezu kokhiye, ivimbela i-CGRP ekubangeleni lezo zimpawu ezibuhlungu.

Lo muthi uthathwa njengomuthi olinganiselwe ngamandla wokwelapha i-migraine. Uqondiswe ngqo kunemithi yokwelapha ubuhlungu endala kodwa kungenzeka awanamandla ngokushesha njengeminye imithi ejovwayo. Kodwa-ke, isenzo sayo esiqondile ngokuvamile sisho imiphumela emincane eminingi kubantu abaningi.

Kufanele Ngiyithathe Kanjani I-Ubrogepant?

Thatha i-ubrogepant njengoba udokotela wakho ekuyala ngayo, ngokuvamile njengemthamo owodwa ongu-50mg noma 100mg uma uzwa i-migraine iqala. Ungayithatha nokudla noma ngaphandle kokudla, nakuba abanye abantu bekuthola kulula esiswini sabo uma ithathwa nesnakhi esilula.

Gwinya ithebhulethi yonke ngamanzi. Ungayichobozi, uyihlukanise, noma uyihlafune, ngoba lokhu kungathinta ukuthi umuthi usebenza kanjani emzimbeni wakho.

Nakhu okufanele ukwazi mayelana nesikhathi sokuthatha nokudla ngaphambi kokuthatha i-ubrogepant:

• Yithathe ngokushesha lapho uqaphela izimpawu ze-migraine ziqala
• Ungadla ngokujwayelekile ngaphambi kokuyithatha, nakuba ukudla okukhulu, okunamafutha kungase kubambezele imiphumela yayo kancane
• Uma i-migraine yakho ibuyela ngemva kokukhululeka kokuqala, ungangathatha umthamo wesibili ngemva kwamahora okungenani ama-2
• Ungathathi ngaphezu kuka-200mg esikhathini samahora angu-24

Lapho uthatha i-ubrogepant ngokushesha ngemva kokuthi i-migraine yakho iqala, kulapho ivame ukusebenza kangcono. Abantu abaningi bakuthola kuphumelela kakhulu uma ithathwa ngesikhathi sehora lokuqala lezimpawu.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Ubrogepant?

I-Ubrogepant ithathwa kuphela uma une-migraine, hhayi njengomuthi wansuku zonke. Ngesikhathi ngasinye oyisebenzisayo, welapha isigameko esisodwa se-migraine esithile.

Udokotela wakho uzoqoka ukuthi ungayisebenzisa kaningi kangakanani i-ubrogepant ngokusekelwe ekuvame kwakho kwe-migraine nezinye izinto zezempilo. Abantu abaningi bangayisebenzisa izikhathi ezingafika kweziyi-8 ngenyanga, kodwa lokhu kuyahluka kuye ngesimo sakho.

Uma uzithola udinga i-ubrogepant kaningi, udokotela wakho angase ancome ukwengeza umuthi wokuvimbela i-migraine ukuze unciphise ukuthi uvame kangakanani ukuthola ama-migraine.

Yiziphi Imiphumela Eceleni Ye-Ubrogepant?

Abantu abaningi bayakwazi ukumelana kahle ne-ubrogepant, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe uqiniseka ngokwengeziwe ngomuthi wakho.

Imiphumela emibi evame kakhulu ngokuvamile imnene futhi yesikhashana:

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• Isicanucanu (sithinta cishe u-4% wabantu)
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• Ukozela noma ukukhathala
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• Umlomo owomile
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• Isiyezi
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• Ukuphatheka kabi kwesisu
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Le miphumela emibi ejwayelekile ivame ukunyamalala emahoreni ambalwa futhi ayidingi ukuyeka umuthi. Kodwa-ke, uma iqhubeka noma iba yimbi, yazisa udokotela wakho.

Imiphumela emibi engavamile kodwa ebucayi ingenzeka, nakuba ingavamile. Lokhu kufaka phakathi ukusabela okukhulu komzimba okunezimpawu ezinjengobunzima bokuphefumula, ukuvuvukala kobuso bakho noma umphimbo, noma ukuqubuka okukhulu kwesikhumba.

Abanye abantu bahlangabezana nalokho okubizwa ngokuthi

Ubrogepant ithengiswa ngaphansi kwegama lomkhiqizo elithi Ubrelvy. Leli yigama lomkhiqizo elilodwa elitholakala njengamanje ngalo mithi e-United States.

I-Ubrelvy iza ngamaphilisi omlomo ngamandla amabili: 50mg kanye ne-100mg. Udokotela wakho uzoqaphela ukuthi yiliphi iqina elingcono kakhulu lephethini yakho ethile ye-migraine nobukhulu bayo.

Njengamanje, akukho inguqulo ejwayelekile ye-ubrogepant etholakalayo, okusho ukuthi i-Ubrelvy ivame ukubiza kakhulu kunezithako ezindala ze-migraine. Kodwa-ke, izinhlelo eziningi zomshuwalense ziyayihlanganisa, futhi umenzi unikeza izinhlelo zokusiza iziguli zalabo abafanelekayo.

Ezinye izindlela ze-Ubrogepant

Uma i-ubrogepant ingasebenzi kahle kuwe noma ibangela imiphumela emibi, ezinye izinketho zokwelashwa kwe-migraine ziyatholakala. Udokotela wakho angakusiza ukuthi uthole enye indlela engcono kakhulu ngokusekelwe ezidingweni zakho ezithile.

Ezinye izitha ze-CGRP receptor zifaka i-rimegepant (Nurtec ODT), encibilika olimini lwakho, kanye ne-zavegepant (Zavzpret), eza njenge-spray yamakhala. Lezi zisebenza ngendlela efanayo ne-ubrogepant kodwa zingakulungela kangcono uma unenkinga yokugwinya amaphilisi.

Imithi yendabuko ye-migraine engasebenza njengezinye izindlela zihlanganisa:

• Ama-Triptans afana ne-sumatriptan noma i-rizatriptan
• Ama-NSAID afana ne-ibuprofen noma i-naproxen
• Imithi ehlanganisiwe ene-caffeine
• Imithi elwa nesicanucanu ye-migraine-associated nausea

Abanye abantu bazuza nasezindleleni ezingezona zemithi njengokusebenzisa okubandayo noma ukushisa, ukuhlala ekamelweni elimnyama elithule, noma ukusebenzisa amasu okuphumula kanye nemithi yabo.

Ingabe i-Ubrogepant ingcono kune-Sumatriptan?

I-Ubrogepant ne-sumatriptan zisebenza ngendlela ehlukile futhi ngalinye linobuhle obuyingqayizivele. I-Sumatriptan, umuthi we-triptan, usetshenziswe isikhathi eside futhi uvame ukusebenza ngokushesha kuma-migraines abukhali, kodwa i-ubrogepant ingase iphephe kubantu abanezimo zenhliziyo.

Inzuzo enkulu ye-ubrogepant ukuthi ayibangeli ukuncipha kwemithambo yegazi okwenziwa yi-triptans. Lokhu kwenza kuphephe kubantu abanezifo zenhliziyo, umfutho wegazi ophezulu, noma izici eziyingozi zesifo sohlangothi abangakwazi ukuthatha i-triptans.

I-Sumatriptan ivame ukunikeza ukukhululeka okusheshayo, ngezinye izikhathi kungakapheli imizuzu engama-30, kuyilapho i-ubrogepant ngokuvamile ithatha amahora angu-1-2 ukufinyelela ekusebenzeni okugcwele. Kodwa-ke, i-ubrogepant ingase ibangele imiphumela emincane engemihle efana nokuqina kwesifuba noma isiyezi abanye abantu abahlangabezana nakho nge-triptans.

Udokotela wakho uzocabangela impilo yakho yenhliziyo, ubukhulu be-migraine, nokuthi udinga ukukhululeka ngokushesha kangakanani lapho ekhetha phakathi kwale mithi. Abanye abantu bathola ukuthi enye isebenza kangcono kunenye, futhi kungase kudingeke ukuthi uzame ukuze uthole inketho yakho engcono kakhulu.

Imibuzo Evame Ukubuzwa Mayelana ne-Ubrogepant

Ingabe i-Ubrogepant iphephile kumfutho wegazi ophezulu?

Yebo, i-ubrogepant ngokuvamile iphephile kubantu abanomfutho wegazi ophezulu. Ngokungafani nemithi ye-triptan, i-ubrogepant ayibangeli ukuncipha kwemithambo yegazi, okuyenza ibe yindlela enhle kubantu abanezinkinga zenhliziyo nemithambo yegazi.

Noma kunjalo, kufanele usatshele udokotela wakho ngesimo sakho somfutho wegazi kanye nanoma yimiphi imithi oyithathayo ngayo. Eminye imithi yomfutho wegazi ingase ihlangane ne-ubrogepant, futhi udokotela wakho angase adinge ukulungisa umthamo noma akuqaphele eduze.

Ngingenzani uma ngiphuthelwa ngisebenzisa i-Ubrogepant eningi kakhulu?

Uma ngempela uthatha ngaphezu komthamo onconyiwe we-ubrogepant, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukuthi izimpawu zivele, njengoba ukuthola isiqondiso kusenesikhathi kuhlale kuphephe.

Ukuthatha i-ubrogepant eningi kakhulu kungakhuphula ingozi yakho yemiphumela engemihle efana nesicanucanu esibi, isiyezi, noma ukukhathala. Ezimweni ezingavamile, ukweqisa kungase kubangele izinkinga ezingathi sína, nakuba le mithi ivame ukubekezelelwa kahle ngisho nasemithini ephezulu.

Gcina umkhondo wokuthi uthatha nini imithamo yakho ukuze ugweme ukuthatha imithamo emibili ngengozi. Uma ungaqiniseki ukuthi usuvele uyithathile yini imithi yakho, kungcono ukulinda ubone ukuthi i-migraine yakho iyathuthuka yini kunokubeka engozini yokuthatha okuningi.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Ubrogepant?

Njengoba i-ubrogepant ithathwa kuphela uma une-migraine, akukho "mthamo oqediwe" ngomqondo wendabuko. Uyayithatha uma uyidinga ngesikhathi sokuhlaselwa yi-migraine.

Uma ukhohlwe ukuthatha i-ubrogepant lapho i-migraine yakho iqala futhi sekudlule amahora amaningana, usengayithatha. Imithi ingase isanikeze ukukhululeka okuthile, nakuba ivame ukusebenza kahle uma ithathwa ekuqaleni kwesigameko se-migraine.

Ungathathi imithi eyengeziwe ukuze "ukulungise" ukungayithathi ngaphambili. Namathela emithamini echaziwe kanye nemihlahlandlela yesikhathi udokotela wakho ayinikezile.

Ngingayeka Nini Ukuthatha I-Ubrogepant?

Ungayeka ukuthatha i-ubrogepant nganoma yisiphi isikhathi ngoba akuyona imithi yansuku zonke umzimba wakho ozoyithola uncike kuyo. Umane uyeke ukuyisebenzisa uma ungasayidingi ekwelapheni i-migraine.

Nokho, ngaphambi kokuyeka, khuluma nodokotela wakho mayelana nokuthi i-ubrogepant isebenza kahle yini kuma-migraines akho. Uma isiza, ngokuvamile akukho sizathu sezokwelapha sokuyeka ngaphandle kokuthi uhlangabezana nemiphumela engemihle.

Uma ama-migraines akho eba mancane noma abe maningi, ungase ngokwemvelo usebenzise i-ubrogepant kaningi. Udokotela wakho angakusiza ukuthi unqume ukuthi udinga ukwelashwa okuhlukile noma ngabe ukusetshenziswa ngezikhathi ezithile kwe-ubrogepant kuqhubeka kuyindlela engcono kakhulu.

Ngingayithatha I-Ubrogepant Neminye Imithi Yokwelapha Ubuhlungu?

Ngokuvamile ungathatha i-ubrogepant nezinhlobo ezivamile zokukhulula ubuhlungu ezingathengiswa ngaphandle kwemvume kadokotela njenge-acetaminophen noma i-ibuprofen, kodwa njalo hlola nodokotela wakho kuqala. Abanye abantu bathola ukuthi ukuhlanganisa ukwelashwa kunikeza ukukhululeka okungcono kwe-migraine.

Noma kunjalo, gwema ukuthatha i-ubrogepant neminye imithi yokwelapha i-migraine kadokotela njengama-triptans ngaphandle uma uqondiswe ngqo ngudokotela wakho. Ukuhlanganisa ukwelashwa okuhlukene kwe-migraine ngezinye izikhathi kungandisa imiphumela emibi noma kunciphise ukusebenza.

Qaphela ikakhulukazi ukuthatha i-ubrogepant nemithi ethinta isibindi sakho, ngoba kokubili kudingeka kucutshungulwe ngama-enzyme esibindi afanayo. Udokotela wakho angabuyekeza yonke imithi yakho ukuze aqinisekise ukuhlanganiswa okuphephile.