Yini i-Umeclidinium kanye ne-Vilanterol: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Umeclidinium kanye ne-vilanterol kuyinhlanganisela yomuthi wokuphefumula osiza abantu abanesifo sokuvinjelwa kwamaphaphu okungapheli (i-COPD) ukuba baphefumule kalula nsuku zonke. Lo muthi oqokiwe uqukethe ama-bronchodilators amabili ahlukene asebenza ndawonye ukuze agcine imigudu yakho yomoya ivulekile futhi anciphise ubunzima bokuphefumula.

Uma uqokiwe lo muthi, cishe ubhekene nezimpawu ze-COPD ezidinga ukuphathwa kwansuku zonke okuqhubekayo. Le nhlanganisela yokuphefumula yakhelwe ukuthi isetshenziswe kanye ngosuku njengokwelashwa kokugcinwa, hhayi ezimweni eziphuthumayo zokuphefumula.

Yini i-Umeclidinium kanye ne-Vilanterol?

I-Umeclidinium kanye ne-vilanterol kuyinhlanganisela yama-bronchodilators amabili eza ngedivayisi eyodwa yokuphefumula. I-Umeclidinium iyi-long-acting muscarinic antagonist (LAMA), kuyilapho i-vilanterol iyi-long-acting beta2-agonist (LABA).

Cabanga ngale mithi emibili njengeqembu elisebenza emaphashini akho. I-Umeclidinium isiza ukuphumuza imisipha ezungeze imigudu yakho yomoya ngokuvimba izimpawu ezithile zemizwa, kuyilapho i-vilanterol iqondisa imisipha ebushelelezi emgudwini wakho womoya. Ngokubambisana, banikeza ukukhululeka kwamahora angama-24 ezimpawu ze-COPD.

Lo muthi wenzelwe ngokuqondile abantu abane-COPD abadinga ukwelashwa kwansuku zonke. Akuhloselwe ukuba lusetshenziswe ngesifuba noma ukwelapha ukuhlaselwa kokuphefumula okungazelelwe.

Yini i-Umeclidinium kanye ne-Vilanterol Esetshenziselwa Yona?

Le nhlanganisela yokuphefumula iqokelwe ngokuqondile ukwelashwa kwesikhathi eside kwesifo sokuvinjelwa kwamaphaphu okungapheli (COPD). Kusiza ukunciphisa ukuvinjelwa kokugeleza komoya futhi kwenza ukuphefumula kwansuku zonke kube lula kubantu abanalesi simo.

Udokotela wakho angase aqoke lo muthi uma unezimpawu ze-COPD njengokukhwehlela okungapheli, ukuphefumula kanzima, noma ukuhoshoza okuphazamisa imisebenzi yakho yansuku zonke. Kuyasiza ikakhulukazi kubantu abadinga ngaphezu kwe-bronchodilator eyodwa ukuze baphathe izimpawu zabo ngempumelelo.

Lo muthi awuvunyelwe ukwelapha isifuba, futhi akufanele neze usetshenziswe njenge-inhaler yokusiza ngesikhathi sezimo eziphuthumayo zokuphefumula. Uma une-COPD nesifuba, udokotela wakho uzodinga ukukucabangela lokhu ngokucophelela lapho ebeka umuthi wakho.

Isebenza Kanjani i-Umeclidinium ne-Vilanterol?

Lo muthi ohlanganisiwe usebenza ngezindlela ezimbili ezihlukene kodwa ezigcwalisanayo ukusiza ukuvula imigudu yakho yomoya. I-Umeclidinium ivimba ama-receptors e-acetylcholine, okuvimbela imisipha ezungeze imigudu yakho yomoya ukuthi ingaqini, kuyilapho i-vilanterol isebenzisa ama-receptors e-beta2, okuphumuzela ngokuqondile imisipha yomoya.

Isenzo esiphindwe kabili sinikeza ukuvulwa komoya okubanzi kakhulu kunanoma yimuphi umuthi ongafinyelela wona uwedwa. Lokhu kwenza kube yinhlanganisela ye-bronchodilator enamandla amancane esebenza kahle kubantu abane-COPD ephakathi nendawo kuya kokukhulu.

Yomibili imithi isebenza isikhathi eside, okusho ukuthi iyaqhubeka nokusebenza cishe amahora angama-24 ngemuva komthamo ngamunye. Lokhu kuvumela ukuthi kuthathwe kanye ngosuku, okutholakala abantu abaningi bekulula kakhulu kunama-inhaler amaningi ansuku zonke.

Kufanele Ngiyithathe Kanjani i-Umeclidinium ne-Vilanterol?

Thatha lo muthi njengoba unjalo njengoba ubekwe ngudokotela wakho, ngokuvamile ukuhogela okukodwa kanye ngosuku ngesikhathi esifanayo nsuku zonke. Umthamo ovamile kakhulu ukuhogela okukodwa kwe-62.5 mcg ye-umeclidinium kanye ne-25 mcg ye-vilanterol.

Ungawuthatha lo muthi ngaphandle kokudla noma ngaphandle kokudla, kodwa ukuqina kubalulekile. Abantu abaningi bakuthola kuwusizo ukuwuthatha ngesikhathi esifanayo njalo ekuseni ukuze basungule umkhuba futhi baqinisekise ukuthi abaphuthelwa imithamo.

Ngaphambi kokusebenzisa i-inhaler yakho, qiniseka ukuthi uyaqonda ukuthi ungayisebenzisa kanjani idivayisi ethile kahle. Umkhemisi wakho noma udokotela kufanele akhombise inqubo efanele, njengoba ukuhogela okufanele kubalulekile ukuthi umuthi ufinyelele emaphashini akho ngempumelelo.

Ngemuva kokuthatha umthamo wakho, geza umlomo wakho ngamanzi bese uwakhipha. Lesi sinyathelo esilula singasiza ekuvikeleni i-thrush, isifo sefungi esingathuthuka emlonyeni wakho emithini ehogelwayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Umeclidinium ne-Vilanterol?

Lo muthi uvame ukunqunywa njengokwelashwa kwesikhathi eside kwe-COPD, okusho ukuthi cishe uzodinga ukuwuthatha unomphela. I-COPD yisimo esingamahlalakhona esidinga ukuphathwa okuqhubekayo ukuvimbela izimpawu ukuthi zingabi zimbi.

Udokotela wakho uzoqapha ukusabela kwakho emuthini futhi angase alungise uhlelo lwakho lokwelashwa ngokuhamba kwesikhathi. Abanye abantu babona ngcono ekuphefumuleni kwabo ezinsukwini ezimbalwa zokuqala, kanti abanye bangase bathathe amasonto ambalwa ukuze bathole izinzuzo eziphelele.

Ungayeki ukuthatha lo muthi ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka ngokuphazima kungase kubangele izimpawu zakho ze-COPD zibe zimbi ngokushesha, okwenza kube nzima ukuphefumula futhi okungenzeka kuholele ezinkingeni ezinzima.

Ziyini Imiphumela Eceleni ye-Umeclidinium ne-Vilanterol?

Njengayo yonke imithi, i-umeclidinium ne-vilanterol kungabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela eminingi emibi imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Nawa amanye imiphumela emibi evamile ongase uyithole:

• Ukutheleleka kwepheshana eliphezulu lokuphefumula (izimpawu ezinjengomkhuhlane)
• Ama-muscle spasms noma ama-cramps
• Ubuhlungu bentamo
• Ubuhlungu besifuba
• Ukuqunjelwa
• Ama-leg cramps

Le miphumela emibi ivame ukuba yesikhashana futhi ilawuleka. Uma ziqhubeka noma ziba yinkinga, khuluma nodokotela wakho ngezindlela zokuzinciphisa.

Imiphumela emibi engavamile kodwa engathi sína ingenzeka, nakuba ingavamile. Lokhu kufaka phakathi:

• I-bronchospasm e-paradoxical (ukwanda okungazelelwe kokuphefumula)
• Ukungezwani komzimba okukhulu nokuvuvukala kobuso, izindebe, noma umphimbo
• Izinkinga zesigqi senhliziyo noma ukwanda kwesilinganiso senhliziyo
• Ukwanda kwe-narrow-angle glaucoma
• Ukuzwa ubunzima bokuchama (ukugcinwa komchamo)

Uma uhlangabezana nanoma yimaphi alawa maphuzu abucayi, funa ukwelashwa ngokushesha. Lezi zimo, nakuba zingavamile, zidinga ukwelashwa ngokushesha.

Ubani Ongafanele Athathe i-Umeclidinium ne-Vilanterol?

Lo muthi awufanele wonke umuntu, futhi izimo ezithile zezempilo zingenza kungaphephile ukuthi uwusebenzise. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuchazela le nhlanganisela ye-inhaler.

Akufanele usebenzise lo muthi uma une-asthma ngaphandle kwe-COPD, njengoba imithi ye-LABA efana ne-vilanterol ingakhuphula ingozi yokufa okubangelwa yi-asthma okubucayi uma isetshenziswa yodwa ekwelapheni i-asthma.

Abantu abanezimo ezithile zezempilo badinga ukuqashwa okukhethekile noma bangase badinge ukugwema lo muthi ngokuphelele:

• Ukungezwani komzimba okukhulu namaprotheni obisi
• I-glaucoma ye-narrow-angle
• Ukugcinwa komchamo noma i-prostate enwetshiwe
• Isifo senhliziyo esibi noma ukushaya kwenhliziyo okungajwayelekile
• Izifo zokuvuvukala
• Isifo sikashukela (ukuqashwa kukashukela wegazi kungase kudingeke)

Uma ukhulelwe noma uncelisa, xoxa ngezinzuzo nezingozi nodokotela wakho. Nakuba lo muthi ungase udingeke empilweni yakho, udokotela wakho uzofuna ukukuqapha wena nomntwana wakho eduze.

Amagama Omkhiqizo we-Umeclidinium ne-Vilanterol

Lo muthi ohlanganisiwe utholakala ngaphansi kwegama lomkhiqizo elithi Anoro Ellipta e-United States. Idivayisi ye-Ellipta iyi-inhaler yempuphu eyomile eletha imithi yomibili ngomthamo owodwa.

Igama lomkhiqizo lingahluka emazweni ahlukene, ngakho-ke hlola njalo nomuthi wakho uma uhamba noma uthola imiyalelo evela ezindaweni ezihlukene. Izithako ezisebenzayo zihlala zinjalo kungakhathaliseki igama lomkhiqizo.

Izinhlobo ezivamile zale nhlanganisela azitholakali kabanzi okwamanje, ngakho-ke abantu abaningi bazothola umuthi wegama lomkhiqizo. Umshwalense wakho ungase uthinte izindleko, ngakho-ke hlola nomhlinzeki wakho mayelana nezinketho zokukhava.

Ezinye izindlela ze-Umeclidinium ne-Vilanterol

Ezinye izinhlanganisela zokuphefumula ezitholakalayo zokwelapha i-COPD, ngayinye inezinhlanganisela ezihlukene zama-bronchodilators. Udokotela wakho angase acabange ezinye izindlela uma lo muthi ungasebenzi kahle kuwe noma ubangela imiphumela emibi.

Ezinye izinhlanganisela ze-LAMA/LABA zihlanganisa i-tiotropium ne-olodaterol, i-glycopyrronium ne-indacaterol, kanye ne-aclidinium ne-formoterol. Inhlanganisela ngayinye inamashejuli okulinganisa ahlukile kanye namaphrofayili emiphumela emibi.

Abanye abantu bangase bazuze ekwelapheni okuthathu okuhlanganisa i-LAMA, LABA, kanye ne-corticosteroid ephefumulwayo. Lokhu kuvame ukugcinelwa abantu abane-COPD enzima kakhulu noma ukuqina okuvamile.

Udokotela wakho uzokhetha inketho engcono kakhulu ngokusekelwe ezimpawini zakho ezithile, ubunzima be-COPD yakho, ukusabela kwakho ekwelashweni kwangaphambilini, kanye nekhono lakho lokusebenzisa amadivayisi okuphefumula ahlukene kahle.

Ingabe i-Umeclidinium ne-Vilanterol Ingcono Kune-Tiotropium?

Yomibili imithi iyasebenza ekwelapheni i-COPD, kodwa isebenza ngendlela ehlukile kancane. I-Tiotropium iyi-bronchodilator eyodwa ye-LAMA, kuyilapho i-umeclidinium ne-vilanterol ihlanganisa i-LAMA ne-LABA ukuze kuthuthukiswe i-bronchodilation ephindwe kabili.

Inhlanganisela ingase inikeze ukulawulwa okungcono kwezimpawu kwabanye abantu ngoba iqondisa izindlela ezimbili ezihlukene emoyeni wakho. Izifundo zikhomba ukuthi i-bronchodilation ephindwe kabili ingasebenza ngempumelelo kune-ejenti elilodwa ekuthuthukiseni ukusebenza kwamaphaphu nokunciphisa izimpawu.

Nokho,

Abantu abanezifo zenhliziyo bangasebenzisa imithi enjalo, kodwa badinga ukuqashwa eduze. Ingxenye ye-vilanterol ngezinye izikhathi ingabangela izinguquko zesigqi senhliziyo noma ukwandisa izinga lenhliziyo, ikakhulukazi uma uqala ukuyithatha.

Uma unesifo senhliziyo, udokotela wakho cishe uzoqala ukukusebenzisa lo muthi kuphela uma izinzuzo zidlula izingozi. Bangase bafune ukuqapha isigqi senhliziyo yakho eduze, ikakhulukazi emasontweni ambalwa okuqala okwelashwa.

Njalo tshela udokotela wakho nganoma yiziphi izinkinga zenhliziyo onazo, okuhlanganisa ukushaya kwenhliziyo okungajwayelekile, umfutho wegazi ophezulu, noma ukuhlaselwa yinhliziyo kwangaphambilini. Bangasiza ekunqumeni ukuthi lo muthi uphephile yini esimweni sakho esithile.

Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi Umeclidinium kanye ne-Vilanterol Okuningi Kakhulu?

Uma ngengozi uthatha ngaphezu komthamo wakho obekiwe, ungesabi, kodwa xhumana nodokotela wakho noma usokhemisi ukuze uthole isiqondiso. Ukuthatha imithamo eyengeziwe kungakhuphula ingozi yakho yemiphumela emibi efana nezinkinga zesigqi senhliziyo noma ukuthuthumela kwemisipha.

Qaphela izimpawu ezinjengokushaya kwenhliziyo okusheshayo, ubuhlungu besifuba, ukuthuthumela, noma ukuzizwa unovalo noma unovalo ngokungavamile. Lokhu kungaba yizimpawu zokuthi uthathe imithi eningi kakhulu futhi ungase udinge ukunakekelwa kwezempilo.

Ukuvimbela ukweqisa ngengozi, gcina umkhondo wokuthi uyithatha nini umthamo wakho wansuku zonke. Abanye abantu bakuthola kuwusizo ukusebenzisa umhleli wamaphilisi noma isikhumbuzi sefoni ukuze bagweme ukuthatha imithamo eyengeziwe ngephutha.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo we-Umeclidinium kanye ne-Vilanterol?

Uma uphuthelwa umthamo wakho wansuku zonke, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma kungasondeli ngesikhathi somthamo wakho olandelayo ohleliwe. Uma sekuseduze nesikhathi somthamo wakho olandelayo, weqa lowo ophuthelwe futhi uqhubeke neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe. Lokhu kungakhuphula ingozi yakho yemiphumela emibi ngaphandle kokuhlinzeka ngezinzuzo ezengeziwe zokuphefumula kwakho.

Uma ukhohlwa njalo imithamo, khuluma nodokotela wakho ngamasu okukusiza ukuthi ukhumbule. Ukusetshenziswa kwansuku zonke okuqhubekayo kubalulekile ekutholeni inzuzo enkulu kule mithi.

Ngingayeka nini ukuthatha i-Umeclidinium ne-Vilanterol?

Kufanele uyeke kuphela ukuthatha le mithi ngaphansi kokuqondiswa ngudokotela wakho. I-COPD yisimo esingamahlala-khona esivame ukudinga ukwelashwa okuqhubekayo ukuvimbela izimpawu ukuthi zingabi zimbi ngokuhamba kwesikhathi.

Udokotela wakho angase acabange ukuyeka noma ukushintsha imithi yakho uma uhlangabezana nemiphumela emibi engathi sína, uma isimo sakho sishintsha kakhulu, noma uma imithi emisha itholakala engasebenza kangcono kuwe.

Noma ngabe uzizwa ungcono kakhulu ngenkathi uthatha le mithi, ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho ze-COPD zibuye ngokushesha. Hlala uxoxa nganoma yiziphi izinkathazo mayelana nokuqhubeka nokwelashwa nomhlinzeki wakho wezempilo.

Ngingasebenzisa i-rescue inhaler nge-Umeclidinium ne-Vilanterol?

Yebo, kufanele uqhubeke nokuthwala nokusebenzisa i-rescue inhaler yakho (njenge-albuterol) ngezinkinga zokuphefumula ezingazelelwe. I-Umeclidinium ne-vilanterol yimithi yokugcinwa esebenza amahora angama-24, kodwa ayenzelwanga ukukhulula ngokushesha ngesikhathi sezimo eziphuthumayo zokuphefumula.

I-rescue inhaler yakho inikeza ukukhululeka okusheshayo uma ukudinga kakhulu, ngenkathi i-inhaler yakho yansuku zonke yokugcinwa isiza ukuvimbela izimpawu ukuthi zingenzeki ekuqaleni. Zombili le mithi idlala izindima ezibalulekile kodwa ezihlukene ekuphathweni kwakho kwe-COPD.

Uma uzithola usebenzisa i-rescue inhaler yakho kaningi kunokujwayelekile, xhumana nodokotela wakho. Lokhu kungaba uphawu lokuthi i-COPD yakho iya iba yimbi noma ukuthi ukwelashwa kwakho kokugcinwa kudinga ukulungiswa.