Yini i-Vaccinia Immune Globulin (Human): Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Vaccinia immune globulin (human) iyimithi ekhethekile eyenziwe nge-plasma yegazi elinikelweyo eliqukethe ama-antibody alwa negciwane le-vaccinia. Le mithi isebenza njengenethi yokuphepha kubantu ababa nezinkinga ezinzima ngenxa yokugonywa kwe-smallpox noma labo abavezwa ngengozi egciwaneni lomgomo lapho bengafanele khona.

Cabanga ngayo njengokuzivikela okubolekiwe kubantu ababhekana ngokuphephile nokuchayeka kwegciwane le-vaccinia. Uma umzimba wakho ungenakukwazi ukulwa nezinkinga ezihlobene nomgomo ngokwawo, lokhu kwelashwa kungena ukukusiza ukuthi ukukhusele ngama-antibody alungile.

Yini i-Vaccinia Immune Globulin Esetshenziselwa Yona?

Le mithi iphatha izinkinga ezinzima ezingenzeka ngemva kokugonywa kwe-smallpox. Yenzelwe ngqo abantu abamasistimu abo omzimba alwa nezifo elwa kanzima ukubhekana negciwane eliphilayo emgomweni, okuholela ezimweni ezingaba yingozi.

Isizathu esivame kakhulu sokuthi odokotela banikeze le mithi ukwelapha i-progressive vaccinia, isimo lapho indawo yokugoma ingelaphi kahle futhi iqhubeka nokusabalala. Esikhundleni sokwakha i-scab ejwayelekile nokuphola, isilonda sikhula sibe sikhulu futhi sijule, ngezinye izikhathi sithinta isikhumba nezicubu ezizungezile.

Ungase futhi udinge le mithi uma uthola i-eczema vaccinatum, okwenzeka lapho igciwane lomgomo lisabalalela ezindaweni zesikhumba sakho ezithinteka yi-eczema noma ezinye izimo zesikhumba. Lokhu kungadala izilonda ezibanzi, ezibuhlungu umzimba wakho ongenakuzilawula ngokwawo.

Esinye isimo esibucayi ukuchayeka ngengozi egciwaneni lomgomo. Uma othile emndenini wakho ethola umgomo we-smallpox futhi unesistimu yokuzivikela komzimba ebuthakathaka, ungangena ngengozi uthole ukutheleleka ngokuthintana okuseduze. Le mithi isiza ukuvimbela noma ukwelapha lokho kutheleleka okungahle kwenzeke.

Isebenza Kanjani I-Vaccinia Immune Globulin?

Lo muthi usebenza ngokunikeza umzimba wakho ama-antibody enziwe ngaphambili aqondiswe ngqo e-vaccinia virus. Lawa ma-antibody avela kubanikeli abanempilo abake bahlangana nezifo ezifanayo, ngakho amasistimu abo omzimba asevele azi ukuthi angawalwa kanjani.

Uma wamukela lokhu kwelashwa nge-IV, lawa ma-antibody abolekiwe aqala ngokushesha ukusebenza egazini lakho. Anamathela kuma-particle e-virus futhi awamake ukuze abhujiswe amasistimu akho omzimba, empeleni afundisa amasistimu omzimba wakho ukuthi yini okufanele ayihlaselwe.

Lokhu kuthathwa njengomuthi oqinile ngoba unikeza ukwesekwa komzimba okusheshayo, okuqondiwe. Kodwa-ke, akunamandla njengokwelashwa komzimba okuthile ngoba kusebenza ngamasistimu akho omzimba akhona kunokuthi uwashintshe ngokuphelele.

Kufanele Ngiyithathe Kanjani I-Vaccinia Immune Globulin?

Uzothola lo muthi ngomugqa we-intravenous (IV) esibhedlela noma endaweni yezokwelapha. Umhlinzeki wezempilo uzofaka ishubhu elincane emthanjeni engalweni yakho, futhi umuthi uzogeleza kancane egazini lakho emahoreni ambalwa.

Ngaphambi kokwelashwa kwakho, akudingeki ukuthi uzile noma ugweme ukudla okuthile. Kodwa-ke, kuyasiza ukuhlala unamanzi ngokwanele ngokuphuza amanzi amaningi emahoreni ngaphambi kokuqokwa kwakho, ngoba lokhu kwenza kube lula ukufaka i-IV futhi kusiza umzimba wakho ukuthi usebenzise umuthi.

Ngesikhathi sokufakwa, uzodinga ukuhlala uhleli noma ulele ngenkathi abasebenzi bezokwelapha bekuqapha eduze. Inqubo ngokuvamile ithatha amahora angu-2-4, kuye ngomthamo wakho othile nokuthi ukubekezelela kahle kangakanani ukwelashwa.

Ithimba lakho lezempilo lizobheka noma yiziphi izindlela zokuphendula ngesikhathi nangemva kokufakwa. Bazohlola umfutho wegazi lakho, izinga lokushaya kwenhliziyo, kanye nezinga lokushisa njalo ukuze baqinisekise ukuthi uphendula kahle ekwelashweni.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Vaccinia Immune Globulin?

Abantu abaningi bathola lo muthi njengokwelashwa okungaqali, nakuba ezinye izimo zingase zidinge umthamo wesibili. Udokotela wakho uzonquma isikhathi esiqondile ngokusekelwe ekutheni izinkinga zakho zinzima kangakanani nokuthi usabela kahle kangakanani ekwelashweni kokuqala.

Ama-antibody avela kulo muthi ahlala esebenza ohlelweni lwakho amasonto amaningana kuya ezinyangeni. Ngesikhathi lesi, aqhubeka enikeza ukuvikelwa ngenkathi amasosha akho omzimba afunda ukubhekana kangcono nesimo.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokuqokwa okulandelayo futhi angase ayale ukuhlolwa kwegazi ukuze ahlolisise ukuthi ukwelashwa kusebenza kahle kangakanani. Uma izimpawu zakho zithuthuka futhi indawo yokugoma iqala ukuphola kahle, cishe ngeke udinge imithamo eyengeziwe.

Yini Imiphumela Eceleni ye-Vaccinia Immune Globulin?

Njengemithi eminingi enikezwa nge-IV, lokhu kwelashwa kungabangela eminye imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Ukuqonda okukulindele kungakusiza ukuthi uzizwe ulungiselelwe kangcono futhi wazi ukuthi ungawaxwayisa nini ithimba lakho lezempilo.

Imiphumela emibi evame kakhulu yenzeka ngesikhathi noma ngemva nje kokufakwa futhi ivame ukuba mnene. Lokhu kufaka phakathi ikhanda, umkhuhlane omnene, ama-chills, noma ukuzizwa ukhathele. Abanye abantu futhi bahlangabezana nobuhlungu bemisipha noma ukuqina kwamalunga, okufana nendlela ongazizwa ngayo ngomkhuhlane omnene.

Ungase uqaphele ukungakhululeki okuthile endaweni ye-IV, njenge:

• Ubuhlungu obuncane noma ukuba nobubele lapho kufakwa inaliti
• Ukuvuvukala okuncane noma ububomvu endaweni ye-IV
• Umuzwa wokubanda noma ukufudumala njengoba umuthi ungena

Lezi zimo zendawo zivamile futhi ngokuvamile zixazululwa emahoreni ambalwa ngemva kokuphela kokwelashwa.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Lokhu kufaka phakathi ukusabela okukhulu komzimba, okungase kubangele ubunzima bokuphefumula, ukuqubuka okubanzi, noma ukuvuvukala okukhulu ebusweni bakho, izindebe, noma umphimbo.

Abanye abantu bangase bahlangabezane nemiphumela emibi ehlobene negazi, njenge:

• Ukuphuma kwegazi okungavamile noma ukulimala
• Izimpawu zamahlule egazi njengobuhlungu obuzumayo emlenzeni noma ubuhlungu besifuba
• Ukukhathala okuqhubekayo noma ubuthakathaka

Ngokuvamile kakhulu, lo muthi ungase uthinte ukusebenza kwezinso, ikakhulukazi kubantu asebenenkinga yezinso. Ithimba lakho lezempilo lizogada ukusebenza kwezinso zakho ngokusebenzisa izivivinyo zegazi uma usengozini enkulu.

Ubani Ongafanele Athathe I-Vaccinia Immune Globulin?

Abantu abathile kufanele bagweme lo muthi noma bawuthole ngaphansi kokuqashwa kwezokwelapha okucophelelayo. Okukhathaza kakhulu ngabantu abake baba nokusabela okukhulu komzimba ezintweni ze-immune globulin esikhathini esidlule.

Uma unesifo esikhulu sephrotheni ebizwa nge-IgA (immunoglobulin A), lo muthi ungase ubangele ukusabela okukhulu komzimba. Udokotela wakho uzohlola lesi simo ngaphambi kokukunika ukwelashwa uma kukhona ukukhathazeka.

Abantu abanezifo ezithile zegazi badinga ukucatshangelwa okukhethekile. Uma unomlando wamahlule egazi, unhlangothi, noma izinkinga zenhliziyo, udokotela wakho uzokala izinzuzo ngokumelene nezingozi ngokucophelela kakhulu. Umuthi ngezinye izikhathi ungakhuphula ingozi yamahlule egazi, ikakhulukazi kubantu abathambekele kuwo.

Uma unesifo sezinso, udokotela wakho uzokugada ngokucophelela okwengeziwe ngesikhathi nangemva kokwelashwa. Umuthi ngezinye izikhathi ungase uqhubeke izinso, ikakhulukazi kubantu abasebenza izinso zabo seziphazamisekile.

Ukukhulelwa kudinga ukucatshangelwa okukhethekile, nakuba umuthi ungase usasetshenziswa uma izinzuzo zidlula izingozi. Udokotela wakho uzoxoxa ngezinketho zonke nawe uma ukhulelwe noma uhlela ukukhulelwa.

Amagama Omkhiqizo we-Vaccinia Immune Globulin

Igama lomkhiqizo elitholakala kakhulu lalo muthi yi-CNJ-016, ekhiqizwa ngqo ukwelapha izinkinga ze-vaccinia virus. Le yinguqulo esetshenziswa kakhulu ezibhedlela nakumakliniki ezimweni eziphuthumayo.

Ngokungafani nemithi eminingi, azikho izinhlobo eziningi zamagama ebhrendi noma izinhlobo ezivamile ezitholakala kalula. Lokhu kungenxa yokuthi ukwelashwa okukhethekile kakhulu okudingeka kuphela ezimweni ezithile, ngakho ukukhiqizwa kukhawulelwe ezindaweni ezihlangabezana nezindinganiso eziqinile zokuphepha.

Umhlinzeki wakho wezempilo uzokwazi ukuthi yimuphi umkhiqizo othile abawusebenzisayo futhi angakunikeza imininingwane enemininingwane mayelana nohlobo oluthile olulutholayo.

Ezinye Izindlela Zokwelapha I-Vaccinia Immune Globulin

Zikhona ezinye izindlela ezilinganiselwe zokwelapha lo muthi othile, ikakhulukazi ngoba wenzelwe izimo ezithile kakhulu. Kodwa-ke, udokotela wakho angase acabangele ezinye izindlela zokwelapha ezisekelayo ngokuya ngesimo sakho esithile.

Kwezinye izinhlobo zezinkinga ze-vaccinia, imithi elwa namagciwane efana ne-cidofovir ingase ibe usizo, nakuba lezi zisebenza ngendlela ehlukile kune-immune globulin. Le mithi ihlasela ngqo igciwane esikhundleni sokuhlinzeka ngama-antibody okulwa nalo.

Ezimweni ezithile, udokotela wakho angase ancome izinyathelo zokunakekela ezisekelayo ezifana nokunakekelwa kwamanxeba, ama-antibiotics ukuvimbela izifo zesibili, noma imithi yokuphatha ubuhlungu nokuvuvukala ngenkathi umzimba wakho uphola.

Ukukhethwa kokwelashwa kuncike kakhulu esimweni sakho esithile, ubukhulu bezinkinga zakho, kanye nesimo sakho sempilo esiphelele. Ithimba lakho lezempilo lizosebenza nawe ukuthola indlela engcono kakhulu.

Ingabe i-Vaccinia Immune Globulin Ingcono Kunezinye Izindlela Zokwelapha?

Ukuqhathanisa lo muthi nezinye izindlela zokwelapha akulula ngoba wenzelwe izimo ezithile kakhulu lapho ezinye izinketho zingase zingasebenzi. Ezinkingeni ze-vaccinia virus, ngokuvamile ukwelashwa okuqondile nokusebenzayo okutholakalayo.

Ngokungafani nemithi elwa namagciwane esebenza kancane ukumisa ukuzala kabusha kwamagciwane, i-immune globulin inikeza ukusekelwa kwama-antibody ngokushesha. Lokhu kwenza kube yigugu ikakhulukazi ezimweni ezinzima lapho isikhathi sibalulekile.

Noma kunjalo, akudingeki ukuthi "kungcono" kunezinye izindlela zokwelapha kuzo zonke izimo. Abanye abantu bangase basabele kahle ekunakekelweni okusekelayo kuphela, kanti abanye bangazuza ezindleleni zokuhlanganisa. Udokotela wakho uzocabangela izimo zakho ezithile ukuze anqume ukwelashwa okufanele kakhulu.

Ukusebenza kahle komuthi kuncike kakhulu ekutheni unikezwa ngokushesha kangakanani ngemuva kokuthi kuvela izinkinga. Ukwelashwa ngaphambi kwesikhathi ngokuvamile kuholela emiphumeleni engcono, yingakho ukunakekelwa kwezokwelapha okusheshayo kubaluleke kakhulu uma uba nezimpawu ezikhathazayo ngemuva kokugonywa kwe-smallpox.

Imibuzo Evame Ukubuzwa Mayelana ne-Vaccinia Immune Globulin

Ingabe i-Vaccinia Immune Globulin iphephile kubantu abanezifo ze-Autoimmune?

Abantu abanezifo ze-autoimmune ngokuvamile bangathola lo muthi, kodwa badinga ukuqashwa eduze ngesikhathi sokwelashwa. Udokotela wakho uzohlola ngokucophelela izinzuzo ngokumelene nezingozi ezingaba khona ngokusekelwe esimweni sakho esithile se-autoimmune kanye nemithi yamanje.

I-immune globulin ngokuvamile ngeke yenze izimo eziningi ze-autoimmune zibe zimbi, kodwa ingase isebenzisane nemithi ethile ecindezela amasosha omzimba oyithathayo. Ithimba lakho lokunakekelwa kwezempilo lizobuyekeza yonke imithi yakho futhi lingase lidingeke ukuthi lilungise imithamo noma isikhathi sokwelashwa.

Ngingenzani uma ngithola i-Vaccinia Immune Globulin eningi ngengozi?

Njengoba lo muthi unikezwa endaweni yesibhedlela elawulwayo, ukweqisa ngengozi akunakwenzeka. Abahlinzeki bezempilo babala umthamo oqondile ngokusekelwe esisindweni sakho kanye nesimo, futhi baqapha ukumnika ngokucophelela kuyo yonke inqubo.

Uma ukhathazekile ngomthamo wakho noma uba nezimpawu ezingavamile ngesikhathi sokwelashwa, khuluma ngokushesha. Ithimba lakho lokunakekelwa kwezempilo lingalungisa izinga lokumnika noma lime ukwelashwa uma kunesidingo. Baqeqeshwe ukuphatha noma yiziphi izinkinga ezingase zivele.

Ngingenzani uma ngiphuthelwa umthamo we-Vaccinia Immune Globulin ohleliwe?

Uma uphuthelwa i-aphoyintimenti ehleliwe yokwelashwa lokhu, xhumana nomhlinzeki wakho wezempilo ngokushesha ukuze uhlele kabusha. Isikhathi singaba sibalulekile ekwelapheni izinkinga ze-vaccinia, ngakho ukubambezeleka kufanele kuncishiswe noma nini lapho kungenzeka.

Udokotela wakho uzoqonda ukuthi ukubambezeleka kuyawuthinta yini uhlelo lwakho lokwelashwa futhi kungase kudingeke ukuthi alungise indlela ngokusekelwe ekutheni izimpawu zakho zithuthuke kanjani. Ungazami ukulinda noma ukuzelapha okwamanje.

Ngingayeka nini Ukuthatha i-Vaccinia Immune Globulin?

Abantu abaningi bayakuthola lokhu njengokwelashwa kwesikhathi esisodwa, ngakho-ke akukho imithi eqhubekayo okufanele iyeke. Isinqumo sokuthi ngabe udinga imithamo eyengeziwe sincike ekutheni usabela kahle kangakanani ekwelashweni kokuqala nokuthi izimpawu zakho zithuthuka kanjani.

Udokotela wakho uzoqapha ukululama kwakho ngama-aphoyintimenti okulandelayo futhi anqume ukuthi ngabe ukwelashwa okwengeziwe kuyadingeka yini. Ama-antibody avela emuthini aqhubeka esebenza emzimbeni wakho amasonto kuya ezinyangeni ngemuva kokufakwa.

Ngingakwazi Ukuthola Imithi Yokugoma Ngemuva Kokuthola i-Vaccinia Immune Globulin?

Kungase kudingeke ulinde ngaphambi kokuthola imithi yokugoma ethile ngemuva kokwelashwa lokhu. I-immune globulin ingaphazamisa ukusabela komzimba wakho emithini yokugoma ephilayo, okwenza ingasebenzi kahle.

Udokotela wakho uzohlinzeka ngesiqondiso esithile mayelana nokuthi kuphephile nini ukuthola eminye imithi yokugoma. Lesi sikhathi siyahluka ngokuya ngohlobo lomuthi wokugoma kanye nezimo zakho ngazinye, kepha ngokuvamile kungamanye izinyanga eziningana ngemuva kokwelashwa.