Yini i-Valbenazine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Valbenazine iyimithi kadokotela esiza ukulawula ukunyakaza okungafuneki, okuphindaphindayo okubizwa ngokuthi i-tardive dyskinesia. Uma ubulokhu ubhekene nokunyakaza kwemisipha okungazithandeli ebusweni bakho, olimini, noma ezinye izingxenye zomzimba wakho, lo muthi ungase unikeze impumuzo obuyilindele.

Lokhu kunyakaza kuvame ukuvela njengomphumela ovela emithini ethile yezengqondo, futhi i-valbenazine isebenza ngokulinganisela amakhemikhali obuchopho alawula ukunyakaza kwemisipha. Yenzelwe ngqo ukusiza abantu ukuthi babuyisele ukulawula imizimba yabo futhi bazizwe bekhululekile ezimpilweni zabo zansuku zonke.

Yini i-Valbenazine?

I-Valbenazine iyimithi eyingxenye yeqembu lezidakamizwa elibizwa ngokuthi ama-VMAT2 inhibitors. Isebenza ngokuvimba iphrotheni ethile ebuchosheni bakho epakisha i-dopamine, isithunywa samakhemikhali esilawula ukunyakaza.

Cabanga ngayo njengohlelo oluthambile lokubamba amasignali okunyakaza okusebenzayo ebuchosheni bakho. Ngokunciphisa inani le-dopamine elitholakala ezindaweni ezithile zobuchopho, i-valbenazine isiza ukuthulisa umsebenzi wemizwa oweqile obangela ukunyakaza okungazithandeli.

Umuthi uza ngesimo samaphilisi futhi uthathwa ngomlomo kanye ngosuku. Ivunyelwe yi-FDA ngqo ukwelapha i-tardive dyskinesia kubantu abadala, okuyenza ibe yindlela yokwelapha eqondiwe yalesi simo esiyinselele.

Isetshenziselwani i-Valbenazine?

I-Valbenazine ikakhulukazi inikezwa ukwelapha i-tardive dyskinesia, isimo esibangela ukunyakaza okungazithandeli, okuphindaphindayo. Lokhu kunyakaza kuvame ukuthinta ubuso bakho, ulimi, izindebe, futhi ngezinye izikhathi izingalo zakho, imilenze, noma umzimba wakho.

I-Tardive dyskinesia ivame ukuvela ngemva kokuthatha imithi ethile yezengqondo izinyanga noma iminyaka. Ukunyakaza kungabandakanya ukukhotha izindebe, ukuphuma kolimi, ukuhlikihla ubuso, noma ukunyakaza kweminwe okuphindaphindayo ongakwazi ukukulawula.

Lesi simo singaba ngesingakhululeki ngokomzimba nangokomzwelo, sithinte ukuzethemba kwakho ezimweni zomphakathi. I-Valbenazine isiza ukunciphisa lezi zinyakazo, ikuvumela ukuthi uzizwe ulawula umzimba wakho futhi ukhululekile emisebenzini yakho yansuku zonke.

Isebenza Kanjani I-Valbenazine?

I-Valbenazine isebenza ngokugxila kuphrotheni ethile ebizwa nge-VMAT2 ebuchosheni bakho. Le phrotheni inesibopho sokupakisha i-dopamine ibe ngama-vesicles okugcina, afana neziqukathi ezincane eziphethe amakhemikhali obuchopho.

Lapho i-valbenazine ivimba i-VMAT2, inciphisa inani le-dopamine elitholakala ezingxenyeni ezithile zobuchopho. Lokhu kusiza ukulinganisela kabusha amakhemikhali obuchopho aphazanyiswe yimithi yangaphambilini, empeleni ithulisa izimpawu ezingaphezu kwamandla ezibangela ukunyakaza okungazithandi.

Umuthi uthathwa njengomuthi onamandla ngokulinganisela futhi usebenza kancane kancane ngokuhamba kwesikhathi. Ungase ungaboni izinguquko ngokushesha, kodwa abantu abaningi baqala ukubona ngcono ekunyakazeni kwabo kungakapheli amasonto ambalwa beqale ukwelashwa.

Kufanele Ngiyithathe Kanjani I-Valbenazine?

Thatha i-valbenazine ngendlela udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngaphandle noma ngaphandle kokudla. Ungayithatha ngamanzi, ubisi, noma ijusi - noma yini ozizwa ukhululekile ngayo.

Gwinya amaphilisi wonke ngaphandle kokuwavula, ukuwachoboza, noma ukuwahlafuna. Umuthi wenzelwe ukuthi ukhishwe kancane emzimbeni wakho, ngakho ukuqhekeza iphilisi kungaphazamisa indlela osebenza ngayo.

Akudingeki ukuthi uhlele umthamo wakho ngesikhathi sokudla, kodwa ukuwuthatha ngesikhathi esifanayo nsuku zonke kusiza ukugcina amazinga aqhubekayo emzimbeni wakho. Abantu abaningi bakuthola kulula ukukhumbula lapho bekuxhumanisa nomkhuba wansuku zonke njengesidlo sasekuseni noma isikhathi sokulala.

Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho ngezinketho. Bangase bakwazi ukusikisela izindlela noma ezinye izindlela ezisebenza kangcono kuwe.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Valbenazine?

Ubude bokwelashwa nge-valbenazine buhlukahluka kumuntu nomuntu futhi kuncike ekutheni usabela kahle kangakanani emuthini. Abanye abantu bayawudinga izinyanga eziningana, kanti abanye bangawuthatha iminyaka.

Udkt wakho ngokuvamile uzoqala ngomthamo ophansi bese ewunyusa kancane kancane emasontweni ambalwa. Lokhu kusiza umzimba wakho ukuthi ujwayele umuthi futhi kuvumela udkt wakho ukuthi athole umthamo osebenza kahle kakhulu onemiphumela emibi embalwa.

Abantu abaningi baqala ukuqaphela ukuthuthuka ekunyakazeni kwabo okungahleliwe phakathi kwamasonto angu-4 kuya kwangu-6 ngemuva kokuqala ukwelashwa. Kodwa-ke, kungathatha izinyanga ezi-3 ukuzwa izinzuzo ezigcwele zomuthi.

Ungayeki ukuthatha i-valbenazine ngokuzumayo ngaphandle kokukhuluma nodkt wakho kuqala. Ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho zibuye noma zibe zimbi, ngakho udkt wakho cishe uzoncoma ukunciphisa umthamo wakho kancane kancane uma sekuyisikhathi sokuyeka umuthi.

Yiziphi Imiphumela Emibi ye-Valbenazine?

Njengayo yonke imithi, i-valbenazine ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi imild kuya kokulingene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Nansi imiphumela emibi evame kakhulu ongase uyithole:

• Ukozela noma ukukhathala
• Isicanucanu noma isisu esibuhlungu
• Ikhanda
• Isiyezi
• Umlomo owomile
• Ukuqunjelwa
• Umbono ongacacile

Le miphumela ngokuvamile yenzeka emasontweni ambalwa okuqala okwelashwa futhi ivame ukungabonakali njengoba umzimba wakho uzivumela. Ukuthatha umuthi nokudla kungasiza ukunciphisa isisu esibuhlungu.

Abanye abantu bangase bathole imiphumela emibi engavamile kodwa ekhathazayo edinga ukunakekelwa kwezokwelapha:

• Ukozela okukhulu okuphazamisa imisebenzi yansuku zonke
• Ushintsho lwemizwa noma ukucindezeleka
• Ubunzima bokugxilisa ingqondo
• Izinkinga zokulinganisela noma ingozi eyengeziwe yokuwa
• Ukuqina kwemisipha okungavamile noma ukuthuthumela

Xhumana nodokotela wakho uma uhlangabezana nanoma yimaphi alawa maphuzu, ikakhulukazi uma eqhubeka noma eba kubi ngokuhamba kwesikhathi.

Imiphumela emibi engavamile kodwa ebucayi ingabandakanya isikhathi eside se-QT (izinguquko zesigqi senhliziyo), ukusabela okukhulu komzimba, noma ukwanda kwezifo zokunyakaza ezikhona. Nakuba lokhu kungavamile, kubalulekile ukukwazi futhi ufune ukwelashwa ngokushesha uma uhlangabezana nobuhlungu besifuba, ubunzima bokuphefumula, noma ukusabela okukhulu kwesikhumba.

Ubani Ongafanele Athathe I-Valbenazine?

I-Valbenazine ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi iphephile yini kuwe. Abanye abantu kufanele bagweme lo muthi ngenxa yezingozi ezingaba khona zempilo.

Akufanele uthathe i-valbenazine uma unokungezwani komzimba nomuthi noma yiziphi izithako zawo. Izimpawu zokungezwani komzimba zihlanganisa ukuqubuka, ukuluma, ukuvuvukala, isiyezi esikhulu, noma ubunzima bokuphefumula.

Abantu abanezimo ezithile zenhliziyo bangase badinge ukugwema i-valbenazine noma badinge ukuqapha okukhethekile:

• I-Long QT syndrome noma ezinye izifo zesigqi senhliziyo
• Ukuhlaselwa yinhliziyo kwakamuva noma isifo senhliziyo esingazinzile
• Ukwehluleka kwenhliziyo okukhulu
• Umlando womndeni wokufa okungazelelwe kwenhliziyo

Udokotela wakho cishe uzo-oda i-electrocardiogram (ECG) ngaphambi kokuqala ukwelashwa ukuze ahlolisise isigqi senhliziyo yakho.

I-Valbenazine ingase ingafaneleki uma unesifo esibi sesibindi noma sezinso, njengoba lezi zitho zisiza ukucubungula umuthi. Udokotela wakho angase adinge ukulungisa umthamo wakho noma akhethe enye indlela yokwelapha.

Uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, xoxa ngezingozi nezinzuzo nodokotela wakho. Ukuphepha kwe-valbenazine ngesikhathi sokukhulelwa nokuncelisa akukatholakali ngokugcwele.

Igama Lomkhiqizo Le-Valbenazine

I-Valbenazine itholakala ngaphansi kwegama lomkhiqizo elithi Ingrezza. Lona ukuphela kwenguqulo yegama lomkhiqizo etholakala njengamanje e-United States.

I-Ingrezza iza ngamaphilisi anamandla ahlukene: 40 mg, 60 mg, kanye no-80 mg. Amaphilisi anemibala ehlukile ukukusiza ukuthi ubone umthamo ofanele odokotela bakho abakuqokele.

Njengamanje, azikho izinhlobo ezivamile ze-valbenazine ezitholakalayo, okusho ukuthi i-Ingrezza iyona kuphela uhlobo lolu lwemithi ongayithola. Lokhu kungase kuthinte izindleko kanye nomshwalense, ngakho-ke kufanelekile ukuxoxa ngezinketho zosizo lwezezimali nodokotela wakho noma usokhemisi.

Ezinye izindlela ze-Valbenazine

Uma i-valbenazine ingakulungele, kukhona ezinye izindlela zokwelapha ezitholakalayo ze-tardive dyskinesia. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho ngokusekelwe esimweni sakho esithile.

I-Deutetrabenazine (Austedo) ingenye i-VMAT2 inhibitor esebenza ngendlela efana ne-valbenazine. Iphinde yamukelwe yi-FDA ye-tardive dyskinesia futhi ingaba enye indlela enhle uma ungenakukwazi ukubekezelela i-valbenazine noma udinga ukuthatha imithi kabili ngosuku.

Abanye odokotela bangase bacabange ukwelapha ngaphandle kwesitifiketi se-tardive dyskinesia, okuhlanganisa:

• I-Clonazepam (i-benzodiazepine engasiza ngokunyakaza kwemisipha)
• I-Amantadine (ngokuyisisekelo umuthi we-Parkinson)
• Ukujova kwe-Botulinum toxin ekunyakazeni okukhawulelwe
• I-Vitamin E (nakuba ubufakazi bunomkhawulo)

Kwezinye izimo, ukulungisa noma ukushintsha imithi eyabangela i-tardive dyskinesia ekuqaleni kungasiza, nakuba lokhu kudingeka kwenziwe ngokucophelela ngesiqondiso sikadokotela wakho wezifo zengqondo.

Enye indlela engcono kakhulu incike ezimpawini zakho ngazinye, umlando wezokwelapha, nokuthi ukusabele kahle kangakanani ekwelashweni kwangaphambilini. Udokotela wakho uzosebenza nawe ukuthola inketho efanelekayo.

Ingabe i-Valbenazine ingcono kune-Deutetrabenazine?

Kokubili i-valbenazine ne-deutetrabenazine ziyindlela yokwelapha esebenzayo ye-tardive dyskinesia, kodwa zinezinye izinto ezihlukile ezingenza enye ikufaneleke kakhulu kunenye.

I-Valbenazine inikeza lula lokuthatha umthamo kanye ngosuku, okutholakala abantu abaningi kulula ukukukhumbula nokunamathela kukho. I-Deutetrabenazine ngokuvamile idinga ukuthathwa kabili ngosuku, okungaba inselele enkulu ukuyigcina njalo.

Ngokuqondene nokusebenza kahle, womabili amakhambi abonisa imiphumela efanayo ekunciphiseni ukunyakaza okungahleliwe. Izifundo zomtholampilo zikhomba ukuthi womabili angathuthukisa kakhulu izimpawu ze-tardive dyskinesia, nabantu abaningi bebona ngcono ngaphakathi kwamasonto angu-4 kuya kwangu-6.

Amaphrofayili emiphumela emibi afana kakhulu, womabili amakhambi angase abangele ukozela, isicanucanu, nokukhathala. Kodwa-ke, abanye abantu bangakwazi ukubekezelela elinye kangcono kunelinye ngenxa yomehluko ngamunye endleleni imizimba yabo ecubungula ngayo le mithi.

Udokotela wakho uzocabangela izinto ezinjengomsebenzi wakho wansuku zonke, eminye imithi oyithathayo, ukusebenza kwezinso, nezintandokazi zakho siqu lapho enquma ukuthi iyiphi imithi engasebenza kangcono kuwe. Akukho

Uma ngabe uthatha i-valbenazine eningi ngengozi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela engemihle efana nokozela okukhulu, isiyezi, noma izinkinga zesigqi senhliziyo.

Ungazami ukuzenza uhlanze noma uthathe noma yimaphi amakhambi asekhaya. Kunalokho, shayela udokotela wakho, iya egumbini eliseduze lezimo eziphuthumayo, noma ushayele ulayini Wosizo Lwezinto Ezinobuthi ku-1-800-222-1222. Letha ibhodlela lemithi nawe ukuze abahlinzeki bezempilo bazi kahle ukuthi uthatheni nokuthi uthathe kangakanani.

Q3. Kufanele Ngenzeni Uma Ngeqe Umthamo We-Valbenazine?

Uma weqa umthamo we-valbenazine, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kuleso simo, weqa umthamo owuqeqile bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuqeqile, ngoba lokhu kungakhuphula ingozi yakho yemiphumela engemihle. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukhumbule.

Q4. Ngingayeka Nini Ukuthatha I-Valbenazine?

Kufanele uyeke kuphela ukuthatha i-valbenazine ngaphansi kwesiqondiso sikadokotela wakho. Ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho ze-tardive dyskinesia zibuye noma zibe zimbi kakhulu, ngezinye izikhathi zingakapheli izinsuku noma amasonto.

Udokotela wakho ngokuvamile uzoncoma ukunciphisa umthamo wakho kancane kancane emavikini amaningana kunokuyeka kungazelelwe. Lokhu kusiza ukunciphisa ingozi yokubuyela emuva kwezimpawu futhi kuvumela umzimba wakho ukuthi uzivumelanise kancane kancane noshintsho lwemithi.

Q5. Ngingashayela Ngenkathi Ngithatha I-Valbenazine?

I-Valbenazine ingabangela ukozela, isiyezi, noma umbono ongacacile, ikakhulukazi uma uqala ukuyithatha. Kufanele ugweme ukushayela noma ukusebenzisa imishini kuze kube yilapho wazi ukuthi imithi ikuthinta kanjani.

Abantu abaningi bangashayela ngokuphepha uma sebeqhelelene nomuthi futhi bengabi nazinye izimpawu ezingathí sina. Kodwa-ke, hlala usebenzisa ukwahlulela kwakho futhi gwema ukushayela uma uzizwa ukozela, unesiyezi, noma ungaziqapheli njengenjwayelo, ngisho noma ubuthatha umuthi isikhathi eside.