Vamorolone (indaba yokumunca)
Imikhiqizo etholakalayo
Agamree
Mayelana naleli khambi
UVamorolone uyasetshenziswa ekwelapheni i-Duchenne muscular dystrophy (DMD). I-DMD iyisifo samathambo esingavamile, esitholakala ezizukulwaneni, esibangelwa ukungabikho kwe-protein ebizwa nge-dystrophin, esiza ekugcineni amangqamuzana emathambo ephilile. UVamorolone uhlobo lwe-corticosteroid. Lo mtholampilo utholakala kuphela ngomyalelo wochwepheshe wezokwelapha. Lo mkhiqizo utholakala ngezindlela zokulinganisela ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekwahluleni kokusebenzisa imithi, kufanele kuqhathaniswe ingozi yokuthatha imithi nezinzuzo ezizoletha. Lo ngumgwebo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluhlukile noma ukusabela okungokwe-alerji kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izibenge, izigcini, noma izilwane. Ngomkhiqizo ongenamithi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubuhlobo bobudala nemiphumela ka-vamorolone kubantwana abaneminyaka engaphansi kwengu-2. Ukuphepha nokuphumelela akukaqiniswa. I-DMD yisifo sabantwana nabantu abadala abasebasha. Ayikho imininingwane etholakalayo ngobudlelwano bobudala nemiphumela ka-vamorolone kubantu abadala. Ayikho izifundo ezifanele kwabesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izimithi kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha kungadingeka. Uma uthatha le mithi, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukuhlangana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akunconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Ezinye izimithi akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshako nanoma iyiphi imithi kungabangela ukuhlangana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshako. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli leyeza kuphela njengoba kunqunyiwe udokotela wakho. Ungalithathi ngokweqile, ungalithathi kaningi, futhi ungalithathi isikhathi eside kunalokho udokotela wakho akuqondile. Leli leyeza liza nemiyalo yokuqondisa. Funda futhi ulandele imiyalo ngokucophelela. Buza udokotela wakho uma unemibuzo. Thatha leli leyeza ngokudla. Ungaluxubani nanoma yiluphi uhlobo lwetshefu ngaphambi kokuthatha noma ukunika leli leyeza. Ukuze usebenzise i-oral liquid: Uma uthola ukwelashwa kwe-steroid (isib. prednisone, deflazacort), udokotela wakho angakushintshela kuleli leyeza nganoma yisiphi isikhathi. Buza udokotela wakho uma unemibuzo. Inani leli leyeza lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemibhalweni. Ulwazi olulandelayo luhlanganisa kuphela amanani ajwayelekile aleli leyeza. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondile ukwenza njalo. Inani leyeza olithathayo lixhomeke emandleni leyeza. Futhi, inani lezinani olithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwezinani, nobude besikhathi olithatha leli leyeza kuya ngenkinga yezokwelapha oyisebenzisela leli leyeza. Uma uphuthelwa yinani leli leyeza, lithathe ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi senani lakho elilandelayo, susa inani eliphuthelwe futhi ubuyele esikhathini sakho sokuthatha imithi. Ungawandisi amanani. Gcina kungafinyeleleki ezinganeni. Ungagcini imithi eliphelile noma imithi engasadingeki. Buza ochwepheshe bakho bezempilo ukuthi kufanele uyilahla kanjani noma iyiphi imithi ongayisebenzisi. Gcina imithi embizeni evaliwe ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungayigandisi. Ungagcina imithi evuliwe esihlalweni. Ungayigandisi. Lahla noma yiluphi ulwetshefu olungasetshenzisiwe ngemuva kwezinyanga ezi-3 zokuvula ibhodlela.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.