Yini i-Vandetanib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Vandetanib iyimithi yomdlavuza eqondiswe ngqo evimba amaprotheni athile asiza amaseli omdlavuza ukuthi akhule futhi asabalale. Isetshenziswa ikakhulu ukwelapha uhlobo olungavamile lomdlavuza wendlala yegilo obizwa ngokuthi i-medullary thyroid carcinoma lapho ukuhlinzwa kungenzeki noma lapho umdlavuza ususabalale kwezinye izingxenye zomzimba.

Le mithi ingeyeqembu lemithi ebizwa ngokuthi ama-tyrosine kinase inhibitors, asebenza njengezikele zamangqamuzana ukusika amasignali atshela amaseli omdlavuza ukuthi aphindaphindeke. Ngenkathi kuyindlela yokwelapha ekhethekile, ukuqonda ukuthi isebenza kanjani nokuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiseleleke uma udokotela wakho eyincoma.

Yini i-Vandetanib?

I-Vandetanib iyimithi yomdlavuza kadokotela eqondise amaprotheni athile abambe iqhaza ekukhuleni kwamaseli omdlavuza. Yilokho odokotela abakubiza ngokuthi

Lo muthi uvunyelwe ngokuqondile iziguli ezinamathumba angeke asuswe ngokuhlinzwa noma umdlavuza wazo osakazekele (usabalale) ezingxenyeni ezikude zomzimba. Lusizo ikakhulukazi kubantu abanezinhlobo zofuzo ze-medullary thyroid carcinoma ezibangelwa izinguquko zofuzo.

Ngezinye izikhathi odokotela bangase banikeze i-vandetanib ngeminye imidlavuza engavamile njengengxenye yezivivinyo zomtholampilo noma izinhlelo zokusetshenziswa ngomusa. Kodwa-ke, ukusetshenziswa kwayo okuyinhloko nokufundwe kahle kakhulu kuhlala ekwelapheni i-medullary thyroid carcinoma ethuthukile lapho ezinye izindlela zokwelapha zingafanele.

Isebenza Kanjani I-Vandetanib?

I-Vandetanib isebenza ngokuvimba amaprotheni amaningi amaseli omdlavuza awasebenzisayo ukuze akhule, asakazeke, futhi akhe imithambo emisha yegazi. Cabanga ngayo njengokubeka izithiyo emgwaqeni omkhulu lapho amaseli omdlavuza ahamba khona ukuze azande futhi asakazeke emzimbeni wakho wonke.

Lo muthi uqondise ngqo amaprotheni abizwa nge-RET, VEGFR, kanye ne-EGFR, okufana nokushintsha okutshela amaseli omdlavuza ukuthi akhule futhi ahlukaniswe. Ngokuvimba lawa mashintshi, i-vandetanib inganciphisa noma imise ukuqhubeka komdlavuza.

Lokhu kuthathwa njengomuthi oqinile womdlavuza. Nakuba ingaqini njengeminye imithi ye-chemotherapy, isinamandla ngokwanele ukuthonya kakhulu ukukhula komdlavuza. Indlela eqondiwe isho ukuthi ngokuvamile iyabekezeleleka kune-chemotherapy yendabuko, nakuba isadinga ukuqashwa ngokucophelela yithimba lakho lezempilo.

Kufanele Ngiyithathe Kanjani I-Vandetanib?

Thatha i-vandetanib ngendlela eqondile udokotela wakho ayiyalela ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Ungayithatha ngaphandle kokudla noma ngaphandle kokudla, kodwa zama ukungaguquguquki ekukhetheni kwakho ukuze usize ukugcina amazinga aqinile emzimbeni wakho.

Gwinya amaphilisi wonke ngengilazi yamanzi egcwele. Ungawachobozi, uwaphule, noma uwahlafune, ngoba lokhu kungathinta indlela umuthi ogaywa ngayo. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinye izindlela.

Kungcono ukuthatha i-vandetanib esiswini esingenalutho uma kungenzeka, njengoba ukudla ngezinye izikhathi kunganciphisa ukuthi umzimba wakho uyithatha kahle kangakanani imithi. Kodwa-ke, uma uhlangabezana nokuphazamiseka kwesisu, udokotela wakho angase ancome ukuyithatha nokudla okulula noma ukudla okulula.

Gwema ama-grapefruit nejusi le-grapefruit ngenkathi uthatha lo muthi, njengoba kungakhuphula amazinga e-vandetanib egazini lakho futhi kungase kubangele imiphumela eminingi emibi. Futhi, zama ukuyithatha okungenani amahora angu-2 ngaphambi noma ngemva kokuthatha izithasiselo ze-calcium noma ama-antacid.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Vandetanib?

Ngokuvamile uzoqhubeka nokuthatha i-vandetanib uma nje ilawula umdlavuza wakho futhi uyayibekezelela kahle. Lokhu ngokuvamile kusho ukuyithatha isikhathi eside, ngezinye izikhathi izinyanga noma ngisho neminyaka, kuye ngokuthi umdlavuza wakho uphendula kanjani.

Udokotela wakho uzoqapha ukusabela kwakho ngokusebenzisa izithombe ezivamile nokuhlolwa kwegazi, ngokuvamile njalo ezinyangeni ezimbalwa. Uma umdlavuza uyeka ukuphendula emuthini noma uma uba nemiphumela emibi engathi sína, udokotela wakho angase alungise umthamo noma acabangele ukushintshela ekwelashweni okuhlukile.

Ubude bokwelashwa buhluka kakhulu kumuntu nomuntu. Abanye abantu bayayithatha iminyaka eminingana ngemiphumela emihle, kanti abanye bangase badinge ukuyeka ngokushesha ngenxa yemiphumela emibi noma ukuqhubeka komdlavuza. Ithimba lakho lezempilo lizosebenza nawe ukuze lithole ukulinganisela okulungile phakathi kokulawula umdlavuza wakho nokugcina izinga lempilo yakho.

Yini Imiphumela Emibi Ye-Vandetanib?

Njengayo yonke imithi yomdlavuza, i-vandetanib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi ilawuleka ngokunakekelwa kwezempilo okufanele nokuqapha.

Nansi imiphumela emibi evame kakhulu ongase uyithole:

• Ukuqunjelwa, okuthinta cishe u-60% wabantu abathatha lo muthi
• Ukuqubuka kwesikhumba noma izinduna ezifana nezinduna ebusweni bakho nasemzimbeni ongenhla
• Umfutho wegazi ophezulu odinga ukuqashwa njalo
• Isicanucanu nokuncipha kwesifiso sokudla
• Ukukhathala nobuthakathaka
• Ukucindezeleka
• Ushintsho ezinzipho zakho zezandla nezinzwane

Le miphumela evamile ivame ukuba milde noma ibephakathi nendawo futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Udokotela wakho angakwazi ukukuyalela imithi ukusiza ukuphatha izimpawu ezinjengokuqunjelwa nesicanucanu.

Imiphumela emibi kakhulu kodwa engavamile ihlanganisa izinguquko zesigqi senhliziyo, ukusabela okukhulu kwesikhumba, nezinkinga zesibindi. Udokotela wakho uzokuqapha eduze ngezivivinyo zegazi ezivamile nokuhlolwa kwesigqi senhliziyo ukuze abambe noma yiziphi izinkinga ezinkulu ekuqaleni.

Ngokungavamile kakhulu, abanye abantu bangase babe nezinkinga ezinkulu zamaphaphu, ukopha okukhulu, noma isimo esibizwa ngokuthi i-tumor lysis syndrome lapho amaseli omdlavuza ewohloka ngokushesha kakhulu. Ngenkathi lokhu kungavamile, kubalulekile ukubika noma yiziphi izimpawu ezingavamile eqenjini lakho lezempilo ngokushesha.

Ubani Ongafanele Athole i-Vandetanib?

I-Vandetanib ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyala. Abantu abanezimo ezithile zenhliziyo, ikakhulukazi labo abanomlando wesigqi senhliziyo esingajwayelekile, kungenzeka bangabi ngabantu abafanelekayo kulo muthi.

Akufanele uthathe i-vandetanib uma ukhulelwe noma uncelisa, njengoba ingalimaza umntwana ongakazalwa noma umntwana oncancisayo. Abesifazane abaneminyaka yokuzala badinga ukusebenzisa izindlela zokulawula inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nasezinyangeni eziningana ngemuva kokuyeka umuthi.

Abantu abanezinkinga ezinkulu zesibindi noma izinso bangase badinge ukulungiswa komthamo noma bangase bangakwazi ukuthatha lo muthi ngokuphepha. Udokotela wakho uzohlola ukusebenza kwesibindi nezinso zakho ngaphambi kokuqala ukwelashwa futhi abaqaphe njalo.

Uma unomlando wezifo zokuphuma igazi, ukuhlinzwa kwamuva, noma usebenzisa imithi yokunciphisa igazi, udokotela wakho uzodinga ukulinganisela ngokucophelela izingozi nezinzuzo. Ngaphezu kwalokho, abantu abanezimo ezithile zofuzo ezithinta ukushaya kwenhliziyo kungenzeka bangafaneleki.

Igama Lomkhiqizo le-Vandetanib

I-Vandetanib ithengiswa ngaphansi kwegama lomkhiqizo elithi Caprelsa. Leli yilo kuphela igama lomkhiqizo elitholakalayo lalo muthi, njengoba lukhiqizwa yi-AstraZeneca pharmaceuticals.

Ungase ubone womabili la magama esetshenziswa ngokushintshana emibhalweni yezokwelapha kanye nasezindleleni zokwelapha. Noma ngabe incwadi yakho kadokotela ithi "vandetanib" noma "Caprelsa," ngumuthi ofanayo onezithako ezisebenzayo ezifanayo nemiphumela efanayo.

Izinhlobo ezivamile ze-vandetanib azikatholakali kabanzi emazweni amaningi, ngakho abantu abaningi bathola umkhiqizo we-Caprelsa. Umshwalense wakho kanye nekhemisi kuzonquma ukuthi iyiphi inguqulo oyitholayo, yize umuthi uqobo usafana.

Ezinye izindlela zokwelapha i-Vandetanib

Uma i-vandetanib ingakulungele noma iyeka ukusebenza ngempumelelo, kunezindlela eziningana zokwelapha ezingenye ezitholakalayo ze-medullary thyroid carcinoma. Udokotela wakho uzocabangela isimo sakho esithile lapho encoma ezinye izindlela.

I-Cabozantinib ingenye indlela yokwelapha eqondiwe esebenza ngendlela efana ne-vandetanib futhi ivame ukusetshenziswa njengenye indlela. Iqondisa amanye amaprotheni afanayo kodwa ingase isebenze kangcono kwabanye abantu noma ibe nomphumela ohlukile.

Ezinye izindlela zokwelapha zihlanganisa imithi yamakhemikhali yendabuko, ukwelashwa ngemisebe, noma ukubamba iqhaza ezivivinyweni zomtholampilo ezihlola izindlela zokwelapha ezintsha eziqondiwe. Enye indlela engcono kakhulu incike ezintweni ezifana nempilo yakho yonke, ukuthi umdlavuza wakho usabele kanjani ekwelashweni kwangaphambilini, kanye nezintandokazi zakho.

Ngezinye izikhathi odokotela bangase batusa ukuhlanganiswa kwezindlela zokwelapha noma bacebise ukuphumula emithini ukuze umzimba wakho ululame ngaphambi kokuzama enye indlela. Okubalulekile ukusebenza eduze nethimba lakho le-oncology ukuze uthole uhlelo lokwelapha olusebenza kahle kakhulu esimweni sakho esithile.

Ingabe i-Vandetanib Ingcono Kune-Cabozantinib?

Kokubili i-vandetanib ne-cabozantinib ziyindlela yokwelapha esebenzayo ye-medullary thyroid carcinoma, kodwa akukho oqokwe njengowinile ocacile osebenza kangcono kuwo wonke umuntu. Ukukhetha phakathi kwazo kuvame ukuncika ezimweni zakho ngazinye nokuthi usabela kanjani emithini ngayinye.

Ucwaningo luphakamisa ukuthi i-cabozantinib ingase isebenze kangcono kancane ekunciphiseni izinso kanye nokulibazisa ukuqhubeka komdlavuza, kodwa futhi kungabangela imiphumela emibi kakhulu kwabanye abantu. I-Vandetanib ivame ukubekezelelwa kangcono yiziguli eziningi, ikakhulukazi mayelana nemiphumela emibi yokugaya ukudla.

Udokotela wakho uzocabangela izinto ezinjengempilo yakho yonke, eminye imithi oyithathayo, kanye nohlobo lwakho oluthile lomdlavuza we-thyroid lapho ekhetha phakathi kwalezi zinketho. Abanye abantu benza ngcono ngomuthi owodwa kunomunye, futhi akunakwenzeka ngaso sonke isikhathi ukuqagela ukuthi yini ezosebenza kangcono kuwe.

Izindaba ezinhle ukuthi ukuba nazo zombili izinketho ezitholakalayo kukunika wena nodokotela wakho ukuguquguquka ekuhleleni ukwelashwa. Uma enye ingasebenzi kahle noma ibangela imiphumela emibi ekhathazayo, ungavame ukushintshela kwenye.

Imibuzo Evame Ukubuzwa Mayelana ne-Vandetanib

Ingabe i-Vandetanib Iphephile Kubantu Abanezifo Zenhliziyo?

I-Vandetanib idinga ukuqapha okukhethekile kubantu abanezimo zenhliziyo ngoba ingathinta isigqi senhliziyo. Udokotela wakho uzokwenza i-electrocardiogram (EKG) ngaphambi kokuqala ukwelashwa futhi aqaphe inhliziyo yakho njalo ngesikhathi sokwelashwa.

Uma unomlando wezinkinga zesigqi senhliziyo, ukuhluleka kwenhliziyo, noma ezinye izimo zenhliziyo ezibalulekile, udokotela wakho uzoqaphela ngokucophelela izingozi nezinzuzo. Ungase udinge ukuqapha kaningi noma umthamo ophansi ukuze uqinisekise ukuphepha kwakho.

Umuthi ungabangela isimo esibizwa ngokuthi i-QT prolongation, ethinta uhlelo lukagesi lwenhliziyo. Nakuba lokhu kulawuleka ngokuqapha okufanele, yingakho ukuhlolwa kwesigqi senhliziyo okuvamile kubaluleke kangaka ngesikhathi sokwelashwa.

Kufanele Ngenzeni Uma Ngithatha I-Vandetanib Eningi Ngengozi?

Uma ngengozi uthatha i-vandetanib eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini, njengoba ukungenelela kwangaphambi kwesikhathi kubalulekile ngemithi yomdlavuza.

Izimpawu zokweqisa zingase zihlanganise isicanucanu esibi, ukuhlanza, isifo sohudo, noma izinguquko esigqini senhliziyo. Uma uhlangabezana nanoma yiziphi lezi zimpawu ngemva kokuthatha umuthi omningi, funa usizo lwezokwelapha ngokushesha.

Ukuvimbela ukweqisa ngengozi, sebenzisa umhleli wamaphilisi noma setha izikhumbuzi ocingweni lwakho. Gcina umuthi ebhodleleni lawo lokuqala elinelebula ecacile, futhi ungalokothi uthathe imithamo eyengeziwe ukuze ubuyisele lezo eziphuthelwe.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Vandetanib?

Uma uphuthelwa umthamo we-vandetanib, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma kungaphezu kwamahora angu-12 kuze kube umthamo wakho olandelayo ohleliwe. Uma kungaphansi kwamahora angu-12 kuze kube umthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho olujwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ubuyisele umthamo ophuthelwe, njengoba lokhu kungandisa ingozi yakho yemiphumela emibi engathí sina. Kungcono ukuphuthelwa umthamo owodwa kunokuphinda kabili futhi okungenzeka kubangele ukulimala.

Cabangela ukusetha izikhumbuzi zansuku zonke ocingweni lwakho noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule imithamo yakho. Ukuqina kubalulekile ekugcineni amazinga aqhubekayo omuthi emzimbeni wakho.

Ngingayeka Nini Ukuthatha I-Vandetanib?

Kufanele uyeke kuphela ukuthatha i-vandetanib uma udokotela wakho ekutshela ukuthi kufanelekile ukwenza kanjalo. Lesi sinqumo ngokuvamile sisekelwe ekutheni umuthi ukulawula kahle kangakanani umdlavuza wakho nokuthi ukubekezelela kahle kangakanani imiphumela emibi.

Udokotela wakho uzohlola njalo impendulo yakho emithini ngokuskena nokuhlolwa kwegazi. Uma umdlavuza uqhubeka naphezu kokwelashwa, noma uma uthola imiphumela emibi engalawuleki, udokotela wakho angase ancome ukuyeka umuthi.

Ungayeki ukuthatha i-vandetanib ngokwakho, ngisho noma uzizwa ungcono noma unomuzwa wemiphumela emibi. Ukuyeka kungazelelwe kungavumela umdlavuza ukuthi ukhule ngokushesha. Hlala uxoxa nganoma yikuphi ukukhathazeka mayelana nokuqhubeka nokwelashwa neqembu lakho lezempilo kuqala.

Ngingathatha Eminye Imithi Ngesikhathi Ngithatha i-Vandetanib?

Eminye imithi ingasebenzisana ne-vandetanib, ngakho-ke kubalulekile ukutshela udokotela wakho ngayo yonke imithi, izithasiselo, nemikhiqizo yamakhambi oyithathayo. Lokhu kuhlanganisa imithi etholakala ngaphandle kwe-oda, amavithamini, ngisho netiye lamakhambi elibonakala lingalimazi.

Imithi ethinta isigqi senhliziyo ibaluleke kakhulu ukuthi ixoxwe, njengoba ukuyihlanganisa ne-vandetanib kungakhuphula ingozi yezinguquko eziyingozi zesigqi senhliziyo. Izinciphisi zegazi, ama-antibiotics athile, nemithi ethile ye-antifungal nayo ingasebenzisana ne-vandetanib.

Udokotela wakho kungadingeka alungise imithamo, akuqaphele eduze, noma ancome eminye imithi ukuze agweme ukusebenzisana okungaba yingozi. Hlala uhlola neqembu lakho lezempilo ngaphambi kokuqala noma iyiphi imithi emisha noma izithasiselo ngenkathi uthatha i-vandetanib.