Yini i-Varenicline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Varenicline iyikhambi elibhalwe ngudokotela elenzelwe ukusiza abantu ukuyeka ukubhema ugwayi. Isebenza ngokugxila kuma-receptor obuchopho afanayo athintwa yi-nicotine, okwenza ugwayi unganelisi kakhulu ngenkathi kunciphisa izimpawu zokuhoxisa nokulangazelela.

Lo muthi usize izigidi zabantu ukuba zikhululeke ekuluthweni lukagwayi. Ukuqonda ukuthi usebenza kanjani nokuthi yini ongayilindela kungakusiza ukuthi wenze izinqumo ezinolwazi mayelana nohambo lwakho lokuyeka ukubhema.

Yini i-Varenicline?

I-Varenicline iyikhambi lokuyeka ukubhema elisebenza kuma-receptor e-nicotine obuchopho bakho. Yenzelwe ngqo ukusiza abantu abadala ukuyeka ukubhema ngokunciphisa kokubili injabulo oyithola kugwayi kanye nezimpawu ezingakhululeki zokuhoxisa.

Lo muthi ungowesigaba semithi ebizwa ngokuthi ama-nicotinic receptor partial agonists. Cabanga ngayo njengendlela ethambile yokufaka esikhundleni esigcwalisa ingxenye yezindawo ezifanayo ebuchosheni bakho ezivame ukuthathwa yi-nicotine. Lesi senzo esiphindwe kabili sisiza ukuqeda umjikelezo wokulutheka ngenkathi kwenza ukuguquka kude nogwayi kulawuleke kalula.

I-Varenicline itholakala kuphela ngemiyalelo kadokotela futhi idinga ukugadwa ngokucophelela kwezokwelapha. Udokotela wakho uzoqaphela ukuthi ngabe yikho okulungile yini okusekelwe emlandweni wakho wokubhema, impilo yonke, neminye imithi ongase uyithathe.

Yini i-Varenicline Esizokwenzelwa Yona?

I-Varenicline isetshenziswa ikakhulukazi ukusiza abantu abadala ukuyeka ukubhema ugwayi. Ivunyelwe ngqo ukuyeka ukusebenzisa ugwayi futhi isebenza kahle uma ihlanganiswe nokwelulekwa nezinhlelo zokusekela.

Lo muthi wenzelwe abantu abazinikele ekuyekeni ukubhema futhi abazame ezinye izindlela ngaphandle kwempumelelo. Ilusizo ikakhulukazi kulabo abahlangabezana nokulangazelela okuqinile noma izimpawu ezimbi zokuhoxisa lapho bezama ukuyeka.

Abanye odokotela bangase futhi banikeze i-varenicline kweminye imikhiqizo kagwayi, nakuba ukubhema ugwayi kuhlala kuyona into esetshenziswa kakhulu. Umuthi awunconyelwe abantu ababhemayo ngezikhathi ezithile noma abantu ababhemayo emphakathini, kodwa kunalokho unconyelwa labo abanokuncika okusunguliwe ku-nicotine.

Isebenza Kanjani I-Varenicline?

I-Varenicline isebenza ngokuvula ingxenye yezamukeli ze-nicotine ebuchosheni bakho ngenkathi ngasikhathi sinye ivimba i-nicotine ekubopheni ngokugcwele kulezi zamukeli ezifanayo. Lokhu kudala umphumela oyingqayizivele wezindlela ezimbili okwenza ukuyeka kube lula.

Uma uthatha i-varenicline, inikeza ukukhuthaza okwanele ukunciphisa izimpawu zokuhoxiswa njengokucasuka, ukukhathazeka, nokulangazelela okukhulu. Ngesikhathi esifanayo, ivimba injabulo eningi nokwaneliseka ovame ukukuthola ekubhemeni, okwenza ugwayi ungabi nemivuzo eminingi.

Lo muthi ubhekwa njengomuthi onamandla ngokulinganisela mayelana nokusebenza kwawo. Izifundo zomtholampilo zibonisa ukuthi ingakwazi ukuphinda kabili noma kathathu amathuba akho okuphumelela ukuyeka uma kuqhathaniswa nentando kuphela. Kodwa-ke, akuyona ikhambi lomlingo futhi isebenza kahle kakhulu uma uzimisele ngempela ukuyeka.

Umphumela wokuvimba usho ukuthi noma ngabe uyabhema ngenkathi uthatha i-varenicline, ngeke uzwe ukugcwala okujwayelekile noma ukwaneliseka. Lokhu kusiza ukuqeda umjikelezo womvuzo wengqondo ogcina abantu beluthwe ugwayi.

Kufanele Ngiyithathe Kanjani I-Varenicline?

I-Varenicline kufanele ithathwe ngendlela eqondile njengoba inikezwe ngudokotela wakho, ngokuvamile iqala ngesonto elilodwa ngaphambi kosuku lwakho oluhleliwe lokuyeka. Umuthi uza ngesimo samaphilisi futhi uvame ukuthathwa kabili ngosuku nokudla nengilazi yamanzi egcwele.

Udkt wakho cishe uzoqala ngomthamo ophansi ezinsukwini ezimbalwa zokuqala, bese uwunyusa kancane kancane. Lokhu kusiza umzimba wakho ukuthi ujwayele umuthi futhi kunciphisa ingozi yemiphumela emibi. Ukuyithatha nokudla kusiza ukuvimbela isicanucanu, esinye sezimpawu ezivamile.

Kubalulekile ukudla ukudla okuvamile noma ukudla okulukhuni ngaphambi kokuthatha umthamo ngamunye. Gwema ukuthatha i-varenicline esiswini esingenalutho, njengoba lokhu kwandisa kakhulu amathuba okuzizwa unesiyezi noma ukuzwa isisu esibuhlungu.

Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo ohlelweni lwakho. Abantu abaningi bakuthola kuwusizo ukuthatha umthamo owodwa ngesidlo sasekuseni nomunye ngesidlo sakusihlwa ukuze basungule isimiso.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Varenicline?

Abantu abaningi bathatha i-varenicline amasonto angu-12 (cishe izinyanga ezi-3) njengengxenye yohlelo lwabo lokuqala lokuyeka ukubhema. Udokotela wakho angase ancome inkambo ende uma uyekile ngempumelelo kodwa udinga ukwesekwa okwengeziwe ukuze ugcine intuthuko yakho.

Umugqa wesikhathi wokwelashwa ovamile uqala ngesonto elilodwa ngaphambi kosuku lwakho lokuyeka futhi uqhubeka amasonto angu-11 ngemva kokuyeka ukubhema. Abanye abantu bangase badinge inkambo eyengeziwe yamasonto angu-12 uma bayekile ngempumelelo kodwa besengozini enkulu yokuphindela emuva.

Udokotela wakho uzoqapha intuthuko yakho futhi angase alungise ubude ngokuya ngokuthi usabela kahle kangakanani ekwelashweni. Izinto ezinjengomlando wakho wokubhema, imizamo yangaphambilini yokuyeka, kanye namazinga akho wamanje okucindezeleka konke kuthonya ukuthi ungase udinge isikhathi esingakanani umuthi.

Kubalulekile ukungayeki ukuthatha i-varenicline ngokuzumayo ngaphandle kokukhuluma nodokotela wakho, ngisho noma uzizwa ungasayidingi. Ukuyeka kancane kancane kusiza ekuvimbeleni noma yimiphi imiphumela yokuhoxiswa okungenzeka emuthini ngokwawo.

Yiziphi Imiphumela Eceleni ye-Varenicline?

I-Varenicline ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Nawa amiphumela emibi ebikwa kaningi ethinta abantu abaningi abathatha i-varenicline:

• Ukugula (kuthinta cishe umuntu oyedwa kwabathathu)
• Amaphupho acacile noma angajwayelekile
• Ukucabeka kwekhanda
• Ubunzima bokulala noma ukuqwasha
• Ukuqunjelwa
• Igesi noma ukuqunjelwa
• Ushintsho ekunambithekeni
• Umlomo owomile

Le miphumela evamile emibi ngokuvamile iyalawuleka futhi ivame ukuncipha ngemva kwamasonto ambalwa okuqala ukwelashwa.

Abanye abantu bahlangabezana nemiphumela emibi ekhathazayo edinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungavamile, kubalulekile ukukwazi:

• Ushintsho lwemizwa, okuhlanganisa ukucindezeleka noma ukukhathazeka
• Imicabango noma ukuziphatha kokuzibulala
• Ukuziphatha okunolaka noma okunobudlova
• Ukuphendula okukhulu komzimba okune-rash, ukuvuvukala, noma ubunzima bokuphefumula
• Izinkinga zesigqi senhliziyo noma ubuhlungu besifuba
• Ukushaywa yisithuthwane (akuvamile kakhulu)
• Ukuhamba ngesikhathi sokulala noma okunye ukuziphatha okungajwayelekile kokulala

Uma uhlangabezana nanoma yimiphi yale miphumela emibi engathi sína, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezempilo eziphuthumayo. Ukuphepha kwakho kuyinto eza kuqala, futhi le miphumela idinga ukuhlolwa kwezokwelapha ngokushesha.

Ubani Ongafanele Athathe I-Varenicline?

I-Varenicline ayifanele wonke umuntu, futhi abantu abathile kufanele bayigweme le mithi ngenxa yobungozi obukhulu. Udokotela wakho uzohlola ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika.

Akufanele uthathe i-varenicline uma wazi ukuthi unokungezwani komzimba nemithi noma yiziphi izithako zayo. Abantu abanezimo ezithile zempilo yengqondo bangase badinge ukuyigwema noma badinge ukuqashwa okwengeziwe.

Nawa amaqembu amakhulu abantu okufanele baqaphele noma bagweme i-varenicline ngokuphelele:

• Abantu abanomlando wokucindezeleka okukhulu noma imicabango yokuzibulala
• Labo abanokuphazamiseka kwe-bipolar noma ezinye izimo ezingokwengqondo ezinzima
• Abantu abanezifo ezinzima zezinso
• Abantu abake baba nokuhlaselwa noma isithuthwane
• Labo abanomlando wezinkinga zenhliziyo noma isifo senhliziyo nemithambo yegazi
• Abesifazane abakhulelwe noma abancelisayo
• Abantu abangaphansi kweminyaka engu-18 ubudala

Udokotela wakho uzoqaphela izinzuzo uma ziqhathaniswa nezingozi zesimo sakho esithile. Ngezinye izikhathi izinzuzo zokuyeka ukubhema zingaphezu kwezingozi ezingaba khona zokuthatha i-varenicline, ngisho nangezimo ezithile zezokwelapha.

Amagama e-Brand ye-Varenicline

I-Varenicline yaziwa kakhulu ngegama layo le-brand elithi Chantix e-United States. Leli yigama lokuqala le-brand lapho umuthi waqala ukuthengiswa futhi usaziwa kakhulu.

Kwamanye amazwe, i-varenicline ingathengiswa ngaphansi kwamagama e-brand ahlukene, okuhlanganisa i-Champix eCanada, e-UK, nakwamanye amazwe amaningi emhlabeni jikelele. Isithako esisebenzayo sihlala sifana ngaphandle kwegama le-brand.

Izinhlobo ze-generic ze-varenicline nazo ziyatholakala kwezinye izifunda, eziqukethe isithako esifanayo esisebenzayo kodwa zingabiza ngaphansi kwezinhlobo zegama le-brand. Umuthi wakho wemithi angakusiza ukuthi uqonde ukuthi iyiphi inguqulo oyitholayo.

Ezinye izindlela ze-Varenicline

Uma i-varenicline ingakulungele, eminye imithi eminingana evunywe yi-FDA ingasiza ekuyekeni ukubhema. Ngamunye usebenza ngendlela ehlukile futhi angase alungele kangcono izidingo zakho ezithile nomlando wezokwelapha.

Ukwelashwa kokushintshwa kwe-nicotine kuvame ukuba enye indlela abantu abazama yona kuqala. Lokhu kuhlanganisa iziqeshana, ushingamu, ama-lozenge, ama-spray emakhaleni, nama-inhaler ahlinzeka ngezilinganiso ezilawulwayo ze-nicotine ngaphandle kwamakhemikhali ayingozi ku-cigarettes.

I-Bupropion (Zyban) ngomunye umuthi kadokotela ongase usize ekuyekeni ukubhema. Ungumuthi wokucindezela onganciphisa nokulangazelela i-nicotine nezimpawu zokuhoxisa, nakuba usebenza ngendlela ehlukile kune-varenicline.

Izindlela ezingezona zemithi ezinjengokwelulekwa, amaqembu okusekela, ukwelashwa kokuziphatha, nezinhlelo zokusebenza zeselula nazo zingase zisebenze, kungaba zodwa noma zihlanganiswe nemithi. Abantu abaningi bathola impumelelo ngokuhlanganisa izindlela kunokuthembela endleleni eyodwa kuphela.

Ingabe i-Varenicline Ingcono Kune-Nicotine Replacement Therapy?

I-Varenicline iboniswe ukuthi isebenza kangcono kune-nicotine replacement therapy ocwaningweni lwezempilo. Ucwaningo lubonisa ukuthi i-varenicline ingasiza cishe ama-20-25% abantu ukuba bayeke ukubhema isikhathi eside, uma kuqhathaniswa nama-10-15% ngamaphashi e-nicotine noma ushingamu.

Nokho,

Udokotela wakho wezifo zenhliziyo nodokotela wakho oqeqeshwe ngemithi yomndeni kufanele basebenzisane ukuze bahlole ukuthi i-varenicline iphephile yini kuwe. Bazocabangela uhlobo lwakho oluthile lwesifo senhliziyo, ukuthi silawulwa kahle kangakanani, kanye nengozi yakho yonke yenhliziyo nemithambo yegazi.

Kubantu abaningi abanezifo zenhliziyo, izinzuzo zokuyeka ukubhema zidlula kakhulu izingozi ezingaba khona zokuthatha i-varenicline. Ukubhema ngokwako kungenye yezinto ezimbi kakhulu ongazenzela zona inhliziyo yakho, ngakho ukuyeka ngempumelelo ngokuvamile kunikeza izinzuzo ezinkulu zenhliziyo nemithambo yegazi.

Kufanele Ngenzeni Uma Ngithatha I-Varenicline Engaphezu Kwemithi Ngengozi?

Uma ngengozi uthatha i-varenicline eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yemiphumela emibi engathi sína efana nokuhlaselwa noma izinkinga zesigqi senhliziyo.

Ungalindi ukubona ukuthi uzizwa ulungile yini. Noma ngabe awuboni izimpawu ngokushesha, ukweqisa kungaba yingozi. Shayela i-Poison Control Center ku-1-800-222-1222 noma funa ukunakekelwa kwezimo eziphuthumayo ngokushesha.

Zama ukuba nebhodlela lemithi nawe uma ushayela noma uya esibhedlela. Lokhu kusiza ochwepheshe bezokwelapha ukuthi bazi kahle ukuthi uthathe malini nokuthi nini, okubalulekile ekwelashweni okufanele.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Varenicline?

Uma uphuthelwa umthamo we-varenicline, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho olujwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe. Lokhu kungakhuphula ingozi yakho yemiphumela emibi ngaphandle kokunikeza izinzuzo ezengeziwe zokuyeka ukubhema.

Uma uvame ukukhohlwa imithamo, zama ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi. Ukulinganisa okuqhubekayo kubalulekile ukuze i-varenicline isebenze ngempumelelo, ngakho ukusungula isimiso kusiza ekuqinisekiseni impumelelo.

Ngingayeka Nini Ukuthatha I-Varenicline?

Kufanele uqede lonke uhlelo lwe-varenicline njengoba kunqunywe udokotela wakho, ngisho noma uzizwa ungasadingi. Abantu abaningi bayayithatha amasonto angu-12, futhi ukuyeka ngaphambi kwesikhathi kungase kwandise ingozi yakho yokuphinda uqale ukubhema.

Uma uhlangabezana nemiphumela engemihle engabekezeleleki, khuluma nodokotela wakho ngaphambi kokuyeka. Bangase bakwazi ukulungisa umthamo wakho noma bacebise izindlela zokuphatha imiphumela engemihle kunokuyeka ngokuphelele umuthi.

Abanye abantu bayazuza ekunciphiseni kancane kancane umthamo kunokuyeka kungazelelwe. Udokotela wakho uzokweluleka ngendlela engcono kakhulu yokuyeka i-varenicline ngokusekelwe entuthukweni yakho kanye nezimo zomuntu ngamunye.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Varenicline?

Kufanele uqaphele kakhulu ngokuphuza utshwala ngenkathi uthatha i-varenicline. Abanye abantu bahlangabezana nokwanda kokuzwela utshwala, okusho ukuthi bazizwa bedakiwe ngokushesha noma ngamandla kunokujwayelekile.

Utshwala bungase futhi lwenze kube kubi eminye yemiphumela engemihle ye-varenicline, ikakhulukazi isicanucanu nesiyezi. Ngaphezu kwalokho, ukuphuza utshwala kungase kwenze kube nzima ukunamathela ohlelweni lwakho lokuyeka ukubhema.

Uma ukhetha ukuphuza, yenza kanjalo ngokulinganisela futhi unake kakhulu ukuthi uzizwa kanjani. Abantu abaningi bakuthola kuwusizo ukugwema utshwala ngokuphelele ngesikhathi sohambo lwabo lokuyeka ukubhema ukuze bazinike ithuba elingcono kakhulu lokuphumelela.