Yini i-Vedolizumab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Vedolizumab iyikhambi eliqondiwe elisiza ukuthulisa ukuvuvukala emathunjini akho uma unezimo ezithile zokugaya ukudla. Cabanga ngayo njengokwelashwa okukhethekile okusebenza ngqo emathunjini akho, kunokuthinta wonke amasosha akho omzimba njengamanye amakhambi.

Lo muthi uza ngezindlela ezimbili - njenge-IV infusion oyithola emtholampilo noma esibhedlela, kanye nomjovo ongazenzela wona ekhaya ngaphansi kwesikhumba. Yenzelwe abantu abanezifo zamathumbu ezivuvukalayo abadinga ukwelashwa okuqhubekayo ukuze balawule izimpawu zabo.

Isetshenziselwani i-Vedolizumab?

I-Vedolizumab ilapha ukwelapha izimo ezimbili eziyinhloko ezibangela ukuvuvukala okungapheli ohlelweni lwakho lokugaya ukudla. Udokotela wakho uyayibhala lapho okunye ukwelashwa kungasebenzi kahle noma lapho udinga indlela eqondiwe.

Ukusetshenziswa okuyinhloko kungokuthi i-ulcerative colitis, isimo lapho umugqa wamathumbu akho amakhulu uvuvukala futhi uthola izilonda. Lokhu kungabangela izimpawu ezinjengokuhuda ngamagazi, ukuqaqamba, kanye nesidingo sokuya endlini yangasese njalo.

Iphinde isetshenziselwe isifo sikaCrohn, esingabangela ukuvuvukala noma yikuphi emathunjini akho kusukela emlonyeni kuya emgodini wendunu. Abantu abanesifo sikaCrohn bavame ukuzwa ubuhlungu besisu, isifo sohudo, ukuncipha kwesisindo, nokukhathala okungathinta kakhulu impilo yansuku zonke.

Udokotela wakho angase acabangele i-vedolizumab uma unezimpawu eziphakathi nendawo kuya kwezinkulu ukuthi eminye imithi efana nama-steroid noma ama-immunosuppressants ayizange ilawulwe ngokwanele. Ilusizo ikakhulukazi kubantu abafuna ukugwema eminye yemiphumela ebanzi yamasosha omzimba yokunye ukwelashwa.

Isebenza Kanjani i-Vedolizumab?

I-Vedolizumab isebenza ngokuvimba amaseli athile omzimba ukuthi angene emathunjini akho lapho abangela ukuvuvukala. Ithathwa njengomuthi onamandla aphakathi nendawo oqondisa ukuvuvukala ngokuqondile.

Umuthi unamathisela kuphrothini ebizwa ngokuthi i-alpha-4 beta-7 integrin kuma-white blood cells athile. Lokhu kuvimbela la maseli avuvukalayo ukuthi angangeni emgqeni wakho wamathumbu, okuyilapho ngokuvamile angalimaza khona futhi abangele izimpawu.

Okuhlukile nge-vedolizumab yisenzo sayo esikhethekile emathunjini. Ngokungafani neminye imithi ecindezela amasosha omzimba ethinta wonke amasosha akho omzimba, le nto isebenza ikakhulukazi emathunjini akho. Le ndlela eqondiwe ingasho imiphumela emibi embalwa kwezinye izingxenye zomzimba wakho.

Ungase uqale ukuqaphela ukuthuthuka ezimpawini zakho kungakapheli amasonto ambalwa, kodwa kungathatha kufika kumaviki angu-14 ukubona izinzuzo eziphelele. Abanye abantu basabela ngokushesha kunabanye, futhi udokotela wakho uzoqapha intuthuko yakho ngokucophelela ngalesi sikhathi.

Kufanele Ngiyithathe Kanjani I-Vedolizumab?

Indlela othatha ngayo i-vedolizumab incike ohlotsheni udokotela wakho alubhala. Zombili izinhlobo ze-IV kanye nejojo zisebenza kahle ngokulinganayo, kodwa ukukhetha kuncike endleleni yakho yokuphila, okuthandayo, nezidingo zakho ezithile zezokwelapha.

Nge-IV, uzothola ukwelashwa esikhungweni sezokwelapha lapho ochwepheshe bezempilo bezokuqapha khona. Ukufakwa kungathatha imizuzu engaba ngu-30, futhi uzodinga ukuhlala ukuze ubhekwe ngemva kwalokho. Akudingeki ukuthi uzile ukudla ngaphambi kwesikhathi, futhi ungadla ngokujwayelekile ngaphambi nangemva kokwelashwa kwakho.

Uma usebenzisa imijovo engaphansi kwesikhumba, uzozijova ngaphansi kwesikhumba, ngokuvamile ethangeni lakho noma esiswini. Ithimba lakho lezempilo lizokufundisa indlela efanele kanye nokujikeleza kwezindawo zokujova. Gcina le mijovo efrijini futhi uyivumele ukuthi ifike ezingeni lokushisa legumbi ngaphambi kokuyijova.

Thatha imithi yakho njengoba kuhleliwe, ngisho noma uzizwa ungcono. Ukweqa imithamo kungaholela ekuqubukeni kwesimo sakho. Uma unokukhathazeka mayelana nenqubo yokujova noma uhlangabezana nezinkinga endaweni yokufakwa, xhumana nomhlinzeki wakho wezempilo ngokushesha.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Vedolizumab?

I-Vedolizumab ngokuvamile iyindlela yokwelapha yesikhathi eside okungenzeka udinga ukuqhubeka nayo izinyanga noma iminyaka. Isikhathi esiqondile sincike ekutheni usabela kahle kangakanani nokuthi isimo sakho siqhubeka kanjani ngokuhamba kwesikhathi.

Abantu abaningi baqala ngesigaba sokungeniswa lapho bethola khona imithamo evame kakhulu ukuze kulawulwe ukuvuvukala. Lokhu kuvame ukubandakanya ukwelashwa ngamasonto 0, 2, kanye no-6 ngohlobo lwe-IV. Ngemva kwalesi sikhathi sokuqala, uzoqhubekela ekunikezeni umthamo wokugcinwa njalo ngamaviki angu-8.

Udokotela wakho uzohlola njalo ukuthi umuthi uyakusebenzela yini ngokusebenzisa ukuhlolwa kwegazi, izifundo zokuthwebula izithombe, kanye nokuqapha izimpawu zakho. Uma wenza kahle futhi uhlala ekuxoleleni, ungaqhubeka nokwelashwa unomphela ukuze uvimbele ukuqubuka.

Abanye abantu bangagcina bekwazi ukunciphisa imvamisa yabo yokunikeza umthamo noma bayeke umuthi uma befinyelela ekuxoleleni okuqhubekayo. Nokho, lesi sinqumo kufanele senziwe ngokucophelela nodokotela wakho, njengoba ukuyeka ngokushesha kungaholela ekubuyeni kwezimpawu.

Yiziphi Izimo Ezingezinhle Ze-Vedolizumab?

Abantu abaningi bayayibekezelela kahle i-vedolizumab, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathi sína ayivamile, futhi abantu abaningi bathola imiphumela emibi emincane noma abayitholi.

Imiphumela emibi evamile ongase uyithole ihlanganisa ikhanda, ubuhlungu emalungeni, isicanucanu, nokukhathala. Lokhu kuvame ukuthuthuka njengoba umzimba wakho uzivumela emuthini. Abanye abantu baphawula nezimpawu ezinjengezimpawu zomkhuhlane njengamakhala avalekile noma umphimbo obuhlungu.

Nansi imiphumela emibi evame kakhulu ethinta abanye abantu abathatha i-vedolizumab:

• Ikhanda elingase livele futhi lihambe ngesikhathi sokwelashwa
• Ukuqaqamba kwamalunga noma ubuhlungu bemisipha, ikakhulukazi emasontweni ambalwa okuqala
• Isicanucanu noma isisu esicasukile ngemva kwemithamo
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Izimpawu eziphezulu zokuphefumula njengokuminyana noma ukukhwehlela
• Ukuphendula kwesikhumba ezindaweni zokujova (ngohlobo olungaphansi kwesikhumba)

Lezi zinto ezivamile ngokuvamile azidingi ukuyeka imithi futhi zivame ukuthuthuka ngokuhamba kwesikhathi. Kodwa-ke, hlala uxoxa nganoma yiziphi izimpawu eziqhubekayo noma eziphazamisayo nomhlinzeki wakho wezempilo.

Imiphumela emibi engathi sína ingenzeka kodwa ayivamile. Ngenxa yokuthi i-vedolizumab ithinta amasosha akho omzimba, ungase ube sengozini enkulu yokuthola izifo ezithile, ikakhulukazi emathunjini akho.

Imiphumela emibi engavamile kodwa engathi sína edinga ukunakekelwa kwezempilo ngokushesha ihlanganisa:

• Izimpawu zokutheleleka okungathi sína njengomkhuhlane oqhubekayo, ubuhlungu obukhulu besisu, noma ukukhathala okungavamile
• Ukungezwani okukhulu komzimba ngesikhathi noma ngemva nje kokufakwa
• Izinkinga ezintsha noma eziqhubekayo zesibindi (ukuphuzi kwesikhumba noma amehlo, umchamo omnyama)
• I-Progressive multifocal leukoencephalopathy (PML) - ukutheleleka kobuchopho okungavamile kakhulu
• Ukuphendula kwesikhumba okukhulu noma ukuqubuka

Ngenkathi le miphumela engathi sína ingavamile, udokotela wakho uzokuhlola njalo ngezivivinyo zegazi nokuhlolwa komtholampilo ukuze abambe noma yiziphi izinkinga ekuqaleni.

Ubani Ongafanele Athole I-Vedolizumab?

I-Vedolizumab ayilungile kuwo wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi iphephile yini kuwe. Izimo zezokwelapha ezithile noma izimo zenza le mithi ingafaneleki noma idinga izinyathelo zokuqapha ezikhethekile.

Akufanele uthathe i-vedolizumab uma unokutheleleka okusebenzayo, okungathi sína noma kuphi emzimbeni wakho. Lokhu kuhlanganisa izifo zamagciwane, amagciwane, isikhunta, noma izifo ze-parasitic ezidinga ukwelashwa. Umuthi ungenza kube nzima ukuthi umzimba wakho ulwe nezifo ngempumelelo.

Abantu abanezinkinga ezithile zesibindi kufanele bagweme i-vedolizumab noma bayisebenzise ngokucophelela okukhulu. Uma une-hepatitis B noma C esebenzayo, noma isifo sesibindi esibi, udokotela wakho uzodinga ukukala ngokucophelela izingozi nezinzuzo.

Nawa amakhondishini angase akwenze ukuthi i-vedolizumab ingakulungeli:

• Isifo somkhuhlane esisebenzayo noma ezinye izifo ezinzima
• Umlando we-PML (i-progressive multifocal leukoencephalopathy)
• Isifo sesibindi esiqinile noma i-hepatitis yegciwane esebenzayo
• Ukungezwani okwaziwayo ne-vedolizumab noma izingxenye zayo
• Ezinye izifo zesimiso somzimba esivikela izifo ezandisa ingozi yokutheleleka
• Imithi yokugoma esanda kutholwa (kuzodingeka ulinde ngaphambi kokuqala ukwelashwa)

Ukukhulelwa nokuncelisa ngamabele kudinga ukucatshangelwa okukhethekile. Ngenkathi i-vedolizumab ingasetshenziswa ngesikhathi sokukhulelwa lapho izinzuzo zidlula izingozi, lesi sinqumo sidinga ukuxoxwa ngokucophelela nethimba lakho lezempilo.

Udokotela wakho uzophinda acabangele impilo yakho yonke, eminye imithi oyithathayo, kanye nomlando wakho wezokwelapha ngaphambi kokuncoma i-vedolizumab. Qiniseka ukuthi wabelana ngomlando wakho wezokwelapha ophelele ngesikhathi sokubonisana kwakho.

Amagama e-Vedolizumab Brand

I-Vedolizumab ithengiswa ngaphansi kwegama lomkhiqizo elithi Entyvio emazweni amaningi okuhlanganisa ne-United States. Leli yigama ozolibona emiyalweni yakho kanye nokupakishwa kwemithi.

Noma ngabe uthola ukumnika kwe-IV noma ukujova okungaphansi kwesikhumba, zombili lezi zinhlobo zidayiswa ngaphansi kwegama elifanayo lomkhiqizo elithi Entyvio. Ukupakishwa nokulebula kuzokhombisa ukuthi iyiphi ifomu olitholayo futhi kunikeze imiyalelo ethile yalelo fomu.

Amanye amazwe angase abe namagama omkhiqizo ahlukene noma izinhlobo ezivamile ezitholakalayo, ngakho-ke hlala uhlola nomphathi wakho wamaphilisi noma umhlinzeki wezempilo uma unemibuzo mayelana nomuthi wakho othile. Isithako esisebenzayo sihlala sifana kungakhathaliseki igama lomkhiqizo.

Ezinye izindlela ze-Vedolizumab

Eminye imithi eminingi ingelapha izifo zamathumbu ezivuvukalayo uma i-vedolizumab ingakulungele noma ingasebenzi kahle ngokwanele. Udokotela wakho uzocabangela isimo sakho esithile, izimpawu, kanye nomlando wezokwelapha lapho kuxoxwa ngezindlela.

Eminye imithi ye-biologic isebenza ngendlela efana ne-vedolizumab kodwa iqondise ezingxenyeni ezihlukene zomzimba wokuzivikela. Lokhu kufaka phakathi i-adalimumab (Humira), i-infliximab (Remicade), kanye ne-ustekinumab (Stelara), ngalinye linenzuzo yalo kanye nohlu lwemiphumela.

Ezinye izindlela ezingezona ze-biologic zifaka phakathi izinto ezicindezela ukuzivikela njenge-azathioprine, i-methotrexate, noma i-6-mercaptopurine. Le mithi isebenza ngendlela ehlukile kune-vedolizumab futhi ingase ilunge uma ungenakukwazi ukusebenzisa ukwelashwa kwe-biologic.

Ukwelashwa kwendabuko njenge-corticosteroids noma ama-aminosalicylates (njenge-mesalamine) kungase futhi kube ezinye izinketho kwabanye abantu, ikakhulukazi ezifweni ezilula noma njengokwelashwa okuxhumanisayo. Udokotela wakho uzokusiza ukuthi uqonde ukuthi yiziphi ezinye izindlela ezingase zisebenze kangcono esimweni sakho.

Ingabe i-Vedolizumab Ingcono Kune-Adalimumab?

Kokubili i-vedolizumab ne-adalimumab ziyindlela yokwelapha esebenzayo yezifo zamathumbu ezivuvukalayo, kodwa zisebenza ngezindlela ezihlukene futhi zingase zifaneleke kangcono kubantu abahlukene. Akukho okukhethwa okujwayelekile okuthi “kungcono” - kuncike ezimweni zakho.

I-Vedolizumab ikhetha amathumbu, okusho ukuthi isebenza ikakhulukazi ohlelweni lwakho lokugaya ukudla, kuyilapho i-adalimumab ithinta wonke umzimba wakho wokuzivikela. Lokhu kwenza i-vedolizumab iphephe kakhulu kubantu abakhathazekile ngezifo noma eminye imiphumela engemihle ehlobene nokuzivikela.

Ucwaningo lubonisa ukuthi kokubili le mithi isebenza ngendlela efanayo ekwelapheni i-ulcerative colitis nesifo sikaCrohn. Kodwa-ke, abanye abantu basabela kangcono komunye kunomunye, futhi akulula ukubikezela ukuthi yini ezosebenza kangcono kuwe.

Ukukhetha phakathi kwale mithi kuvame ukuncika ezintweni ezifana nezintandokazi zakho zokuphila (imijovo vs. ukumnika), ukubekezelela imiphumela emibi, ezinye izimo zempilo, kanye nokusabela kokwelashwa kwangaphambilini. Udokotela wakho uzokusiza ukuthi ulinganise lezi zinto ukuze wenze isinqumo esingcono kakhulu esimweni sakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Vedolizumab

Ingabe i-Vedolizumab iphephile kubantu abanezifo zesibindi?

I-Vedolizumab idinga ukucatshangelwa ngokucophelela uma unezinkinga zesibindi. Ngenkathi ngokuvamile iphephe kakhulu esibindini kunezinye izidakamizwa ezicindezela amasosha omzimba, abantu abane-hepatitis esebenzayo noma isifo sesibindi esibi badinga ukuqashwa okukhethekile.

Udokotela wakho uzohlola ukusebenza kwesibindi sakho ngaphambi kokuqala ukwelashwa futhi akuqaphele njalo ngenkathi uthatha i-vedolizumab. Uma unezinkinga zesibindi ezilula, ungase ukwazi ukusebenzisa lo muthi ngaphansi kokuqashwa okuseduze futhi mhlawumbe ulungise umthamo.

Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Vedolizumab Eningi Kakhulu?

Uma ngengozi uthola i-vedolizumab eningi kakhulu, xhumana nomhlinzeki wakho wezempilo ngokushesha. Ngenkathi ukweqisa kungavamile, ikakhulukazi ngohlobo lwe-IV olunikezwa ezindaweni zezokwelapha, kubalulekile ukubika noma yimaphi amaphutha emithamo ngokushesha.

Ngefomu lokujova, uma ngengozi uzinika umthamo owengeziwe, ungesabi kodwa shayela ihhovisi likadokotela wakho. Bangase bafune ukukuqapha eduze noma balungise umthamo wakho olandelayo ohleliwe. Ungalokothi uzame "ukuqaqa" imithamo ukuze ulungise eyodwa eyengeziwe ngaphandle kwesiqondiso sezokwelapha.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Vedolizumab?

Uma uphuthelwa umthamo ohleliwe we-vedolizumab, xhumana nomhlinzeki wakho wezempilo ngokushesha ngangokunokwenzeka ukuze uhlele kabusha. Isikhathi somthamo wakho olandelayo sincike ekutheni sekunesikhathi esingakanani kusukela kumthamo wakho ophuthelwe nokuthi yiluphi uhlobo oluluthathayo.

Ukwelashwa kwe-IV, ithimba lakho lezokwelapha lizokusiza ukuthi uhlele kabusha futhi linqume ukuthi ngabe udinga ukulungisa uhlelo lwakho lokuthatha imithi. Ngemithamo ezijovwa nguwe, thatha umthamo ophuthelwe ngokushesha lapho ukhumbula, bese uqhubeka nohlelo lwakho olujwayelekile ngaphandle uma udokotela wakho ekweluleka ngenye indlela.

Ngingayeka Nini Ukuthatha I-Vedolizumab?

Ungalokothi uyeke ukuthatha i-vedolizumab ngaphandle kokuxoxa ngayo nodokotela wakho kuqala. Noma ngabe uzizwa umuhle, ukuyeka kungazelelwe kungaholela ekubuyeni kwezimpawu zakho, ngezinye izikhathi zibe zimbi kakhulu kunakuqala.

Udktela wakho uzohlola njalo ukuthi usasidinga yini imithi ngokusekelwe ezimpawini zakho, ukuhlolwa kwegazi, futhi ngezinye izikhathi izifundo zokuthwebula izithombe. Uma ube sesimweni sokuzola isikhathi eside, bangase bacabange ukunciphisa kancane kancane umthamo wakho noma ukwelula isikhathi phakathi kokwelashwa esikhundleni sokuyeka ngokuphelele.

Ngingakwazi yini ukuthola imithi yokugoma ngenkathi ngithatha i-Vedolizumab?

Ungathola imithi eminingi yokugoma ngenkathi uthatha i-vedolizumab, kodwa isikhathi nohlobo kubalulekile. Imithi yokugoma ephilayo (njengomuthi wokugoma umkhuhlane ngamakhala noma i-MMR) kufanele igwenywe ngenkathi uselashwa, kodwa imithi yokugoma engasebenzi ngokuvamile iphephile futhi iyatuswa.

Hlela ukuthola imithi yakho yokugoma ejwayelekile, okuhlanganisa umjovo womkhuhlane waminyaka yonke, ngaphambi kokuqala i-vedolizumab uma kungenzeka. Uma udinga imithi yokugoma ngenkathi uselashwa, udktela wakho uzokweluleka ngezinketho eziphephe kakhulu nesikhathi. Njalo yazisa abahlinzeki bezempilo ukuthi uthatha i-vedolizumab ngaphambi kokuthola noma yimiphi imithi yokugoma.