Vemurafenib (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Zelboraf
Mayelana naleli khambi
I-Vemurafenib isetshenziswa ekwelapheni i-melanoma (uhlobo lomdlavuza wesikhumba) oluye lwabhebhetheka noma olungasuswa ngokuthunga. Isetshenziswa kuphela uma amangqamuzana e-melanoma enomgudu we-BRAF V600E. Udokotela wakho uzosebenzisa ukuhlolwa okukhethekile ukubheka lo mgudu. I-Vemurafenib isetshenziswa futhi ekwelapheni i-Erdheim-Chester Disease (ECD), okuyilo uhlobo lomdlavuza wegazi olungathinta izicubu zomzimba namalungu. Isetshenziswa kuphela uma amangqamuzana omdlavuza enomgudu we-BRAF V600. I-Vemurafenib iyingxenye yamayeza abizwa ngokuthi yi-antineoplastics (amayeza omdlavuza). Lolu lwemi iyatholakala kuphela ngomyalo wodokotela. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekwahluleni kokusebenzisa imithi, izingozi zokuthatha imithi kufanele ziqhathaniswe nezinzuzo ezizokwenza. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo olulodwa noma ukusabela okungokwe-allergy kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bezempilo uma unanoma yiluphi olunye uhlobo lwe-allergies, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenaso iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubudlelwano bobudala nemiphumela yevemurafenib kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingakhawulela ukusebenzisa kwevemurafenib kubantu abadala. Noma kunjalo, abantu abadala banamathuba amaningi okuba nemiphumela engathandeki (isib. izinkinga zesikhumba, ukunciphisa ukudla, ukushaya kwenhliziyo okusheshayo, isicanucanu, noma ukukhula kwezandla, izinyawo, noma imilenze) okungadinga ukuqapha kubantu abamukela ivemurafenib. Ayikho izifundo ezifanele kwabesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izimithi kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthatha le mithi, kubaluleke kakhulu ukuthi ochwepheshe bezempilo bakwazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukuhlangana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ashintshe ezinye izimithi ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile ayinconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Ezinye izimithi akufanele zisetshenziswe ngesikhathi noma eduze kwesikhathi sokudla ukudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshaba nezinye izimithi kungabangela ukuhlangana. Ukuhlangana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo kungabangela ukwanda kengozi yemiphumela emibi ethile kodwa kungaphepheki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unanoma yiziphi ezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Imithi ebizwa ngokuthi i-anticancer inamandla kakhulu futhi ingaba nemiphumela eminingi emibi. Ngaphambi kokusebenzisa le mithi, qiniseka ukuthi uyayiqonda yonke imingcele nezinzuzo. Kubalulekile ukuthi usebenzisane eduze nodokotela wakho phakathi nokwelashwa kwakho. Thatha le mithi ngokuqondile njengoba udokotela wakho ekutshele. Ungayithathi ngaphezulu, ungayithathi kaningi, futhi ungayithathi isikhathi eside kunalokho udokotela wakho akuyalile. Le mithi iza ne-Medication Guide. Funda futhi ulandele lezi zinkomba ngokucophelela. Buza udokotela wakho uma unemibuzo. Gwinya ithebulethi yonke ngeglasi lamanzi. Ungayicwili, ungayaphula, noma ungayikhinya. Ungayithatha le mithi ngokudla noma ngaphandle kokudla. Uma uphuka ngemuva kokuthatha le mithi, ungayithathi enye i-dose. Linda bese uthatha i-dose yakho elandelayo ngesikhathi esivamile. I-dose yale mithi izobahlukene kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela ama-dose ajwayelekile ale mithi. Uma i-dose yakho ihlukile, ungayishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani lemithi oyithatha lixhomeke emandleni emithi. Futhi, inani lama-dose owathatha nsuku zonke, isikhathi esivunyelwe phakathi kwama-dose, nobude besikhathi othatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi. Uma uphuthelwa i-dose yale mithi, yithatha ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi se-dose yakho elandelayo, susa i-dose oyiphuthelwe bese ubuyela esimweni sakho sokuthatha imithi. Ungawandisi ama-dose. Uma uphuthelwa i-dose futhi sekudlule amahora angaphezu kwama-4 ngaphambi kwe-dose yakho elandelayo, thatha ithebulethi ngokushesha okukhulu. Uma uphuthelwa i-dose futhi sekusele amahora angaphansi kwama-4 kuze kube yisikhathi sakho esivamile sokuthatha imithi, susa i-dose oyiphuthelwe bese uthatha i-dose yakho elandelayo ngesikhathi esivamile. Gcina imithi esitsheni esivalekile ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungayivumeli ukuba iqhube. Gcina ingafinyeleleki kubantwana. Ungagcini imithi esele iphelile noma imithi engasasetshenziswa. Buza ochwepheshe bakho bezempilo ukuthi kufanele uyilahla kanjani noma iyiphi imithi ongase uyisebenzisi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.