Venetoclax (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Venclexta
Mayelana naleli khambi
I-Venetoclax isetshenziswa yodwa noma kanye nezinye izidakamizwa (um., i-rituximab) ukwelapha i-chronic lymphocytic leukemia (CLL) noma i-small lymphocytic lymphoma (SLL), ngokunokwenzeka noma ngaphandle kokususwa kwe-17p, kubantu abake bamukela okungenani ukwelashwa okukodwa ngaphambili. Isetshenziswa futhi kanye ne-obinutuzumab ukwelapha i-CLL noma i-SLL engakaqalwa. I-Venetoclax isetshenziswa futhi kanye nezinye izidakamizwa (um., i-azacitidine, i-decitabine, i-cytarabine ephansi) ukwelapha i-acute myeloid leukemia (AML) esanda kuxilongwa kubantu abadala abangaphezu kweminyaka engu-75 ubudala noma abaneminye imibandela yezokwelapha evimbela ukusetshenziswa kwe-chemotherapy ejwayelekile. I-Venetoclax iyilungu lokulwa nomdlavuza (umuthi womdlavuza). Iphazamisa ukukhula kwamaseli omdlavuza, aqothulwa ekugcineni umzimba. Lona umuthi utholakala kuphela ngesikripthi sedokotela wakho. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekubeni kunqunywe ukuthi kusetshenziswe imithi, izingozi zokuthatha imithi kufanele ziqhathaniswe nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Ngale mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluhlukile noma ukusabela okungokwe-alerji kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unanoma yiluphi olunye uhlobo lwe-alerji, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenaso iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubuhlobo bobudala nemiphumela ye-venetoclax kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kwe-venetoclax kubantu abadala. Ukuphepha nokuphumelela kuye kwaqinisekiswa. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha kungase kudingeke. Uma uthatha le mithi, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlanganisiwe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayinconywa. Udokotela wakho angase anqume ukungakwelaphi ngale mithi noma ashintshe ezinye izidakamizwa ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile ayinconywa, kodwa kungase kudingeke kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imithi. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo kungabangela ukwanda kengozi yezinye izingozi ezibekiwe, kodwa ukusebenzisa kokubili imithi kungaba ukwelashwa okuhle kuwe. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi noma eduze kwesikhathi sokudla ukudla noma ukudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba ngezidakamizwa ezithile kungase futhi kubangele ukusebenzisana. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile ayinconywa, kodwa kungase kungakhuphuki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unanoma yiziphi ezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli lemithi njengoba nje udokotela wakho ekuqondisile. Ungalithathi ngokweqile, ungalithathi njalo, futhi ungalithathi isikhathi eside kunalokho udokotela wakho akuqondisile. Ungashintshi umthamo wakho noma uyeke ukusebenzisa le mithi ngaphandle kokubuza udokotela wakho kuqala. Le mithi ifika ne-Medication Guide. Funda futhi ulandele lezi zinkomba ngokucophelela. Buza udokotela wakho uma unemibuzo. Thatha le mithi ngokudla namanzi ngesikhathi esifanayo nsuku zonke. Gwinya ithebulethi yonke. Ungayaphula, uyicindezele, noma uyigaye. Phuza amanzi amaningi nsuku zonke ukusiza ukuvimbela umphumela ongathandeki okuthiwa yi-tumor lysis syndrome. Udokotela wakho anganika nemithi yokunciphisa i-uric acid egazini (eg, allopurinol). Ungadli noma uphuze imikhiqizo ye-grapefruit, i-starfruit, noma ama-Seville oranges ngale mithi. Umthamo wale mithi uzobahlukile kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esempahleni. Ulwazi olulandelayo luhlanganisa kuphela imithamo yale mithi. Uma umthamo wakho uhlukile, ungawushintshi ngaphandle kokuthi udokotela wakho akuqondise ukwenza njalo. Inani lemithi oyithatha lixhomeke emandleni emithi. Futhi, inani lemithamo oyithatha nsuku zonke, isikhathi esivunyelwe phakathi kwemithamo, nobude besikhathi oyithatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi. Uma uphuthelwa umthamo wale mithi, uyithathe ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi somthamo wakho olandelayo, skip umthamo ophuthelwe bese ubuyela esikimini sakho sokuthola imithi. Ungawandisi imithamo. Uma uphuthelwa umthamo futhi kungamahora angu-8 noma ngaphansi kwesikhathi sakho esivamile, uyithathe ngokushesha okukhulu bese uqhubeka nesikimu sakho esivamile. Uma kungaphezu kwamahora angu-8 ngemuva kwesikhathi sakho esivamile, skip umthamo ophuthelwe bese ubuyela esikimini sakho esivamile. Uma uhlanza ngemuva kokuthatha umthamo, ungathathi umthamo owengeziwe. Thatha umthamo olandelayo ngesikhathi esivamile ngosuku olulandelayo. Gcina ungafinyeleleki ezinganeni. Ungagcini imithi eliphelile noma imithi engasasetshenziswa. Buza ochwepheshe bezempilo ukuthi kufanele ulahle imithi oyisebenzisi. Gcina imithi esitsheni esivalekile ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungaganduki. Gcina amathebulethi ephakheji yokuqala phakathi kwamasonto angu-4 okuqala kokwelashwa. Ungadluliseli imithi ebhokisini le-pill noma esitsheni esinye.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.