Zanubrutinib (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Akukho lulimi olutholakala ngaphansi kwesihloko esithi "Brukinsa". Sicela uqale kabusha ngolwimi olufanele.
Mayelana naleli khambi
I-Zanubrutinib isetshenziswa ekwelapheni i-mantle cell lymphoma (MCL) kubantu abake bamukela okungenani ukwelashwa okukodwa ngaphambili kokukhuluphala kwabo. Lolu lwelapha futhi lusetshenziswa ekwelapheni i-Waldenström macroglobulinemia (WM). Lusetshenziswa futhi ekwelapheni i-marginal zone lymphoma (MZL) ebuyile (relapsed) noma engaphendulanga ekwelapheni (refractory) kubantu abake bamukela okungenani ukwelashwa okukodwa ngaphambili (eg, ukwelashwa okuqondene ne-anti-CD20). Lolu lwelapha futhi lusetshenziswa ekwelapheni i-chronic lymphocytic leukemia (CLL) noma i-small lymphocytic lymphoma (SLL). I-Zanubrutinib isetshenziswa futhi ndawonye ne-obinutuzumab ekwelapheni i-follicular lymphoma (FL) ebuyile noma engaphendulanga ekwelapheni kubantu abake bamukela okungenani ukwelashwa okubili ngaphambili. I-Zanubrutinib iyilwelo lokulwa nomdlavuza (ilwelapha lomdlavuza). Iphazamisa ukukhula kwamaseli omdlavuza, aqedwa ekugcineni umzimba. Lolu lwelapha lutholakala kuphela ngomyalo wezokwelapha. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma ukhetha ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokusebenzisa imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqhelile noma oluhambisana nokwaleka kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokwaleka, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Azikho izifundo ezifanele ezenziwe ngokuphathelene nobudlelwano bobudala nemiphumela yezanubrutinib kubantu abancane. Ukuphepha nokuphumelela akukaqinisiswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kwezanubrutinib kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokusebenzisa le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha kungase kudingeke. Uma uthatha le mithi, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlwini elingezansi. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akunconywa, kodwa kungase kudingeke kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungase futhi kubangele ukusebenzisana. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ngokuvamile akunconywa, kodwa kungase kungakhuphuki kwezinye izimo. Uma kusetshenziswa ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani le mithi, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Imithi ebizwa ngokuthi i-anticancer inamandla kakhulu futhi ingaba nemiphumela eminingi emibi. Ngaphambi kokusebenzisa le mithi, qiniseka ukuthi uyayiqonda yonke imingcele nezinzuzo. Kubalulekile ukusebenzisana eduze nodokotela wakho phakathi nokwelashwa kwakho. Thatha le mithi ngokuqondile njengoba uqondiswe udokotela wakho. Ungayithathi ngaphezulu, ungayithathi kaningi, futhi ungayithathi isikhathi eside kunalokho oqondiswe udokotela wakho. Le mithi ifika nephephapheshe eliqukethe ulwazi lwabaguli. Funda futhi ulandele lezi zinkomba ngokucophelela. Buza udokotela wakho uma unemibuzo. Gwinya ikhaphsuli yonke ngeglasi lamanzi. Ungayivuli, ungayiqhekeza, ungayaphula, noma ungayikhinya. Ungayithatha le mithi ngokudla noma ngaphandle kokudla. Inani lemithi elizothathwa lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemhloleni. Ulwazi olulandelayo luqukethe kuphela amanani aphakathi ale mithi. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani lemithi olithathayo lixhomeke emandleni emithi. Futhi, inani lemithi olithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwamadosi, nobude besikhathi olithatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi. Uma uphuthelwe umthamo wale mithi, uthathe ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi somthamo wakho olandelayo, susa umthamo ophuthelwe bese ubuyela esimweni sakho sokuthatha imithi. Ungawandisi amathuba. Gcina imithi esitsheni esivalekile ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungayivumeli ukuba iqhube. Gcina ingafinyeleleki kubantwana. Ungagcini imithi esele iphelile noma imithi engasasetshenziswa. Buza ochwepheshe bakho bezempilo ukuthi kufanele uyilahla kanjani noma iyiphi imithi ongayisebenzisi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.