Yini i-Zileuton: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Zileuton iyimithi kadokotela esiza ukuvimbela ukuhlaselwa yisifuba somoya ngokunciphisa ukuvuvukala emoyeni wakho. Ingowesigaba semithi ebizwa ngokuthi ama-leukotriene inhibitors, asebenza ngendlela ehlukile kuma-inhalers ajwayelekile okusindisa noma ama-steroids ongase uwajwayele.

Le mithi akuyona into ongayifinyelela ngesikhathi sokuhlaselwa yisifuba somoya. Kunalokho, yakhelwe ukuthi ithathwe nsuku zonke njengengxenye yohlelo lwakho lokuphatha isifuba somoya sesikhathi eside, isiza ukugcina imigudu yakho yomoya ithule futhi ingasabeli ngokuhamba kwesikhathi.

Isetshenziselwani i-Zileuton?

I-Zileuton ikakhulukazi inikezwa ukuthi ivimbele izimpawu zesifuba somoya kubantu abadala kanye nezingane ezineminyaka engu-12 nangaphezulu. Udokotela wakho angase ancome le mithi uma uhlangabezana nokuqubuka kwesifuba somoya njalo naphezu kokusebenzisa ezinye izindlela zokwelapha.

Le mithi isebenza kahle kakhulu kubantu abanesifuba somoya esibonakala sidalwe ukuzivocavoca, umoya obandayo, noma ama-allergen afana ne-pollen kanye nezimuncwana zothuli. Kungase futhi kube usizo uma unesifuba somoya esizwela i-aspirin, uhlobo oluthile lapho izidambisi zokucasuka ezithile zingabangela izinkinga zokuphefumula.

Abanye odokotela baphinda banikeze i-zileuton ngaphandle kwethekhi yezinye izimo ezivuvukalayo, nakuba ukuvimbela isifuba somoya kuhlala kuyindlela yayo esemqoka evunyelwe ukusetshenziswa. Umhlinzeki wakho wezempilo uzoqaphela ukuthi le mithi ilingana nesimo sakho esithile nezidingo zempilo.

Isebenza Kanjani i-Zileuton?

I-Zileuton isebenza ngokuvimba i-enzyme ebizwa ngokuthi i-5-lipoxygenase emzimbeni wakho. Le enzyme isiza ukudala amakhemikhali avuvukalayo abizwa ngokuthi ama-leukotrienes, angabangela ukuthi imigudu yakho yomoya iqine, ivuvuke, futhi ikhiqize amafinyila engeziwe.

Cabanga ngama-leukotrienes njengabantu abanobunzima ohlelweni lwakho lokuphefumula. Uma esebenza, enza imigudu yakho yomoya ibe sensitive kakhulu futhi isabele kuma-triggers afana nama-allergens noma ama-irritants. Ngokunciphisa lawa makhemikhali, i-zileuton isiza ukugcina imigudu yakho yomoya iphumule kakhulu futhi ingasabeli ngokweqile.

Lo muthi uthathwa njengomuthi olinganiselwe uma uqhathaniswa neminye imithi evimbela isifuba somoya. Awunamandla njenge-antihistamines ethile, kodwa futhi awunamandla njenge-steroids enezilinganiso eziphakeme. Abantu abaningi bayawuthola usebenza kahle uma usetshenziswa njalo njengengxenye yenqubo yabo yansuku zonke.

Kufanele Ngiyithathe Kanjani I-Zileuton?

I-Zileuton iza ngezinhlobo ezimbili: amaphilisi akhishwa ngokushesha athathwa izikhathi ezine ngosuku kanye namaphilisi akhishwa isikhathi eside athathwa kabili ngosuku. Udokotela wakho uzokhetha uhlobo olusebenza kahle kakhulu esimisweni sakho nezidingo zakho.

Ungathatha i-zileuton ngaphandle noma ngaphandle kokudla, nakuba abanye abantu bekuthola kulula esiswini sabo uma kuthathwa nesnakhi esilula noma ukudla. Uma ukhetha inguqulo yokukhishwa ngokushesha, zama ukuhlukanisa imithamo yakho ngokulinganayo usuku lonke, njengayo yonke amahora ayisithupha.

Amaphilisi akhishwa isikhathi eside kufanele agwinywe wonke futhi angaze achotshozwe, ahlunywe, noma ahlukaniswe. Ukwenza kanjalo kungakhipha umuthi omningi ngesikhathi esisodwa, okungaphephile. Thatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze usize ukugcina amazinga aqhubekayo ohlelweni lwakho.

Ungakhathazeki uma kwesinye isikhathi udinga ukulungisa isikhathi sakho ngehora elilodwa noma amabili. Okubalulekile ukugcina inqubo eqhubekayo ongayinamathisela isikhathi eside.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Zileuton?

I-Zileuton ngokuvamile iyindlela yokwelapha yesikhathi eside, okusho ukuthi cishe uzoyithatha izinyanga noma iminyaka kunamaviki ambalwa nje. Abantu abaningi badinga ukuyisebenzisa ngokuqhubekayo ukuze bagcine imiphumela yayo yokuvikela ezimpawini zesifuba somoya.

Ungase uqale ukuqaphela ukuthuthuka okuthile ezinsukwini ezimbalwa, kodwa kungathatha amasonto amabili ukuzwa izinzuzo eziphelele. Lokhu kuthuthuka kancane kancane kuvamile futhi akusho ukuthi umuthi awusebenzi.

Udokotela wakho uzoqapha njalo inqubekela phambili yakho futhi angase alungise uhlelo lwakho lokwelapha ngokusekelwe ekutheni isifuba somoya sakho silawulwa kahle kangakanani. Abanye abantu bangagcina behlisa umthamo wabo noma bashintshele kweminye imithi, kanti abanye bayazuza ngokuhlala ku-zileuton isikhathi eside.

Ungayeki ukuthatha i-zileuton ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka kungazelelwe kungaholela ekubuyeni kwezimpawu zesifuba somoya noma kuze kubangele ukuqubuka okukhulu.

Ziyini Imiphumela Eceleni Ye-Zileuton?

Njengayo yonke imithi, i-zileuton ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ngokuvamile ithambile futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Nansi imiphumela emibi ongase uyithole, ihlelwe ngokuthi ivame kangakanani:

Imiphumela emibi evamile (ethinta abantu abangaphezu koyedwa kwabayi-10):

• Ukucabuka kwekhanda
• Ukucanuzela kwenhliziyo noma ukuphazamiseka kwesisu
• Ukuqunjelwa
• Ukuba buhlungu kwemisipha noma ubuthakathaka
• Isiyezi

Imiphumela emibi engavamile (ethinta umuntu oyedwa kwabayi-100):

• Ukuqubuka kwesikhumba noma ukuluma
• Izinkinga zokulala noma ukuqwasha
• Ubuhlungu besifuba
• Umkhuhlane
• Ushintsho ekunambitheni

Imiphumela emibi engavamile kodwa ebucayi (ethinta abantu abangaphansi koyedwa kwabayi-1,000):

• Izinkinga zesibindi (ukuphuzi kwesikhumba noma amehlo, umchamo omnyama, ukukhathala okukhulu)
• Ukuphendula okukhulu komzimba (ubunzima bokuphefumula, ukuvuvukala kobuso noma umphimbo)
• Ushintsho olungavamile lwemizwa noma ukucindezeleka
• Ubuhlungu obukhulu besisu
• Izimpawu zokutheleleka (umkhuhlane oqhubekayo, ubuthakathaka obungavamile)

Imiphumela emibi ehlobene nesibindi ifanelwe ukunakwa okukhethekile ngoba udokotela wakho uzodinga ukuqapha ukusebenza kwesibindi sakho ngokuhlolwa kwegazi okuvamile. Lokhu kuqapha kuvamile futhi kusiza ukubamba noma yiziphi izinkinga ekuqaleni lapho zikwazi ukwelashwa kakhulu.

Imiphumela emibi eminingi iyalawuleka futhi ayidingi ukuyeka umuthi. Nokho, xhumana nomhlinzeki wakho wezempilo uma uhlangabezana nezimpawu eziqhubekayo noma ezikhathazayo.

Ubani Ongafanele Athatha I-Zileuton?

IZileuton ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela. Umuthi kungenzeka awukulungele uma unezimo zempilo ezithile noma usebenzisa imithi ethile.

Akufanele usebenzise i-zileuton uma unezifo zesibindi ezisebenzayo noma ama-enzyme esibindi aphakeme kakhulu. Njengoba umuthi ungathinta ukusebenza kwesibindi, ukuqala ngesibindi esivele sonakele kungaba yingozi.

Abantu abanomlando wokungezwani komzimba okukhulu ne-zileuton noma yiziphi izithako zayo kufanele bagweme lo muthi. Ngaphezu kwalokho, uma ukhulelwe noma uncelisa, xoxa ngobungozi nezinzuzo ngokucophelela nodokotela wakho, njengoba idatha yokuphepha kulezi zimo ilinganiselwe.

IZileuton ingasebenzisana neminye imithi eminingi, okuhlanganisa i-warfarin (i-blood thinner), i-theophylline (omunye umuthi wesifuba somoya), kanye nemithi ethile yokuhlaselwa yisithuthwane. Udokotela wakho uzodinga ukulungisa imithamo noma akuqaphele eduze uma usebenzisa noma yikuphi kwalokhu.

Izingane ezingaphansi kweminyaka engu-12 ubudala akufanele zithathe i-zileuton, njengoba ukuphepha kwayo nokusebenza kwayo kungakahlolwa kuleli qembu leminyaka. Udokotela wakho wezingane angase ancome ezinye izindlela ezifanele zezingane ezincane ezinomoya.

Amagama Omkhiqizo we-Zileuton

IZileuton iyatholakala ngaphansi kwegama lomkhiqizo elithi Zyflo, nenguqulo yokukhishwa okwandisiwe ebizwa ngokuthi Zyflo CR. Zombili ziqukethe isithako esifanayo esisebenzayo kodwa zenziwe ngendlela ehlukile yezinhlelo ezihlukene zokulinganisa.

Izinhlobo ezivamile ze-zileuton nazo ziyatholakala, eziqulathe isithako esifanayo esisebenzayo kodwa zingase zibukeke zihlukile noma zivela kubakhiqizi abahlukene. Umuthi wakho wezidakamizwa angakusiza ukuthi uqonde ukuthi iyiphi inguqulo oyitholayo futhi uqinisekise ukuthi uyayithatha ngendlela efanele.

Noma ngabe usebenzisa igama lomkhiqizo noma inguqulo ejwayelekile, umuthi usebenza ngendlela efanayo. Abanye abantu bakhetha enye ngaphezu kwenye ngokusekelwe ezindlekweni, umshwalense, noma okuthandwa ngumuntu siqu mayelana nosayizi wethebhulethi noma ukuma.

Ezinye izindlela ze-Zileuton

Uma i-zileuton ingasebenzi kahle kuwe noma idala imiphumela engathandeki, imithi eminingi ehlukile ingasiza ekuvikeleni izimpawu zesifuba somoya. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho ngokusekelwe ezidingweni zakho ezithile.

Ezinye izithiyo ze-leukotriene zihlanganisa i-montelukast (Singulair) kanye ne-zafirlukast (Accolate). Lezi zisebenza ngendlela efanayo ne-zileuton kodwa zingase zibe nemiphumela ehlukile noma amashejuli okulinganisa angahambisana kangcono nendlela yakho yokuphila.

Ama-corticosteroids aphefumulwayo njenge-fluticasone (Flovent) noma i-budesonide (Pulmicort) avame ukucatshangelwa njengemithi yokuqala yokuvimbela isifuba somoya. Le mithi ihanjiswa ngqo emaphashini akho futhi ingasebenza kahle kakhulu ngemiphumela emincane yohlelo.

Kubantu abanesifuba somoya esibi, imithi emisha ye-biologic efana ne-omalizumab (Xolair) noma i-dupilumab (Dupixent) ingase ibe yizinketho. Lezi zivame ukugcinelwa amacala lapho ezinye izindlela zokwelapha zingazange zinikeze ukulawula okwanele.

Ama-inhalers ahlanganisiwe aqukethe kokubili i-steroid kanye ne-bronchodilator esebenza isikhathi eside angaba ezinye izindlela ezisebenzayo, enikeza lula nokuphathwa okuphelele kwesifuba somoya kudivayisi eyodwa.

Ingabe i-Zileuton Ingcono Kune-Montelukast?

Kokubili i-zileuton ne-montelukast ziyizithiyo ze-leukotriene, kodwa zisebenza kancane ngendlela ehlukile futhi zinezinzuzo ezihlukile. Ukukhetha

Into okukhulu kwe-zileuton uma kuqhathaniswa ne-montelukast ukudingeka kokuqapha isibindi njalo kanye nokuthatha imithi kaningi. I-Montelukast ihlotshaniswa nezinguquko zemizwa kwabanye abantu, kanti izinkinga eziyinhloko ze-zileuton zihlobene nokusebenza kwesibindi.

Udokotela wakho uzocabangela umlando wakho wezokwelapha, indlela yakho yokuphila, kanye nobukhulu besifuba somoya lapho ekhetha phakathi kwale mithi. Ngezinye izikhathi, okusebenza kahle kumuntu oyedwa kungase kungabi kuhle komunye, ngisho noma benamaphethini afanayo esifuba somoya.

Imibuzo Evame Ukubuzwa Mayelana ne-Zileuton

Ingabe i-Zileuton iphephile ezigulini zenhliziyo?

I-Zileuton ngokuvamile ithathwa njengephephile kubantu abanezifo zenhliziyo, njengoba ngokuvamile ingawuthinti umfutho wenhliziyo noma umfutho wegazi. Kodwa-ke, udokotela wakho wenhliziyo kanye nodokotela wamaphaphu kufanele bahlele ukunakekelwa kwakho ukuze baqinisekise ukuthi yonke imithi yakho isebenza kahle ndawonye.

Abanye abantu abanezifo zenhliziyo bathatha izinciphisi zegazi, ezingase zisebenzisane ne-zileuton. Udokotela wakho uzoqapha izikhathi zakho zokujiya kwegazi eduze futhi kungase kudingeke ukuthi alungise imithamo yakho yemithi ngokufanele.

Uma unesifuba somoya kanye nesifo senhliziyo, ukulawula isifuba somoya sakho ngemithi efana ne-zileuton kungazuza inhliziyo yakho ngempela ngokunciphisa ukucindezeleka okubangelwa ubunzima bokuphefumula ohlelweni lwakho lwe-cardiovascular.

Ngingenzani uma ngiphuzile i-Zileuton eningi ngengozi?

Uma ngengozi uthatha i-zileuton eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Nakuba ukweqisa kungavamile, ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi, ikakhulukazi izinkinga zesibindi.

Ungazami ukuthi "ulungise" ukweqisa ngokweqa umthamo wakho olandelayo. Kunalokho, landela isiqondiso somhlinzeki wakho wezempilo sokuthi uzobuyela nini esimisweni sakho esijwayelekile sokuthatha imithi.

Izimpawu zokuthi kungenzeka ukuthi uthathe okuningi zihlanganisa isicanucanu esibi, ukuhlanza, ukozela okukhulu, noma ukudideka. Funani ukunakekelwa kwezokwelapha ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ngemva kokuthatha imithi eyengeziwe.

Kumele Ngenzeni Uma Ngiphuthelwa Umthamo We-Zileuton?

Uma uphuthelwa umthamo we-zileuton, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho esivamile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uthatha inguqulo yokukhishwa okweluliwe, lokhu kubaluleke kakhulu ukukugwema.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi. Ukusetshenziswa kwansuku zonke okuqhubekayo kubalulekile ukuze i-zileuton isebenze ngempumelelo ekuvikeleni izimpawu zesifuba somoya.

Ngingayeka Nini Ukuthatha I-Zileuton?

Kufanele uyeke kuphela ukuthatha i-zileuton ngaphansi kokuqondisa kukadokotela wakho. Abantu abaningi badinga ukuqhubeka nomuthi isikhathi eside ukuze bagcine imiphumela yawo yokuvikela ezimpawini zesifuba somoya.

Udokotela wakho angase acabange ukuyeka noma ukunciphisa i-zileuton uma isifuba somoya sakho silawulwe kahle isikhathi eside, uma uba nemiphumela emibi engabekezeleleki, noma uma ezinye izindlela zokwelapha zibonakala zisebenza kahle esimweni sakho.

Isinqumo sokuyeka sizosekelwa ekulawuleni kwakho konke kwesifuba somoya, eminye imithi oyithathayo, kanye nezici zakho eziyingozi. Ungalokothi uyeke ngokuzumayo, ngoba lokhu kungaholela ekubuyeni kwezimpawu noma kuqale ukuqubuka kwesifuba somoya.

Ngingayithatha I-Zileuton Ngesikhathi Sokukhulelwa?

Ukuphepha kwe-Zileuton ngesikhathi sokukhulelwa akukatholakali ngokugcwele, ngakho udokotela wakho uzohlola ngokucophelela izinzuzo ngokumelene nezingozi ezingaba khona. Isifuba somoya esingalawulwa ngesikhathi sokukhulelwa singaba yingozi kuwe nakumntwana wakho, ngakho ukugcina ukulawulwa okuhle kwesifuba somoya kubalulekile.

Uma uhlela ukukhulelwa noma uthola ukuthi ukhulelwe ngenkathi uthatha i-zileuton, xoxa ngezinketho zakho nodokotela wakho wezifo zabesifazane kanye nodokotela wamaphaphu. Bangase batusa ukushintshela emuthini onedatha yokuphepha yokukhulelwa eyengeziwe.

Iqembu lakho lezempilo lizosebenza nawe ukuthola indlela ephephe kakhulu nephumelelayo yokuphatha isifuba sakho somoya ngesikhathi sokukhulelwa kwakho, ukuqinisekisa ukuthi impilo yakho nempilo yengane yakho zivikelekile.