Yini i-Deutetrabenazine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokunye

I-Deutetrabenazine iyimithi kadokotela esiza ukulawula ukunyakaza okungafuneki kubantu abanezimo ezithile zemizwa. Isebenza ngokunciphisa kancane umsebenzi wamakhemikhali athile obuchopho angabangela ukunyakaza kwemisipha okungahleliwe, inikeze ithemba nempilo engcono kulabo ababhekene nezifo zokunyakaza.

Yini i-Deutetrabenazine?

I-Deutetrabenazine ingeyeqembu lemithi ebizwa ngokuthi ama-VMAT2 inhibitors. Cabanga ngayo njengesistimu yamabhuleki emnene yesikhungo sakho sokulawula ukunyakaza kobuchopho. Umuthi usiza ukulawula i-dopamine, ikhemikhali yobuchopho edlala indima ebalulekile ekulawuleni ukunyakaza kwemisipha.

Lo muthi wenzelwe ngqo ukuthi uhlale isikhathi eside futhi ubangele imiphumela emincane eceleni kunemithi emidala efanayo. Ithathwa ngomlomo ngamaphilisi futhi idinga ukuqashwa ngokucophelela ngumhlinzeki wakho wezempilo ukuze uthole umthamo ofanele wezidingo zakho ezithile.

Isetshenziselwani i-Deutetrabenazine?

I-Deutetrabenazine ikakhulukazi inikezwa izimo ezimbili eziyinhloko ezibangela ukunyakaza okungahleliwe. Udokotela wakho angase ancome lo muthi uma ubhekene ne-chorea ehambisana nesifo sikaHuntington noma i-tardive dyskinesia.

I-Huntington's disease chorea ihlanganisa ukunyakaza okungazelelwe, okungalindelekile okungathinta izingalo zakho, imilenze, ubuso, nomzimba. Lokhu kunyakaza kuvame ukubonakala uma ucindezelekile noma uzama ukugxila. I-Deutetrabenazine ingasiza ukunciphisa ubukhulu balokhu kunyakaza, okwenza imisebenzi yansuku zonke iphatheke kalula.

I-Tardive dyskinesia ngokuvamile ithuthuka ngemva kokusetshenziswa isikhathi eside kwemithi ethile yengqondo. Lesi simo sibangela ukunyakaza okuphindaphindiwe, okungahleliwe, okuvame ukuthinta ubuso, ulimi, nomhlathi. Ungase uqaphele ukushaya izindebe, ukuphuma kolimi, noma ukuhlikihla ubuso ongakwazi ukukulawula.

Isebenza kanjani i-Deutetrabenazine?

I-Deutetrabenazine isebenza ngokuvimba iphrotheni ebizwa nge-VMAT2 ebuchosheni bakho. Le phrotheni inesibopho sokupakisha i-dopamine ezindaweni zokugcina ngaphakathi kwamaseli ezinzwa. Ngokunciphisa umsebenzi we-dopamine ezingxenyeni ezithile zobuchopho, umuthi usiza ukuthulisa izimpawu zokunyakaza ezisebenza ngokweqile.

Lokhu kuthathwa njengomuthi onamandla aphakathi nendawo odinga ukulungiswa komthamo kancane kancane. Udokotela wakho uzoqala ngomthamo ophansi bese ewunyusa kancane kancane emavikini ambalwa. Le ndlela eqaphelayo isiza umzimba wakho ukuthi ujwayele futhi inciphisa imiphumela engemihle engaba khona.

Umuthi awelaphi isimo esiyisisekelo kodwa unikeza ukukhululeka okukhulu kwezimpawu. Abantu abaningi baqaphela ukuthuthuka ekulawuleni kwabo ukunyakaza kungakapheli amasonto ambalwa beqala ukwelashwa, nakuba izinzuzo eziphelele zingathatha izinyanga ezimbalwa ukuthi zivele.

Kufanele Ngiyithathe Kanjani I-Deutetrabenazine?

Thatha i-deutetrabenazine njengoba unjalo njengoba uyalelwe udokotela wakho, ngokuvamile kabili ngosuku ngokudla. Ukuyithatha ngokudla kusiza umzimba wakho ukuthi umunce umuthi kangcono futhi kunciphisa ithuba lokuthi isisu singakhathazeki. Ungayithatha nganoma yiluphi uhlobo lokudla, kodwa ukuqina ngesikhathi kusiza ukugcina amazinga aqinile ohlelweni lwakho.

Gwinya amaphilisi wonke ngengilazi yamanzi egcwele. Ungawachobozi, uwahlafune, noma uwaphule amaphilisi, njengoba lokhu kungathinta indlela umuthi okhululwa ngayo emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nomuthi wakho mayelana nezinketho ezingezinye.

Udokotela wakho uzoqala ngomthamo ophansi bese ewunyusa kancane kancane njalo ngesonto elilodwa noma amabili. Lokhu kwanda kancane kusiza umzimba wakho ukuthi ujwayele futhi kuvumela ithimba lakho lezempilo ukuthi liqaphe noma yimiphi imiphumela engemihle. Ungalokothi ulungise umthamo wakho ngokwakho, ngisho noma uzwa sengathi umuthi awusebenzi njengoba kulindelekile.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Deutetrabenazine?

I-Deutetrabenazine ngokuvamile iyindlela yokwelapha yesikhathi eside okungenzeka udinga ukuyithatha izinyanga noma iminyaka. Ubude besikhathi sincike esimweni sakho esithile nokuthi usabela kanjani emuthini. Udokotela wakho uzohlola njalo ukuthi ngabe izinzuzo zisaqhubeka yini nokwedlula noma yiziphi izingozi ezingaba khona.

Ngesifo sikaHuntington, kungadingeka ukuthi uthathe lo muthi iminyaka eminingi njengoba isimo siqhubeka. Udokotela wakho uzolungisa umthamo wakho ngokuhamba kwesikhathi ngokuya ngezimpawu zakho kanye nesimo sempilo yakho esiphelele. Ukuhlolwa okuvamile kusiza ukuqinisekisa ukuthi umuthi uhlala usebenza kahle futhi uphephile kuwe.

Uma une-tardive dyskinesia, umugqa wakho wesikhathi sokwelashwa ungahluka. Abanye abantu babona ngcono izimpawu zabo ngokuhamba kwesikhathi futhi bangakwazi ukunciphisa umthamo wabo noma bayeke umuthi ngaphansi kokuqondiswa kwezokwelapha okucophelelayo. Ungayeki ukuthatha i-deutetrabenazine ngokuzumayo, ngoba lokhu kungabangela ukuthi izimpawu zakho zibuye noma zibe zimbi.

Yiziphi Imiphumela Eceleni ye-Deutetrabenazine?

Njengayo yonke imithi, i-deutetrabenazine ingabangela imiphumela emibi, yize abantu abaningi beyibekezelela kahle. Ukuqonda okulindelekile kungakusiza ukuthi uzizwe ulungiswe kangcono futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi evame kakhulu ivame ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Ukozela noma ukukhathala
• Ukuqunjelwa noma isicanucanu
• Umlomo owomile
• Ukuhluleka ukulala
• Ukukhathazeka noma ukungazinzi

Le miphumela emibi yansuku zonke ivame ukuba ngaphansi kokuphazamisa ngemuva kwamasonto ambalwa okwelashwa. Ukuhlala unamanzi, ukudla ukudla okuvamile, nokugcina imikhuba emihle yokulala kungasiza ekunciphiseni le miphumela.

Abanye abantu bangahlangabezana nemiphumela emibi ekhathazayo edinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi izimpawu zokucindezeleka, imicabango yokuzilimaza, ukozela okukhulu okuphazamisa imisebenzi yansuku zonke, noma izinkinga ezintsha zokunyakaza njengokuqina kwemisipha noma ukuthuthumela.

Ngokuvamile, i-deutetrabenazine ingabangela isimo esibucayi esibizwa nge-neuroleptic malignant syndrome. Lokhu kuhlanganisa umkhuhlane ophezulu, ukuqina kwemisipha, ukudideka, kanye nezinguquko emazingeni okushaya kwenhliziyo noma umfutho wegazi. Nakuba kungavamile, lokhu kudinga ukunakekelwa kwezempilo okuphuthumayo uma kwenzeka.

Ubani Ongafanele Athatha I-Deutetrabenazine?

Abantu abathile kufanele bagweme i-deutetrabenazine ngenxa yengozi eyengeziwe yezinkinga ezinzima. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi ukuze aqinisekise ukuthi uphephile kuwe.

Akufanele uthathe i-deutetrabenazine uma unezinkinga ezinkulu zesibindi, njengoba umzimba wakho ungase ungakwazi ukucubungula umuthi ngendlela efanele. Abantu abanomlando wokucindezeleka noma imicabango yokuzibulala badinga ukucatshangelwa okukhethekile, njengoba umuthi ungase uqhubekisele phambili lezi zimo kwabanye abantu.

Uma uthatha imithi ethile, i-deutetrabenazine ingase ingakulungele. Lokhu kuhlanganisa ama-MAO inhibitors, ezinye izidambisi zokucindezeleka, kanye nemithi engabangela ukushaya kwenhliziyo okungajwayelekile. Usokhemisi wakho nodokotela bazobukeza yonke imithi yakho yamanje ukuze bahlole ukuthi kungenzeka yini ukuthi kuxhumane.

Abesifazane abakhulelwe noma abancelisa ngamabele kufanele baxoxe ngezingozi nezinzuzo ngokucophelela nomhlinzeki wabo wezempilo. Nakuba umuthi ungakahlolisiswa kakhulu ekukhulelweni, udokotela wakho angase awuncome uma izinzuzo zidlula izingozi ezingase zibe khona kuwe nomntwana wakho.

Amagama Omkhiqizo we-Deutetrabenazine

I-Deutetrabenazine itholakala ngaphansi kwegama lomkhiqizo elithi Austedo e-United States. Le yindlela evame kakhulu yokuyalelwa yomuthi futhi iza ngamandla amaningana amaphilisi ukuze kuvunyelwe ukulinganisa okunembile.

Ezinye izindawo zingase zibe namagama omkhiqizo ahlukene noma izinguqulo ezivamile ezitholakalayo. Hlola njalo nosokhemisi wakho ukuze uqinisekise ukuthi uthola umuthi ofanele, ikakhulukazi uma uhamba noma uthuthela kwenye indawo.

Ezinye izindlela ze-Deutetrabenazine

Uma i-deutetrabenazine ingakulungele, imithi eminingi ehlukile ingasiza ekuphatheni izimpawu zakho zokuphazamiseka kokunyakaza. Udokotela wakho uzocabangela isimo sakho esithile, umlando wezokwelapha, kanye nemigomo yokwelashwa lapho ehlola ezinye izinketho.

Nge-Huntington's disease chorea, i-tetrabenazine iyimithi endala esebenza ngendlela efanayo kodwa ingase ibangele imiphumela eminingi engemihle. Abanye abantu futhi bayazuza emithini ye-antipsychotic efana ne-haloperidol noma i-risperidone, nakuba lezi zinezingozi zazo nezinzuzo zazo.

I-Tardive dyskinesia nayo ingelashwa nge-valbenazine, enye i-VMAT2 inhibitor efana ne-deutetrabenazine. Abanye abantu bathola impumelelo nge-vitamin E supplements noma ukushintshela emithini ehlukene yezengqondo engase ingabangeli izinkinga zokunyakaza.

Izindlela ezingezona zemithi ezifana ne-physical therapy, i-occupational therapy, kanye ne-speech therapy zingagcwalisa noma yimuphi umuthi. Lezi zindlela zokwelapha zikusiza ukuthi uthuthukise amasu okuphatha izimpawu futhi ugcine ukuzimela kwakho emisebenzini yansuku zonke.

Ingabe i-Deutetrabenazine Ingcono Kune-Tetrabenazine?

I-Deutetrabenazine inikeza izinzuzo eziningi ngaphezu kwe-tetrabenazine, nakuba yomibili imithi isebenza ngezindlela ezifanayo. Umehluko omkhulu ukuthi udinga ukuyithatha kaningi kangakanani nokuthi imiphumela yayo emibi injani.

I-Deutetrabenazine ngokuvamile idinga kuphela ukulinganiswa kabili ngosuku, kuyilapho i-tetrabenazine ivame ukudinga ukuthathwa kathathu ngosuku. Lolu hlelo olulula lungakwenza kube lula ukukhumbula umuthi wakho futhi ugcine amazinga aqhubekayo ohlelweni lwakho usuku lonke.

Abantu abaningi bathola imiphumela embalwa engemihle nge-deutetrabenazine, ikakhulukazi ukulala ngobuthongo okuncane nokucindezeleka. Umuthi futhi mancane amathuba okuthi ubangele ukwehla okukhulu kwengcindezi yegazi uma usukuma ngokushesha. Kodwa-ke, izimpendulo zomuntu ngamunye ziyahlukahluka, futhi abanye abantu bangase benze kangcono nge-tetrabenazine.

Udktela wakho uzocabangela izimpawu zakho ezithile, indlela yokuphila, kanye nomlando wakho wezokwelapha lapho ekhetha phakathi kwale mithi. Inketho "engcono" incike ngokuphelele ekutheni imithi ngayinye isebenza kahle kangakanani esimweni sakho esiyingqayizivele nokuthi yiziphi izimo ezingezinhle ongazithwala kalula.

Imibuzo Evame Ukubuzwa Mayelana ne-Deutetrabenazine

Ingabe i-Deutetrabenazine iphephile ezigulini ezinomdlavuza wenhliziyo?

I-Deutetrabenazine ingasetshenziswa ngokuphepha kubantu abaningi abanomdlavuza wenhliziyo, kodwa idinga ukuqapha okucophelelayo. Umuthi ngezinye izikhathi ungathinta ukushaya kwenhliziyo, ngakho udktela wakho cishe uzohlola ukusebenza kwenhliziyo yakho ngaphambi kokuqala ukwelashwa futhi ngezikhathi ezithile ngesikhathi sokwelashwa.

Uma unomlando wokushaya kwenhliziyo okungajwayelekile noma usebenzisa imithi yezifo zenhliziyo, udktela wakho angase ayalele i-electrocardiogram (EKG) ukuhlola umsebenzi kagesi wenhliziyo yakho. Lokhu kusiza ukuqinisekisa ukuthi umuthi ngeke usebenzisane ngendlela engemihle nesimo senhliziyo yakho noma eminye imithi yenhliziyo.

Ngingenzani uma ngiphuzile i-Deutetrabenazine eningi ngengozi?

Uma ngengozi uphuza i-deutetrabenazine eningi kunaleyo ebekiwe, xhumana nodktela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuphuza okuningi kungabangela ukozela okukhulu, ukudideka, ukuqina kwemisipha, noma izinkinga zokuphefumula ezidinga ukunakekelwa kwezokwelapha.

Ungazami ukuzenza uhlanze noma uphuze eminye imithi ukuze ulwe nokweqisa. Kunalokho, funa usizo lwezokwelapha ngokushesha, ikakhulukazi uma uzizwa ukozela kakhulu, unenkinga yokuphefumula, noma uzwa ukuqina kwemisipha. Letha ibhodlela lakho lemithi nawe ukuze usize abahlinzeki bezempilo baqonde kahle ukuthi yini nokuthi ungakanani oyiphuzile.

Ngingenzani uma ngiphuthelwa umthamo we-Deutetrabenazine?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle kwalapho usondela emthozini wakho olandelayo obekiwe. Uma sekudlule amahora angaphezu kwayi-6 kusukela emthozini wakho ophuthelwe futhi usendaweni yamahora ambalwa emthozini wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ongekho, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi ukukusiza ukuthi ukhumbule isimiso sakho semithi.

Ngingayeka nini ukuthatha i-Deutetrabenazine?

Ungalokothi uyeke ukuthatha i-deutetrabenazine ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho zokunyakaza zibuye ngokushesha futhi zingase zibe zimbi kakhulu kunangaphambi kokuthi uqale ukwelashwa.

Udokotela wakho uzokusiza ukuthi unciphise kancane umthamo wakho emasontweni ambalwa uma udinga ukuyeka umuthi. Le nqubo yokunciphisa kancane ivumela umzimba wakho ukuthi uzivumelanise futhi isiza ekuvikeleni izimpawu zokuhoxiswa noma ukubuya okungazelelwe kwezimpawu zakho zokuphazamiseka kokunyakaza.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Deutetrabenazine?

Kungcono ukugwema utshwala ngenkathi uthatha i-deutetrabenazine, njengoba zombili lezi zinto zingabangela ukozela futhi zithinte ukuxhumana kwakho. Ukuzihlanganisa kungakhuphula ingozi yakho yokuwa, izingozi, kanye nokuzola ngokweqile okungaba yingozi.

Uma ukhetha ukuphuza ngezikhathi ezithile, zilinganisele ezingxenyeni ezincane futhi unake kakhulu ukuthi uzizwa kanjani. Ungalokothi ushayele noma usebenzise imishini ngemva kokuphuza ngenkathi usebenzisa lo muthi, futhi ngaso sonke isikhathi xoxa ngokusebenzisa kwakho utshwala ngobuqotho nomhlinzeki wakho wezempilo ukuze bakwazi ukukuqapha ngendlela efanele.