Yini i-Eluxadoline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Eluxadoline iyimithi kadokotela eyenzelwe ngqo ukwelapha i-irritable bowel syndrome enesifo sohudo (IBS-D) kubantu abadala. Lokhu kwelashwa okuhloswe ngakho kusebenza ngokulawula ukunyakaza kwamathumbu nokunciphisa ukuqaqamba nokushesha okungenza impilo yansuku zonke ibe yinselele kubantu abane-IBS-D.

Uma ubulokhu ulwa nesifo sohudo esivamile, ubuhlungu besisu, kanye nemvelo engabikezelwa yezimpawu ze-IBS, i-eluxadoline imelela indlela entsha yokuphatha lezi zinkinga. Iyingxenye yekilasi lemithi esebenza ngqo ohlelweni lwakho lwamathumbu ukusiza ukubuyisela ukusebenza kwamathumbu okuvamile.

Yini i-Eluxadoline?

I-Eluxadoline iyimithi esebenza kabili eqondisa izamukeli ezithile emathunjini akho ukulawula izimpawu ze-IBS-D. Ingowesigaba semithi ebizwa ngokuthi ama-modulators e-opioid receptor axubekile, okusho ukuthi isebenza ezindleleni ezifanayo ezilawula ubuhlungu nokusebenza kwamathumbu, kodwa ngendlela eqondiwe kakhulu.

Ngokungafani nokwelashwa okudala kwe-IBS okusebenza emzimbeni wakho wonke, i-eluxadoline yenzelwe ukuthi isebenze ikakhulukazi ohlelweni lwakho lokugaya ukudla. Le ndlela egxilile isiza ukunciphisa imiphumela kwezinye izingxenye zomzimba wakho ngenkathi ibhekana nezindlela eziyisisekelo ezibangela izimpawu ze-IBS-D.

Umuthi wathola imvume ye-FDA ngo-2015, okwenza kube enye yezinketho ezintsha ezitholakalayo kubantu abanezimpawu ze-IBS-D ezingazange zisabele kahle ekushintsheni kokudla noma kwezinye izindlela zokwelapha.

Yini i-Eluxadoline Esetshenziselwa Yona?

I-Eluxadoline inikezwa ngokuqondile kubantu abadala abane-irritable bowel syndrome enesifo sohudo (IBS-D). Lesi simo sithinta izigidi zabantu futhi sihlanganisa ubuhlungu besisu, ukuqaqamba, kanye nezihlalo ezivame ukuba lukhuni noma ezinamanzi ezingathinta kakhulu izinga lempilo yakho.

Udktela wakho angase acabangele i-eluxadoline uma uhlangabezana neziqephu eziphindaphindayo zohudo kanye nokungakhululeki kwesisu okuhlala okungenani izinyanga eziyisithu.

Umuthi ulusizo ikakhulukazi kubantu abanezihlalo ezintathu noma ngaphezulu ezixekile ngosuku ngokwesilinganiso, okuhlanganiswe nesidingo esiphuthumayo sokuba nokunyakaza kwamathumbu.

Kubalulekile ukuqonda ukuthi i-eluxadoline ayisetshenziselwa ezinye izinhlobo ze-IBS, njenge-IBS enokuqunjelwa (IBS-C) noma amaphethini e-IBS axubile. Umuthi awufaneleki futhi ukwelapha isifo sohudo esibukhali esivela ezifweni, ubuthi bokudla, noma ezinye izimbangela zesikhashana.

Isebenza Kanjani I-Eluxadoline?

I-Eluxadoline isebenza ngokuxhumana nezinhlobo ezintathu ezihlukene zama-opioid receptors emathunjini akho, ngalinye lidlala indima ethile ekulawuleni ukusebenza kwamathumbu. Lokhu kuyenza lokho odokotela abakubiza ngokuthi

Umthamo ojwayelekile wokuqala uvame ukuba ngu-100 mg kabili ngosuku, kodwa udokotela wakho angase akunike umthamo ophansi ongu-75 mg kabili ngosuku uma unezici ezithile eziyingozi. Lokhu kufaka phakathi umlando wezinkinga ze-gallbladder, izinkinga zesibindi, noma uma usebenzisa eminye imithi engase ihlangane ne-eluxadoline.

Kufanele uthathe umthamo ngamunye nokudla okukhulu kunokuba nje ukudla okulula. Lokhu kusho ukuthatha imithi ekuseni nakusihlwa, noma emini nakusihlwa, kuye ngeshejuli yakho yokudla. Ukudla akudingeki kube namafutha amaningi noma okunzima, kodwa kufanele kube ukudla okujwayelekile ukusiza umzimba wakho ukuthi usebenze imithi ngempumelelo.

Uma ukhohlwa umthamo, ungaqedi umthamo wakho olandelayo. Vele uthathe umthamo wakho olandelayo ohleliwe nokudla njengenjwayelo. Ukuthatha imithi eyengeziwe ngeke ikwenze ukuthi isebenze kangcono futhi kungase kwandise ingozi yakho yemiphumela emibi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Eluxadoline?

Ubude bokwelashwa nge-eluxadoline buyahluka kumuntu nomuntu futhi kuncike ekutheni usabela kahle kangakanani emithini nokuthi ingena kanjani ohlelweni lwakho jikelele lokuphatha i-IBS. Abantu abaningi bayayithatha izinyanga eziningana kuya eminyakeni njengengxenye yamasu abo okuphatha i-IBS-D yesikhathi eside.

Udokotela wakho cishe uzofuna ukuxhumana nawe ngemva kwamasonto ambalwa okuqala ukuze abone ukuthi usabela kanjani emithini. Abanye abantu baqaphela ukuthuthuka kwezimpawu zabo ngesonto lokuqala, kanti abanye bangase badinge amasonto ambalwa ukuze bathole izinzuzo ezigcwele.

Ngenxa yokuthi i-IBS-D ngokuvamile iyisimo esingapheli, i-eluxadoline yenzelwe ukusetshenziswa isikhathi eside kunokuba ukukhululeka kwesikhashana. Kodwa-ke, udokotela wakho angase ancome ukuphumula ngezikhathi ezithile emithini ukuze ahlulele ukuthi izimpawu zakho zithuthuke zodwa noma ngabe usadinga ukwelashwa.

Ungayeki ukuthatha i-eluxadoline ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala, ikakhulukazi uma ubuthathe izinyanga eziningana. Nakuba ingenzi umlutha ngendlela yendabuko, ukuyeka kungazelelwe kungase kubangele izimpawu zakho ze-IBS-D ukuthi zibuye ngamandla.

Yiziphi Imiphumela Eceleni ye-Eluxadoline?

Njengayo yonke imithi, i-eluxadoline ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi okulindelekile kungakusiza ukuthi uzizwe ulungile futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi ejwayelekile ivamise ukuba milde futhi ithambekele ekuthuthukiseni njengoba umzimba wakho uzivumela emuthini emasontweni ambalwa okuqala kokwelashwa.

Imiphumela emibi ejwayelekile ongase uyithole ihlanganisa:

• Ukuqunjelwa (umphumela ovamile kakhulu, othinta cishe u-8% wabantu)
• Ukucanuzela kwenhliziyo, okuvame ukuthuthuka uma kuthathwa nokudla
• Ubuhlungu besisu noma ukugcwala, ngokuvamile kulula kunezimpawu zakho zokuqala ze-IBS
• Izifo ezingaphezulu zokuphefumula njengomkhuhlane
• Ukuphalaza, ikakhulukazi ezinsukwini ezimbalwa zokuqala zokwelashwa
• I-Flatulence noma igesi eyengeziwe

Le miphumela emibi ejwayelekile ivamise ukulawuleka futhi ivame ukwehla njengoba umzimba wakho ujwayela umuthi. Abantu abaningi bathola ukuthi ukuthatha i-eluxadoline ngokudla okwanele kusiza ukunciphisa isicanucanu nokucasuka kwesisu.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha:

• Ubuhlungu obukhulu besisu obungathuthuki noma buqhubeke bubi
• I-Pancreatitis (ukuqubuka kwamanyikwe), okubangela ubuhlungu obukhulu besisu obungase bukhanye emhlane wakho
• Ukuqunjelwa okukhulu okuhlala izinsuku ezingaphezu kwezimbili
• I-Sphincter of Oddi spasm, okubangela ubuhlungu obukhulu besisu esiphezulu
• Izimpawu zokungezwani komzimba nezinto ezithile njengokuqubuka, ubunzima bokuphefumula, noma ukuvuvukala

Uma uzwa ubuhlungu obukhulu besisu, ikakhulukazi uma kuhambisana nesicanucanu, ukuhlanza, noma umkhuhlane, xhumana nodokotela wakho ngokushesha. Lokhu kungaba yizimpawu ze-pancreatitis, okuyinkinga enkulu kodwa engavamile edinga ukunakekelwa kwezokwelapha ngokushesha.

Ubani Ongafanele Athatha I-Eluxadoline?

I-Eluxadoline ayiphephile kuwo wonke umuntu, futhi kunezimo eziningi ezibalulekile lapho udokotela wakho engeke akubhalele lo muthi. Ukwethembeka ngomlando wakho wezokwelapha kusiza ekuqinisekiseni ukuthi uthola ukwelashwa okuphephile nokusebenzayo.

Akufanele uthathe i-eluxadoline uma unezimo ezithile zokugaya ukudla noma zesibindi ezingenza umuthi ube yingozi kuwe.

Izinto ezingavumelekile ngokuphelele zihlanganisa:

• Akunaso isikhwama sebile (i-cholecystectomy) - lokhu kwandisa kakhulu ingozi yakho ye-pancreatitis
• Ukuvinjelwa kwemigudu yebile okwaziwayo noma okusolwayo
• Ukungasebenzi kahle noma i-spasm ye-Sphincter of Oddi
• Izinkinga ezinkulu zesibindi (ukukhubazeka kwesibindi)
• Umlando we-pancreatitis
• Isifo esibi sezinso
• Ukuqunjelwa okungapheli noma okukhulu
• Ukuvaleka kwamathumbu okwaziwayo

Udokotela wakho uzophinda aqaphele ngokubhala i-eluxadoline uma unomlando wokusebenzisa utshwala ngokweqile, njengoba lokhu kungandisa ingozi yakho ye-pancreatitis. Ngaphezu kwalokho, uma uthatha imithi ethile ethinta ama-enzyme esibindi afanayo aqhuba i-eluxadoline, udokotela wakho angase akhethe enye indlela yokwelapha.

Izinto ezikhethekile zisebenza ku:

• Abantu abaneminyaka engaphezu kwengama-65, abangase bazwe imiphumela emibi kakhulu
• Labo abanezinkinga zesibindi ezilula kuya kweziphakathi
• Noma ubani othatha imithi exhumana ne-eluxadoline
• Abantu abanomlando wokusebenzisa izidakamizwa
• Labo abakhulelwe noma abancelisa ibele

Uma ukhulelwe noma uhlela ukukhulelwa, xoxa ngalokhu nodokotela wakho. Nakuba i-eluxadoline ingakahlolisiswa kakhulu kwabesifazane abakhulelwe, ngokuvamile ayinconywa ngesikhathi sokukhulelwa ngaphandle uma izinzuzo zicacisa ukuthi zidlula izingozi.

Amagama Omkhiqizo we-Eluxadoline

I-Eluxadoline itholakala ngaphansi kwegama lomkhiqizo elithi Viberzi e-United States. Lolu okwamanje ukuphela kwenguqulo yegama lomkhiqizo etholakalayo, njengoba umuthi usamusha futhi izinguqulo ezivamile azitholakali kabanzi okwamanje.

Lapho udokotela wakho ekunika i-eluxadoline, ngokuvamile bazobhala umuthi we-Viberzi, oza ngamandla amabili: amaphilisi angu-75 mg kanye nama-100 mg. Zombili lezi zinhlobo zamaphilisi anesimo se-oval okufanele uwathathe ngomlomo kanye nokudla.

Uma ufuna umuthi wakho ekhemisi noma uxoxa ngawo nethimba lakho lezempilo, ungase uzwe womabili la magama esetshenziswa ngokushintshana. Ezinye izinhlelo zomshuwalense zingase ziwafake ngaphansi kwegama elivamile elithi eluxadoline, kanti ezinye zisebenzisa igama lomkhiqizo elithi Viberzi emafomuleni abo.

Ezinye Izindlela Zokwelapha ze-Eluxadoline

Uma i-eluxadoline ingakulungele noma inganikezi ukukhululeka okwanele kwezimpawu, ezinye izinketho zokwelapha ziyatholakala zokuphatha i-IBS-D. Udokotela wakho angakusiza ukuthi uhlole lezi zindlela ezingezinye ngokusekelwe ezimpawini zakho ezithile kanye nomlando wakho wezokwelapha.

Eminye imithi kadokotela ye-IBS-D ihlanganisa i-alosetron (Lotronex), eyenzelwe ngqo abesifazane abane-IBS-D enzima, kanye ne-rifaximin (Xifaxan), i-antibiotic engasiza ukusetha kabusha amagciwane akho emathunjini. Kukhona futhi i-loperamide (Imodium), okuyindlela etholakala ngaphandle kwekhawunta abantu abaningi abayizama ngaphambi kokuthi baye ekwelashweni okudinga incwadi kadokotela.

Izindlela ezingezona zemithi ezingagcwalisa noma ngezinye izikhathi zithathe indawo ye-eluxadoline zihlanganisa:

• Ukuguqulwa kokudla njengokudla okuphansi kwe-FODMAP
• Ama-probiotics ukusekela amagciwane amathumbu anempilo
• Izindlela zokuphatha ingcindezi ezihlanganisa ukwelashwa noma ukuzindla
• Ukuvivinya umzimba njalo kanye nenhlanzeko yokulala
• Izithasiselo ze-fiber ezincibilikayo
• Imithi ye-Antispasmodic yokuqina

Abantu abaningi bathola ukuthi ukuhlanganisa imithi nezinguquko zokuphila kunikeza imiphumela engcono kakhulu yesikhathi eside. Udokotela wakho angase ancome ukuqala nge-eluxadoline ngenkathi esebenza nasezintweni ezibangela ukudla kanye nezindlela zokuphatha ingcindezi.

Ingabe i-Eluxadoline ingcono kune-Loperamide?

I-Eluxadoline ne-loperamide (Imodium) zisebenza ngendlela ehlukile futhi zisebenzela izindima ezihlukene ekwelashweni kwe-IBS-D, ngakho-ke ukuziqhathanisa akulula. Inketho ethi "ngcono" incike ezimpawini zakho ezithile, ubukhulu, nokuthi usabela kahle kangakanani emithini ngayinye.

I-Loperamide iyimithi etholakala ngaphandle kwemvume kadokotela esheshisa ukunyakaza kwamathumbu ukunciphisa isifo sohudo. Ivame ukuba yikhambi lokuqala abantu abalizama ngoba litholakala kalula futhi alibizi. Kodwa-ke, ikakhulukazi ibhekana nengxenye yesifo sohudo se-IBS-D ngaphandle kokugxila ebuhlungwini besisu nasekugcineni abantu abaningi ababa nakho.

I-Eluxadoline, ngakolunye uhlangothi, yakhelwe ukubhekana kokubili nesifo sohudo kanye nezici zobuhlungu besisu ze-IBS-D. Lesi senzo esiphindwe kabili singenza sisebenze kahle kubantu abanokuqina okukhulu nokungakhululeki kanye nezimpawu zabo zamathumbu.

Odokotela abaningi batusa ukuzama i-loperamide kuqala, ikakhulukazi ekuqubukeni kwezimpawu ngezikhathi ezithile, ngaphambi kokuthuthela ezinkethweni zokubhala imithi njenge-eluxadoline. Uma i-loperamide inganikezi ukukhululeka okwanele noma uma udinga imithi yansuku zonke ukuphatha izimpawu zakho, i-eluxadoline ingase ibe yisixazululo esingcono sesikhathi eside.

Abanye abantu bathola ukuthi bangasebenzisa imithi yomibili ngamasu - i-eluxadoline yokuphatha kwansuku zonke kanye ne-loperamide yezimpawu zokuphuma noma izinsuku eziyinselele ngempela. Hlala uxoxa ngale ndlela nodokotela wakho ngaphambi kokuhlanganisa ukwelashwa.

Imibuzo Evame Ukubuzwa Nge-Eluxadoline

Ingabe i-Eluxadoline Iphephile Kubantu Abanesifo Sikashukela?

I-Eluxadoline ngokuvamile ingasetshenziswa ngokuphepha ngabantu abanesifo sikashukela, kodwa kunezinye izinto ezibalulekile okufanele zixoxwe nodokotela wakho. Umuthi ngokwawo awuthinti ngokuqondile amazinga kashukela egazini, kodwa izimpawu zokugaya ukudla kanye nezinguquko emikhubeni yamathumbu ngezinye izikhathi zingathinta indlela umzimba wakho ogaya ngayo izakhamzimba nemithi.

Uma unesifo sikashukela, udokotela wakho uzofuna ukukuqapha eduze lapho uqala i-eluxadoline, ikakhulukazi uma unezinkinga ezihlobene nesifo sakho sikashukela ezithinta uhlelo lwakho lokugaya ukudla. Abantu abane-diabetic gastroparesis noma ezinye izinkinga zokugaya ukudla bangase badinge ukucatshangelwa okukhethekile.

Kufanelekile futhi ukuqaphela ukuthi ukulawulwa okungcono kwe-IBS-D kungasiza ngempela ukuzinzisa impilo yakho yonke, okuhlanganisa nokwenza kube lula ukugcina amaphethini okudla aqhubekayo aseka ukuphathwa okuhle kwesifo sikashukela.

Ngingenzani Uma Ngithatha I-Eluxadoline Eningi Ngengozi?

Uma ngengozi uthatha i-eluxadoline eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma ungezwa izimpawu ngokushesha. Ukuthatha i-eluxadoline eningi kungakhuphula ingozi yakho yemiphumela emibi engathí sina, ikakhulukazi ukuqunjelwa okukhulu noma ubuhlungu besisu.

Ungazami ukulinganisa ukweqisa ngokweqa imithamo yesikhathi esizayo noma ukuthatha imithi encane. Lokhu kungenza izimpawu zakho zingabikezeleki futhi zibe yingozi. Kunalokho, thembeka kumhlinzeki wakho wezempilo ngalokho okwenzekile ukuze akwazi ukukuqapha ngendlela efanele.

Uma uzwa ubuhlungu obukhulu besisu, ubunzima bokuphefumula, noma ezinye izimpawu ezinzima ngemva kokuthatha imithi eningi kakhulu, funa ukunakekelwa kwezempilo okuphuthumayo ngokushesha. Letha ibhodlela lemithi nawe ukuze ochwepheshe bezokwelapha bazi kahle ukuthi uthathe ini nokuthi uthathe kangakanani.

Kufanele Ngenzeni Uma Ngeqa Umthamo We-Eluxadoline?

Uma ugeqa umthamo we-eluxadoline, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma ungayithatha nokudla. Uma sekuseduze isikhathi somthamo wakho olandelayo, weqa umthamo ogeqiwe bese uqhubeka nesheduli yakho yokuthatha imithi.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ogeqiwe. Lokhu kungakhuphula ingozi yakho yemiphumela engemihle ngaphandle kokuhlinzeka ngezinzuzo ezengeziwe. I-Eluxadoline isebenza kahle kakhulu uma ithathwa njalo, kodwa ukugeqa umthamo ngezikhathi ezithile ngeke kukulimaze noma kulithinte kakhulu ukwelashwa kwakho.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni. Ukuthatha imithi njalo kusiza ukugcina amazinga aqhubekayo omuthi ohlelweni lwakho ukuze kulawulwe izimpawu ngendlela efanele.

Ngingayeka Nini Ukuthatha I-Eluxadoline?

Isinqumo sokuyeka ukuthatha i-eluxadoline kufanele senziwe ngaso sonke isikhathi ngokubonisana nodokotela wakho kunokuba uzenzele wena. Njengoba i-IBS-D ngokuvamile iyisimo esingamahlalakhona, abantu abaningi badinga ukwelashwa okuqhubekayo ukuze balawule izimpawu.

Udokotela wakho angase acabange ukuyeka noma ukunciphisa i-eluxadoline uma izimpawu zakho zikade zilawulwa kahle isikhathi eside, uma wenze izinguquko ezinkulu zokuphila ezilawula i-IBS-D yakho, noma uma uzwa imiphumela engemihle edlula izinzuzo.

Abanye abantu bathola ukuthi bangathatha amakhefu ku-eluxadoline ngezikhathi lapho izimpawu zabo ze-IBS-D zingasebenzi kangako ngokwemvelo. Kodwa-ke, lokhu kufanele kuhlelwe nomhlinzeki wakho wezempilo ukuze uqinisekise ukuthi unezindlela zokwenza uma izimpawu zibuyela.

Uma uyeka ukuthatha i-eluxadoline, udokotela wakho ngokuvamile uzoncoma ukunciphisa kancane kancane kunokuyeka kungazelelwe, ikakhulukazi uma ubuthatha izinyanga eziningi. Lokhu kusiza ekuvikeleni ukubuya okungazelelwe kwezimpawu ezingase zibe namandla kunezimpawu zakho zokuqala ze-IBS-D.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Eluxadoline?

Ngokuvamile kunconywa ukugwema noma ukunciphisa kakhulu utshwala ngenkathi uthatha i-eluxadoline, ikakhulukazi uma unomlando wezinkinga ezihlobene notshwala. Utshwala bungakhuphula ingozi yakho yokuthuthukisa i-pancreatitis, okuyinto engavamile kodwa engathi sína ye-eluxadoline.

Uma ukhetha ukuphuza utshwala ngezikhathi ezithile, xoxa ngalokhu nodokotela wakho kuqala. Bangakusiza ukuthi uqonde izici zakho eziyingozi futhi banikeze isiqondiso semikhawulo ephephile. Abantu abanomlando wokusebenzisa kabi utshwala kufanele bagweme ngokuphelele utshwala ngenkathi bethatha i-eluxadoline.

Khumbula ukuthi utshwala bungase futhi buqale izimpawu ze-IBS-D kubantu abaningi, ngakho ukunciphisa ukusetshenziswa kotshwala kungase kusize ukuthuthukisa ukulawulwa kwakho kwezimpawu ngaphezu nje kokucatshangelwa kokuphepha kwemithi.