Yini i-Ertugliflozin ne-Sitagliptin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Ertugliflozin ne-sitagliptin iyinhlanganisela yemithi esiza ukuphatha isifo sikashukela sohlobo 2 ngokusebenza ngezindlela ezimbili ezihlukene emzimbeni wakho. Le ndlela yokusebenza kabili ingasebenza kahle kakhulu kunokusebenzisa imithi eyodwa, ikunikeza ukulawula okungcono ushukela wegazi lapho ukudla nokuzivocavoca kunganele ngokwako.

Cabanga ngale nhlanganisela njengomzamo weqembu ngaphakathi emzimbeni wakho. Ngenkathi i-ertugliflozin isiza izinso zakho ukukhipha ushukela owedlulele ngomchamo, i-sitagliptin isebenza nesistimu yakho yokugaya ukudla ukusiza umzimba wakho ukukhiqiza i-insulin eyengeziwe lapho ushukela wegazi unyuka ngemva kokudla.

Yini i-Ertugliflozin ne-Sitagliptin?

Le mithi ihlanganisa imithi emibili ehlukene yesifo sikashukela ibe yiphilisi elilodwa elilula. I-Ertugliflozin ingeyodwa yeqembu elibizwa ngokuthi ama-SGLT2 inhibitors, kuyilapho i-sitagliptin iyingxenye yomndeni we-DPP-4 inhibitor.

I-Ertugliflozin isebenza ngokuvimba iphrotheni ezinso zakho evame ukumunca ushukela emuva egazini lakho. Esikhundleni salokho, lo shukela owedlulele uyahlungwa ngomchamo wakho. I-Sitagliptin isiza umzimba wakho ukuthi ukhiphe i-insulin eyengeziwe ngemva kokudla futhi inciphisa inani likashukela isibindi sakho esikhiqizayo.

Ngokubambisana, le mithi ibhekana noshukela wegazi ophezulu emazingeni amaningi. Le ndlela yokuhlanganisa ivame ukusebenza kangcono kunomuthi ngamunye uwedwa, ikakhulukazi kubantu abashukela wegazi labo ohlala ephakeme naphezu kokunye ukwelashwa.

Isetshenziselwani i-Ertugliflozin ne-Sitagliptin?

Le nhlanganisela yemithi yenzelwe ngokuqondile ukwelapha isifo sikashukela sohlobo 2 kubantu abadala. Udokotela wakho angase ayinikeze uma i-metformin yodwa ingalawuli amazinga akho kashukela wegazi ngempumelelo.

Umuthi usebenza kahle kakhulu njengengxenye yohlelo oluphelele lokuphatha isifo sikashukela oluhlanganisa ukudla okunempilo nomsebenzi womzimba ovamile. Ilusizo ikakhulukazi kubantu abadinga ukulawula okungcono ushukela wegazi usuku lonke, hhayi nje ngemva kokudla.

Abanye odokotela bayakwazisa nokuthi i-ertugliflozin ingase inikeze ezinye izinzuzo ezingaphezu kokulawulwa kukashukela wegazi, njengokuncipha kwesisindo esincane kanye nezinzuzo ezingaba khona zenhliziyo. Kodwa-ke, lezi akuzona izizathu eziyinhloko zokunikeza lo muthi.

Isebenza Kanjani I-Ertugliflozin ne-Sitagliptin?

Le nhlanganisela isebenza njengomuthi wesifo sikashukela olawulayo oqondiswe kushukela wakho wegazi ngezindlela ezimbili ezihlukene. Akuyona imithi enamandla kakhulu yesifo sikashukela etholakalayo, kodwa isebenza kahle kubantu abaningi.

Ingxenye ye-ertugliflozin isebenza njengesihlungi esithambile ezinso zakho, ivumela ushukela owedlulele ukuthi uphume emzimbeni wakho ngomchamo kunokuhlala egazini lakho. Okwamanje, i-sitagliptin isebenza njengomsizi ohlakaniphile, isiza umzimba wakho ukuthi ukhiqize inani elifanele le-insulin uma uyidinga kakhulu.

Okuhle ngale nhlanganisela ukuthi le mithi emibili ayiphazamisi omunye nomunye. Kunalokho, basebenzisana ukuhlinzeka ngokulawulwa okubanzi kukashukela wegazi kunalokho okungafinyelelwa ngamunye.

Umuthi uvamise ukuqala ukusebenza ezinsukwini ezimbalwa, nakuba ungase ungazizwa uhlukile kakhulu. Udokotela wakho uzoqapha intuthuko yakho ngokuhlolwa okuvamile kukashukela wegazi kanye nezilinganiso ze-A1C.

Kufanele Ngiwuthathaphi I-Ertugliflozin ne-Sitagliptin?

Thatha lo muthi njengoba nje udokotela wakho ekunqumele, ngokuvamile kanye ngosuku ekuseni. Ungawuthatha nokudla noma ngaphandle kokudla, noma yikuphi okuzizwa kukufanele kakhulu.

Gwinya ithebhulethi yonke ngengilazi yamanzi egcwele. Ungayichobozi, uyihlafune, noma uyiphule ithebhulethi, ngoba lokhu kungathinta indlela umuthi ogaywa ngayo emzimbeni wakho.

Ukuwuthatha ekuseni kuvame ukusebenza kangcono ngoba i-ertugliflozin ikhuphula ukuchama, okungenzeka ukuthi kuphazamise ukulala kwakho uma uthathwa kamuva emini. Zama ukuwuthatha ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo ohlelweni lwakho.

Uma uphinde usebenzise neminye imithi yesifo sikashukela, udokotela wakho uzokunikeza imiyalelo ethile mayelana nesikhathi. Eminye imithi isebenza kangcono uma ithathwa ndawonye, ​​kanti eminye kufanele ihlukaniswe.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Ertugliflozin ne-Sitagliptin?

Abantu abaningi abanesifo sikashukela sohlobo 2 badinga ukuthatha lo muthi isikhathi eside ukuze bagcine ukulawulwa okuhle kukashukela wegazi. Uhlobo 2 lwesifo sikashukela yisimo esingapheli esidinga ukuphathwa okuqhubekayo kunokwelashwa kwesikhashana.

Udokotela wakho uzoqapha ukusabela kwakho emuthini ngokuhlolwa kwegazi njalo nokuhlolwa. Uma amazinga akho kashukela egazi ethuthuka kakhulu futhi ahlala ezinzile, udokotela wakho angase alungise umthamo wakho noma uhlelo lokwelapha, kodwa ukuyeka kungazelelwe akuvami ukunconywa.

Abanye abantu bangase badinge ukushintshela emithini ehlukene ngokuhamba kwesikhathi uma isifo sabo sikashukela siqhubeka noma uma bethola imiphumela emibi. Lokhu kuvamile ngokuphelele futhi akusho ukuthi umuthi wehlulekile.

Ungalokothi uyeke ukuthatha lo muthi ngaphandle kokukhuluma nodokotela wakho kuqala, ngisho noma uzizwa ungcono. Ukuyeka kungazelelwe kungabangela amazinga akho kashukela egazi ukuthi anyuke ngendlela eyingozi.

Yiziphi Imiphumela Eceleni Ye-Ertugliflozin ne-Sitagliptin?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela eminingi emibi ithambile futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini.

Imiphumela emibi evame kakhulu ongase uyithole ivamise ukuhlobana nendlela i-ertugliflozin esebenza ngayo ezinso zakho nasezinhlelweni zomchamo:

• Ukunyela okwandayo, ikakhulukazi emasontweni ambalwa okuqala
• Ukomela okwandayo njengoba umzimba wakho uzivumela ukulahlekelwa uketshezi olwengeziwe
• Izifo zomgudu womchamo, ikakhulukazi kwabesifazane
• Izifo zemvubelo endaweni yezitho zangasese
• Isicanucanu esithambile noma isisu esicasukile
• Isiyezi lapho usukuma ngokushesha
• Ukucindezeleka

Lezi zimo ezivamile ezibangelwa imithi ngokuvamile ziba ngaphansi kokukhathaza njengoba umzimba wakho ujwayela imithi. Ukuphuza amanzi amaningi nokugcina inhlanzeko enhle kungasiza ekuvikeleni ezinye zalezi zinkinga.

Kukhona futhi ezinye izimo ezingavamile kodwa ezinzima kakhulu ezibangelwa imithi ezidinga ukunakekelwa kwezempilo ngokushesha. Nakuba lezi zinto zingavamile, kubalulekile ukwazi ukuthi yini okufanele uyibheke:

• Ukuphelelwa amanzi emzimbeni okukhulu ngezimpawu ezinjengokoma okukhulu, umlomo owomile, nobuthakathaka
• I-Ketoacidosis, isimo esibucayi lapho umzimba wakho ukhiqiza ama-ketone amaningi kakhulu
• Izinkinga ezinzima zezinso, ikakhulukazi uma uphelelwa amanzi emzimbeni
• Ukungezwani komzimba okukhulu nezimpawu ezinjengokuqubuka, ukuvuvukala, noma ubunzima bokuphefumula
• Ubuhlungu obukhulu emalungeni obuthuthuka ngokuphazima kweso
• I-Necrotizing fasciitis, ukutheleleka kwesikhumba okungavamile kodwa okubucayi endaweni yamalunga obulili

Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezinzima, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezempilo eziphuthumayo. Lezi zinkinga azivamile, kodwa ukwelashwa ngokushesha kubalulekile uma zenzeka.

Ubani Ongafanele Athathe I-Ertugliflozin ne-Sitagliptin?

Le mithi ayifanele wonke umuntu, futhi udokotela wakho uzocabangela ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Abantu abanesifo sikashukela sohlobo 1 akufanele neze bathathe le nhlanganisela, njengoba yenzelwe ngqo isifo sikashukela sohlobo 2.

Uma unesifo sezinso esibucayi, le mithi ngokuvamile ayinconywa ngoba zombili izidakamizwa zincike ekusebenzeni kahle kwezinso ukuze zisebenze ngokuphepha. Udokotela wakho uzohlola ukusebenza kwezinso zakho ngemivivinyo yegazi ngaphambi kokuqala ukwelashwa.

Ezinye izimo eziningi zingenza le mithi ingakulungele:

• Isifo sesibindi esibucayi
• Umlando we-diabetic ketoacidosis
• Ukwehluleka kwenhliziyo okukhulu
• Umlando we-pancreatitis
• Ukutheleleka kwemigudu yomchamo njalo
• Ukuphelelwa amanzi emzimbeni okukhulu noma ukungalingani kwama-electrolyte

Ukukhulelwa nokuncelisa nazo izinto ezibalulekile okufanele zicatshangelwe. Lo muthi awunconyelwe ngesikhathi sokukhulelwa, futhi uma uhlela ukukhulelwa, udokotela wakho cishe uzokushintshela kwenye indlela ephephile njenge-insulin.

Udokotela wakho uzobuye acabangele iminyaka yakho, njengoba abadala bengase bazwe kalula imiphumela yokuphelelwa amanzi emzimbeni ye-ertugliflozin. Lokhu akusho ukuthi awukwazi ukuyithatha, kodwa ungase udinge ukuqashwa okuseduze.

Amagama Omkhiqizo we-Ertugliflozin ne-Sitagliptin

Lo muthi ohlanganisiwe utholakala ngaphansi kwegama lomkhiqizo elithi Steglujan. Izingxenye ngazinye nazo ziyatholakala ngokuhlukana njenge-Steglatro (ertugliflozin) ne-Januvia (sitagliptin).

Ikhemisi lakho lingase libe nezinhlobo ezivamile zemithi ngazinye, kodwa ifomu elihlanganisiwe lingase litholakale kuphela njengomkhiqizo wegama lomkhiqizo. Izinketho ezivamile ngokuvamile zishibhile uma zitholakala.

Uma izindleko zikhathaza, buza udokotela wakho mayelana nokuthatha imithi ngazinye ngokuhlukana, njengoba izinhlobo ezivamile zingase zibe ngentengo engcono. Kodwa-ke, ukuthatha iphilisi elilodwa elihlanganisiwe kuvame ukuba lula kakhulu kunokuthatha imithi emibili ehlukene.

Ezinye izindlela ze-Ertugliflozin ne-Sitagliptin

Ezinye izinhlanganisela zemithi zingahlinzeka ngezinzuzo ezifanayo zokuphatha isifo sikashukela sohlobo 2. Udokotela wakho angase acabangele lezi zindlela ezingezinye ngokuya ngezidingo zakho ezithile nomlando wezokwelapha.

Ezinye izinhlanganisela ze-SGLT2 inhibitor zihlanganisa i-empagliflozin ne-linagliptin (Glyxambi) noma i-dapagliflozin ne-saxagliptin (Qtern). Lezi zisebenza ngendlela efanayo ne-ertugliflozin ne-sitagliptin kodwa zingase zibe nemiphumela emincane ehlukile.

Uma ungenakukwazi ukuthatha ama-SGLT2 inhibitors, udokotela wakho angase asikisele ezinye izindlela zokuhlanganisa:

• I-Metformin ene-DPP-4 inhibitor efana ne-sitagliptin yodwa
• I-Metformin ene-GLP-1 receptor agonist injection
• I-Metformin ne-insulin
• I-Metformin ngemithi ye-sulfonylurea

Ngamunye umuthi onamathuba awo okuzuzisa kanye nemiphumela engemihle. Udokotela wakho uzokusiza ukuthola inketho engcono kakhulu ngokusekelwe ekulawuleni ushukela wegazi lakho, indlela yakho yokuphila, kanye nemigomo yakho yezempilo iyonke.

Ingabe i-Ertugliflozin ne-Sitagliptin ingcono kune-Metformin?

Lezi zithako zombili kanye ne-metformin zisebenza ngezindlela ezihlukene ekuphathweni kwesifo sikashukela, ngakho ukuqathanisa ngqo akulula. I-Metformin ivamise ukuba yimithi yokuqala odokotela abayinqumayo yesifo sikashukela sohlobo 2 ngoba iphephile, iyasebenza, futhi isetshenziswe amashumi eminyaka.

Inhlanganisela ye-ertugliflozin ne-sitagliptin ivamise ukunqunywa uma i-metformin yodwa inganikezi ukulawulwa okwanele kukashukela wegazi. Akudingeki ukuthi "ingcono" kune-metformin, kodwa isebenza ngendlela ehlukile futhi ingasebenza kahle kakhulu kwabanye abantu.

Abantu abaningi empeleni bathatha le nhlanganisela kanye ne-metformin, okudala indlela yokusebenzisa imithi emithathu eqondiswe kushukela wegazi ngezindlela eziningi. Lokhu kungasebenza kahle ikakhulukazi kubantu abanesifo sikashukela esithuthukile.

I-Metformin ivame ukuba nemiphumela emibi embalwa futhi ibiza kakhulu kune-medication ehlanganisiwe. Kodwa-ke, uma i-metformin ingakulawuli kahle ushukela wegazi lakho, inhlanganisela ingase ifanele izindleko ezengeziwe kanye nemiphumela engemihle.

Imibuzo Evame Ukubuzwa Mayelana ne-Ertugliflozin ne-Sitagliptin

Ingabe i-Ertugliflozin ne-Sitagliptin iphephile kubantu abanezifo zenhliziyo?

Le nhlanganisela ingaba usizo ngempela kubantu abanezinhlobo ezithile zezifo zenhliziyo. Ucwaningo lubonise ukuthi izithiyo ze-SGLT2 ezifana ne-ertugliflozin zingasiza ekunciphiseni ingozi yokuhluleka kwenhliziyo nezinye izinkinga zenhliziyo nemithambo yegazi kubantu abanesifo sikashukela.

Kodwa-ke, uma unokuhluleka kwenhliziyo okukhulu noma ezinye izimo zenhliziyo ezinzima, udokotela wakho uzodinga ukukuqapha eduze. Imithi ngezinye izikhathi ingabangela ukushoda kwamanzi emzimbeni, okungase kuthinte ukusebenza kwenhliziyo yakho uma usuvele ubhekene nezinkinga zenhliziyo.

Njalo tshela udokotela wakho nganoma yiziphi izimo zenhliziyo onazo ngaphambi kokuqala lo muthi. Bangase bafune ukulungisa umthamo wakho noma bakuqaphe kaningi ukuze baqinisekise ukuthi impilo yakho yenhliziyo ihlala izinzile.

Kufanele Ngenzeni Uma Ngithatha Ngengozi I-Ertugliflozin ne-Sitagliptin Engaphezu Kwemithamo?

Uma ngengozi uthatha okungaphezu komthamo wakho obekiwe, ungangeni ekuqhumeni, kodwa xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yokuphelelwa amanzi emzimbeni kanye noshukela ophansi egazini.

Ziqaphelele izimpawu ezinjengokoma ngokweqile, ukuchama njalo, isiyezi, noma ukuzizwa ubuthakathaka. Uma uhlangabezana nezimpawu ezinzima ezinjengobunzima bokuphefumula, isiyezi esikhulu, noma ukudideka, funa ukunakekelwa kwezempilo okuphuthumayo ngokushesha.

Ungazami ukuthi "ulungise" umthamo owengeziwe ngokweqa umthamo wakho olandelayo ohleliwe. Kunalokho, landela imiyalelo kadokotela wakho yokubuyela esimisweni sakho esijwayelekile ngokuphepha.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Ertugliflozin ne-Sitagliptin?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka nesimiso sakho esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Ukuphuthelwa umthamo ngezikhathi ezithile ngeke kubangele ukulimala ngokushesha, kodwa ukuphuthelwa imithamo njalo kungaholela ekulawuleni ushukela ophansi egazini. Uma unenkinga yokukhumbula ukuthatha umuthi wakho, khuluma nodokotela wakho ngamasu angasiza.

Ngingayeka Nini Ukuthatha I-Ertugliflozin ne-Sitagliptin?

Kufanele uyeke kuphela ukuthatha lo muthi ngaphansi kwesiqondiso sikadokotela wakho. Uhlobo 2 lukashukela yisimo esingamahlalakhona esivame ukudinga ukuphathwa kwemithi okuqhubekayo, ngakho ukuyeka kungazelelwe kungabangela ukuthi amazinga akho kashukela egazini anyuke ngokuphawulekayo.

Udktela wakho angase acabange ukwehlisa umthamo wakho noma ashintshe imithi uma isifo sikashukela sakho sithuthuka kakhulu ngezinguquko zokuphila, kodwa lesi sinqumo kufanele senziwe ndawonye ngaso sonke isikhathi. Abanye abantu banganciphisa imithi yabo yesifo sikashukela ngokulahlekelwa isisindo esikhulu noma ukuthuthukiswa okukhulu kwendlela yokuphila.

Uma uhlangabezana nemiphumela engemihle ekwenza ufune ukuyeka umuthi, khuluma nodokotela wakho kuqala. Bangase bakwazi ukulungisa umthamo wakho noma baphakamise izindlela zokuphatha imiphumela engemihle kunokuyeka umuthi ngokuphelele.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Ertugliflozin ne-Sitagliptin?

Ngokuvamile ungafaka amanani aphakathi nendawo otshwala ngenkathi uthatha lo muthi, kodwa udinga ukuqaphela kakhulu amazinga kashukela egazini lakho. Utshwala bungakhuphula ingozi yakho yamazinga kashukela aphansi egazini nokuphelelwa amanzi emzimbeni.

Njengoba lo muthi usuvele ukhuphula ukuchama, utshwala bungenza ukuthi kube lula ukuthi umzimba uphelelwe amanzi. Qiniseka ukuthi uphuza amanzi amaningi futhi ungaluphuzi utshwala esiswini esingenalutho lapho uthatha imithi yesifo sikashukela.

Xoxa nodokotela wakho ngalokho okubalulekile ekusetshenzisweni kotshwala okuphephile esimweni sakho esithile. Bangase batusa ukukhawulela utshwala noma ukukugwema ngokuphelele uma unezinye izimo zempilo noma uthatha eminye imithi engase ihlangane.