Yini i-Infliximab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Infliximab iyimithi enamandla kadokotela esiza ukuthulisa amasosha akho omzimba uma ehlasela umzimba wakho. Inikezwa nge-IV (intravenous) infusion esibhedlela noma emtholampilo, lapho ochwepheshe bezempilo bengakuqapha eduze ngesikhathi sokwelashwa.

Le mithi ingeyeqembu elibizwa ngokuthi ama-biologics, enziwa ngamaseli aphilayo kunamakhemikhali. Cabanga nge-infliximab njengomsizi oqondiwe ovimba izimpawu ezithile kumasosha akho omzimba ezibangela ukuvuvukala nokulimala kwezicubu.

Yini i-Infliximab Esetshenziselwa Yona?

I-Infliximab iphatha izimo eziningi ze-autoimmune lapho amasosha akho omzimba ehlasela ngokungaqondile izingxenye ezinempilo zomzimba wakho. Udokotela wakho angase ayibhale uma ezinye izindlela zokwelapha zingazange zinikeze ukukhululeka okwanele ezimpawini zakho.

Umuthi uvunyelwe yi-FDA ngalezi zimo ezithile:

• I-Rheumatoid arthritis (uma ihlanganiswe ne-methotrexate)
• Isifo sikaCrohn kanye ne-ulcerative colitis
• I-Ankylosing spondylitis
• I-Psoriatic arthritis
• I-Plaque psoriasis

Ngayinye yalezi zimo ihlanganisa ukuvuvukala okungapheli okungabangela ubuhlungu obukhulu futhi kuphazamise imisebenzi yansuku zonke. I-Infliximab isiza ukunciphisa lokhu kuvuvukala, okungaholela ekulawuleni okungcono kwezimpawu kanye nempilo engcono.

Isebenza Kanjani i-Infliximab?

I-Infliximab isebenza ngokuvimba iphrotheni ebizwa ngokuthi i-tumor necrosis factor-alpha (TNF-alpha) edlala indima ebalulekile ekuvuvukeni. Lapho amasosha akho omzimba ekhiqiza i-TNF-alpha eningi kakhulu, ingabangela ukuvuvukala okubuhlungu nokulimala kwezicubu okubonakala ezifweni ze-autoimmune.

Ngokubopha ku-TNF-alpha nokuyivimbela ukuthi ingasebenzi, i-infliximab isiza ukuqeda umjikelezo wokuvuvukala. Yingakho ibizwa ngokuthi i-TNF blocker noma i-TNF inhibitor.

Lo muthi uthathwa njengokwelashwa okuqondiswe ngqo, okuqinile. Ngokuvamile ugcinelwe amacala aphakathi nendawo kuya kwangaqine kangako lapho eminye imithi ingasebenzi ngokwanele. Imiphumela ivamise ukubonakala phakathi namasonto ambalwa kuya ezinyangeni ezimbalwa ngemuva kokuqala ukwelashwa.

Kufanele Ngiyithathe Kanjani I-Infliximab?

I-Infliximab inikezwa kuphela njenge-IV infusion endaweni yezokwelapha efana nesibhedlela, umtholampilo, noma isikhungo se-infusion. Awukwazi ukuthatha lo muthi ekhaya noma ngomlomo.

Inqubo ye-infusion ngokuvamile ithatha amahora angu-2-3, futhi uzoqashwa ochwepheshe bezempilo kuyo yonke leyo nkathi. Abantu abaningi bathola imithamo yabo emithathu yokuqala ngamasonto 0, 2, kanye no-6, bese beqhubeka ne-infusion njalo ngemva kwamasonto angu-8.

Ngaphambi kwe-infusion ngayinye, ithimba lakho lezempilo lizohlola izimpawu zakho ezibalulekile futhi libuze nganoma yiziphi izimpawu noma izinkathazo. Akudingeki ukuthi uzile ukudla ngaphambi kokwelashwa, kodwa kuyasiza ukudla ukudla okulula futhi uhlale unamanzi.

Ungase uzizwe ukhululekile ngokuletha incwadi, ithebulethi, noma eminye imisebenzi ethule ngoba uzohlala phansi amahora ambalwa. Abanye abantu bazizwa bekhathele ngemva kokwelashwa, ngakho-ke cabangela ukuhlela ukuthi othile akuqhubele ekhaya.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Infliximab?

Ubude bokwelashwa nge-infliximab buhluka kakhulu kuye ngesimo sakho esithile nokuthi usabela kahle kangakanani emuthini. Abanye abantu bangase badinge ukwelashwa izinyanga eziningana, kanti abanye bangase baqhubeke iminyaka eminingi.

Udokotela wakho uzohlola njalo ukuthi umuthi usebenza kahle kangakanani nokuthi ngabe uhlangabezana nanoma yiziphi izimpawu ezingakhathazi. Bazosebenzisa ukuhlolwa kwegazi, izifundo zokuthwebula izithombe, kanye nemibiko yakho yezimpawu ukwenza lezi zinqumo.

Kubalulekile ukungayeki i-infliximab ngokuzumayo ngaphandle kokuxoxa ngayo nodokotela wakho kuqala. Ukuyeka ngokuphazima kungabangela ukuthi izimpawu zakho zibuye, ngezinye izikhathi zibe zimbi kakhulu kunakuqala. Ithimba lakho lezempilo lizokwenza uhlelo olulungele isimo sakho.

Ziyini Imiphumela Eceleni Ye-Infliximab?

Njengazo zonke izidakamizwa, i-infliximab ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini okufanele uyibheke kukusiza ukuthi uhlale uphephile futhi uthole inzuzo enkulu ekwelashweni.

Imiphumela emibi ejwayelekile abantu abaningi abayitholayo ihlanganisa:

• Ikhanda nokukhathala
• Ukutheleleka okuphezulu kwemigudu yokuphefumula njengomkhuhlane
• Ubuhlungu besisu noma isicanucanu
• Ukuphendula endaweni yokufakwa
• Ukulimala kwemisipha noma amalunga

Le miphumela emibi ivamise ukuba mncane futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Nokho, kufanele njalo ubike noma yiziphi izimpawu ezintsha noma eziqhubekayo eqenjini lakho lezempilo.

Imiphumela emibi engathi sína idinga ukunakekelwa kwezempilo ngokushesha, nakuba ingavamile:

• Izimpawu zokutheleleka okukhulu (umkhuhlane, amaqhwa, ukukhwehlela okuqhubekayo, izimpawu ezinjengomkhuhlane)
• Ukukhathala okungavamile noma ubuthakathaka
• Ushintsho esikhumbeni okuhlanganisa ukukhula okusha noma izilonda
• Ubuhlungu besisu obuqhubekayo noma izinguquko ekuhambeni kwamathumbu
• Ukuphefumula kanzima noma ubuhlungu besifuba

Ngenxa yokuthi i-infliximab ithinta amasosha akho omzimba, ungase ube sengozini enkulu yokutheleleka. Udokotela wakho uzokugada eduze futhi angase ancome ukugwema imithi yokugoma ethile noma izindawo ezigcwele abantu ngezikhathi zokugula eziphezulu.

Ubani Ongafanele Athole I-Infliximab?

I-Infliximab ayiphephile kuwo wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile zezempilo noma izimo zenza lo muthi ungafaneleki noma uyingozi.

Akufanele uthole i-infliximab uma une:

• Ukutheleleka okusebenzayo, ikakhulukazi i-tuberculosis noma i-hepatitis B
• Ukuhluleka kwenhliziyo (okulinganiselwe kuya kokukhulu)
• Ukungezwani okwaziwayo ne-infliximab noma izingxenye zayo
• Izinhlobo ezithile zomdlavuza noma umlando we-lymphoma

Udktela wakho uzosebenzisa ukuqapha okwengeziwe uma unesifo sikashukela, izinkinga zesibindi, noma umlando wokutheleleka okuphindaphindayo. Bangase badinge ukuhlolwa okwengeziwe noma ukuqapha ngaphambi kokuqala ukwelashwa.

Ukukhulelwa nokuncelisa ngamabele kudinga ukucatshangelwa okukhethekile. Ngenkathi i-infliximab ingasetshenziswa ngesikhathi sokukhulelwa ezimweni ezithile, kubalulekile ukuxoxa ngobungozi nezinzuzo ngokucophelela nethimba lakho lezempilo.

Amagama Omkhiqizo we-Infliximab

Igama lomkhiqizo le-infliximab yi-Remicade, okuyinguqulo yokuqala yalo muthi. Ungase futhi uhlangane nezinguqulo ze-biosimilar, okuyimithi efana kakhulu esebenza ngendlela efanayo.

Amagama ajwayelekile e-biosimilar afaka i-Inflectra, i-Renflexis, ne-Ixifi. Lezi zinto ze-biosimil ziye zafakazelwa ukuthi zisebenza kahle futhi ziphephile njenge-Remicade yasekuqaleni, yize ukumbozwa kwakho komshuwalense kungahluka phakathi kwezinguqulo ezahlukene.

Udktela wakho nomuthi bazosebenzisana ukunquma ukuthi iyiphi inguqulo engcono kakhulu kuwe ngokusekelwe ekusebenzeni, ukutholakala, kanye nokucatshangelwa kwezindleko.

Ezinye izindlela ze-Infliximab

Uma i-infliximab ingakulungele noma iyeka ukusebenza ngempumelelo, ezinye izinketho zokwelapha ziyatholakala. Udktela wakho angakusiza ukuthi uhlole lezi ezinye izindlela ngokusekelwe esimweni sakho esithile kanye nomlando wezokwelapha.

Ezinye izivimbeli ze-TNF zifaka i-adalimumab (Humira), i-etanercept (Enbrel), kanye ne-certolizumab (Cimzia). Lezi zisebenza ngendlela efana ne-infliximab kodwa zingase zinikezwe njengemijovo ongayenza ekhaya.

Ama-non-TNF biologics afana ne-rituximab, tocilizumab, noma i-abatacept aqondise izingxenye ezahlukene zesimiso somzimba sokuzivikela. Imithi yendabuko yokuguqula izifo efana ne-methotrexate, sulfasalazine, noma i-hydroxychloroquine nayo ingaba yizinketho.

Ukukhetha kuncike ezintweni ezifana nokuxilongwa kwakho okuthile, ukwelashwa kwangaphambilini, izintandokazi zokuphila, nokuthi umzimba wakho usabela kanjani emithini ehlukene.

Ingabe i-Infliximab ingcono kune-Adalimumab?

Kokubili i-infliximab ne-adalimumab ziyizivimbeli ze-TNF ezisebenzayo, kodwa zinezinzuzo ezihlukene kuye ngesimo sakho. Akukho noyedwa othi "ungcono" kunomunye.

I-Infliximab inikezwa njenge-IV infusion njalo ngamaviki angu-8, okusho ukuthi ukuthatha imithi okungavamile kodwa kudinga ukuvakashelwa emtholampilo. I-Adalimumab iyisijovo ozithatha wena uqobo esinikezwa njalo ngemva kwesonto ekhaya, okuhlinzeka ngokulula kodwa ukuthatha imithi kaningi.

Abanye abantu basabela kangcono emuthini owodwa kunomunye, futhi lokhu akukwazi ukubikezelwa kusengaphambili. Udokotela wakho angase akhethe omunye ngokuya ngesimo sakho esithile, indlela yokuphila, umshwalense, noma umlando wokwelashwa wangaphambilini.

Yomibili imithi inokusebenza okufanayo kanye namaphrofayili emiphumela emibi. Isinqumo sivame ukwehla ekukhetheni komuntu siqu mayelana nokuvakashelwa emtholampilo vs. izijovo zasekhaya.

Imibuzo Evame Ukubuzwa Mayelana ne-Infliximab

Q1. Ingabe i-Infliximab iphephile kubantu abanesifo sikashukela?

I-Infliximab ingasetshenziswa kubantu abanesifo sikashukela, kodwa idinga ukuqapha okwengeziwe nezinyathelo zokuphepha. Njengoba isifo sikashukela singathinta amasosha akho omzimba nokuphola, udokotela wakho uzokubheka eduze ukuze abone izimpawu zokutheleleka.

Uzodinga ukuhlolwa kwegazi njalo ukuze uqaphe amazinga akho kashukela egazini nempilo yakho yonke. Kubaluleke kakhulu ukugcina ukulawula okuhle kukashukela egazini ngenkathi uthatha i-infliximab, njengoba lokhu kusiza amasosha akho omzimba ukuthi asebenze ngempumelelo ngangokunokwenzeka.

Q2. Kufanele ngenzeni uma ngithola i-Infliximab eningi ngengozi?

Njengoba i-infliximab inikezwa endaweni yezokwelapha, ukweqisa ngengozi akuvamile kakhulu. Ochwepheshe bezempilo babala ngokucophelela futhi baqaphe umthamo wakho ngesikhathi ngasinye sokufakwa.

Uma ukhathazekile ngokuthola umthamo ongalungile, unganqikazi ukucela ithimba lakho lezempilo ukuthi liqinisekise imininingwane yakho kanye nokulinganisa ngaphambi kokuthi ukwelashwa kuqale. Kufanele ngaso sonke isikhathi bahlole ubuwena futhi babuyekeze uhlelo lwakho lokwelashwa nawe.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Infliximab?

Uma uphuthelwa ukufakwa okuhleliwe, xhumana nomhlinzeki wakho wezempilo ngokushesha ngangokunokwenzeka ukuze uhlele kabusha. Ungazami ukwenza isinxephezelo somthamo ophuthelwe ngokuthola imithi eyengeziwe kamuva.

Udokotela wakho uzoqoka indlela engcono kakhulu yokukubuyisela emgqeni ngohlelo lwakho lokwelashwa. Lokhu kungasho ukulungisa isikhathi somthamo wakho olandelayo noma ukuhlola kabusha uhlelo lwakho lokwelashwa.

Q4. Ngingayeka nini ukuthatha i-Infliximab?

Isinqumo sokuyeka i-infliximab kufanele senziwe ngaso sonke isikhathi ngesiqondiso sikadokotela wakho. Abanye abantu bangase bakwazi ukuyeka ngemva kokufinyelela ekuxoleleni kwesikhathi eside, kanti abanye bangase badinge ukwelashwa okuqhubekayo.

Udokotela wakho uzoqwalasela izinto ezifana nokuthi isimo sakho silawulwa kahle kangakanani, ukuthi usunesikhathi esingakanani uzinzile, kanye nobungozi bakho bokuqubuka. Bangase banciphise kancane umthamo wakho noma banwebe isikhathi phakathi kokufakwa ngaphambi kokuyeka ngokuphelele.

Q5. Ngingakwazi yini ukuthola imigomo ngenkathi ngithatha i-Infliximab?

Imigomo eminingi iphephile ngenkathi kuthathwa i-infliximab, kodwa imigomo ebukhoma kufanele igwenywe. Udokotela wakho uzobuyekeza ukuthi yimiphi imigomo oyidingayo nokuthi uzoyithola nini.

Kuvame ukunconywa ukuthi ubuyekeze imigomo yakho ngaphambi kokuqala ukwelashwa nge-infliximab. Imigomo evamile efana nokugonywa komkhuhlane kanye nomgomo we-pneumonia ibaluleke kakhulu ngoba i-infliximab ingakhuphula ingozi yakho yokutheleleka.