Yini i-Ledipasvir kanye ne-Sofosbuvir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Ledipasvir kanye ne-sofosbuvir yimithi ehlanganisiwe elapha i-hepatitis C, ukutheleleka ngegciwane okuthinta isibindi sakho. Lo muthi kadokotela uqukethe imithi emibili enamandla yokulwa namagciwane esebenza ngokubambisana ukuvimbela igciwane le-hepatitis C ukuthi lingaphindaphindi emzimbeni wakho. Abantu abaningi abathatha lo muthi bangalindela ukwelashwa i-hepatitis C phakathi kwamasonto angu-8 kuya kwangu-24 okwelashwa.

Yini i-Ledipasvir kanye ne-Sofosbuvir?

I-Ledipasvir kanye ne-sofosbuvir yimithi eqondile yokulwa namagciwane (DAV) eqondiswe ngqo egciwaneni le-hepatitis C. Lo muthi uhlanganisa imithi emibili ehlukene yokulwa namagciwane ibe ithebhulethi eyodwa, okwenza ukwelashwa kube lula futhi kuphumelele. Le nhlanganisela ingeyigaba lemithi ebizwa ngokuthi ama-NS5A inhibitors kanye nama-nucleotide polymerase inhibitors.

Lo muthi uza njengamaphilisi omlomo owathatha kanye ngosuku. Yenzelwe ukuhlasela igciwane le-hepatitis C ezigabeni ezihlukene zomjikelezo walo wokuphila, okwenza kube nzima kakhulu ukuthi igciwane likwazi ukumelana. Le ndlela ephindwe kabili ishintshe kakhulu ukwelashwa kwe-hepatitis C, inikeza amazinga okuphulukisa angaphezu kuka-95% ezigulini eziningi.

Isetshenziselwani i-Ledipasvir kanye ne-Sofosbuvir?

Lo muthi welapha ukutheleleka okungamahlalakhona ngegciwane le-hepatitis C (HCV) kubantu abadala kanye nezingane ezineminyaka emi-3 nangaphezulu. I-Hepatitis C yigciwane elitholakala egazini elibangela ukuvuvukala nokulimala esibindini sakho ngokuhamba kwesikhathi. Ngaphandle kokwelashwa, i-hepatitis C engamahlalakhona ingaholela ezinkingeni ezinkulu zesibindi ezihlanganisa i-cirrhosis, ukwehluleka kwesibindi, nomdlavuza wesibindi.

Lo muthi usebenza ngokumelene nezinhlobo eziningana (ama-genotypes) ehlukene egegciwane le-hepatitis C. Udokotela wakho uzoqaphela ukuthi yiluphi uhlobo olunalolo ngegazi, njengoba lokhu kusiza ukunquma indlela engcono yokwelapha wena. Ngokuvamile, ilapha i-genotype 1 hepatitis C, okuyiluphi uhlobo oluvame kakhulu olutholakala e-United States.

Ngesinye isikhathi udokotela wakho angase akunikeze lo muthi kanye ne-ribavirin, omunye umuthi olwa namagciwane. Le ndlela yokuhlanganisa ivame ukusetshenziselwa abantu abanezifo zesibindi eziqhubukayo noma labo abaye bazama ezinye izindlela zokwelapha i-hepatitis C ngaphambili.

Isebenza Kanjani I-Ledipasvir ne-Sofosbuvir?

Lo muthi uthathwa njengendlela eqinile nesebenza kahle kakhulu yokwelapha i-hepatitis C. Lezi zinto ezimbili zisebenza njengeqembu elinamandla lokuvimbela igciwane ukuthi lingazali emzimbeni wakho. I-Ledipasvir ivimba iphrotheni ebizwa nge-NS5A edingwa yigciwane le-hepatitis C ukuze liphindaphindeke, kanti i-sofosbuvir iphazamisa ikhono legciwane lokukopisha izinto zalo zofuzo.

Cabanga ngayo njengokubeka izingidi ezimbili ezihlukene emnyango. Igciwane le-hepatitis C lidinga zombili izihluthulelo ukuze liqhubeke nokuzala, kodwa lo muthi ususa zombili izihluthulelo ngesikhathi esisodwa. Lesi senzo esiphindwe kabili senza kube nzima kakhulu ukuthi igciwane lisinde futhi liphindaphindeke ohlelweni lwakho.

Umuthi usebenza ngokuqondile egciwaneni ngokwalo, kunokuba umane ukhulise amasosha akho omzimba. Le ndlela eqondiwe isho imiphumela emibi embalwa uma iqhathaniswa nezindlela zokwelapha i-hepatitis C ezindala, kuyilapho isebenza kahle kakhulu ekuqothuleni igciwane ngokuphelele.

Kufanele Ngiyithathe Kanjani I-Ledipasvir ne-Sofosbuvir?

Thatha lo muthi ngendlela enconwa ngayo udokotela wakho, ngokuvamile ithebhulethi eyodwa kanye ngosuku. Ungayithatha ngaphandle kokudla noma ngaphandle kokudla, kodwa zama ukuyithatha ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho. Gwinya ithebhulethi yonke ngamanzi futhi ungayichobozi, uyihlephule, noma uyihlafune.

Akudingeki ukuthi ugweme noma yikuphi ukudla okuthile ngenkathi uthatha lo muthi. Kodwa-ke, kubalulekile ukuqhubeka nokuthatha zonke izithako zakho ngisho noma uqala ukuzizwa ungcono. Ukweqa izithako noma ukuyeka ngaphambi kwesikhathi kungavumela igciwane ukuthi libuye futhi libe nokuqina emuthini.

Uma uthatha ama-antacid aqukethe i-aluminium noma i-magnesium, wahlukanise kumthamo wakho we-ledipasvir ne-sofosbuvir okungenani ngamahora angu-4. Lokhu kungaphazamisa ukuthi umzimba wakho umunca kahle kangakanani umuthi. Udokotela wakho noma usokhemisi angakusiza ukuthi uhlele ezinye izidakamizwa ngendlela efanele.

Kufanele Ngithathe Isikhathi Esingakanani I-Ledipasvir ne-Sofosbuvir?

Abantu abaningi bathatha lo muthi amasonto angu-8 kuya kwangu-24, kuye ngezinto eziningana udokotela wakho azohlola. Ubude obuqondile buxhomeke ohlotsheni lwakho lwe-hepatitis C, ukuthi ngabe wake wathola ukwelashwa ngaphambilini, nokuthi unomonakalo omkhulu kangakanani esibindini. Udokotela wakho uzokwenza uhlelo lokwelashwa olwenzelwe ngqo isimo sakho.

Abantu abane-genotype 1 hepatitis C futhi abangazange bathole ukwelashwa ngaphambilini bavame ukuthatha umuthi amasonto angu-12. Labo abanesifo sesibindi esithuthuke kakhulu noma ukwehluleka kokwelashwa kwangaphambilini bangase badinge amasonto angu-24. Abanye abantu abanesifo esingathuthukanga kangako bangase badinge amasonto angu-8 kuphela okwelashwa.

Udokotela wakho uzoqapha inqubekela phambili yakho ngezivivinyo zegazi ezivamile ngesikhathi sokwelashwa. Lezi zivivinyo zihlola amazinga akho e-virus nomsebenzi wesibindi ukuze kuqinisekiswe ukuthi umuthi usebenza kahle. Kubalulekile ukuqeda inkambo ephelele yokwelashwa, ngisho noma uzizwa kahle ngokuphelele, ukuze kuqinisekiswe ukuthi igciwane liqedwe ngokuphelele.

Yiziphi Imiphumela Eceleni Ye-Ledipasvir ne-Sofosbuvir?

Abantu abaningi bawuthatha kahle lo muthi, nemiphumela emibi ngokuvamile iba mnene futhi ilawuleka. Imiphumela emibi evame kakhulu ithinta cishe u-10-20% wabantu abathatha umuthi. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiswe futhi uqiniseke ngesikhathi sokwelashwa.

Nawa amanye imiphumela emibi ebikwa njalo ongase uyithole:

• Ukukhathala nokuzizwa ukhathele kalula kunokujwayelekile
• Ikhanda elingase livele futhi lihambe usuku lonke
• Isicanucanu noma isisu esincane
• Ubunzima bokulala noma izinguquko emaphethini okulala
• Ukucasuka okuncane noma izinguquko zemizwa

Lezi zimo ezingajwayelekile zivame ukuthuthuka njengoba umzimba wakho ujwayela imithi futhi zivame ukunyama ngokuphelele ngemva kokuqeda ukwelashwa.

Imiphumela engavamile kodwa ebucayi idinga ukunakekelwa kwezempilo ngokushesha. Nakuba kungavamile, kubalulekile ukuqaphela uma kufanele uxhumane nomhlinzeki wakho wezempilo ngokushesha:

• Ukukhathala okukhulu okuphazamisa imisebenzi yansuku zonke
• Ubuhlungu obungavamile bemisipha noma ubuthakathaka
• Ukuphuzi kwesikhumba noma amehlo (i-jaundice)
• Umchamo omnyama noma izitulo eziphuthukile
• Ubuhlungu obukhulu besisu noma isicanucanu esiqhubekayo
• Izimpawu zokucindezeleka noma imicabango yokuzilimaza

Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezinzima, xhumana nodokotela wakho ngokushesha. Bangasiza ekutholeni ukuthi ngabe izimpawu zihlobene yini nemithi futhi balungise ukwelashwa kwakho uma kudingeka.

Ubani Ongafanele Athathe i-Ledipasvir ne-Sofosbuvir?

Le mithi ayifanele wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zingenza kungaphephile kuwe. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha kanye nesimo sakho sempilo yamanje ngaphambi kokukuyala le mithi. Ukuvuleka mayelana nezimo zakho zempilo kusiza ekuqinisekiseni ukuthi uthola ukunakekelwa okuphephe kakhulu nokusebenzayo.

Akufanele uthathe le mithi uma unezimo ezithile zezokwelapha noma uthatha imithi ethile:

• Isifo esibi sezinso noma uma use-dialysis
• Isifo esibi sesibindi ngaphandle kwalokho okubangelwe yi-hepatitis C
• Ukungezwani ne-ledipasvir, i-sofosbuvir, noma yiziphi izithako eziqukethwe ithebhulethi
• Njengamanje uthatha imithi ethile yenhliziyo efana ne-amiodarone
• Uthatha imithi ethile yokulwa nokuvuvukala noma ama-HIV protease inhibitors

Ukuqapha okukhethekile kuyadingeka uma unezimo ezithile ezidinga ukuqapha eduze ngesikhathi sokwelashwa:

• Izinkinga zenhliziyo noma ukushaya kwenhliziyo okungajwayelekile
• Isifo sezinso noma ukusebenza kwezinso okunciphile
• Umlando wokutheleleka nge-hepatitis B
• Ukucindezeleka noma izimo zempilo yengqondo
• Ukukhulelwa noma ukuhlela ukukhulelwa

Udokotela wakho uzoqondanisa izinzuzo nezingozi ezingase zibe khona esimweni sakho esithile. Bangase bancomise ukuqapha okwengeziwe noma balungise uhlelo lwakho lokwelapha ukuze baqinisekise ukuphepha kwakho kuyo yonke inqubo.

Amagama Omkhiqizo we-Ledipasvir kanye ne-Sofosbuvir

Igama elivamile lomkhiqizo lalesi sithako esihlanganisiwe yi-Harvoni. I-Harvoni iqukethe kokubili i-ledipasvir kanye ne-sofosbuvir kuthebhulethi eyodwa, okwenza kube lula ukuthatha iphilisi elilodwa kuphela nsuku zonke. Lo mkhiqizo ukhiqizwa yi-Gilead Sciences futhi utholakala kabanzi emakhemisi.

Izinhlobo ze-generic zalolu hlobo oluhlanganisiwe zingase zitholakale ngokuhamba kwesikhathi, kodwa okwamanje, i-Harvoni isahlala iyona brand version eyinhloko. Umshuwalense wakho ungase ube nezintandokazi zemikhiqizo ethile noma izinhlobo ze-generic, ngakho-ke kufanelekile ukuxoxa ngezinketho zokumboza nodokotela wakho kanye nosokhemisi.

Ezinye izindlela ze-Ledipasvir kanye ne-Sofosbuvir

Ezinye izindlela zokwelapha i-hepatitis C ezisebenzayo ziyatholakala uma lo muthi ungalungile kuwe. Ukwelashwa kwesimanje kwe-hepatitis C kunezinketho eziningi ezinhle, ngakho wena nodokotela wakho ningathola indlela esebenza kahle esimweni sakho esithile. Enye nanye indlela enye inezinzuzo zayo kanye nokucatshangelwa kwayo.

Ezinye izinhlanganisela eziqondile zokulwa namagciwane udokotela wakho angase azicabange zihlanganisa:

• I-Sofosbuvir kanye ne-velpatasvir (Epclusa) - isebenza ngokumelene nazo zonke izinhlobo ze-hepatitis C
• I-Glecaprevir kanye ne-pibrentasvir (Mavyret) - isikhathi sokwelashwa esifushane kwabanye iziguli
• I-Elbasvir kanye ne-grazoprevir (Zepatier) - inketho enhle yezinhlobo ezithile
• I-Sofosbuvir yodwa ihlanganiswe neminye imithi

Udktela wakho uzobheka izinto ezifana nohlobo lwakho lwe-hepatitis C, ukusebenza kwezinso, eminye imithi oyithathayo, kanye nomlando wokwelashwa kwangaphambilini lapho ekhetha elinye elingcono kakhulu. Zonke lezi zindlela zokwelapha zesimanje zinamazinga aphezulu okuphulukisa futhi zibekezeleleka kakhulu kunezindlela zokwelapha ze-hepatitis C ezindala.

Ingabe i-Ledipasvir ne-Sofosbuvir Ingcono Kunezinye Izindlela Zokwelapha I-Hepatitis C?

Lo muthi uthathwa njengenye yezindlela zokwelapha i-hepatitis C eziphumelela kakhulu ezitholakalayo, ngamazinga okuphulukisa adlula ama-95% kwiziguli eziningi. Uma kuqhathaniswa nezindlela zokwelapha ezindala ezazisebenzisa imijovo ye-interferon, lo muthi omlomo unikeza ukubekezeleleka okungcono kakhulu nokulula. Indlela yokuhlanganisa yenza iphumelele kakhulu ngenkathi kulula kakhulu ukuyithatha.

Uma iqhathaniswa nezinye izindlela zokwelapha i-hepatitis C zesimanje, lo muthi usebenza kahle ngendlela efanayo mayelana nokusebenza. Umehluko omkhulu phakathi kwezindlela zokwelapha zamanje uvame ukwehla esikhathini sokwelashwa, amaphrofayili emiphumela emibi, nokuthi yiziphi izinhlobo ze-hepatitis C ezisebenza kangcono kuzo. Udktela wakho angakusiza ukuthi uqonde ukuthi iyiphi inketho engasebenza kangcono esimweni sakho esithile.

Amandla omuthi alele emlandweni wawo oqinisekisiwe kanye nolwazi olubanzi lomtholampilo. Kwakungenye yezindlela zokwelapha zokuqala eziphumelela kakhulu, ezibekezeleleka kahle ngomlomo ze-hepatitis C, futhi odokotela baneminyaka yokuhlangenwe nakho beziqhubela ngempumelelo. Lokhu okuhlangenwe nakho okubanzi kusho ukuthi ithimba lakho lezempilo lazi kahle ukuthi yini okufanele ilindele nokuthi ingazisingatha kanjani izinkinga ezingase zivele.

Imibuzo Evame Ukubuzwa Mayelana ne-Ledipasvir ne-Sofosbuvir

Ingabe i-Ledipasvir ne-Sofosbuvir Iphephile Kubantu Abanezifo Zezinso?

Lo muthi ungasetshenziswa ngokuphepha kubantu abanezifo ezinzima eziya ngokuya ziba nzima ezinso, kodwa kudinga ukuqapha ngokucophelela. Udokotela wakho uzohlola ukusebenza kwezinso zakho ngaphambi kokuqala ukwelashwa futhi angase alungise umthamo noma uhlelo lokuqapha ngokusekelwe ekutheni izinso zakho zisebenza kahle kangakanani. Kubantu abanezifo ezinzima ezinso noma labo abenza i-dialysis, lo muthi ngokuvamile awunconyelwe.

Uma unesifo sezinso nganoma yiliphi izinga, qiniseka ukuthi udokotela wakho uyazi ngakho ngaphambi kokuqala ukwelashwa. Bangase bafune ukwenza ezinye izivivinyo zegazi ukuqapha ukusebenza kwezinso zakho ngesikhathi sokwelashwa futhi baqinisekise ukuthi umuthi awubangeli zinkinga.

Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Ledipasvir ne-Sofosbuvir Eningi Kakhulu?

Uma ngengozi uthatha ngaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukuthi izimpawu zivele, njengoba ukuthola iseluleko sezokwelapha ngokushesha kubalulekile. Thatha ibhodlela lomuthi nawe uma udinga ukuya egumbini eliphuthumayo ukuze abahlinzeki bezempilo bazi kahle ukuthi uthathe ini nokuthi uthathe okungakanani.

Ngenkathi kungekho umuthi oqondile wokweqisa umthamo, abahlinzeki bezempilo bangakuqapha nganoma yimaphi imiphumela emibi futhi banikeze ukunakekelwa okusekelayo uma kudingeka. Into ebaluleke kakhulu ukuthola ukunakekelwa kwezokwelapha ngokushesha kunokuzama ukuphatha isimo wedwa.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Ledipasvir ne-Sofosbuvir?

Uma uphuthelwa umthamo futhi sekudlule amahora angaphansi kwama-18 kusukela ngesikhathi sakho esijwayelekile sokuthatha umuthi, thatha umthamo owuphuthelwe ngokushesha lapho ukhumbula. Uma sekudlule amahora angaphezu kwama-18, weqa umthamo owuphuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuphuthelwe.

Zama ukusetha izikhumbuzi zokukusiza ukuthi ukhumbule umthamo wakho wansuku zonke, njengama-alamu ocingo noma izihleli zamaphilisi. Ukuphuthelwa imithamo kunganciphisa ukusebenza kokwelashwa futhi kungenzeka kuvumele igciwane ukuthi likhule ukumelana nomuthi.

Ngingayeka nini Ukuthatha i-Ledipasvir ne-Sofosbuvir?

Misa kuphela ukuthatha lo muthi uma udokotela wakho ekutshela ukuthi wenze njalo, ngokuvamile ngemva kokuqeda inkambo ephelele yokwelashwa. Ngisho noma uzizwa kahle ngokuphelele futhi izimpawu zakho zithuthukile, kubalulekile ukuqeda yonke inkambo yokwelashwa ukuqinisekisa ukuthi igciwane liqedwe ngokuphelele emzimbeni wakho.

Udokotela wakho uzokwenza izivivinyo zegazi ngemva kokuqeda ukwelashwa ukuqinisekisa ukuthi igciwane le-hepatitis C alisakwazi ukutholakala egazini lakho. Uma igciwane lisakhona, ungase udinge ukwelashwa okwengeziwe noma indlela ehlukile yemithi.

Ngingakwazi yini Ukuphuza Utshwala Ngenkathi Ngithatha i-Ledipasvir ne-Sofosbuvir?

Kungcono ukugwema utshwala ngokuphelele ngenkathi uthatha lo muthi kanye nangezinyanga eziningana ngemva kokwelashwa. Utshwala bungase luqhubeke lonakalise isibindi esibangelwa yi-hepatitis C futhi lungase luphazamise ikhono lomzimba wakho lokwelapha. Njengoba isibindi sakho sesivele sibhekene nemiphumela ye-hepatitis C, ukwengeza utshwala kubeka ingcindezi eyengeziwe kulesi sitho esibalulekile.

Uma ukhathazeka ngokusebenzisa utshwala, khuluma nodokotela wakho mayelana nezinsiza zokusekela nezinketho zokwelashwa. Bangakusiza ukuthi uthuthukise uhlelo lokugwema utshwala ngesikhathi sokwelashwa futhi basekele ukululama kwakho konke kwempilo.