Yini i-Linagliptin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Linagliptin iyimithi kadokotela esiza ukulawula amazinga kashukela egazini kubantu abadala abanesifo sikashukela sohlobo 2. Ingaphansi kohlobo lwemithi ebizwa ngokuthi ama-DPP-4 inhibitors, asebenza ngokusiza umzimba wakho ukuthi ukhiqize i-insulin eyengeziwe lapho ushukela wakho wegazi uphezulu futhi kunciphisa inani likashukela isibindi sakho esikwenzayo.

Le mithi ivamise ukunqunywa lapho ukudla nokuzivivinya kuphela kunganele ukulawula isifo sakho sikashukela. Ungase uyazi kangcono ngegama layo lomkhiqizo, i-Tradjenta, futhi ivame ukusetshenziswa kanye neminye imithi yesifo sikashukela ukuhlinzeka ngokuqapha okungcono ushukela wegazi.

Yini i-Linagliptin Esetshenziselwa Yona?

I-Linagliptin isetshenziselwa ikakhulukazi ukwelapha isifo sikashukela sohlobo 2 kubantu abadala. Isiza ukwehlisa amazinga kashukela wakho egazini ngokusebenza ngohlelo lomzimba lwemvelo lokukhiqiza i-insulin.

Udokotela wakho angase anqume i-linagliptin lapho izinguquko zokuphila njengokudla nokuzivivinya zinganele ukugcina ushukela wakho wegazi ebangeni elinempilo. Ivamise ukusetshenziswa njengengxenye yohlelo olubanzi lokuphatha isifo sikashukela oluhlanganisa ukudla okunempilo, ukuzivivinya njalo, nokuqapha ushukela wegazi.

Ngezinye izikhathi, i-linagliptin ihlanganiswa neminye imithi yesifo sikashukela efana ne-metformin ukuhlinzeka ngokuqapha okungcono ushukela wegazi. Le ndlela yokuhlanganisa ingasebenza ngempumelelo kakhulu kunokusebenzisa umuthi owodwa kuphela.

Isebenza Kanjani i-Linagliptin?

I-Linagliptin isebenza ngokuvimba i-enzyme ebizwa ngokuthi i-DPP-4 emzimbeni wakho. Le enzyme ngokuvamile ichitha ama-hormone asiza ukulawula ushukela wegazi, ngakho-ke ngokuyivimba, i-linagliptin ivumela la ma-hormone awusizo ukuthi asebenze isikhathi eside.

Uma udla, umzimba wakho ngokwemvelo ukhipha ama-hormone abizwa ngokuthi ama-incretins atshela amanyikwe akho ukuthi enze i-insulin eyengeziwe nesibindi sakho ukuthi senze ushukela omncane. I-Linagliptin isiza la ma-hormone ukuthi ahlale esebenza isikhathi eside, okusho ukulawula okungcono ushukela wegazi ngemva kokudla.

Izindaba ezinhle ukuthi i-linagliptin ithathwa njengomuthi wesifo sikashukela onamandla aphakathi nendawo. Inobumnene kunezinye izinketho futhi ngokuvamile ibangela imiphumela emibi embalwa, okuyenza ibe yindlela enhle kubantu abaningi abanesifo sikashukela sohlobo 2.

Kufanele Ngiyithathe Kanjani I-Linagliptin?

Thatha i-linagliptin ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku. Ungayithatha nokudla noma ngaphandle kokudla, okwenza kube lula ukuyifaka emsebenzini wakho wansuku zonke.

Abantu abaningi bakuthola kuwusizo ukuthatha i-linagliptin ngesikhathi esifanayo nsuku zonke ukuze bagcine amazinga aqhubekayo emzimbeni wabo. Noma ngabe ukhetha ekuseni noma kusihlwa akubalulekile njengokuhlala uqhubeka ngesikhathi sakho.

Uma uthatha eminye imithi, i-linagliptin ngokuvamile idlala kahle kakhulu nayo. Kodwa-ke, ngaso sonke isikhathi tshela udokotela wakho ngayo yonke imithi nezithasiselo ozithathayo ukuze ugweme noma yikuphi ukusebenzisana okungenzeka.

Gwinya ithebhulethi yonke ngenkomishi yamanzi. Ungayichobozi, uhlafune, noma uhlukanise ithebhulethi ngaphandle uma udokotela wakho ekutshela ngqo ukuthi wenze kanjalo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Linagliptin?

I-Linagliptin ngokuvamile iyimithi yesikhathi eside oyoyithatha uma nje isiza ukulawula isifo sakho sikashukela ngempumelelo. Uhlobo 2 lwesifo sikashukela yisimo esingapheli esidinga ukuphathwa okuqhubekayo.

Udokotela wakho uzoqapha amazinga kashukela egazini lakho njalo ngemibandela efana ne-A1C ukuze abone ukuthi i-linagliptin ikusebenzela kahle kangakanani. Lokhu kuhlolwa kuvame ukwenzeka njalo ezinyangeni ezi-3 kuya kwezi-6, kuye ngokuthi isifo sakho sikashukela silawulwa kahle kangakanani.

Abanye abantu bangase badinge ukushintsha imithi noma bangeze ezinye ngokuhamba kwesikhathi njengoba isifo sabo sikashukela sishintsha. Lokhu kujwayelekile futhi akusho ukuthi umuthi uyekile ukusebenza, kumane nje ukuthi uhlelo lwakho lokwelapha ludinga ukulungiswa.

Ungayeki ukuthatha i-linagliptin ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka imithi yesifo sikashukela ngokuzumayo kungabangela ukuthi ushukela wakho wegazi ukhuphuke ufinyelele emazingeni ayingozi.

Yiziphi Imiphumela Emibi Ye-Linagliptin?

Abantu abaningi bayamukela kahle i-linagliptin, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathí sina ayivamile, futhi abantu abaningi ababi nemiphumela emibi nakancane.

Ake sibheke imiphumela emibi evame kakhulu ongase uyithole, sikhumbula ukuthi lezi zivame ukuba mnene futhi zivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Ikhala elivaliwe noma eligelezayo
• Umphimbo obuhlungu
• Ikhanda elibuhlungu
• Ubuhlungu bemisipha
• Ukuqunjelwa

Le miphumela emibi yansuku zonke ngokuvamile ayidingi ukunakekelwa kwezokwelapha ngaphandle uma iba yisicefe noma inganyamalali ngemva kwamasonto ambalwa okwelashwa.

Nakuba kungavamile, kunezinye imiphumela emibi engathí sina edinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu akwenzeki kubantu abaningi, kodwa kubalulekile ukwazi ukuthi yini okufanele uyibheke:

• Izimpawu ze-pancreatitis (ubuhlungu obukhulu besisu obungase buye emhlane wakho)
• Ukuphendula komzimba ngaphandle (ukuqubuka, ukuluma, ukuvuvukala, ubunzima bokuphefumula)
• Ubuhlungu obukhulu emalungeni
• Izimpawu zokuhluleka kwenhliziyo (ukukhathala okungavamile, ukuvuvukala emilenzeni noma ezinyaweni)

Uma uhlangabezana nanoma yiziphi lezi zimpawu ezingathí sina, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezimo eziphuthumayo.

Ubani Ongafanele Athathwe I-Linagliptin?

I-Linagliptin ayilungile kuwo wonke umuntu, futhi zikhona izimo ezithile lapho udokotela wakho cishe ezokuncoma omunye umuthi esikhundleni salokho.

Akufanele uthathe i-linagliptin uma unokungezwani nayo noma nganoma yiziphi izithako zayo. Abantu abanesifo sikashukela sohlobo 1 noma i-diabetic ketoacidosis kufanele futhi bagweme lo muthi, njengoba wenzelwe ngokuqondile uhlobo 2 lwesifo sikashukela.

Udokotela wakho uzoba nenhlonipho eyengeziwe mayelana nokunquma i-linagliptin uma unezimo ezithile zempilo ezingenza imiphumela emibi ibe maningi:

• Umlando we-pancreatitis
• Isifo sezinso
• Ukuhluleka kwenhliziyo
• Izinkinga ze-gallbladder
• Umlando wokuphendula komzimba okukhulu emithini efanayo

Ukukhulelwa nokuncelisa nazo zidinga ukucatshangelwa okukhethekile. Ngenkathi i-linagliptin ingakabonakali ilimaza ngesikhathi sokukhulelwa, odokotela abaningi bakhetha eminye imithi yesifo sikashukela eye yahlolwa kabanzi kwabesifazane abakhulelwe.

Amagama Omkhiqizo we-Linagliptin

I-Linagliptin ivame ukuthengiswa ngaphansi kwegama lomkhiqizo elithi Tradjenta. Le yinguqulo ongahlangana nayo kakhulu ekhemisi lakho.

Ungase futhi ubone imithi ehlanganisiwe ehlanganisa i-linagliptin kanye neminye imithi yesifo sikashukela. Lawa maphilisi ahlanganisiwe angaba lula uma udinga imithi eminingi ukuze ulawule ushukela wakho wegazi.

Ezinye izinhlobo ezivamile zokuhlanganisa zihlanganisa i-Jentadueto (i-linagliptin kanye ne-metformin) ne-Glyxambi (i-linagliptin kanye ne-empagliflozin). Lezi zinhlanganisela zingenza lula inqubo yakho yemithi ngokunciphisa inani lamaphilisi okudingeka uwathathe nsuku zonke.

Ezinye izindlela ze-Linagliptin

Uma i-linagliptin ingakulungele, kunezinye izindlela eziningi zemithi yesifo sikashukela udokotela wakho angazicabangela. Ngayinye inezinzuzo zayo kanye nokubi okungenzeka.

Ezinye izithiyo ze-DPP-4 zisebenza ngendlela efanayo ne-linagliptin futhi zingaba ezinye izindlela ezinhle uma uthanda indlela le kilasi lemithi esebenza ngayo kodwa udinga enye indlela. Lokhu kuhlanganisa i-sitagliptin (Januvia) ne-saxagliptin (Onglyza).

Kubantu abadinga ukulawulwa okunamandla koshukela wegazi, udokotela wakho angase aphonse ezinye izinhlobo zemithi:

• I-Metformin - ngokuvamile iyindlela yokuqala yesifo sikashukela sohlobo 2
• Izithiyo ze-SGLT2 - zisiza izinso zakho ukususa ushukela ngomchamo
• Ama-GLP-1 receptor agonists - imithi ejovwayo esiza nokunciphisa isisindo
• I-Insulin - yabantu abadinga ukulawulwa okujulile koshukela wegazi

Enye indlela engcono kakhulu incike esimweni sakho sempilo esithile, eminye imithi oyithathayo, kanye nemigomo yakho yokwelashwa.

Ingabe i-Linagliptin ingcono kune-Metformin?

I-Linagliptin kanye ne-metformin zisebenza ngendlela ehlukile futhi zivame ukusetshenziswa ndawonye kunokuba zibe izinketho eziqhudelanayo. I-Metformin ngokuvamile iyikhambi lokuqala odokotela abalibhala ngoba lesifo sikashukela sohlobo 2 ngoba selisetshenziswe ngokuphepha amashumi eminyaka.

I-Metformin ivame ukusebenza kahle ekwehliseni amazinga kashukela egazini futhi ingasiza ekuphathweni kwesisindo. Kodwa-ke, ingabangela ukuphazamiseka kwesisu futhi ayifanele abantu abanezinkinga ezithile zezinso.

I-Linagliptin, ngakolunye uhlangothi, inobungane esiswini futhi ingasetshenziswa ngokuphepha kubantu abanezifo ezinso eziphakathi nendawo. Ivame ukungezwa ku-metformin lapho i-metformin yodwa inganikezi ukulawulwa okwanele kukashukela egazini.

Abantu abaningi empeleni bathatha womabili amakhambi ndawonye, ​​njengoba egcwalisana kahle. Udokotela wakho uzosiza ekunqumeni indlela engcono kakhulu esekelwe ezidingweni zakho zempilo kanye nokuthi ukubekezelela kahle kangakanani ikhambi ngalinye.

Imibuzo Evame Ukubuzwa Mayelana ne-Linagliptin

Ingabe i-Linagliptin iphephile kubantu abanezifo zezinso?

Yebo, i-linagliptin ngokuvamile iphephile kubantu abanezifo zezinso, okuhlanganisa nalabo abanezinkinga ezinzima zezinso. Ngokungafani neminye imithi yesifo sikashukela, i-linagliptin ayidingi ukulungiswa kwemithamo ngokuya ngomsebenzi wezinso.

Lokhu kwenza i-linagliptin ibe yindlela enhle kubantu abanezifo zezinso ezikhawulela izinketho zabo zemithi. Kodwa-ke, udokotela wakho usazofuna ukuqapha umsebenzi wakho wezinso njalo, njengoba isifo sikashukela ngokwaso singathinta impilo yezinso ngokuhamba kwesikhathi.

Ngingenzani uma ngiphuthelwa ngithatha i-Linagliptin eningi kakhulu?

Uma ngengozi uthatha i-linagliptin eningi kunaleyo ebekiwe, ungangeni ekuvaleni. Ukweqisa kwe-Linagliptin akuvamile futhi ngokuvamile akubangeli izimpawu ezisongela impilo.

Xhumana nodokotela wakho noma usokhemisi ukuze uthole isiqondiso, ikakhulukazi uma uthathe ngaphezu kwemithamo yakho ejwayelekile. Bangakunikeza iseluleko sokuthi yini okufanele uyibheke nokuthi ngabe udinga ukunakekelwa kwezempilo yini. Ezimweni eziningi, bazokutshela ukuthi weqe umthamo wakho olandelayo bese ubuyela esimisweni sakho esijwayelekile.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Linagliptin?

Uma uphuthelwa umthamo we-linagliptin, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kuleso simo, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngasikhathi sinye ukuze ulungise umthamo ophuthelwe. Lokhu kungandisa ingozi yakho yemiphumela engemihle ngaphandle kokuhlinzeka ngokuqapha ushukela wegazi okungcono. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Ngingayeka nini ukuthatha i-Linagliptin?

Kufanele uyeke kuphela ukuthatha i-linagliptin ngaphansi kwesiqondiso sikadokotela wakho. Njengoba isifo sikashukela sohlobo 2 siyisimo esingamahlalakhona, abantu abaningi badinga ukuqhubeka nokuthatha imithi yesifo sikashukela isikhathi eside ukuze bagcine ukulawulwa okuhle kukashukela egazini.

Udokotela wakho angase acabange ukuyeka noma ukushintsha imithi yakho uma wenze izinguquko ezinkulu zokuphila eziye zathuthukisa ukulawulwa kukashukela egazini lakho, noma uma uhlangabezana nemiphumela engemihle edlula izinzuzo. Njalo xoxa nganoma yikuphi ukukhathazeka mayelana nemithi yakho nomhlinzeki wakho wezempilo kunokuyeka ngokwakho.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Linagliptin?

Ukuphuza utshwala ngokulinganisela kuvamile ukuthi kulungile ngenkathi kuthathwa i-linagliptin, kodwa kubalulekile ukuqapha. Utshwala bungathinta amazinga kashukela egazini futhi bungandisa ingozi kashukela ophansi, ikakhulukazi uma uthatha eminye imithi yesifo sikashukela.

Uma ukhetha ukuphuza, kwenze ngokulinganisela futhi njalo ngemva kokudla. Qaphela ushukela wakho wegazi eduze uma uphuza utshwala, futhi uqaphele izimpawu zikashukela ophansi. Xhumana nodokotela wakho mayelana nokusetshenziswa kotshwala ukuze uqinisekise ukuthi kungena ngokuphepha ohlelweni lwakho lokulawula isifo sikashukela.