Yini i-Lofexidine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Lofexidine iyimithi kadokotela esiza abantu abadlula ekuhoxisweni kwe-opioid ngokunciphisa izimpawu ezingakhululeki. Isebenza ngokuthulisa uhlelo lwakho lwezinzwa ngalesi sikhathi esinzima, okwenza inqubo ibe lula futhi ingabi nkulu kakhulu.

Le mithi imelela isinyathelo esibalulekile phambili ekwelashweni kokulutheka. Ngokungafani nezinye izindlela, i-lofexidine iqondise ngqo ukungakhululeki komzimba wokuhoxiswa ngaphandle kokuba yi-opioid ngokwayo.

Yini i-Lofexidine?

I-Lofexidine iyimithi engeyona i-opioid engaphansi kwesigaba semithi ebizwa ngokuthi i-alpha-2 adrenergic agonists. Cabanga ngayo njengebhegi elithambile lohlelo lwakho lwezinzwa olusebenza ngokweqile ngesikhathi sokuhoxiswa kwe-opioid.

Uma uyeka ukusebenzisa ama-opioid, umzimba wakho uqala ukuzama ukuzivumelanisa. I-Lofexidine isiza ukunciphisa le mpendulo enamandla ngokusebenza kuma-receptors athile ebuchosheni bakho kanye nohlelo lwezinzwa. Lokhu kudala umphumela wokuthulisa okwenza izimpawu zokuhoxiswa zikwazi ukuthwaleka kakhulu.

Lo muthi uza ngamaphilisi omlomo futhi ungumuthi wokuqala ovunyelwe yi-FDA, ongeyona i-opioid owenzelwe ngqo izimpawu zokuhoxiswa kwe-opioid. Lokhu kusho ukuthi ihlolwe ngokucophelela futhi yafakazelwa ukuthi iphephile futhi iyasebenza ngale njongo ethile.

Isetshenziselwani i-Lofexidine?

I-Lofexidine isetshenziswa ikakhulukazi ukusiza ukuphatha izimpawu zomzimba zokuhoxiswa kwe-opioid kubantu abadala. Yenzelwe ukwenza inqubo ye-detox ibe ntofontofo futhi ikhulise amathuba akho okuphothula ngempumelelo ukuhoxiswa.

Lo muthi usebenza kahle kakhulu njengengxenye yohlelo lokwelashwa olubanzi. Ngenkathi ibhekana nokungakhululeki komzimba, cishe uzodinga ukwesekwa okwengeziwe kwezici ezingokomzwelo nezingokwengqondo zokululama. Ithimba lakho lokunakekelwa kwezempilo lingahlanganisa i-lofexidine nokwelulekwa, amaqembu okusekela, noma eminye imithi.

Abanye odokotela bangase futhi banikeze i-lofexidine kwezinye izimo ezihilela izimpendulo ezingaphezu kwamandla zesimiso sezinzwa, nakuba lokhu kungavamile. Njalo landela imiyalelo ethile kadokotela wakho mayelana nokuthi kungani ekunikeza yona.

Isebenza Kanjani I-Lofexidine?

I-Lofexidine isebenza ngokugxila kuma-alpha-2 receptors ebuchosheni bakho nasohlelweni lwakho lwezinzwa. Uma la ma-receptors esebenza, asiza ukunciphisa ukukhululwa kwe-norepinephrine, ikhemikhali ebangela izimpawu eziningi zokuhoxiswa.

Ngesikhathi sokuhoxiswa kwe-opioid, umzimba wakho ukhiqiza i-norepinephrine eningi kakhulu, okuholela ezimpawini ezinjengokukhathazeka, ukujuluka, ukushaya kwenhliziyo okusheshayo, nobuhlungu bemisipha. I-Lofexidine isiza ukubuyisela ibhalansi ngokunciphisa lokhu kukhiqizwa ngokweqile, idale umphumela ozolile emzimbeni wakho wonke.

Lo muthi uthathwa njengomuthi oqinile ngokulinganisela wokuphatha ukuhoxiswa. Unamandla ngokwanele ukuhlinzeka ngokuqeda okukhulu kodwa uthambile ngokwanele ukugwema ukubangela ukuthula okukhulu noma eminye imiphumela emibi kubantu abaningi. Imiphumela ngokuvamile iqala kungakapheli amahora ambalwa ngemva kokuthatha umthamo wakho wokuqala.

Kufanele Ngiyithathe Kanjani I-Lofexidine?

Thatha i-lofexidine ngendlela eqondile udokotela wakho ayiyalayo, ngokuvamile kathathu ngosuku ngaphandle noma ngaphandle kokudla. Ungayithatha ngamanzi, futhi asikho isidingo sokugwema ubisi noma ezinye iziphuzo ngaphandle uma udokotela wakho ekweluleka ngokuqondile ngenye indlela.

Udokotela wakho cishe uzoqala ngomthamo ophansi futhi awunyuse kancane kancane ngokusekelwe endleleni ozosabela ngayo. Le ndlela eqaphelayo isiza ukunciphisa imiphumela emibi ngenkathi iqinisekisa ukuthi uthola ukukhululeka okudingayo. Abantu abaningi baqala ngo-0.18 mg kathathu ngosuku, nakuba umthamo wakho ungase uhluke.

Ukuthatha i-lofexidine ngezikhathi ezifanayo usuku lonke kusiza ukugcina amazinga aqhubekayo emzimbeni wakho. Abantu abaningi bakuthola kuwusizo ukuthatha imithamo ngokudla ukuze bayikhumbule kalula. Uma unenkinga yokugwinya amaphilisi, ungaqoba futhi uhlanganise nokudla okuthambile njenge-applesauce.

Akudingeki ukuthi udle ukudla okuthile ngaphambi kokuthatha i-lofexidine, kodwa ukuba nokuthile okulula esiswini kungasiza ekuvimbeleni isicanucanu esincane. Gwema utshwala ngenkathi uthatha lo muthi, njengoba ungaqhubukisa ukozela neminye imiphumela emibi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Lofexidine?

Abantu abaningi bathatha i-lofexidine cishe izinsuku eziyi-14, nakuba udokotela wakho engase alungise lesi sikhathi ngokuya ngesimo sakho esithile. Isikhathi esivamile sokwelashwa sihlanganisa isigaba esinamandla kakhulu sezimpawu zokuhoxiswa kwe-opioid.

Udokotela wakho uzokwenza isimiso esinciphisa kancane kancane umthamo wakho ngesikhathi sokwelashwa. Le ndlela yokunciphisa isiza ekuvikeleni umzimba wakho ukuthi ungaqhubuki ukuncika ku-lofexidine ngenkathi uqinisekisa ukuthi ugcina ukukhululeka kwezimpawu kuyo yonke inkathi ebalulekile yokuhoxiswa.

Abanye abantu bangase badinge inkambo emfushane yezinsuku eziyi-7-10, kanti abanye bangazuza ekwelashweni okude kancane. Ithimba lakho lezempilo lizogada inqubekela phambili yakho futhi lilungise ubude ngokuya ngendlela ozabela ngayo nokuthi yiziphi ezinye izindlela zokwelapha ozitholayo.

Ungayeki ukuthatha i-lofexidine ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka kungazelelwe kungabangela ukuthi umfutho wegazi lakho ukhuphuke, okungaba yingozi. Udokotela wakho uzohlinzeka ngemiyalelo ethile yokuyeka ngendlela ephephile umuthi.

Yiziphi Imiphumela Emibi Ye-Lofexidine?

Njengayo yonke imithi, i-lofexidine ingabangela imiphumela emibi, nakuba kungabona bonke abantu abayitholayo. Imiphumela eminingi emibi imnene futhi yesikhashana, kodwa kubalulekile ukwazi ukuthi yini okufanele uyibheke.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa ukozela, isiyezi, umlomo owomile, nomfutho wegazi ophansi. Le miphumela ivamise ukulawuleka futhi ithambekele ekuthuthukiseni njengoba umzimba wakho ujwayela umuthi.

Imiphumela Ejwayelekile Emibi

Le miphumela emibi yenzeka kubantu abaningi abathatha i-lofexidine, kodwa ngokuvamile imnene futhi ayidingi ukuyeka umuthi:

• Ukozela noma ukukhathala
• Isiyezi, ikakhulukazi uma usukuma
• Umlomo owomile
• Umfutho wegazi ophansi
• Ukushaya kwenhliziyo okuhamba kancane
• Ukukhathala
• Isicanucanu
• Ubunzima bokulala

Le miphumela ivame ukuba yesikhashana futhi ingancipha njengoba umzimba wakho ujwayela umuthi. Ukuhlala unamanzi futhi uhamba kancane lapho ushintsha izikhundla kungasiza ekuphatheni isiyezi nomfutho wegazi ophansi.

Imiphumela engavamile

Abanye abantu bangase babe nemiphumela emibi engavamile, okufanele ibikwe kudokotela wakho:

• Ukuqunjelwa
• Ubuthakathaka noma ukuntula amandla
• Ukukhathazeka noma ukwesaba
• Ubuhlungu bemisipha noma amajaqamba
• Ukuphendula kwesikhumba noma ukuqubuka
• Ushintsho ekudleni
• Ushintsho lwemizwa

Ngenkathi le miphumela emibi ingavamile, ingase ithinte impilo yakho yansuku zonke. Udokotela wakho angakusiza ekuphatheni lezi zimpawu noma alungise ukwelashwa kwakho uma kudingeka.

Imiphumela emibi engathi sína

Imiphumela emibi engavamile kodwa engathi sína idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nodokotela wakho noma funa ukunakekelwa okuphuthumayo uma uhlangabezana:

• Ukwehla okukhulu komfutho wegazi ngokuquleka
• Ukushaya kwenhliziyo okuhamba kancane kakhulu noma okungajwayelekile
• Ubunzima bokuphefumula
• Ukuphendula okukhulu komzimba okungalungile nokuvuvukala noma ukuqubuka
• Ubuhlungu besifuba noma izinguquko zesigqi senhliziyo
• Isiyezi esikhulu esingathuthuki

Le miphumela emibi engathi sína ayivamile kodwa ingaba yingozi uma yenzeka. Ithimba lakho lezempilo lizokuqapha ngokucophelela, ikakhulukazi lapho uqala ukwelashwa, ukuze ubambe noma yiziphi izinguquko ezikhathazayo ekuqaleni.

Ubani okungafanele athathe i-Lofexidine?

I-Lofexidine ayiphephile kuwo wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile nemithi kungenza i-lofexidine ibe yingozi noma ingasebenzi.

Abantu abanezimo ezithile zenhliziyo, umfutho wegazi ophansi kakhulu, noma labo abathatha imithi ethile bangase badinge ukugwema i-lofexidine noma bayisebenzise ngokuqapha okwengeziwe. Udokotela wakho uzoqaphela izinzuzo uma ziqhathaniswa nezingozi ezingase zibe khona esimweni sakho esithile.

Uma unanoma yiziphi zalezi zimo, qiniseka ukuthi uxoxa ngazo nodokotela wakho ngaphambi kokuqala i-lofexidine:

• Ukuphazamiseka kwesigqi senhliziyo noma isifo senhliziyo
• Umfutho wegazi ophansi kakhulu (hypotension)
• Isifo esibi sezinso noma sesibindi
• Umlando wokuquleka noma izigameko zokugajwa
• Ukuthatha imithi yomfutho wegazi
• Ukusebenzisa eminye imithi ethinta isigqi senhliziyo
• Ukukhulelwa noma ukuncelisa
• Ukungezwani ne-lofexidine noma imithi efanayo

Udokotela wakho angase akwazi ukukuyala i-lofexidine uma unezinye zalezi zimo, kodwa bazokuqapha ngokucophelela futhi mhlawumbe balungise umthamo wakho. Ukwethembeka ngomlando wakho wezokwelapha ophelele kusiza ekuqinisekiseni ukuphepha kwakho.

Igama Lomkhiqizo we-Lofexidine

I-Lofexidine itholakala ngaphansi kwegama lomkhiqizo elithi Lucemyra e-United States. Lena inguqulo evunywe yi-FDA eyenzelwe ngqo ukuphathwa kokuhoxiswa kwe-opioid.

Amaphilisi e-Lucemyra eza ngamandla athile aklanyelwe ukwelashwa kokuhoxiswa. Ngenkathi i-lofexidine isetshenziswe kwamanye amazwe ngaphansi kwamagama ahlukene emikhiqizo ezimweni ezihlukahlukene, i-Lucemyra iyona kuphela inguqulo evunyelwe e-US yokuhoxiswa kwe-opioid.

Njalo sebenzisa umkhiqizo oqondile kanye nokwakheka okuyalelwe udokotela wakho. Izinhlobo ezahlukene zomuthi ofanayo zingaba namandla ahlukahlukene noma amaphethini okukhishwa okuthinta ukuthi zisebenza kahle kangakanani esimweni sakho esithile.

Ezinye izindlela ze-Lofexidine

Eminye imithi eminingi ingasiza ngezimpawu zokuhoxiswa kwe-opioid, nakuba ngayinye isebenza ngendlela ehlukile futhi inezinzuzo zayo nezingozi zayo. Udokotela wakho uzokhetha inketho engcono kakhulu ngokusekelwe ezidingweni zakho ezithile nomlando wezokwelapha.

Ezinye izindlela ezivamile zihlanganisa i-clonidine, esebenza ngendlela efana ne-lofexidine kodwa ingase ibangele imiphumela eminingi emibi. I-Buprenorphine ingenye inketho engasiza ekuhoxisweni ngenkathi futhi inikeza ukwelashwa kwesikhathi eside.

Eminye imithi esekelayo ingahlanganisa:

• I-Clonidine yokukhululeka kwezimpawu okufanayo
• I-Buprenorphine yokuhoxiswa nokugcinwa
• I-Methadone yezimo zokuhoxiswa okukhulu
• Imithi yokunethezeka yezimpawu ezithile
• Imithi elwa nesicanucanu
• Izisiza ukulala zokungalali

Ukukhetha phakathi kwalezi zinketho kuncike ezintweni eziningi, okuhlanganisa ubukhulu bezimpawu zakho zokuhoxiswa, impilo yakho yonke, kanye nemigomo yakho yokululama yesikhathi eside. Ithimba lakho lokunakekelwa kwezempilo lizosebenza nawe ukuthola indlela yokwelapha efanelekayo.

Ingabe i-Lofexidine Ingcono Kune-Clonidine?

I-Lofexidine ne-clonidine zisebenza ngezindlela ezifanayo, kodwa i-lofexidine yenzelwe ngqo ukuhoxiswa kwe-opioid futhi ingase ibangele imiphumela emibi embalwa. Yomibili imithi iqondisa izamukeli ezifanayo ohlelweni lwakho lwezinzwa, kodwa i-lofexidine ikhetha kakhulu ezenzweni zayo.

Inzuzo enkulu ye-lofexidine ukuthi mancane amathuba okuthi ibangele ukwehla okukhulu kwengcindezi yegazi uma iqhathaniswa ne-clonidine. Lokhu kuyenza iphephe kubantu abaningi futhi kunciphisa isidingo sokuqapha okukhulu ngesikhathi sokwelashwa.

I-Clonidine isetshenziswe ukuphatha ukuhoxiswa iminyaka eminingi futhi ngokuvamile ayibizi kakhulu kune-lofexidine. Kodwa-ke, idinga ukuqapha okucophelelayo futhi ingase ibangele ukozela okwengeziwe kanye nezinguquko zengcindezi yegazi.

Udokotela wakho uzocabangela izinto ezinjengengcindezi yakho yegazi, impilo yenhliziyo, eminye imithi, kanye nomshwalense lapho ekhetha phakathi kwalezi zinketho. Zombili zingasebenza, kodwa ukugunyazwa kwe-lofexidine okuthile kokwelashwa kokuhoxiswa kanye nephrofayili yokuphepha ethuthukisiwe kuyenza ibe yinketho ekhethwayo ezigulini eziningi.

Imibuzo Evame Ukubuzwa Mayelana ne-Lofexidine

Ingabe iLofexidine iphephile kubantu abanezifo zenhliziyo?

ILofexidine ingasetshenziswa kubantu abanezifo zenhliziyo, kodwa idinga ukuqashwa ngokucophelela yithimba lakho lezempilo. Umuthi ungase uthinte izinga lokushaya kwenhliziyo yakho nomfutho wegazi, okungase kube ngukukhathazeka uma usuvele unezinkinga zenhliziyo.

Udkt wakho cishe uzofuna ukwenza i-electrocardiogram (ECG) ngaphambi kokuqala ukwelashwa futhi angase aqaphele ukushaya kwenhliziyo yakho eduze ngenkathi uthatha i-lofexidine. Bangase futhi bakuqale ngomthamo ophansi bese bewukhulisa kancane kancane.

Abantu abanezifo ezithile zokushaya kwenhliziyo noma izifo zenhliziyo ezinzima bangase badinge ukusebenzisa ezinye izindlela zokwelapha. Hlala uxoxa ngomlando wakho ophelele wenhliziyo nodokotela wakho ngaphambi kokuqala noma yimuphi umuthi omusha.

Kufanele ngenzeni uma ngiphuzile i-Lofexidine eningi ngengozi?

Uma ngengozi uphuza i-lofexidine eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma ukulawulwa ngokushesha. Ukuphuza okuningi kungabangela umfutho wegazi ophansi ngokuyingozi, ukozela okukhulu, noma izinkinga zokuphefumula.

Izimpawu zokweqisa zihlanganisa isiyezi esikhulu, ukuquleka, ukushaya kwenhliziyo okuhamba kancane kakhulu, ubunzima bokuhlala uphapheme, noma ukuhlupheka ukuphefumula. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, funa ukunakekelwa kwezempilo eziphuthumayo ngokushesha.

Ungazami ukuzenza uhlanze noma uthathe eminye imithi ukuze ulwe nokweqisa. Ochwepheshe bezokwelapha badinga ukuqapha nokwelapha noma yiziphi izinkinga ezingase zivele ngenxa yokuphuza i-lofexidine eningi.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Lofexidine?

Uma uphuthelwa umthamo we-lofexidine, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze nesikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma ungaqiniseki ngesikhathi, xhumana nodokotela wakho noma usokhemisi ukuze uthole isiqondiso.

Ukushoda kwemithamo ngezikhathi ezithile ngeke kukulimaze, kodwa zama ukugcina ukuthatha imithi ngendlela efanayo ukuze ulawule izimpawu ngendlela engcono kakhulu. Cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukuze ukusize ukhumbule imithi yakho.

Ngingayeka nini ukuthatha i-Lofexidine?

Kufanele uyeke kuphela ukuthatha i-lofexidine ngaphansi kwesiqondiso sikadokotela wakho, ulandela isimiso sokunciphisa kancane kancane. Ukuyeka kungazelelwe kungabangela ukwanda okuyingozi komfutho wegazi kanye nokubuyela kwezimpawu zokuhoxiswa.

Abantu abaningi baqeda ukwelashwa kwabo nge-lofexidine emasontweni amabili, kodwa udokotela wakho uzonquma isikhathi esifanele sakho. Bazokwehlisa kancane kancane umthamo wakho ezinsukwini ezimbalwa ukuze basize umzimba wakho ukuthi ujwayele ngokuphepha.

Qhubeka nokuthatha i-lofexidine ngisho noma uzizwa ungcono, njengoba izimpawu zokuhoxiswa zingabuyela uma uyeka ngokushesha kakhulu. Udokotela wakho uzokwazisa ukuthi kuphephile nini ukuyeka umuthi ngokusekelwe entuthukweni yakho kanye nohlelo lokwelashwa olujwayelekile.

Ngingashayela ngenkathi ngithatha i-Lofexidine?

I-Lofexidine ingabangela ukozela nesiyezi, okungase kuthinte ikhono lakho lokushayela ngokuphepha. Gwema ukushayela noma ukusebenzisa imishini uze wazi ukuthi umuthi ukuthinta kanjani wena uqobo.

Abantu abaningi bazizwa bekozela kakhulu ezinsukwini zokuqala zokwelashwa. Uma uzizwa uqaphile futhi uzinzile ngemva kwalesi sikhathi sokujwayela, ungase ukwazi ukushayela, kodwa ngaso sonke isikhathi yenza ngokucophelela.

Xoxa nodokotela wakho mayelana nokuthi kungaba nini kuphephile ukuthi uqale kabusha ukushayela. Bangahlola ukusabela kwakho emuthini futhi banikeze isiqondiso esiqondene nawe esisekelwe esimweni sakho esithile kanye nemithetho yendawo.