Yini i-Mesalamine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Mesalamine iyimithi eyenzelwe ngqo ukwelapha izifo zamathumbu ezivuvukalayo njenge-ulcerative colitis nesifo sikaCrohn. Lo muthi olwa nokuvuvukala usebenza ngqo emathunjini akho ukunciphisa ukuvuvukala, ubuhlungu, nezinye izimpawu ezingakhululeki ezihambisana nalezi zimo.

Uma unikezwe i-mesalamine, cishe ubhekene nezinselelo eziqhubekayo zokugaya ukudla ezithinta impilo yakho yansuku zonke. Lo muthi ungasiza ukuletha impumuzo futhi ukunikeze ukulawula izimpawu zakho, okukuvumela ukuthi ugxile kulokho okubaluleke kakhulu kuwe.

Yini i-Mesalamine?

I-Mesalamine iyimithi elwa nokuvuvukala eyingxenye yeqembu lezidakamizwa elibizwa ngokuthi ama-aminosalicylates. Empeleni ukwelashwa okuqondiwe okusebenza ngqo emathunjini akho ukuthulisa ukuvuvukala emathunjini akho nasekoloni.

Cabanga nge-mesalamine njengomsizi omnene, ogxilile oqonda ngqo lapho ukuvuvukala kwenzeka khona. Ngokungafani neminye imithi ethinta umzimba wakho wonke, i-mesalamine yenzelwe ukusebenza endaweni ethile ohlelweni lwakho lokugaya ukudla. Le ndlela eqondiwe isho ukuthi ingasebenza kahle ngenkathi ngokuvamile ibangela imiphumela emincane eceleni kunezidakamizwa ezibanzi.

Umuthi uza ngezindlela ezahlukene okuhlanganisa amaphilisi, amaphilisi, nezinhlobo ezikhishwe isikhathi eside. Udokotela wakho uzokhetha ifomu elifanele ngokuya ngokuthi ukuvuvukala kwakho kukuphi nokuthi izimpawu zakho zinzima kangakanani.

Isetshenziselwani i-Mesalamine?

I-Mesalamine isetshenziswa ikakhulukazi ukwelapha i-ulcerative colitis nesifo sikaCrohn, izinhlobo ezimbili eziyinhloko zesifo samathumbu esivuvukalayo. Lezi zimo zibangela ukuvuvukala okungapheli ezingxenyeni ezihlukene zokugaya ukudla kwakho, okuholela ezimpawini ezinjengobuhlungu besisu, isifo sohudo, nokopha.

Nge-ulcerative colitis, i-mesalamine isiza ukunciphisa ukuvuvukala emathunjini akho amakhulu nase-rectum. Ingasiza ngesikhathi sokugqashuka lapho izimpawu zisebenza, futhi isetshenziswa njengokwelashwa kokugcina ukusiza ukuvimbela ukuqashuka okuzayo ukuthi kungenzeki.

Ngesifo sikaCrohn, i-mesalamine iyasiza ikakhulukazi lapho ukuvuvukala kuthinta amathumbu akho amancane noma ingxenye yokuqala yamathumbu akho amakhulu. Ngenkathi kungenzeka kungabi yindlela yokuqala yazo zonke izinhlobo zesifo sikaCrohn, ingasebenza kahle kakhulu ngezinhlobo ezithile zesimo.

Udokotela wakho angase futhi akubhalele i-mesalamine uma unezinye izinhlobo zezimo zamathumbu ezivuvukalayo ezisabela kahle kulolu hlobo lokwelashwa okuvuvukalayo.

Isebenza Kanjani I-Mesalamine?

I-Mesalamine isebenza ngokuvimba amakhemikhali athile emzimbeni wakho abangela ukuvuvukala emathunjini akho. Ngokuqondile, ivimbela ukukhiqizwa kwezinto ezinjenge-prostaglandins kanye ne-leukotrienes, okuyizinto ezibalulekile ezinqubweni zokuvuvukala.

Uma uthatha i-mesalamine, ihamba ngohlelo lwakho lokugaya ukudla futhi ikhiphe isithako esisebenzayo lapho ngqo ukuvuvukala kwenzeka khona. Lolu hlelo lokulethwa okuqondile lisho ukuthi imithi ingasebenza ngempumelelo emthonjeni wezimpawu zakho.

Njengomuthi olwa nokuvuvukala, i-mesalamine ithathwa njengemodareyithi eqinile. Ayinamandla njenge-steroids njenge-prednisone, kodwa iphephe kakhulu ekusetshenzisweni kwesikhathi eside. Lokhu kuyenza ibe yindlela enhle kakhulu yokugcina ukuxolelwa nokuvimbela ukuqashuka ngokuhamba kwesikhathi.

Umuthi ngokuvamile uqala ukusebenza phakathi nezinsuku ezimbalwa kuya emavikini, nakuba abanye abantu bengase babone ngcono ngokushesha. Izinzuzo ezigcwele zivame ukubonakala ngemva kwamasonto amaningana okusetshenziswa okuqhubekayo.

Kufanele Ngiyithathe Kanjani I-Mesalamine?

Thatha i-mesalamine ngendlela udokotela wakho ayikuyala ngayo, ngokuvamile ngengilazi yamanzi egcwele. Izinhlobo eziningi zingathathwa ngokudla noma ngaphandle kokudla, kodwa ukuyithatha ngokudla kungasiza ukunciphisa noma yikuphi ukuphatheka kwesisu ongase ukuzwe.

Uma uthatha amaphilisi noma amaphilisi akhishwa isikhathi eside, wagwinye wonke ngaphandle kokuwachoboza, ukuwahlafuna, noma ukuwaqhekeza. Lawa mafomula akhethekile aklanyelwe ukukhipha imithi kancane kancane njengoba idlula ohlelweni lwakho lokugaya ukudla.

Ukuze uthole imiphumela engcono kakhulu, zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke. Lokhu kusiza ukugcina amazinga aqhubekayo omuthi ohlelweni lwakho. Abantu abaningi bakuthola kuwusizo ukuxhumanisa imithamo yabo nemisebenzi ejwayelekile efana nokudla noma isikhathi sokulala.

Uma uthatha imithamo eminingi ngosuku, yihlukanise ngokulinganayo usuku lonke. Isibonelo, uma uyithatha kabili ngosuku, hlela amahora angaba ngu-12 phakathi kwemithamo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Mesalamine?

Ubude bokwelashwa kwe-mesalamine buhluka kakhulu kumuntu nomuntu futhi kuncike esimweni sakho esithile nokuthi usabela kahle kangakanani emuthini. Abantu abaningi abanezifo zamathumbu ezivuvukalayo bathatha i-mesalamine izinyanga noma iminyaka njengokwelashwa kokugcinwa.

Ngesikhathi sokugqashuka okusebenzayo, ungase uthathe i-mesalamine amasonto amaningana kuya ezinyangeni kuze kube yilapho izimpawu zakho zithuthuka futhi ukuvuvukala kwehla. Uma usufinyelele ekuthetheleleni, udokotela wakho angase ancome ukuqhubeka nomuthi ngomthamo ophansi ukuze usize ekuvikeleni ukuqubuka okuzayo.

Ukwelashwa kokugcinwa, abanye abantu bahlala ku-mesalamine iminyaka ngoba kusiza ukugcina isimo sabo sizinzile futhi kuvimbela izimpawu ukuthi zingabuyi. Lokhu kusetshenziswa kwesikhathi eside kuvamile ukuthi kuphephile futhi kutholakala kahle ngabantu abaningi.

Ungayeki ukuthatha i-mesalamine ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala, ngisho noma uzizwa ungcono. Ukuyeka ngokushesha kungase ngezinye izikhathi kubangele ukuqubuka kwezimpawu zakho.

Yiziphi Imiphumela Eceleni Ye-Mesalamine?

Abantu abaningi bayayibekezelela kahle i-mesalamine, nemiphumela emibi ngokuvamile iba mnene futhi ilawuleka. Imiphumela emibi evame kakhulu ongase uyithole ihlobene nohlelo lwakho lokugaya ukudla futhi ivame ukuba yesikhashana njengoba umzimba wakho uzivumela emuthini.

Nawa amanye imiphumela evamile ongase uyibone:

• Ukucanuzela kwenhliziyo noma ukuphathwa yisisu okuncane
• Ukopha ikhanda
• Ukuphuma isifo sohudo noma izinguquko ekuhambeni kwamathumbu
• Ubuhlungu besisu noma ukuqaqamba
• Igesi noma ukuqunjelwa
• Isiyezi
• Ukukhathala noma ukuzizwa ukhathele

Le miphumela evamile ivame ukuthuthuka ezinsukwini ezimbalwa kuya emavikini ambalwa njengoba umzimba wakho ujwayela umuthi. Ukuthatha i-mesalamine nokudla kungasiza ukunciphisa imiphumela emibi ehlobene nesisu.

Nakuba kungavamile, kunemiphumela ethile emibi edinga ukunakekelwa okwengeziwe. Lokhu kungabandakanya ukuqaqamba kwekhanda okuqhubekayo okukhulu, ukukhathala okungavamile, noma ukwanda kwezimpawu zakho zokugaya ukudla. Uma uhlangabezana nanoma yikuphi kwalokhu, kubalulekile ukuxhumana nomhlinzeki wakho wezempilo.

Ngokuvamile, abanye abantu bangase babe nemiphumela emibi engathi sína njengezinkinga zezinso, izinkinga zesibindi, noma ukusabela okukhulu komzimba. Izimpawu zalezi zinkinga ezingavamile zihlanganisa izinguquko ezingavamile ekuchameni, ukuphuzi kwesikhumba noma amehlo, noma ukuqubuka okukhulu kwesikhumba.

Ubani Ongafanele Athathwe I-Mesalamine?

I-Mesalamine ayifanele wonke umuntu, futhi zikhona izimo ezithile lapho udokotela wakho angase ancome indlela ehlukile yokwelapha. Abantu abanokungezwani komzimba okwaziwayo ne-mesalamine noma imithi efanayo njenge-sulfasalazine kufanele bagweme lo muthi.

Uma unesifo sezinso noma ukusebenza kwezinso okuncishisiwe, udokotela wakho uzodinga ukukuqapha eduze noma angase akhethe omunye umuthi. I-Mesalamine icutshungulwa ngezinso zakho, ngakho noma yiziphi izinkinga zezinso ezikhona zingathinta ukuthi umzimba wakho uyiphatha kahle kangakanani imithi.

Abantu abanezimo ezithile zesibindi bangase badinge ukucatshangelwa okukhethekile ngaphambi kokuqala i-mesalamine. Udokotela wakho cishe uzohlola ukusebenza kwesibindi sakho ngaphambi nangemva kokwelashwa ukuze aqinisekise ukuthi umuthi uphephile kuwe.

Uma ukhulelwe noma uhlela ukukhulelwa, xoxa ngalokhu nodokotela wakho. Nakuba i-mesalamine ngokuvamile ithathwa njengephephile kuneziningi zeminye imithi ye-IBD ngesikhathi sokukhulelwa, udokotela wakho uzofuna ukulinganisela ngokucophelela izinzuzo nezingozi zesimo sakho esithile.

Amagama Omkhiqizo we-Mesalamine

I-Mesalamine itholakala ngaphansi kwamagama amaningi omkhiqizo, ngalinye linokwakheka okuhlukile okwenzelwe ukuletha umuthi ezingxenyeni ezithile zohlelo lwakho lokugaya ukudla. Amagama omkhiqizo avamile afaka i-Asacol, Pentasa, Lialda, kanye ne-Apriso.

I-Asacol ne-Asacol HD zenzelwe ukukhipha umuthi emathunjini akho amakhulu, okwenza zisebenze ikakhulukazi ku-ulcerative colitis. I-Pentasa ikhipha umuthi kuyo yonke amathumbu akho amancane namakhulu, okungasiza ezinhlotsheni ezithile zesifo sikaCrohn.

I-Lialda iyindlela yokwakheka yansuku zonke abantu abaningi abayithola ilula, kuyilapho i-Apriso iyinye inketho yokukhishwa okweluliwe. Udokotela wakho uzokhetha umkhiqizo othile nokwakheka okusekelwe lapho ukuvuvukala kwakho kutholakala khona nokuthi izimpawu zakho zinzima kangakanani.

Izinhlobo ezivamile ze-mesalamine nazo ziyatholakala futhi zisebenza ngempumelelo njengezinhlobo zomkhiqizo. Umuthi wakho wemithi angakusiza ukuthi uqonde ukuthi iyiphi inguqulo oyitholayo futhi aqinisekise ukuthi uyithatha ngendlela efanele.

Ezinye Izindlela ze-Mesalamine

Uma i-mesalamine ingasebenzi kahle kuwe noma ibangela imiphumela engemihle ongakwazi ukuyibekezelela, kunezindlela eziningana zokwelapha ezingenye udokotela wakho angazicabangela. Ukukhethwa kwezinye izindlela kuncike esimweni sakho esithile, ubunzima bezimpawu, nokuthi usabele kanjani kwezinye izindlela zokwelapha.

I-Sulfasalazine ngumuthi ohlobene osebenza ngendlela efanayo ne-mesalamine kodwa uhlanganisa enye ingxenye. Abanye abantu abangayiphenduli kahle i-mesalamine bangase bathole i-sulfasalazine isebenza kahle kakhulu, nakuba ingaba nemiphumela engemihle ehlukene.

Ngemuva kokuvuvukala okukhulu, udokotela wakho angase ancome imithi yokucindezela amasosha omzimba njenge-azathioprine noma i-methotrexate. Lezi zisebenza ngendlela ehlukile kune-mesalamine ngokucindezela ukusabela komzimba wakho okubangela ukuvuvukala.

Imithi emisha ye-biologic efana ne-infliximab, adalimumab, noma i-vedolizumab ingase icatshangelwe ezimweni eziphakathi nendawo kuya kwezinkulu ezingasabeli ekwelashweni kwendabuko. Lezi ngokuvamile zigcinelwa izimo ezingathi sína ngenxa yezindleko zazo nemiphumela engemihle engaba khona.

Ingabe i-Mesalamine Ingcono Kune-Sulfasalazine?

I-Mesalamine ne-sulfasalazine ziyimithi ehlobene eduze, kodwa zomehluko obalulekile ongase wenze enye ifaneleke kakhulu kuwe kunenye. Zombili ziyasebenza ekwelapheni isifo samathumbu esivuvukalayo, kodwa zisebenza kancane emzimbeni wakho.

I-Mesalamine ivame ukubekezelelwa kangcono kune-sulfasalazine ngoba ibangela imiphumela emibi embalwa. I-Sulfasalazine ingabangela isicanucanu, ikhanda, futhi ngezinye izikhathi imiphumela emibi engathi sína njengezifo zegazi noma izinkinga zesibindi kaningi kune-mesalamine.

Nokho, i-sulfasalazine ingase isebenze kahle kwabanye abantu, ikakhulukazi labo abane-rheumatoid arthritis kanye nesimo sabo samathumbu. Futhi ngokuvamile ibiza kancane kune-mesalamine, okungaba yinto ebalulekile okufanele icatshangelwe ekwelashweni kwesikhathi eside.

Udokotela wakho uzokusiza ukuthi unqume ukuthi iyiphi imithi engcono esimweni sakho esithile ngokusekelwe ezimpawini zakho, umlando wezokwelapha, nokuthi uyikubekezelela kangakanani inketho ngayinye. Ngezinye izikhathi kuthatha ukuzama zombili ukuze ubone ukuthi iyiphi esebenza kahle kuwe.

Imibuzo Evame Ukubuzwa Nge-Mesalamine

Ingabe i-mesalamine iphephile kubantu abanezifo zezinso?

I-Mesalamine idinga ukuqapha ngokucophelela uma unezifo zezinso ngoba imithi icutshungulwa ngezinso zakho. Udokotela wakho cishe uzohlola ukusebenza kwezinso zakho ngezivivinyo zegazi ngaphambi kokuqala ukwelashwa futhi njalo ngenkathi uthatha imithi.

Uma unezinkinga ezincane zezinso, ungase ukwazi ukuqhubeka nokuthatha i-mesalamine, kodwa mhlawumbe ngomthamo omncane. Ezifweni ezinzima zezinso, udokotela wakho angase ancome indlela ehlukile yokwelapha ngokuphelele. Njalo qiniseka ukuthi utshela umhlinzeki wakho wezempilo iqiniso nganoma yiziphi izinkinga zezinso owake waba nazo esikhathini esidlule.

Kufanele ngenzeni uma ngiphuzile i-mesalamine eningi ngengozi?

Uma ngengozi uphuza i-mesalamine eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuphuza i-mesalamine eningi kungase kubangele izinkinga zezinso, isicanucanu esibi, ukuhlanza, noma eminye imiphumela emibi.

Ungalindi ukubona ukuthi ngabe uba nezimpawu. Noma ngabe uzizwa kahle, kubalulekile ukuthola iseluleko sezokwelapha mayelana nokuthi yini okufanele uyenze ngokulandelayo. Udokotela wakho angase afune ukukuqapha eduze noma enze ezinye izivivinyo ukuze aqinisekise ukuthi imithi eyengeziwe ayibangeli zinkinga.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-mesalamine?

Uma uphuthelwa umthamo we-mesalamine, uyithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho yokuthatha imithi.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi ocingweni lwakho noma ukuxhumanisa izikhathi zakho zokuthatha imithi nemisebenzi yansuku zonke ejwayelekile njengokudla.

Ngingayeka nini ukuthatha i-mesalamine?

Yeka kuphela ukuthatha i-mesalamine uma udokotela wakho ekutshela ukuthi kuphephile ukwenza kanjalo. Noma ngabe uzizwa ungcono kakhulu futhi izimpawu zakho zinyamalele, ukuyeka ngaphambi kwesikhathi kuvame ukuholela ekubuyeni kokuvuvukala nezimpawu.

Udokotela wakho ngokuvamile uzofuna ukukubona ugcina ukuxolelwa isikhathi esithile ngaphambi kokucabangela ukuthi ngabe kufanele unciphise umthamo wakho noma uyeke imithi. Lesi sinqumo sincike ezintweni ezifana nokuthi isimo sakho sinzima kangakanani, ukuthi usunesikhathi esingakanani ungenazo izimpawu, kanye nengozi yakho yokuqubuka okuzayo.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-mesalamine?

Ukuphuza utshwala ngokulinganisela ngokuvamile kubhekwa njengokuphephile ngenkathi uthatha i-mesalamine, kodwa ngaso sonke isikhathi kungcono ukuxoxa ngalokhu nodokotela wakho. Utshwala ngezinye izikhathi bungathukuthelisa uhlelo lwakho lokugaya ukudla, okungase kwenze izimpawu zesifo samathumbu esivuvukalayo zibe zimbi kakhulu.

Uma ukhetha ukuphuza utshwala, qaphela ukuthi buthinta kanjani izimpawu zakho. Abanye abantu abane-IBD bathola ukuthi utshwala buqala ukuqubuka noma benze izimpawu zabo zibe zimbi kakhulu, kanti abanye bayakubekezelela kahle. Udokotela wakho angakusiza ukuthi uqonde ukuthi yini engcono kakhulu esimweni sakho esithile.