Yini i-Mesalamine (Indlela ye-Rectal): Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Mesalamine rectal route iyimithi eletha imithi elwa nokuvuvukala ngqo e-rectum yakho nasekoloni elingezansi ukuze ilaphe izimo zokuvuvukala kwamathumbu. Iza ngesimo sama-suppositories, ama-enemas, noma igwebu olifaka e-rectum yakho, okwenza imithi isebenze ngqo lapho ukuvuvukala kwenzeka khona emathunjini akho.

Le ndlela eqondiswe ngqo isiza ukunciphisa ukuvuvukala emgqeni we-rectum yakho kanye ne-sigmoid colon. Abantu abaningi bathola ukuthi i-mesalamine ye-rectal iyasiza ikakhulukazi ngoba iletha imithi ngqo endaweni ethintekile kunokuba idlule ohlelweni lwakho lonke lokugaya kuqala.

Yini i-Mesalamine?

I-Mesalamine iyimithi elwa nokuvuvukala eyingxenye yeqembu lezidakamizwa elibizwa ngokuthi ama-aminosalicylates. Isebenza ngqo emathunjini akho ukuzolisa ukuvuvukala nokusiza ukwelapha izicubu ezilimele emgqeni wamathumbu akho.

Uhlobo lwe-rectal lwenza imithi ifinyelele ezindaweni zekholoni yakho ezingase zibe nzima ukuzelapha ngemithi yomlomo kuphela. Cabanga ngayo njengokusebenzisa imithi ngqo esilondeni kunokuthatha iphilisi futhi unethemba lokuthi lizofinyelela endaweni efanele.

Le mithi yaziwa nangegama layo lamakhemikhali elithi 5-aminosalicylic acid noma 5-ASA. Isetshenziswe ngokuphepha amashumi eminyaka ukwelapha izimo zokuvuvukala kwamathumbu futhi inerekhodi elihle lokusebenza.

Isetshenziselwani i-Mesalamine?

I-Mesalamine rectal route isetshenziswa ikakhulukazi ukwelapha i-ulcerative colitis, ikakhulukazi lapho ukuvuvukala kuthinta i-rectum yakho kanye nekoloni elingezansi. Isebenza kahle ikakhulukazi ekwelapheni i-ulcerative proctitis, okuyisifo sokuvuvukala ngqo e-rectum.

Udokotela wakho angase ancome i-mesalamine ye-rectal uma unezinkinga zokuphuma igazi, ubuhlungu, noma ukuzwa ukuthi udinga ukuya endlini yangasese ngokushesha okuhlobene nokuvuvukala engxenyeni engezansi yekholoni yakho. Ingasetshenziswa yodwa ngezimpawu ezilula kuya kweziphakathi noma ihlanganiswe ne-mesalamine yomlomo ukuze kuvuvukale kakhulu.

Abanye odokotela bayayibhala futhi ngenxa yesifo iCrohn uma sithinta i-rectum, nakuba lokhu kungavamile. Umuthi usiza ukunciphisa izimpawu ezinjengokuphuma igazi ngemuva, ukukhishwa kwamafinyila, kanye nesifiso esivame ukuba nokunyakaza kwamathumbu.

Isebenza Kanjani I-Mesalamine?

I-Mesalamine isebenza ngokuvimba amakhemikhali athile emzimbeni wakho abangela ukuvuvukala emgqeni wakho wamathumbu. Ithathwa njengomuthi olwa nokuvuvukala onamandla aphakathi nendawo owenzelwe ngqo ukusebenza emathunjini akho.

Uma usebenzisa ifomu le-rectal, umuthi umboza ngqo izicubu ezivuvukele futhi zimuncwa odongeni lwesisu. Lokhu kuyivumela ukuthi inciphise ukuvuvukala, inciphise ukukhiqizwa kwezinto ezivuthayo, futhi isize umugqa wakho wamathumbu ukuthi uphole.

Umuthi futhi usiza amasosha akho omzimba ukuthi asabele ngendlela ejwayelekile endaweni ethintekile. Esikhundleni sokusabela ngokweqile nokubangela ukuvuvukala okuqhubekayo, i-mesalamine isiza ukubuyisela ibhalansi enempilo ekuphenduleni komzimba wamathumbu.

Kufanele Ngiyithathe Kanjani I-Mesalamine?

Indlela othatha ngayo i-mesalamine incike ohlotsheni olubhalwe ngudokotela wakho - i-suppository, i-enema, noma igwebu. Uhlobo ngalunye lunemiyalelo ethile okubalulekile ukuyilandela ukuze umuthi usebenze kahle.

Nge-suppositories, ngokuvamile uzofaka eyodwa e-rectum yakho kanye noma kabili ngosuku, ngokuvamile ngesikhathi sokulala. Zama ukukhipha amathumbu akho ngaphambi kokufaka uma kungenzeka, bese ulala ngohlangothi lwakho ngenkathi ucindezela ngobumnene i-suppository ngemuva kwe-anal sphincter yakho.

Uma usebenzisa ama-enemas, uzolala ngohlangothi lwakho lwesobunxele bese ufaka ngobumnene ithiphu ye-applicator e-rectum yakho. Cindezela okuqukethwe kancane bese uzama ukugcina umuthi isikhathi eside ngangokunokwenzeka - okungcono amahora angu-8 noma ubusuku bonke.

Ngemithi yegwebu, nyakazisa kahle ithini bese ufaka ithiphu ye-applicator ngaphakathi kwe-rectum yakho. Cindezela ikepisi ukuze ukhulule igwebu, bese uzama ukuligcina amahora ambalwa uma kungenzeka.

Akudingeki ukuthi uthathe lo muthi nokudla ngoba awudluli esiswini sakho. Nokho, ukuhlala unamanzi njalo kuyasiza uma uphatha izimo zamathumbu ezivuvukalayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Mesalamine?

Ubude bokwelashwa nge-mesalamine buyahluka ngokuya ngesimo sakho esithile nokuthi usabela kahle kangakanani emuthini. Ukuvuvukala okusebenzayo, ungase ukusebenzise nsuku zonke amasonto angu-3-6 kuze kube yilapho izimpawu zithuthuka.

Abanye abantu badinga ukusebenzisa i-mesalamine ngomzila we-rectal ukuze bathole ukwelashwa kokugcinwa ukuvimbela ukuqubuka. Kulezi zimo, ungase uyisebenzise kaningi - mhlawumbe ngosuku olulodwa noma izikhathi ezimbalwa ngesonto - njengoba kuqondiswe udokotela wakho.

Udokotela wakho uzoqapha inqubekela phambili yakho futhi alungise uhlelo lokwelashwa ngokusekelwe ekutheni izimpawu zakho zisabela kanjani. Abanye abantu bathola ukuthi bangayeka umuthi uma ukuvuvukala kwabo kuphola, kanti abanye bayazuza ekwelashweni okuqhubekayo kokugcinwa.

Ungayeki ukuthatha i-mesalamine ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Noma ngabe uzizwa ungcono, ukuyeka ngaphambi kwesikhathi kungavumela ukuvuvukala ukuthi kubuye ngaphambi kokuthi umugqa wakho wamathumbu ululame ngokugcwele.

Yiziphi Imiphumela Eceleni Ye-Mesalamine?

Abantu abaningi bayayibekezelela i-mesalamine ngomzila we-rectal kahle, kodwa njenganoma yimuphi umuthi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathi sína ayivamile, futhi abantu abaningi ababi nemiphumela emibi nhlobo.

Nawa amanye imiphumela emibi ejwayelekile ongase uyithole:

• Ukuvuvukala kwe-rectal noma ukusha
• Ukuqina kwegesi noma ukuqunjelwa
• Ukugcwala kwesisu okuncane
• Ikhanda
• Isicanucanu
• Isiyezi
• Ukwanda okwesikhashana kwesifo sohudo

Lezi zimpawu zivame ukuba mnene futhi zivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Ukuvuvukala kwe-rectal kuvame ukwehla ngemva kokusetshenziswa kokuqala okumbalwa.

Imiphumela emibi engavamile kodwa ebucayi idinga ukunakekelwa kwezokwelapha ngokushesha. Lezi zinkinga ezingavamile zingabandakanya ukusabela okukhulu komzimba, izinkinga zezinso, noma izifo zegazi.

Qaphela lezi zimpawu zokuxwayisa bese uthintana nodokotela wakho ngokushesha uma uhlangabezana:

• Ubuhlungu obukhulu besisu noma ukuqaqamba
• Umkhuhlane noma amaqhafuva
• Ukuphuma kwegazi okungavamile noma ukulimala
• Ikhanda elibuhlungu elibuhlungu noma ubuhlungu besifuba
• Ukuphefumula noma ukugwinya kanzima
• Ukuqubuka kwesikhumba noma imihuzuko
• Ushintsho ekuchameni noma ekusebenzeni kwezinso

Le miphumela emibi ebucayi ayivamile, kodwa kubalulekile ukuyazi ukuze ukwazi ukufuna usizo uma kudingeka.

Ubani Ongafanele Athole I-Mesalamine?

Ngenkathi i-mesalamine ivikelekile ngokujwayelekile kubantu abaningi, zikhona izimo ezithile lapho kungenzeka ingeyona inketho efanele. Udokotela wakho uzobuyekeza umlando wakho wezokwelapha ukuze aqiniseke ukuthi kuphephile kuwe.

Akufanele usebenzise i-mesalamine ngomzila we-rectal uma unokungezwani komzimba ne-mesalamine, i-sulfasalazine, noma i-aspirin. Abantu abanezifo ezinzima zezinso nabo bangase badinge ukugwema lo muthi noma bawusebenzise ngokuqapha okwengeziwe.

Nazi izimo ezidinga ukucatshangelwa okukhethekile ngaphambi kokusebenzisa i-mesalamine:

• Isifo sezinso noma ukusebenza kwezinso okuncishisiwe
• Isifo sesibindi
• Isifo senhliziyo
• Isifuba somoya noma ezinye izinkinga zokuphefumula
• Izifo zegazi
• Izilonda zesisu

Uma ukhulelwe noma uncelisa, khuluma nodokotela wakho mayelana nezingozi nezinzuzo. I-Mesalamine ngokuvamile ithathwa njengephephile ngesikhathi sokukhulelwa, kodwa udokotela wakho uzofuna ukukuqapha eduze.

Abantu abathatha imithi ethile, ikakhulukazi ama-blood thinners noma ezinye izidakamizwa ezilwa nokuvuvukala, bangase badinge ukulungiswa komthamo noma ukuqapha okwengeziwe.

Amagama Omkhiqizo we-Mesalamine

I-Mesalamine rectal route itholakala ngaphansi kwamagama amaningi omkhiqizo, ngamunye unezindlela ezihlukene kancane. Imikhiqizo ejwayelekile kakhulu ihlanganisa i-Rowasa, i-Canasa, ne-sfRowasa.

I-Rowasa ngokuvamile iza njenge-enema, kuyilapho i-Canasa itholakala njengama-suppositories. I-sfRowasa iyindlela entsha engenayo i-sulfite eyenzelwe abantu abazwela kuma-sulfites.

Udokotela wakho uzokhetha uhlobo oluthile kanye nokwakheka okusekelwe esimweni sakho, indawo yokuvuvukala kwakho, kanye nezintandokazi zakho. Zonke izinhlobo ziqukethe isithako esifanayo esisebenzayo kodwa zingase zibe nezithako ezingasebenzi ezihlukene.

Ezinye izindlela ze-Mesalamine

Uma i-mesalamine ingasebenzi kahle kuwe noma ibangela imiphumela emibi, zikhona ezinye izindlela zokwelapha ezitholakalayo. Udokotela wakho angase aphonse imithi ehlukene noma ukwelashwa okuhlanganisiwe.

Ezinye izinketho ezilwa nokuvuvukala zihlanganisa i-sulfasalazine, equkethe i-mesalamine ehlanganiswe nomuthi we-sulfa. Abanye abantu basabela kangcono kuma-corticosteroid enemas afana ne-hydrocortisone ukuze asetshenziswe ngesikhathi esifushane ngesikhathi sokugqashuka.

Ezimweni ezinzima kakhulu, udokotela wakho angase ancome imithi ecindezela amasosha omzimba noma imithi ye-biologic. Lezi ngokuvamile zigcinelwe abantu abangasabeli ku-mesalamine noma abanezifo ezinolaka olukhulu.

Izindlela ezingezona zemithi ezifana nezinguquko zokudla, ukuphatha ingcindezi, kanye nama-probiotics nazo zingagcwalisa uhlelo lwakho lokwelapha. Udokotela wakho uzosebenza nawe ukuthola inhlanganisela engcono kakhulu yokwelapha.

Ingabe i-Mesalamine ingcono kune-Sulfasalazine?

Kokubili i-mesalamine ne-sulfasalazine ziyindlela yokwelapha ephumelelayo yezimo zamathumbu ezivuvukalayo, kodwa zisebenza ngendlela ehlukile futhi zinezinhlobo ezihlukene zemiphumela emibi. Ukukhetha phakathi kwazo kuncike esimweni sakho esithile.

I-Mesalamine ngokuvamile itholakala kangcono ngoba ayiqukethe isici se-sulfa esingabangela ukungezwani komzimba kwabanye abantu. Futhi ivame ukubangela imiphumela emibi embalwa efana nesicanucanu, ikhanda, kanye nokusabela kwesikhumba.

ISulfasalazine ingase isebenze kahle kubantu abathile ngoba iqukethe kokubili i-mesalamine ne-sulfapyridine, ezisebenza ngokubambisana ukunciphisa ukuvuvukala. Kodwa-ke, ingxenye ye-sulfa isho ukuthi ayifanele abantu abanezifo ze-sulfa.

Udokotela wakho uzocabangela umlando wakho wezokwelapha, izifo zokungezwani nezinto ezithile, nokuthi uye wasabela kahle kangakanani ekwelashweni kwangaphambilini lapho enza lesi sinqumo. Abantu abaningi baqala nge-mesalamine ngenxa yephrofayili yayo engcono yokubekezelela.

Imibuzo Evame Ukubuzwa Nge-Mesalamine

Q1. Ingabe i-Mesalamine iphephile ukusetshenziswa isikhathi eside?

Yebo, i-mesalamine ngokuvamile iphephile ukusetshenziswa isikhathi eside uma iqashwe udokotela wakho. Abantu abaningi bayayisebenzisa ekwelashweni kokugcina ukuvimbela ukuqubuka kwe-ulcerative colitis.

Udokotela wakho uzohlola njalo ukusebenza kwezinso zakho ngezivivinyo zegazi ngoba ukusetshenziswa isikhathi eside kungase kuthinte izinso zakho. Abantu abaningi bangasebenzisa i-mesalamine iminyaka ngaphandle kwezinkinga ezinkulu uma iqashwe kahle.

Q2. Kufanele ngenzeni uma ngisebenzisa i-Mesalamine eningi ngengozi?

Uma ngengozi usebenzisa i-mesalamine eningi kunaleyo ebekiwe, ungangeni ekuqhumeni. Ukweqisa nge-mesalamine ye-rectal akuvamile ngoba umuthi usetshenziswa endaweni kunokuthathwa ngomlomo.

Kodwa-ke, uma usebenzise ngaphezu kwesilinganiso sakho esibekiwe, xhumana nodokotela wakho noma usokhemisi ukuze uthole isiqondiso. Qaphela imiphumela emibi eyengeziwe efana nokuhambisa kakhulu, isicanucanu, noma ukucasuka kwe-rectal, futhi funa ukwelashwa uma lokhu kwenzeka.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Mesalamine?

Uma uphuthelwa umthamo we-mesalamine, yithathe ngokushesha lapho ukhumbula. Uma sekuyisikhathi somthamo wakho olandelayo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungaphindi kabili imithamo ukuze ulungise eyodwa ephuthelwe. Lokhu kungakhuphula ingozi yakho yemiphumela emibi ngaphandle kokuhlinzeka ngenzuzo eyengeziwe. Ukuqina kubaluleke kakhulu kunokulungisa imithamo ephuthelwe ngezikhathi ezithile.

Q4. Ngingayeka nini ukuthatha i-Mesalamine?

Misa ukuthatha i-mesalamine kuphela uma udokotela wakho ekutshela ukuthi kuphephile ukwenza kanjalo. Noma ngabe izimpawu zakho zithuthukile, ukuyeka ngokushesha kungavumela ukuvuvukala ukuthi kubuye.

Udkt wakho ngokuvamile uzofuna ukukubona ungenazo izimpawu amasonto amaningana ngaphambi kokucabangela ukuyeka umuthi. Abanye abantu badinga ukuhlala ekwelashweni kokugcinwa ukuvimbela ukuqubuka okuzayo.

Q5. Ngingayisebenzisa i-Mesalamine Ngesikhathi Sokukhulelwa?

I-Mesalamine ngokuvamile ithathwa njengephephile ngesikhathi sokukhulelwa futhi ivame ukuba yindlela yokwelapha ekhethwayo yezimo zamathumbu ezivuthayo kubantu besifazane abakhulelwe. Izinzuzo zokulawula ukuvuvukala ngokuvamile zidlula noma yiziphi izingozi ezingaba khona.

Kodwa-ke, hlala uxoxa ngalokhu nodokotela wakho ngaphambi kokusebenzisa noma yimuphi umuthi ngesikhathi sokukhulelwa. Udokotela wakho uzofuna ukukuqapha eduze futhi angashintsha uhlelo lwakho lokwelapha njengoba kudingeka ngesikhathi sokukhulelwa kwakho.