Yini i-Metyrosine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Metyrosine iyimithi ekhethekile evimbela umzimba wakho ukuthi ukwazi ukukhiqiza amahomoni athile okucindezeleka abizwa ngokuthi ama-catecholamines. Lo muthi oqoshwe ngudokotela usetshenziswa ikakhulukazi ukwelapha isimo esingavamile kodwa esibi esibizwa ngokuthi i-pheochromocytoma, lapho amathumba abangela ukunyuka okuyingozi komfutho wegazi ngokukhipha i-adrenaline eningi kakhulu nama-hormone afanayo.

Ngenkathi i-metyrosine ingelona igama elivamile njengeminye imithi eminingi, isebenza njengenketho yokwelapha ebalulekile kubantu ababhekene namathumba akhiqiza amahomoni. Cabanga ngayo njengokubeka amabhuleki ohlelweni lwakho lomzimba lokuphendula ukucindezeleka kwangaphakathi lapho lusebenza ngokweqile ngenxa yala mathumba.

Yini i-Metyrosine?

I-Metyrosine iyimithi eyenziwe ngendlela yokwenziwa esebenza ngokuvimba i-enzyme ebizwa ngokuthi i-tyrosine hydroxylase. Le enzyme inesibopho sesinyathelo sokuqala ekwenzeni amahomoni okucindezeleka afana ne-dopamine, i-norepinephrine, ne-epinephrine (i-adrenaline) emzimbeni wakho.

Ngokuvimbela le enzyme ukuthi ingasebenzi kahle, i-metyrosine ngempumelelo inciphisa ukukhiqizwa kwala mahomoni anamandla. Lokhu kuyenza ibaluleke ikakhulukazi uma ubhekene namathumba akhiqiza amanani amakhulu alezi zinto, okusiza ukulawula izimpawu eziyingozi ezingazibangela.

Lo muthi ungowesigaba semithi ebizwa ngokuthi ama-enzyme inhibitors, futhi uthathwa njengokwelashwa okukhethekile okudinga ukugadwa ngokucophelela kwezokwelapha. Udokotela wakho ngokuvamile uzokunika i-metyrosine kuphela ngemva kokuqinisekisa ukuthi unesimo esibangela ukukhiqizwa kwe-catecholamine okweqile.

Isetshenziselwani i-Metyrosine?

I-Metyrosine ikakhulukazi iqoshwe ukwelapha i-pheochromocytoma, ithumba elingavamile elivela ezinqeni ze-adrenal futhi likhiqize amanani amakhulu amahomoni okucindezeleka. Lawa mathumba angabangela ukunyuka okusongela impilo komfutho wegazi, izinga lokushaya kwenhliziyo, nezinye izimpawu eziyingozi.

Umuthi uvame kakhulu ukusetshenziswa njengokwelashwa okulungiselelayo ngaphambi kokususwa kwalezi zicubu ngokuhlinzwa. Ngokunciphisa ukukhiqizwa kwamahomoni ngaphambili, i-metyrosine isiza ukwenza ukuhlinzwa kuphephe futhi kulawuleke kalula kuwe nakwiqembu lakho lokuhlinza.

Kwezinye izimo, i-metyrosine ingase futhi isetshenziswe ekuphathweni kwesikhathi eside lapho ukuhlinzwa kungenzeki ngokushesha noma kungakwazi ukwelulekwa. Lokhu kungenzeka uma unezicubu eziningi, uma isicubu sitholakala endaweni eyenza ukuhlinzwa kube yingozi kakhulu, noma uma udinga isikhathi sokuthuthukisa impilo yakho yonke ngaphambi kwenqubo.

Ngokuvamile, odokotela bangase babhale i-metyrosine ye-paraganglioma, okuyizicubu ezifanayo ezikhiqiza amahomoni ezingenzeka kwezinye izingxenye zomzimba wakho ngaphandle kwamadlala e-adrenal. Lezi zicubu zingabangela izimpawu ezifanayo futhi zizuze endleleni efanayo yokuvimba amahomoni.

Isebenza Kanjani I-Metyrosine?

I-Metyrosine isebenza ngokuvimba isinyathelo sokuqala ekukhiqizweni komzimba wakho kwamahomoni okucindezeleka. Iqondise ngqo i-enzyme ebizwa ngokuthi i-tyrosine hydroxylase, eguqula i-amino acid tyrosine ibe yinhlanganisela ebizwa ngokuthi i-L-DOPA.

Ngaphandle kwalokhu kuguqulwa, umzimba wakho awukwazi ukuqhubeka nokwenza i-dopamine, i-norepinephrine, noma i-epinephrine. Lokhu kubaluleke kakhulu uma ubhekene nezicubu ezikhiqiza amahomoni, njengoba lokhu kukhula kungakha amanani ayingozi alezi zinto umzimba wakho ongenakuzisingatha ngokuphepha.

Umuthi uthathwa njengonamandla ngokulinganisela emiphumeleni yawo, ngokuvamile unciphisa ukukhiqizwa kwe-catecholamine ngo-50-80% uma isetshenziswa ngemithamo yokwelapha. Lokhu kuncishiswa okukhulu kusiza ukulawula izimpawu ezinzima ezihambisana nokukhiqizwa kwamahomoni amaningi, njengomfutho wegazi ophezulu kakhulu, izinga lokushaya kwenhliziyo elisheshayo, nokujuluka okukhulu.

Imiphumela ye-metyrosine iyabuyiseka, okusho ukuthi uma uyeka ukuthatha umuthi, umzimba wakho uzobuyela kancane kancane emikhubeni yawo ejwayelekile yokukhiqiza amahomoni. Lokhu kuyenza ithuluzi elibalulekile lokuphatha okwesikhashana ngenkathi ulungiselela ukwelashwa okuqinisekile njengokuhlinzwa.

Kufanele Ngiyithathe Kanjani I-Metyrosine?

I-Metyrosine kufanele ithathwe ngendlela eqondile njengoba inqatshelwe udokotela wakho, ngokuvamile iqala ngomthamo ophansi okhuphuka kancane kancane ezinsukwini ezimbalwa. Abantu abaningi baqala nge-250 mg izikhathi ezine ngosuku, ngemithamo ehlukaniswe ngokulinganayo usuku lonke ukuze kugcinwe amazinga aqhubekayo egazini lakho.

Ungathatha i-metyrosine ngokudla noma ngaphandle kokudla, kodwa ukuyithatha ngokudla kungasiza ukunciphisa ukuquleka kwesisu uma uhlangabezana nokungakhululeki kokugaya ukudla. Uma uthola ukuthi umuthi uphazamisa isisu sakho, zama ukuwuthatha ngesnakhi esilula noma ingilazi yobisi.

Kubalulekile ukugcina ukuthatha uketshezi olwanele ngenkathi uthatha i-metyrosine, njengoba umuthi ngezinye izikhathi ungabangela ukushoda kwamanzi emzimbeni. Ukuphuza amanzi amaningi usuku lonke kuzosiza umzimba wakho ukuthi usebenze umuthi ngempumelelo futhi kunciphise ingozi yemiphumela emibi.

Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze usize ukugcina amazinga aqhubekayo omuthi ohlelweni lwakho. Ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi kungakusiza ukuthi uhlale emgqeni ngeshejuli yakho yokulinganisa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Metyrosine?

Ubude bokwelashwa nge-metyrosine buhlukahluka kakhulu kuye ngesimo sakho esithile kanye nemigomo yokwelashwa. Uma ulungiselela ukuhlinzwa ukuze ususe umdlavuza okhiqiza amahomoni, ngokuvamile uzothatha umuthi izinsuku eziyi-5-7 ngaphambi kwenqubo.

Ngesikhathi salesi sikhathi sangaphambi kokuhlinzwa, udokotela wakho uzoqapha ngokucophelela umfutho wegazi lakho nezimpawu ukuze aqinisekise ukuthi umuthi usebenza ngempumelelo. Umgomo uwukuzuza umfutho wegazi ozinzile nezimpawu ezincishisiwe ngaphambi kokuqhubeka nokuhlinzwa.

Kwabanye abantu abangakwazi ukuhlinzwa ngokushesha, i-metyrosine ingasetshenziswa isikhathi eside njengokwelashwa okuyibhuloho. Lokhu kungase kweluleke amasonto amaningana noma izinyanga ngenkathi wenza ezinye izivivinyo, uthuthukisa impilo yakho, noma ulinda isikhathi esifanele senqubo yakho.

Ezimweni ezingavamile lapho ukuhlinzwa kungenzeki ngenxa yendawo yethumba noma isimo sakho sempilo esiphelele, i-metyrosine ingase isetshenziswe njengesu lokuphatha isikhathi eside. Kodwa-ke, lokhu kudinga ukugadwa kwezokwelapha okuqhubekayo nokuqapha njalo ukuqinisekisa ukuthi imithi iyaqhubeka nokusebenza ngempumelelo nangokuphepha.

Yiziphi Imiphumela Eceleni ye-Metyrosine?

Njengemithi eminingi ethinta ukukhiqizwa kwamahomoni, i-metyrosine ingabangela uhla lwemiphumela eceleni njengoba umzimba wakho uzivumela ezingeni le-catecholamine. Ukuqonda le miphumela engaba khona kungakusiza ukuthi uyibone kusenesikhathi futhi usebenze nethimba lakho lezempilo ukuze uziphatha ngempumelelo.

Imiphumela ejwayelekile ongase uyithole ihlanganisa ukuthula, ukukhathala, kanye nomuzwa ojwayelekile wokungaqapheli njengenjwayelo. Le miphumela yenzeka ngoba i-metyrosine inciphisa ukukhiqizwa kwe-dopamine, okudlala indima ebalulekile ekugcineni ukuqwashisa nokuqonda kwengqondo.

Nansi imiphumela eceleni ongase uhlangabezane nayo:

• Ukozela nokukhathala okungase kuqhubeke usuku lonke
• Ukuqunjelwa, okungase ngezinye izikhathi kube yinkinga enkulu
• Ubunzima ngenkulumo, okuhlanganisa amazwi alukhuni noma ubunzima ekutholeni amazwi afanele
• Ukuthuthumela noma ukuthuthumela okuncane, ikakhulukazi ezandleni zakho
• Ukuminyana kwamakhala okuzizwa kufana nokuba nomkhuhlane
• Ukuncipha kwesifiso sokudla nokulahlekelwa isisindo okungenzeka
• Ushintsho lwemizwa, okuhlanganisa ukuzizwa ungenaso isisusa noma ucindezelekile kancane

Le miphumela ejwayelekile ngokuvamile iyaphathwa futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emithini ezinsukwini zokuqala zokwelashwa.

Imiphumela engavamile kodwa ekhathazayo ingase yenzeke, nakuba ithinta abantu abambalwa abathatha i-metyrosine. Le miphumela ingase idinge ukuqashwa okuseduze noma ukulungiswa kohlelo lwakho lokwelapha.

Nawa amanye amaphutha angavamile okufanele uwaqaphele:

• I-Crystalluria, lapho amakristalu akheka emchamweni wakho, okungenzeka ukuthi kubangele izinkinga zezinso
• Ukucindezeleka okukhulu noma ukukhathazeka okuphazamisa imisebenzi yansuku zonke
• Ukudideka okukhulu noma ukulahlekelwa yisikhundla
• Ukuqina kwemisipha noma ubunzima bokuhlela
• Ukwanda kwamabele emadodeni (i-gynecomastia)
• Izikhathi ezingajwayelekile zokuya esikhathini kwabesifazane
• Ubuhlungu obukhulu besisu noma isicanucanu esiqhubekayo

Uma uhlangabezana nanoma yimiphi yale miphumela engathi sína, kubalulekile ukuxhumana nomhlinzeki wakho wezempilo ngokushesha ukuze uxoxe ngokuthi ngabe kudingeka yini ukulungiswa ekwelashweni kwakho.

Ubani Ongafanele Athatha I-Metyrosine?

I-Metyrosine ayifanele wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zenza kube kubalulekile ukugwema lo muthi. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokunquma i-metyrosine ukuze aqinisekise ukuthi iphephile esimweni sakho esithile.

Akufanele uthathe i-metyrosine uma wazi ukuthi unokungezwani komzimba nomuthi noma yiziphi izithako zawo. Izimpawu zokungezwani komzimba zingabandakanya ukuqubuka, ukuluma, ukuvuvukala, isiyezi esikhulu, noma ubunzima bokuphefumula.

Abantu abanezimo ezithile zezokwelapha badinga ukuqapha okwengeziwe noma bangase badinge ukugwema i-metyrosine ngokuphelele. Umhlinzeki wakho wezempilo uzodinga ukwazi nganoma yiziphi izinkinga zempilo ezikhona ngaphambi kokuqala lo muthi.

Nawa amaphutha angase enze i-metyrosine ingafaneleki noma idinge izinyathelo zokuphepha ezikhethekile:

• Isifo esibi sezinso, njengoba umuthi ungenza umsebenzi wezinso ube nzima nakakhulu
• Isifo sesibindi esisebenzayo noma ukukhubazeka okukhulu kwesibindi
• Ukucindezeleka okukhulu noma umlando wemicabango yokuzibulala
• Isifo sikaParkinson noma ezinye izifo zokunyakaza
• Isifo senhliziyo esibi noma ukuhlaselwa yinhliziyo kwakamuva
• Izifo zokuphuma igazi ezisebenzayo noma ukuphuma igazi okukhulu kwakamuva
• Ukukhulelwa noma ukuncelisa (kudinga ukuhlolwa ngokucophelela kobungozi-inzuzo)

Ngaphezu kwalokho, i-metyrosine ingasebenzisana neminye imithi, ngakho udokotela wakho udinga ukwazi ngayo yonke imithi kadokotela, imithi etholakala ngaphandle kwemvume kadokotela, kanye nezithasiselo ozithathayo njengamanje.

Amagama e-Brand e-Metyrosine

I-Metyrosine itholakala ngaphansi kwegama le-brand elithi Demser e-United States. Lolu uhlobo oluyinhloko lwe-brand olutholakala emathilini amaningi futhi odokotela abaningi bajwayele ukulubhala.

Umuthi ungase futhi utholakale njengokwakheka okujwayelekile kwezinye izifunda, nakuba ukutholakala kungahluka kuye ngendawo yakho kanye nethilomu. Izinhlobo ezijwayelekile ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efanayo nenguqulo yegama le-brand.

Lapho ugcwalisa umuthi wakho, kubalulekile ukunamathela kunguqulo yomkhiqizi ofanayo ngesikhathi sakho sokwelashwa uma kungenzeka. Lokhu kusiza ukuqinisekisa ukulinganisa okungaguquki futhi kunciphisa ingozi yezinguquko ezingalindelekile endleleni umuthi okuthinta ngayo.

Ezinye izindlela ze-Metyrosine

Ngenkathi i-metyrosine ivame ukuba yimithi ekhethwayo yokuphatha imithombo yama-hormone, kunezinye izinketho zokwelapha ezitholakalayo ngokuya ngesimo sakho esithile. Udokotela wakho angase acabange ezinye izindlela uma i-metyrosine ingakulungele noma uma kudingeka ukulawulwa kwezimpawu ezengeziwe.

Ama-alpha-blockers afana ne-phenoxybenzamine avame ukusetshenziswa kanye noma esikhundleni se-metyrosine ukusiza ukulawula umfutho wegazi kubantu abane-pheochromocytoma. Le mithi isebenza ngokuvimba imiphumela yamahomoni amaningi kunokumisa ukuwakhiqiza.

Ama-beta-blockers afana ne-propranolol angase futhi asetshenziswe ukusiza ukulawula izinga lokushaya kwenhliziyo nokunciphisa ezinye izimpawu ezibangelwa ama-catecholamines amaningi. Kodwa-ke, lawa ngokuvamile asetshenziswa ngokuhlangana nama-alpha-blockers kunokuba abe yizindlela zokwelapha ezizimele.

Kwabanye abantu, ama-calcium channel blockers afana ne-nifedipine noma i-amlodipine angase abe usizo ekuphatheni izimpawu zomfutho wegazi. Lawa asebenza ngokusiza imithambo yegazi ukuthi iphumule futhi angaba usizo ikakhulukazi kubantu abangaphenduli kahle kwezinye izindlela.

Ingabe i-Metyrosine Ingcono Kune-Phenoxybenzamine?

I-Metyrosine ne-phenoxybenzamine zisebenza ngezindlela ezingafani ngokuyisisekelo, okuzenza zibe izindlela zokwelapha ezihambisanayo kunokuncintisana. I-Metyrosine inciphisa ukukhiqizwa kwamahomoni amaningi, kuyilapho i-phenoxybenzamine ivimba imiphumela yamahomoni asevele ekhona.

Odokotela abaningi empeleni bakhetha ukusebenzisa womabili lawo machiza ndawonye kunokukhetha elilodwa ngaphezu kwelinye. Le ndlela yokuhlanganisa inganikeza ukulawulwa okuphelele kwezimpawu futhi ilungiselele kangcono iziguli ukuhlinzwa ngokubhekana nenkinga evela ezingxenyeni eziningi.

I-Metyrosine ingase ithandwe uma udinga ukunciphisa ukukhiqizwa kwamahomoni esewonke ngokuhamba kwesikhathi, ikakhulukazi ukuphathwa kwesikhathi eside ngaphambi kokuhlinzwa. Kungaba usizo ikakhulukazi lapho izinso zikhiqiza amazinga aphezulu kakhulu e-catecholamines okunzima ukuwalawula ngama-ejenti okuvimba kuphela.

I-Phenoxybenzamine ingase ikhethwe njengendlela yokwelapha eyinhloko lapho ukulawulwa okusheshayo komfutho wegazi kudingeka, noma lapho othile engakwazi ukubekezelela imiphumela engemihle ye-neurological eyenzeka ngezinye izikhathi nge-metyrosine. Ukukhetha kuvame ukuncika ezimpawini zakho ngazinye, ukubekezelela, kanye nomugqa wesikhathi wokwelashwa.

Imibuzo Evame Ukubuzwa Mayelana ne-Metyrosine

Ingabe i-Metyrosine iphephile kubantu abanesifo sikashukela?

I-Metyrosine ngokuvamile ingasetshenziswa ngokuphepha kubantu abanesifo sikashukela, kodwa idinga ukuqapha okucophelelayo kwamazinga kashukela egazini. Umuthi ngezinye izikhathi ungathinta indlela umzimba wakho osabela ngayo ezingeni likashukela egazini, ikakhulu ngezikhathi zokucindezeleka noma ukugula.

Udkt wakho cishe uzofuna ukuqapha i-glucose yakho yegazi kaningi lapho uqala i-metyrosine, ikakhulukazi uma uthatha i-insulin noma eminye imithi yesifo sikashukela. Abanye abantu bathola ukuthi amaphethini abo kashukela egazini ashintsha kancane ngenkathi bethatha i-metyrosine, ngakho-ke ukuxhumana eduze nethimba lakho lezempilo kubalulekile.

Ngingenzani uma ngithatha i-Metyrosine eningi ngengozi?

Uma ngengozi uthatha i-metyrosine eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungabangela ukuthula okukhulu, ukudideka, ubunzima bokuphefumula, noma ukwehla okuyingozi komfutho wegazi.

Ungazami ukuzelapha ngokweqile ngokuthatha eminye imithi noma izikhuthazi. Kunalokho, funa usizo lwezokwelapha ngokushesha. Uma kungenzeka, letha ibhodlela lomuthi nawe ukuze usize abahlinzeki bezempilo baqonde kahle ukuthi uthathe ini nokuthi ungakanani.

Ezimweni zokweqisa okukhulu, kungase kudingeke uye egumbini eliphuthumayo ukuze uqashwe futhi unakekelwe kuze kube yilapho umuthi owedlulele ususuka ohlelweni lwakho.

Ngingenzani uma ngiphuthelwa umthamo we-Metyrosine?

Uma uphuthelwa umthamo we-metyrosine, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho lokulinganisa olujwayelekile.

Ungalokothi uthathe umthamo ophindwe kabili ukuze ulungise lowo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingweni noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgwaqeni.

Uma uphuthelwa imithamo eminingi noma unokukhathazeka ngokuthi imithamo ephuthelwe ithinta ukwelashwa kwakho, xhumana nodokotela wakho ukuze uthole isiqondiso sokuthi uqhubeke kanjani ngokuphepha.

Ngingayeka nini ukuthatha i-Metyrosine?

Kufanele uyeke kuphela ukuthatha i-metyrosine ngaphansi kokuqondiswa okuqondile kwezokwelapha. Uma uyithatha ngaphambi kokuhlinzwa, udokotela wakho ngokuvamile uzokucela ukuthi uyeke umuthi ngosuku lwenqubo yakho noma ngaphambi nje kwalokho.

Kubantu abasebenzisa i-metyrosine ukuze balawule isikhathi eside, ukuyeka umuthi kudingeka kwenziwe kancane kancane futhi ngokuqapha ngokucophelela. Udokotela wakho uzofuna ukuqinisekisa ukuthi umfutho wegazi lakho nezimpawu zihlala zizinzile njengoba umuthi usuka emzimbeni wakho.

Ungalokothi uyeke ukuthatha i-metyrosine ngokuzumayo wedwa, ngoba lokhu kungaholela emiphumeleni eyingozi lapho izimpawu zakho zibuyela ngokushesha futhi mhlawumbe zibe zimbi kakhulu kunakuqala.

Ngingashayela ngesikhathi ngithatha i-Metyrosine?

I-Metyrosine ivame ukubangela ukozela, ukukhathala, nokuncipha kokuqapha, okungase kuphazamise kakhulu ikhono lakho lokushayela ngokuphepha. Abantu abaningi bathola ukuthi izikhathi zabo zokuphendula zihamba kancane futhi ukugxila kwabo kunciphile ngenkathi bethatha lo muthi.

Ngokuvamile kunconywa ukugwema ukushayela, ikakhulukazi uma uqala ukuthatha i-metyrosine noma lapho umthamo wakho ukhuphuka. Uma usuqonda ukuthi umuthi ukuthinta kanjani wena uqobo, wena nodokotela wakho ningaxoxa ngokuthi kuphephile yini ukuthi uqhubeke nokushayela.

Uma kufanele ushayele, yenza kanjalo kuphela ngezikhathi lapho uzizwa uqaphele kakhulu, gwema uhambo olude, futhi ngaso sonke isikhathi ube nohlelo lokubuyela ekhaya ngokuphepha uma uqala ukuzwa ukozela noma ukudideka.