

Health Library
October 10, 2025
Question on this topic? Get an instant answer from August.
I-Mexiletine iyimithi kadokotela esiza ukulawula ukushaya kwenhliziyo okungajwayelekile ngokuzinzisa umsebenzi kagesi wenhliziyo yakho. Le mithi yomlomo ingeyeqembu lezidakamizwa elibizwa ngokuthi ama-antiarrhythmics, asebenza njengabalawuli abancane kagesi ukugcina inhliziyo yakho ishaya ngesigqi esiqinile, esinempilo.
Ungase uzizwe ukhungathekile ukuzwa ngemithi yesigqi senhliziyo, kodwa i-mexiletine isetshenziswe ngokuphepha amashumi eminyaka ukusiza abantu ukuthi baphile impilo enethezekile. Cabanga ngayo njengomngane osekelayo enhliziyweni yakho, eyisiza ukuthi igcine isigqi sayo semvelo lapho izinto ziba nesiphithiphithi.
I-Mexiletine iyi-sodium channel blocker eqondise ngqo izindlela zikagesi emsipheni wenhliziyo yakho. Yilokho odokotela abakubiza ngokuthi imithi ye-antiarrhythmic ye-Class IB, okusho ukuthi isebenza ngokunciphisa amasiginali kagesi athile angabangela inhliziyo yakho ukuthi ishaye ngokungajwayelekile.
Le mithi iza ngesimo se-capsule futhi ivamise ukuthathwa ngomlomo izikhathi ezimbili kuya kwezintathu ngosuku. Udokotela wakho uzokunika i-mexiletine uma ezinye izindlela zokwelapha zingasebenzi noma uma uhlobo lwakho oluthile lwenkinga yesigqi senhliziyo lusabela kangcono kule mithi ethile.
Lesi sidakamizwa besilokhu sikhona kusukela ngeminyaka yawo-1970 futhi sinomlando wokuphepha oqinile uma sisetshenziswa ngaphansi kokuqondiswa okufanele kwezokwelapha. Kuthathwa njengomuthi wenhliziyo olungile odinga ukuqashwa ngokucophelela kodwa ongaletha imiphumela emihle kakhulu ezigulini ezifanele.
I-Mexiletine ikakhulukazi inikezwa ukwelapha ama-ventricular arrhythmias, okuyizigqi zenhliziyo ezingajwayelekile eziqala emagumbini aphansi enhliziyo yakho. Lezi zinhlobo zezinkinga zesigqi zingazizwa sengathi inhliziyo yakho yehlisa ukushaya, igijima, noma ishaya kanzima kakhulu.
Udktela wakho angase ancome i-mexiletine uma uhlangabezana nokushaya kwenhliziyo okusheshayo (ama-PVC) avamile abangela izimpawu eziphazamisayo. Ama-PVC angukushaya kwenhliziyo okwengeziwe okungenza uzizwe sengathi inhliziyo yakho iyaxhuma noma ishaya ngamandla, ikakhulukazi uma uzama ukuphumula noma ukulala.
Umuthi futhi usetshenziselwa ukuvimbela ukushaya kwenhliziyo okungathi sína, okuhlanganisa i-ventricular tachycardia, okuyilapho inhliziyo yakho ishaya ngokushesha okuyingozi. Kwezinye izimo, odokotela bawunika iziguli ezisindile ezinhlobonhlobo zokuhlaselwa yinhliziyo futhi zidinga ukuvikelwa okuqhubekayo ezinkingeni zesigqi.
Ngokuvamile, i-mexiletine ingasetshenziswa ngaphandle kwetheyibuli ngezimo ezithile zobuhlungu bemizwa noma izifo zemisipha, nakuba lokhu kudinga ukugadwa kwezokwelapha okukhethekile kakhulu. Udktela wakho uzocabangela lezi zindlela zokusebenzisa kuphela uma ukwelashwa okujwayelekile kungazange kunikeze ukukhululeka okwanele.
I-Mexiletine isebenza ngokuvimba iziteshi ze-sodium emangqamuzaneni emisipha yenhliziyo yakho, okusiza ukunciphisa amasiginali kagesi angabangela ukushaya kwenhliziyo okungajwayelekile. Cabanga ngakho njengokufaka izithiyo zejubane emigwaqeni kagesi yenhliziyo yakho ukuvimbela amasiginali ukuthi angagijimi ngokushesha kakhulu.
Lapho amangqamuzana enhliziyo yakho ethola amasiginali kagesi, ngokuvamile avula iziteshi ezivumela i-sodium ukuthi ingene, okubangela ukushaya kwenhliziyo. I-Mexiletine ivimba ngokwengxenye lezi ziteshi, okwenza kube nzima ukuthi amasiginali kagesi angajwayelekile abangele ukushaya okungajwayelekile ngenkathi isavumela isigqi senhliziyo esijwayelekile ukuthi siqhubeke.
Lo muthi ubhekwa njengonamandla ngokulinganisela phakathi kwemithi yesigqi senhliziyo. Ayinamandla njengeminye imithi ye-Class I antiarrhythmics, kodwa inamandla kakhulu kune-beta-blockers elula, okwenza isebenze ezinkingeni zesigqi ezinzima ezingasabeli ekwelashweni okuthambile.
Umuthi uvame ukuqala ukusebenza emahoreni ambalwa ngemva kokuwuthatha, kodwa ungase ungazizwa izinzuzo eziphelele izinsuku eziningana noma amasonto. Inhliziyo yakho idinga isikhathi sokuzivumelanisa nemiphumela yomuthi, futhi udokotela wakho uzoqapha impendulo yakho ngokucophelela ngalesi sikhathi.
Thatha i-mexiletine njengoba nje udokotela wakho ekuyala ngayo, ngokuvamile izikhathi ezimbili kuya kwezintathu ngosuku ngokudla noma ubisi. Ukuyithatha ngokudla kusiza ukunciphisa ukuphathwa yisisu futhi kungathuthukisa ngempela ukuthi umzimba wakho umunca kahle kangakanani umuthi.
Gwinya amaphilisi wonke ngamanzi agcwele, bese uzama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke. Lokhu kusiza ukugcina amazinga aqhubekayo omuthi egazini lakho, okubalulekile ekulawuleni ukushaya kwenhliziyo okungaguquki.
Ungathatha i-mexiletine ngokudla okuningi, kodwa gwema ukudla noma iziphuzo eziningi ezinama-asidi eduze kwezikhathi zomthamo, njengoba lokhu kungase kuthinte indlela umzimba wakho osebenza ngayo umuthi. Ukudla okuvamile kusebenza kahle, futhi asikho isidingo sokulandela ukudla okukhethekile ngaphandle uma udokotela wakho ekuncoma.
Uma unenkinga yokukhumbula imithamo, cabangela ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi. Isikhathi esiqhubekayo sisiza umuthi ukuthi usebenze ngempumelelo enkulu, ngakho ukuthuthukisa umkhuba osebenza neshejuli yakho yansuku zonke kubaluleke kakhulu.
Ungalokothi uchoboze noma uvule amaphilisi, ngoba lokhu kungathinta indlela umuthi okhululwa ngayo emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezindlela zokwakheka ezingezinye noma amasu angase asize.
Ubude bokwelashwa nge-mexiletine buhluka kakhulu kuye ngesimo sakho esithile nokuthi usabela kahle kangakanani emuthini. Abanye abantu bayayidinga izinyanga ezimbalwa nje, kanti abanye bangase bayithathe iminyaka noma isikhathi eside ukuze bagcine ukuzinza kokushaya kwenhliziyo.
Udktela wakho ngokuvamile uzoqala ngesikhathi sokuhlola samaviki amaningana ukuze abone ukuthi inhliziyo yakho isabela kanjani nokuthi ngabe uhlangabezana nanoma yimaphi imiphumela engathandeki. Ngesikhathi lesi, cishe uzoba nokuhlolwa okuvamile futhi mhlawumbe nokuqapha ukushaya kwenhliziyo ukuze ulandelele intuthuko yakho.
Kubantu abanezinkinga zokushaya kwenhliziyo ezingapheli, i-mexiletine ingase ibe umuthi wesikhathi eside, ofana nendlela abanye abantu abathatha ngayo imithi yokucindezela igazi impilo yabo yonke. Umgomo uwukuthola ukulinganisela okulungile phakathi kokulawula izimpawu zakho nokunciphisa noma yimiphi imiphumela emibi.
Ungayeki ukuthatha i-mexiletine ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka ngokuphazima kungase ngezinye izikhathi kubangele ukuthi izinkinga zakho zokushaya kwenhliziyo zibuye ngendlela engathi sína kakhulu kunangaphambili, into ebizwa ngokuthi i-rebound arrhythmias.
Udktela wakho uzobuyekeza ngezikhathi ezithile ukuthi ngabe usadinga yini umuthi futhi angase alungise umthamo wakho noma asikisele ukuzama ukuphumula ekwelashweni uma ukushaya kwenhliziyo yakho bekuzinzile isikhathi eside.
Njengemithi eminingi yenhliziyo, i-mexiletine ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle uma umzimba wabo usujwayele umuthi. Imiphumela emibi evame kakhulu ivamise ukuba mnene futhi ivame ukuthuthuka ngemva kwamasonto ambalwa okuqala ukwelashwa.
Nansi imiphumela emibi ongase uyithole, uqala ngaleyo evame kakhulu evame ukungabi yingozi:
Le miphumela emibi evamile ivame ukushabalala njengoba umzimba wakho ujwayela umuthi, kodwa yazisa udokotela wakho uma iqhubeka noma ikukhathaza kakhulu.
Abanye abantu bahlangabezana nemiphumela emibi ekhathazayo edinga ukunakekelwa kwezokwelapha. Nakuba lokhu kungavamile, kubalulekile ukukubona:
Ngokuvamile, i-mexiletine ingabangela imiphumela emibi kakhulu edinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi ukusabela okukhulu komzimba, izinkinga zesibindi, noma izifo zegazi, nakuba lokhu kwenzeka ngaphansi kuka-1% wabantu abathatha umuthi.
Xhumana nodokotela wakho ngokushesha uma uba nokuqubuka, ukuphuzi kwesikhumba sakho noma amehlo, ukulimala okungavamile, noma umkhuhlane oqhubekayo ngenkathi uthatha i-mexiletine. Lezi zimpawu azivamile kodwa zingase zibonise ukusabela okukhulu okudinga ukunakekelwa ngokushesha.
I-Mexiletine ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile zenhliziyo zenza i-mexiletine ingaphephile noma ingaba yingozi ukuyisebenzisa.
Akufanele uthathe i-mexiletine uma unezinhlobo ezithile zokuvinjwa kwenhliziyo noma ukuhluleka okukhulu kwenhliziyo, njengoba umuthi ungenza lezi zimo zibe zimbi kakhulu. Udokotela wakho uzoqhuba i-electrocardiogram (ECG) ukuze ahlolisise umsebenzi kagesi wenhliziyo yakho ngaphambi kokuqala ukwelashwa.
Abantu abanezinkinga zesibindi kungenzeka bangakwazi ukuthatha i-mexiletine ngokuphepha, njengoba isibindi sisebenzisa lo muthi. Uma unomlando wesifo sesibindi noma uthatha eminye imithi ethinta ukusebenza kwesibindi, udokotela wakho uzodinga ukukuqapha eduze kakhulu.
Abesifazane abakhulelwe ngokuvamile kufanele bagweme i-mexiletine ngaphandle kwalapho izinzuzo ziqeda izingozi, njengoba imiphumela yayo ezinganeni ezisakhulayo ingaqondakali ngokugcwele. Uma uncelisa, i-mexiletine ingadlulela obisini lwebele futhi ingase imthinte umntwana wakho.
Xoxa nodokotela wakho ngayo yonke imithi oyithathayo, okuhlanganisa nemithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo. I-Mexiletine ingasebenzisana neminye imithi eminingi, ikakhulukazi eminye imithi yokulawula ukushaya kwenhliziyo, ama-antibiotics athile, kanye neminye imithi yokucindezeleka.
Uma unezinkinga zezinso, izifo zokuquleka, noma umlando wezimo zengqondo, udokotela wakho uzodinga ukukala izinzuzo nezingozi ngokucophelela ngaphambi kokukuchazela i-mexiletine.
I-Mexiletine itholakala ngaphansi kwamagama amaningi omkhiqizo, i-Mexitil iyona evame ukwaziwa kakhulu. Kodwa-ke, amakhemisi amaningi manje anezinhlobo ze-mexiletine ezivamile, ezisebenza kahle njengezinhlobo zamagama omkhiqizo.
I-mexiletine ejwayelekile isitholakala iminyaka eminingi futhi ihlangabezana namazinga ekhwalithi afanayo nemithi yamagama omkhiqizo. Umshwalense wakho ungase ukhethe uhlobo olujwayelekile, futhi ngokuvamile luthengeka kakhulu ngaphandle kokuba nomthelela ekusebenzeni.
Amanye amagama omkhiqizo ongase uwabone ahlanganisa i-Mexitil kanye nezinhlobo ezahlukahlukene ezivamile ezivela kubakhiqizi abahlukene. Into ebalulekile yisithako esisebenzayo, i-mexiletine hydrochloride, efana kungakhathaliseki ukuthi umkhiqizo ungowani.
Uma ushintsha phakathi kwabakhiqizi abahlukene be-mexiletine ejwayelekile, yazisa udokotela wakho, ngoba kungase kube khona umehluko omncane endleleni izinhlobo ezahlukene ezithathwa ngayo umzimba wakho.
Uma i-mexiletine ingakulungele noma ingalawuli ukushaya kwenhliziyo yakho ngempumelelo, eminye imithi eminingi ingelapha izimo ezifanayo. Udokotela wakho angase acabangele eminye imithi elwa nokushaya kwenhliziyo okungavamile njenge-flecainide, propafenone, noma i-amiodarone.
I-Flecainide ingenye i-Class I antiarrhythmic esebenza ngendlela efana ne-mexiletine kodwa ingase ithandwe kangcono abanye abantu. Ivame ukusetshenziselwa izinhlobo ezifanayo zezinkinga zokushaya kwenhliziyo futhi ingaba yindlela uma i-mexiletine idala imiphumela eminingi engemihle.
Ama-beta-blockers afana ne-metoprolol noma i-atenolol ayizindlela ezinobumnene ezingase zisebenze ezinkingeni ezingahambisani kangako. Le mithi yehlisa izinga lokushaya kwenhliziyo yakho futhi ingasebenza ezinhlotsheni ezithile zokushaya kwenhliziyo okungajwayelekile ngaphandle kwemiphumela emibi enamandla ye-mexiletine.
Ezinkingeni ezingathi sína zokushaya kwenhliziyo, udokotela wakho angase acabangele i-amiodarone, okuyimithi enamandla kakhulu yokulwa nokushaya kwenhliziyo okungajwayelekile. Kodwa-ke, i-amiodarone ineqoqo layo lemiphumela emibi futhi idinga ukuqashwa ngokucophelela.
Ukwelashwa okungekona okwemithi njenge-catheter ablation noma amadivayisi afakelwayo kungase kube ezinye izindlela zabanye abantu, ikakhulu uma imithi ingalawuli izimpawu zabo ngempumelelo.
Ukuthi i-mexiletine ingcono kune-flecainide kuncike ngokuphelele esimweni sakho senhliziyo esithile nokuthi umzimba wakho usabela kanjani emithini ngayinye. Zombili le mithi zisebenza ezinkingeni zokushaya kwenhliziyo, kodwa zinamandla ahlukene kanye namaphrofayili emiphumela emibi.
I-Mexiletine ivame ukukhethwa kubantu abaye bahlaselwa yinhliziyo noma abanezinkinga ezithile zesakhiwo senhliziyo, njengoba ngokuvamile iphephe kulezi zimo kune-flecainide. Iphinde ithandwe uma abantu beke baba nokusabela okubi kweminye imithi yokulwa nokushaya kwenhliziyo okungajwayelekile.
I-Flecainide ingase ithandwe kubantu abanezinhliziyo ezijwayelekile ezingenasakhiwo ezinokushaya kwenhliziyo okungajwayelekile noma izinhlobo ezithile ze-supraventricular tachycardia. Ivame ukubekezelelwa kangcono futhi ingase idinge ukulinganiswa okungavamile kune-mexiletine.
Udokotela wakho uzocabangela izinto ezinjengohlobo lwakho oluthile lwe-arrhythmia, impilo yakho yonke yenhliziyo, ezinye izimo zezokwelapha onazo, kanye nokusabela kwakho kwangaphambilini emithini yenhliziyo lapho ukhetha phakathi kwalezi zinketho.
Ngezinye izikhathi odokotela bazama umuthi owodwa kuqala bese beshintshela komunye uma ukukhetha kokuqala kungasebenzi kahle noma kubangela imiphumela emibi ekhathazayo. Le ndlela yokulinga nephutha ivamile futhi ijwayelekile ekuphathweni kokushaya kwenhliziyo.
I-Mexiletine ngokuvamile iphephile kubantu abanesifo sikashukela, kodwa idinga ukuqashwa ngokucophelela ngoba isifo sikashukela singathinta inhliziyo yakho nemithambo yegazi. Udokotela wakho uzodinga ukucabangela ukuthi isifo sikashukela sakho silawulwa kahle kangakanani nokuthi ngabe unazo yini izinkinga zenhliziyo ezihlobene nesifo sikashukela.
Umuthi awuthinti ngokuqondile amazinga kashukela egazini, ngakho ngeke uphazamise imithi yakho yesifo sikashukela noma ukulawulwa kashukela egazini. Kodwa-ke, uma uhlangabezana nesicanucanu noma isisu esicasukile esivela ku-mexiletine, lokhu kungathinta izindlela zakho zokudla nokuphathwa kukashukela egazini.
Abantu abanesifo sikashukela abanezinkinga zesigqi senhliziyo bavame ukudinga i-mexiletine ngoba isifo sikashukela sandisa ingozi yokuthuthukisa ama-arrhythmias. Udokotela wakho uzosebenza nawe ukuqinisekisa ukuthi zombili izimo ziphathwa ngokuphepha ndawonye.
Uma ngengozi uphuza i-mexiletine eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuphuza okuningi kungabangela izinkinga ezinzima zesigqi senhliziyo ezingase zingabonakali ngokushesha.
Ungazami ukuzenza uhlanze noma uthathe eminye imithi ukuze ulwe nokweqisa. Kunalokho, funa ukwelashwa ngokushesha, ikakhulukazi uma uzizwa unesiyezi, unezinhlungu esifubeni, noma uqaphela inhliziyo yakho ishaya ngokungajwayelekile.
Letha ibhodlela lomuthi nawe egumbini eliphuthumayo ukuze abasebenzi bezokwelapha bakwazi ukubona kahle ukuthi yini oyiphuzile nokuthi ingakanani. Isikhathi sibalulekile ekweqiseni imithi yenhliziyo, ngakho-ke ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini.
Ukuvimbela ukweqisa ngengozi, cabanga ukusebenzisa umhleli wamaphilisi nokusetha izikhumbuzi ocingweni lwakho. Uma uhlala nabanye, bazise ngohlelo lwakho lwemithi ukuze bakwazi ukusiza ukulandela umkhondo.
Uma uphuthelwa umthamo we-mexiletine, yithathe ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho olujwayelekile lokuthatha imithi.
Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungadala izinkinga eziyingozi zokushaya kwenhliziyo. Kungcono ukweqa umthamo owodwa kunokubeka engcupheni yokuthatha imithi eningi kakhulu ngesikhathi esisodwa.
Uma uvame ukukhohlwa imithamo, khuluma nodokotela wakho ngamasu okukusiza ukuthi ukhumbule. Ukuthatha imithi njalo kubalulekile ukuze i-mexiletine isebenze ngempumelelo, ngakho-ke ukuthola isimiso esikusebenzelayo kubaluleke kakhulu.
Ukuphuthelwa imithamo ngezikhathi ezithile ngokuvamile akuyona ingozi, kodwa ukuphuthelwa imithamo njalo kungavumela izinkinga zakho zokushaya kwenhliziyo ukuthi zibuye futhi zibe zimbi ngokuhamba kwesikhathi.
Kufanele uyeke kuphela ukuthatha i-mexiletine ngaphansi kokuqondiswa ngudokotela wakho, ngisho noma uzizwa ungcono ngokuphelele. Ukuyeka imithi yokushaya kwenhliziyo kungazelelwe ngezinye izikhathi kungadala ukuthi ukushaya kwenhliziyo kwakho okungajwayelekile kubuye ngendlela enzima kakhulu kunakuqala.
Udkt wakho ngokuvamile uzokwehlisa umthamo wakho kancane kancane ezinsukwini ezimbalwa noma emasontweni kunokuyeka konke ngesikhathi esisodwa. Lokhu kunika inhliziyo yakho isikhathi sokuzivumelanisa futhi kunciphisa ingozi yokuphinda kwenzeke ama-arrhythmias.
Isinqumo sokuyeka i-mexiletine sincike ekutheni usuyithatha isikhathi esingakanani, kungani wayidinga ekuqaleni, nokuthi ngabe isimo senhliziyo yakho esingaphansi sithuthukile yini. Abanye abantu badinga ukwelashwa isikhathi eside, kanti abanye bangagcina beyeka ukuthatha imithi.
Ukuqokwa okuvamile kokulandela nodokotela wakho kuzosiza ukunquma isikhathi esifanele sokucabangela ukuyeka i-mexiletine. Udokotela wakho angase afune ukuqapha ukushaya kwenhliziyo yakho isikhathi esithile ngemuva kokuyeka ukuqinisekisa ukuthi ama-arrhythmias akho awabuyi.
Kungcono ukunciphisa ukusetshenziswa kotshwala ngenkathi uthatha i-mexiletine, njengoba utshwala bungakhuphula eminye imiphumela engemihle efana nesiyezi nezinkinga zokuxhumana. Kokubili i-mexiletine notshwala kungathinta isimiso sakho sezinzwa, ngakho ukuzihlanganisa kungakwenza uzizwe ungaqinile noma udidekile.
Utshwala bungabangela nezinkinga zesigqi senhliziyo kwabanye abantu, okungase kusebenze ngokumelene nalokho i-mexiletine ezama ukukufeza. Uma ukhetha ukuphuza ngezikhathi ezithile, kwenze ngokulinganisela futhi unake ukuthi uzizwa kanjani.
Xoxa nodokotela wakho mayelana nemikhuba yakho yokusetshenziswa kotshwala ukuze bakunikeze iseluleko esiqondene nawe esisekelwe esimweni sakho esithile. Abanye abantu bangase badinge ukugwema utshwala ngokuphelele, kanti abanye bangase bakwazi ukuphuza ngezikhathi ezithile ngokuphepha.
Uma uqaphela ukuthi ngisho namanani amancane otshwala akwenza uzizwe unesiyezi noma ungazizwa kahle ngenkathi uthatha i-mexiletine, kungcono ukugwema utshwala ngokuphelele ngenkathi usebenzisa lo muthi.
Get clear medical guidance
on symptoms, medications, and lab reports.