Yini i-Midodrine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Midodrine iyimithi kadokotela esiza ukukhuphula umfutho wegazi kubantu abomfutho wabo wegazi wehla kakhulu lapho bemi. Lesi simo, esibizwa ngokuthi i-orthostatic hypotension, singakwenza uzizwe unesiyezi, ubuthakathaka, noma sikwenze uquleke lapho usukuma uhleli noma ulele.

Udkt wakho angase akubhalele i-midodrine uma umfutho wakho wegazi ophansi uthinta kakhulu imisebenzi yakho yansuku zonke futhi ezinye izindlela zokwelapha azisebenzi kahle ngokwanele. Kuthathwa njengomuthi okhethekile odinga ukuqashwa ngokucophelela, kodwa kungaba usizo ngempela kubantu abahlushwa yilesi simo esiyinselele.

Yini i-Midodrine?

I-Midodrine iyimithi yomfutho wegazi esebenza ngendlela ehlukile kunabanye abaningi ongase ubazi. Ngenkathi imithi eminingi yomfutho wegazi yehlisa umfutho wakho, i-midodrine empeleni iyawukhuphula ngokuqinisa imithambo yakho yegazi.

Lo muthi ungowesigaba esibizwa ngokuthi ama-alpha-1 agonists, okusho ukuthi isebenzisa izamukeli ezithile emithanjeni yakho yegazi. Cabanga ngakho njengokunikeza imithambo yakho yegazi ukuminyana okuncane ukuze kusize ukugcina ukuhamba kwegazi okungcono uma uqonde.

I-Midodrine iza ngamaphilisi owathatha ngomlomo, ngokuvamile kathathu ngosuku. Itholakala kuphela ngemvume kadokotela ngoba idinga ukugadwa ngokucophelela kwezokwelapha ukuze kuqinisekiswe ukuthi isebenza ngokuphepha esimweni sakho esithile.

Yini i-Midodrine Esetshenziselwa Yona?

I-Midodrine ikakhulukazi ibhalelwe i-orthostatic hypotension, isimo lapho umfutho wakho wegazi wehla kakhulu uma usukuma. Lokhu kwenzeka lapho umzimba wakho unenkinga yokulungisa ukuhamba kwegazi njengoba ushintsha izikhundla.

Abantu abanalesi simo bavame ukuzwa izimpawu ezinzima ezingathinta ngempela izinga lempilo yabo. Ungase uzizwe unesiyezi noma unomuzwa wokukhanya lapho umi, uzwe ubuthakathaka noma ukukhathala, noma uquleke ngokungalindelekile.

Udktela wakho ngokuvamile uzocabangela i-midodrine uma izinguquko zendlela yokuphila kanye neminye imithi inganikezanga ukukhululeka okwanele. Lo muthi uvunyelwe ngokuqondile kubantu abanomfutho wegazi ophansi obenza bangakwazi ukwenza imisebenzi yabo yansuku zonke.

Ngezinye izikhathi odokotela bangase banikeze i-midodrine kwezinye izimo ezihilela umfutho wegazi ophansi, nakuba lokhu kungabhekwa njengokusebenzisa ngaphandle kwemvume okudinga ukwahlulela okucophelelayo kwezokwelapha.

Isebenza Kanjani I-Midodrine?

I-Midodrine isebenza ngokuba esebenzayo emzimbeni wakho ngemva kokuyithatha. Umuthi ngokwawo awusebenzi kuze kube yilapho isibindi sakho siwuguqula sibe yifomu elisebenzayo, elibizwa ngokuthi i-desglymidodrine.

Uma isivuliwe, ivuselela ama-alpha-1 receptors emithanjeni yakho yegazi, okubangela ukuthi anciphise noma aqine. Lokhu kuncipha kusiza ukugcina umfutho wegazi ophakeme, ikakhulukazi uma umi uqonde.

Lo muthi ubhekwa njengonamandla ngokulinganisela emiphumeleni yawo. Awunamandla njengeminye imithi yezimo eziphuthumayo yomfutho wegazi, kodwa unamandla kunezinketho eziningi ezingathengwa ngaphandle kwemvume kadokotela noma izinguquko ezilula zendlela yokuphila.

Okuthakazelisayo nge-midodrine ukuthi ithinta ikakhulukazi imithambo yegazi ezingalweni nasemilenzeni yakho, kunokuba inhliziyo yakho. Lesi senzo esiqondiswe ngqo sisiza ukukhuphula umfutho wegazi ngaphandle kokubeka ingcindezi enkulu emisipheni yenhliziyo yakho.

Kufanele Ngiyithathe Kanjani I-Midodrine?

Thatha i-midodrine njengoba udktela wakho ekuyala ngayo, ngokuvamile kathathu ngosuku ngamahora okungenani angu-3-4 phakathi kwemithamo. Ishejuli ejwayelekile yasekuseni, emini, nasekuseni kakhulu, kodwa ungalithathi umthamo wakho wokugcina ngemva kuka-6 PM.

Ungayithatha i-midodrine ngaphandle noma ngaphandle kokudla, nakuba abanye abantu bekuthola kulula esiswini sabo uma ithathwa nesnakhi esincane. Amanzi alungile ngokuphelele ukuyithatha nawo, futhi awudingi ubisi noma isiphuzo esikhethekile.

Ngaphambi kokuthatha imithi yakho, kuyasiza ukudla okuthile okulula uma ungakadli muva nje. Lokhu kungasiza ekuvikeleni noma yikuphi ukuphazamiseka kwesisu, nakuba kungadingeki ngokuphelele.

Isikhathi somthamo wakho wokugcina sibalulekile ngoba i-midodrine ingakhuphula umfutho wegazi lakho ngisho nalapho ulele phansi. Ukuyithatha sekwephuzile emini kungase kubangele umfutho wegazi lakho ukuthi ube phezulu kakhulu ngenkathi ulele.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Midodrine?

Ubude bokwelashwa nge-midodrine buhlukahluka kakhulu kumuntu nomuntu, kuye ngesimo sakho esiyisisekelo nokuthi usabela kanjani emuthini. Abanye abantu bayayidinga izinyanga ezimbalwa nje, kanti abanye bangase badinge ukwelashwa isikhathi eside.

Udokotela wakho uzohlola njalo ukuthi usayidinga yini i-midodrine ngokubheka izimpawu zakho nokusabela komfutho wegazi. Bangase baphakamise ukuphumula ngezikhathi ezithile emuthini ukuze babone ukuthi isimo sakho sithuthuke ngokwemvelo.

Kwabanye abantu abanezimo ezingapheli ezibangela i-orthostatic hypotension, i-midodrine ingase idingeke isikhathi eside. Kodwa-ke, udokotela wakho uzohlala ehlose ukusebenzisa umthamo ophansi osebenzayo isikhathi esifushane esidingekayo.

Ungayeki ukuthatha i-midodrine ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Bangase bafune ukunciphisa umthamo wakho kancane kancane ukuze bavimbele umfutho wegazi lakho ukuthi wehle ngokushesha.

Ziyini Imiphumela Eceleni ye-Midodrine?

Njengayo yonke imithi, i-midodrine ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi ihlobene nemiphumela yayo yokukhuphula umfutho wegazi futhi ivame ukuba milde kuya esimweni esiphakathi.

Imiphumela emibi evame kakhulu ongase uyibone ihlanganisa ukuzwa ukuluma noma ukugwaza ekhanda lakho, ama-goosebumps, noma ukuzwa kubanda. Lezi zinzwa zenzeka ngoba i-midodrine ithinta imithambo yegazi esikhumbeni sakho futhi ngokuvamile iba ngaphansi uma umzimba wakho ujwayela.

Nawa amanye imiphumela emibi ejwayelekile abantu abayitholayo:

• Ukuqaqamba kwekhanda noma imizwa yokugwaza
• Ukuqina kwesikhumba noma izinwele zimi ngqi
• Ukuzizwa kubanda noma kubanda
• Ukuthola ubunzima bokuchama noma ukugcinwa komchamo
• Isicanucanu noma ukungakhululeki kwesisu
• Ikhanda elibuhlungu
• Isiyezi ngenkathi elele

Le miphumela ejwayelekile ivamise ukulawuleka futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Udokotela wakho angakusiza ukuthi uthole izindlela zokunciphisa noma yikuphi ukungakhululeki okuhlangenwe nakho.

Abanye abantu bangase babe nemiphumela emibi kakhulu edinga ukunakekelwa kwezempilo ngokushesha. Lokhu akuvamile kodwa kubalulekile ukuqaphela:

• Umfutho wegazi ophezulu kakhulu ngenkathi elele
• Izinga lokushaya kwenhliziyo elihamba kancane noma ukushaya kwenhliziyo okungajwayelekile
• Ubuhlungu besifuba noma ukucindezela
• Ikhanda elibuhlungu elingathuthuki
• Ushintsho lombono noma umbono ongacacile
• Ubunzima bokuphefumula
• Ubuhlungu obukhulu besisu

Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezempilo eziphuthumayo. Le miphumela ayivamile kodwa idinga ukunakwa ngokushesha ukuze kuqinisekiswe ukuphepha kwakho.

Ubani Ongafanele Athathwe I-Midodrine?

I-Midodrine ayiphephile kuwo wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zikwenza kungafaneleki noma kube yingozi. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Abantu abanezimo ezithile zenhliziyo kufanele bagweme i-midodrine ngoba ingafaka ingcindezi eyengeziwe ohlelweni lwe-cardiovascular. Lokhu kuhlanganisa labo abanezifo zenhliziyo ezinzima, izinhlobo ezithile zezinkinga zesigqi senhliziyo, noma ukuhluleka kwenhliziyo okukhulu.

Nawa amakhondishini amakhulu avamile ukwenza i-midodrine ingafaneleki:

• Isifo senhliziyo esibi noma ukuhluleka kwenhliziyo okungazelelwe
• Ukwanda kwamahomoni e-thyroid (hyperthyroidism)
• I-glaucoma ebanzi
• Isifo sezinso esibi
• I-Pheochromocytoma (ithumba elingavamile le-adrenal gland)
• Umfutho wegazi ophezulu oqhubekayo ngenkathi elele
• Ukukhulelwa noma ukuncelisa

Udokotela wakho uzophinda aqaphele ngokuqoka i-midodrine uma unesifo sikashukela, izinkinga zesibindi, noma izinkinga zokugcinwa komchamo. Lezi zimo azikuvimbeli ngempela ukuthatha imithi, kodwa zidinga ukuqapha okwengeziwe.

Ubudala bungaba yisici, njengoba abadala bengase bazwe kalula imiphumela ye-midodrine. Udokotela wakho angase aqale ngomthamo ophansi futhi akuqaphele eduze uma uneminyaka engaphezu kwengama-65.

Amagama e-Midodrine Brand

I-Midodrine itholakala ngaphansi kwamagama amaningi ebhrendi, i-ProAmatine iyona eyaziwa kakhulu e-United States. Leli kwakuyigama lokuqala lebhrendi lapho imithi yayivunywa okokuqala.

Amanye amagama ebhrendi afaka i-Orvaten, nakuba i-ProAmatine isaqashelwa kakhulu. Izinhlobo ze-midodrine ezivamile nazo ziyatholakala futhi zisebenza ngendlela efanayo nezinhlobo zamagama ebhrendi.

Noma ngabe uthola i-midodrine yegama lebhrendi noma ejwayelekile, isithako esisebenzayo nokusebenza kwayo kufana. Ikhemisi lakho lingase libe nezinhlobo ezahlukene zabakhiqizi, kodwa zonke zihlangabezana nezindinganiso ezifanayo zekhwalithi nokuphepha.

Uma unezinkathazo ngokushintsha phakathi kwezinhlobo ezahlukene ze-midodrine, khuluma nodokotela wakho noma usokhemisi. Bangaphendula noma yimiphi imibuzo mayelana nokuvumelana noma ukusebenza.

Ezinye izindlela ze-Midodrine

Ezinye izindlela ze-midodrine ziyatholakala zokwelapha i-orthostatic hypotension, nakuba ukukhetha okungcono kuncike esimweni sakho esithile nezimbangela ezingaphansi. Udokotela wakho uzocabangela lezi zinketho uma i-midodrine ingakulungele noma ingasebenzi kuwe.

I-Fludrocortisone ngomunye umuthi ovame ukusetshenziselwa ukwehla kwegazi uma usukuma. Isebenza ngendlela ehlukile kune-midodrine ngokusiza umzimba wakho ukuthi ugcine usawoti namanzi, okwandisa ivolumu yegazi nomfutho wegazi.

Izindlela ezingasebenzisi imithi nazo zingasebenza kahle kakhulu ekuphatheni ukwehla kwegazi uma usukuma. Lawa maqhinga endlela yokuphila avame ukusebenza kahle wodwa noma ngokuhlangana nemithi:

• Ukugqoka amasokisi okucindezela ukuze kuthuthukiswe ukugeleza kwegazi
• Ukwandisa ukudla usawoti (ngaphansi kokuqondisa kwezokwelapha)
• Ukuphuza uketshezi oluningi, ikakhulukazi amanzi
• Ukusukuma kancane usuka ekuhlaliseni noma ekulaleni
• Ukulala nekhanda lakho liphakeme
• Ukugwema izindawo ezishisayo nokugeza isikhathi eside

Udokotela wakho angase futhi ancome ukwelapha noma yiziphi izimo ezingaphansi ezifaka isandla ekwehleni kwegazi uma usukuma. Ngezinye izikhathi ukubhekana nembangela kungathuthukisa kakhulu izimpawu zakho ngaphandle kokudinga imithi efana ne-midodrine.

Ingabe i-Midodrine Ingcono Kune-Fludrocortisone?

Akukho kokubili i-midodrine noma i-fludrocortisone engcono kunenye ngaso sonke isikhathi. Ukukhetha kuncike ezimweni zakho, izimo zempilo ezingaphansi, nokuthi usabela kahle kangakanani emithini ngayinye.

I-Midodrine ivame ukusebenza ngokushesha futhi inemiphumela emincane yesikhathi eside, okuyenza ibe yindlela enhle yokuqala kubantu abaningi. Futhi ayibangeli ukugcinwa koketshezi okungenziwa yi-fludrocortisone, okubalulekile uma unezinkinga zenhliziyo noma izinso.

I-Fludrocortisone, ngakolunye uhlangothi, ingasebenza kahle kakhulu kwabanye abantu futhi ingathathwa kaningi. Kodwa-ke, ingabangela imiphumela emibi kakhulu ngokuhamba kwesikhathi, okuhlanganisa amazinga e-potassium aphansi kanye nokwanda kwengozi yokutheleleka.

Udokotela wakho uzocabangela izinto ezinjengezinye izimo zakho zezokwelapha, imithi yamanje, nendlela yokuphila lapho enquma ukuthi iyiphi inketho engasebenza kangcono kuwe. Abanye abantu baze bazuze ekuthathweni kwemithi yomibili ndawonye ngaphansi kokuqondisa okucophelelayo kwezokwelapha.

Imibuzo Evame Ukubuzwa Mayelana ne-Midodrine

Umbuzo 1. Ingabe i-Midodrine iphephile kubantu abanesifo sikashukela?

I-Midodrine ingasetshenziswa ngokuphepha kubantu abanesifo sikashukela, kodwa idinga ukuqapha okwengeziwe nokuqapha. Isifo sikashukela singathinta imithambo yakho yegazi nemizwa, okungashintsha indlela umzimba wakho osabela ngayo emuthini.

Udokotela wakho uzodinga ukuqapha umfutho wakho wegazi eduze futhi angase akuqale ngomthamo ophansi. Isifo sikashukela singathinta nokuthi umzimba wakho ulawula kanjani umfutho wegazi ngokwemvelo, ngakho imiphumela ye-midodrine ingase ivele kakhulu.

Uma unesifo sezinso esibangelwa isifo sikashukela, udokotela wakho uzocophelela ekunikezeni i-midodrine, njengoba izinkinga zezinso zingathinta indlela umzimba wakho osebenzisa ngayo umuthi. Hlala utshela udokotela wakho ngokuphathwa kwakho isifo sikashukela kanye nanoma yiziphi izinkinga oye wahlangabezana nazo.

Umbuzo 2. Kufanele ngenzeni uma ngiphuzile i-Midodrine eningi ngengozi?

Uma ngengozi uphuze i-midodrine eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma ukulawulwa kwobuthi ngokushesha, ikakhulukazi uma uphuze okuningi kakhulu kunomthamo wakho ovamile. Ukuphuza okuningi kungabangela umfutho wegazi ophezulu ngendlela eyingozi.

Izimpawu zokuphuza i-midodrine eningi zihlanganisa ikhanda elibuhlungu elibuhlungu, umbono ongacacile, ubuhlungu besifuba, noma ukuzwa sengathi inhliziyo yakho ishaya ngokungajwayelekile. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, funa ukunakekelwa kwezempilo okuphuthumayo ngokushesha.

Ngenkathi ulinde usizo lwezokwelapha, lala phansi bese uzama ukuhlala uzolile. Gwema noma yimiphi imisebenzi engase ikhuphule umfutho wakho wegazi ngokuqhubekayo, njengokuzivocavoca noma izimo ezicindezelayo.

Ukuvimbela ukweqisa ngengozi, cabanga ngokusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi zocingo ukukusiza ukuthi ulandelele ukuthi uwuthathile nini umuthi wakho.

Umbuzo 3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Midodrine?

Uma uphuthelwa umthamo we-midodrine, yithathe ngokushesha lapho ukhumbula, ngaphandle kwalapho iseduze nomthamo wakho olandelayo ohleliwe. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise eyodwa ephuthelwe.

Uma kungaphakathi kwamahora angu-2 emthamo wakho olandelayo, weqa umthamo owuphuthelwe bese uqhubeka neshejuli yakho ejwayelekile. Lokhu kusiza ekuvikeleni ukuthi umfutho wegazi lakho ungafinyeleli phezulu kakhulu ngenxa yemithamo ehlanganayo.

Khumbula ukuthi umthamo wakho wokugcina akufanele uthathwe ngemva kuka-6 PM, ngisho noma uphuthelwe umthamo wangaphambilini. Ukuthatha i-midodrine sekwephuze kakhulu emini kungabangela umfutho wegazi ophezulu ngenkathi ulele.

Uma uvame ukukhohlwa imithamo, khuluma nodokotela wakho mayelana namaqhinga okukusiza ukuthi ukhumbule, njengokuxhumanisa imithamo nokudla noma imisebenzi yansuku zonke.

Q4. Ngingayeka nini ukuthatha i-Midodrine?

Kufanele uyeke kuphela ukuthatha i-midodrine ngaphansi kwesiqondiso sikadokotela wakho, njengoba bedinga ukuqinisekisa ukuthi kuphephile futhi kufanele esimweni sakho. Ukuyeka kungazelelwe kungabangela ukuthi umfutho wegazi lakho wehle ngokushesha, okungenzeka kuholele ekuzizweni unesiyezi noma ukuquleka.

Udkt wakho ngokuvamile uzofuna ukunciphisa kancane umthamo wakho ezinsukwini eziningana noma emasontweni kunokuyeka kungazelelwe. Bazophinde baqaphe izimpawu zakho nomfutho wegazi ngalesi sikhathi.

Isinqumo sokuyeka i-midodrine sincike ezintweni eziningana, okuhlanganisa ukuthi isimo sakho esingaphansi sithuthuke kangakanani nokuthi ngabe wenze izinguquko zendlela yokuphila ezisiza ukuphatha umfutho wegazi lakho ngokwemvelo.

Abanye abantu bangagcina beyekile ukuthatha i-midodrine uma isimo sabo sithuthuka, kanti abanye bangase bayidinge isikhathi eside. Udokotela wakho uzohlola njalo ukuthi usayidinga yini imithi futhi alungise uhlelo lwakho lokwelapha ngokufanele.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Midodrine?

Kungcono ukugwema utshwala noma ukuphuza amanani amancane kakhulu ngenkathi uthatha i-midodrine, njengoba utshwala bungaphazamisa ukusebenza kahle komuthi futhi kwandise ingozi yakho yemiphumela emibi.

Utshwala bunganciphisa umfutho wegazi lakho futhi lenze i-orthostatic hypotension ibe yimbi, okungenzeka yenze izimpawu zakho zibe zimbi nakuba uthatha i-midodrine. Kungase futhi kwandise ingozi yakho yokuzizwa unesiyezi nokuquleka.

Uma ukhetha ukuphuza ngezikhathi ezithile, khuluma nodokotela wakho mayelana nemikhawulo nezinyathelo zokuphepha. Bangase batusa ukugwema utshwala ngokuphelele noma ukuzinciphisa ezingxenyeni ezincane kakhulu ngokudla.

Njalo qapha ukuthi uzizwa kanjani uma uphuza ngenkathi uthatha i-midodrine, futhi gwema imisebenzi efana nokushayela noma ukusebenzisa imishini uma uzizwa unesiyezi noma ungaqinile.