Yini i-Neostigmine Methylsulfate ne-Glycopyrrolate: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Neostigmine methylsulfate ne-glycopyrrolate iyinhlanganisela yemithi enikezwa nge-IV ukubuyisela emuva imiphumela yezinto eziphumuza imisipha ezisetshenziswa ngesikhathi sokuhlinzwa. Le mithi ejovwayo isiza imisipha yakho ukuthi ibuyele emsebenzini wayo ovamile ngemuva kwe-anesthesia ejwayelekile, ikuvumela ukuthi uphefumule futhi uhambe kahle uwedwa futhi.

Inhlanganisela isebenza njengeqembu - i-neostigmine yenza umsebenzi onzima ngokubuyisela emuva ukukhubazeka kwemisipha, kuyilapho i-glycopyrrolate ivikela inhliziyo yakho futhi ivimbela imiphumela engathandeki eceleni. Cabanga ngayo njengobambiswano olulinganiswe ngokucophelela olusiza ukuguqula umzimba wakho ngokuphepha usuka ekamelweni lokuhlinzela ubuyele emsebenzini ovamile.

Yini i-Neostigmine Methylsulfate ne-Glycopyrrolate?

Le mithi ihlanganisa izithako ezimbili ezisebenzayo ezisebenza ndawonye ukubuyisela emuva imiphumela ye-anesthesia ngokuphepha. I-Neostigmine methylsulfate iyi-cholinesterase inhibitor evimba ama-enzyme avimbela ukunyakaza kwemisipha, kuyilapho i-glycopyrrolate iyi-anticholinergic elwa nemiphumela engathandeki yenhliziyo nokugaya ukudla.

Uzothola le mithi kuphela esibhedlela noma esikhungweni sokuhlinzwa. Abahlinzeki bezempilo bayisebenzisa ngokuqondile ngesikhathi sokululama kokuhlinzwa lapho sekuyisikhathi sokuvusa imisipha yakho futhi kubuyiselwe ukuphefumula okujwayelekile. Inhlanganisela iqinisekisa ukuguquka okubushelelezi, okuphephe kakhulu kusuka ku-anesthesia.

Isetshenziselwani i-Neostigmine Methylsulfate ne-Glycopyrrolate?

Le mithi ibuyisela emuva i-neuromuscular blockade, okuyigama lezokwelapha lokukhubazeka kwemisipha okwesikhashana okusetshenziswa ngesikhathi sokuhlinzwa. Uma ungaphansi kwe-anesthesia ejwayelekile, odokotela bavame ukunikeza izinto eziphumuza imisipha ukukugcina unganyakazi ngokuphelele futhi benze ukuphefumula kube lula nge-ventilator.

Ukusetshenziswa okuyinhloko ukusiza iziguli ukuthi zibuyisele ukulawula imisipha ekupheleni kwezinqubo zokuhlinzwa. Ngaphandle kwalesi sithako sokuguqula, izidambisi zemisipha zingathatha amahora ukuthi ziphele ngokwemvelo, zikugcine emshinini wokuphefumula isikhathi eside kunesidingo.

Ezimweni eziphuthumayo ezingavamile, odokotela bangase futhi basebenzise le nhlanganisela ukwelapha ubuthakathaka obukhulu bemisipha obubangelwa ezinye izimo zezokwelapha. Kodwa-ke, lokhu kumelela iphesenti elincane kakhulu lokusetshenziswa kwayo kwezokwelapha, futhi lezo zinqumo zidinga ukuhlolwa ngokucophelela kwezingozi nezinzuzo.

Isebenza Kanjani I-Neostigmine Methylsulfate ne-Glycopyrrolate?

Lokhu kuthathwa njengomuthi onamandla aphakathi nendawo osebenza ngendlela eqondile yezinto eziphilayo. I-Neostigmine ivimba i-acetylcholinesterase, i-enzyme evame ukwehlisa i-acetylcholine - isithunywa samakhemikhali esitshela imisipha yakho ukuthi iqine.

Lapho i-acetylcholinesterase ivalekile, i-acetylcholine eningi iyatholakala ukuze isebenzise imicu yemisipha. Lokhu kunqoba izidambisi zemisipha ezisase-system yakho futhi kuvumela ukuthi umsebenzi wemisipha ojwayelekile ubuyele. Le nqubo ngokuvamile iqala ukusebenza ngemizuzu engu-1-2 ngemuva komjovo.

I-Glycopyrrolate idlala indima yokuvikela ngokuvimba ama-muscarinic receptors emzimbeni wakho wonke. Ngaphandle kwalokhu kuvikelwa, i-acetylcholine eyengeziwe ingabangela imiphumela eyinkinga efana nezinga lokushaya kwenhliziyo elihamba kancane, ukukhiqizwa okukhulu kwamathe, kanye nokugcwala kwamathumbu. Le nhlanganisela iqinisekisa ukuthi ukululama kwemisipha kwenzeka ngokuphepha.

Kufanele Ngiyithathe Kanjani I-Neostigmine Methylsulfate ne-Glycopyrrolate?

Ngeke uzithathe wena lo muthi - unikezwa kuphela ochwepheshe bezempilo abaqeqeshiwe ezikhungweni zezokwelapha. Umjovo uqondiswa ngqo emgqeni wakho we-IV ngenkathi usaqashwe ngokwezokwelapha ekamelweni lokuhlinzwa noma endaweni yokululama.

Udokotela wakho we-anesthetist noma umhlengikazi we-anesthetist uzobala umthamo oqondile ngokusekelwe esisindweni sakho, uhlobo lwe-muscle relaxant esetshenzisiwe, nokuthi umzimba wakho usabela kanjani. Bazoqapha ukuphefumula kwakho, izinga lokushaya kwenhliziyo, namandla emisipha ngokuqhubekayo ngesikhathi nangemva komjovo.

Akukho ukulungiselela okukhethekile okudingekayo ngakho ngoba cishe uzobe usalala ngoba uthole i-anesthesia. Ithimba lakho lezokwelapha liphatha zonke izici zesikhathi nokuphathwa ukuqinisekisa ukululama okuphephe kakhulu emsebenzini wakho wokuhlinzwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Neostigmine Methylsulfate kanye ne-Glycopyrrolate?

Lo muthi unikezwa njengomjovo owodwa noma uchungechunge lwemijovo ngesikhathi senqubo eyodwa yezokwelapha. Ngokungafani nemithi yansuku zonke ongayithatha ekhaya, le nhlanganisela isetshenziswa kuphela ngesikhathi esithile lapho ululama ku-anesthesia.

Imiphumela ivame ukuhlala imizuzu engama-30-60, okuyisikhathi esanele sokuthi ama-muscle relaxants asuke emzimbeni wakho ngokwemvelo. Ithimba lakho lezokwelapha lizokuqapha ngalesi sikhathi sonke ukuqinisekisa ukuthi imisipha yakho nokuphefumula kwakho kubuyela emandleni ajwayelekile.

Ngeke udinge ukuqhubeka nalo muthi ngemva kokushiya esibhedlela. Uma ukuhlinzwa kwakho sekuqediwe futhi usululame ku-anesthesia, akukho ukwelashwa okuqhubekayo okudingekayo ngale nhlanganisela ethile.

Yiziphi Imiphumela Eceleni ye-Neostigmine Methylsulfate kanye ne-Glycopyrrolate?

Abantu abaningi abanayo imiphumela eminingi emibi ngoba umuthi ulinganiselwe ngokucophelela futhi unikezwa ngaphansi kokuqashwa kwezokwelapha okuseduze. Nokho, umzimba wakho ungase usabele njengoba uzivumelanisa nesimo se-anesthetized ubuyela emsebenzini ojwayelekile.

Imiphumela evamile ongase uyibone ihlanganisa isicanucanu esincane, umlomo owomile, noma uzizwe unesiyezi kancane lapho uvuka. Le miphumela ivame ukuba yesikhashana futhi kaningi kunzima ukuyihlukanisa nezimpawu ezijwayelekile zokululama ngemva kokuhlinzwa. Ithimba lakho lezokwelapha lilindele lezi zimpendulo futhi linganikeza izindlela zokunethezeka uma kudingeka.

Imiphumela engavamile kodwa ebonakalayo ingabandakanya:

• Ukwanda kwesivinini senhliziyo noma ukushaya kwenhliziyo okungajwayelekile
• Ukuthuthumela kwemisipha noma ubuthakathaka
• Ubunzima bokugxilisa umbono wakho
• Ukungazinzi noma ukudideka
• Ukujuluka ngokweqile

Le miphumela ngokuvamile iyanyamalala ngokushesha njengoba umzimba wakho uzivumela, kodwa ithimba lakho lezokwelapha lizokuqapha ngokucophelela futhi linikeze ukwelashwa uma kukhona okungakhululeki noma okukhathazayo.

Imiphumela engavamile kodwa ebucayi idinga ukunakekelwa kwezokwelapha ngokushesha futhi ihlanganisa ukusabela okukhulu komzimba, ubunzima obukhulu bokuphefumula, noma izinguquko ezinkulu zesigqi senhliziyo. Abahlinzeki bakho bezempilo baqeqeshwe ukubona nokwelapha lezi zinkinga ngokushesha, okwenza ukusabela okukhulu kulawuleke kakhulu endaweni yasesibhedlela.

Ubani Ongafanele Athole I-Neostigmine Methylsulfate kanye ne-Glycopyrrolate?

Izimo ezithile zezokwelapha zenza lo muthi ungafaneleki noma zidinga izinyathelo zokuphepha ezikhethekile. Abantu abanezinkinga ezinkulu zesigqi senhliziyo, i-glaucoma engelashwa, noma isifo esibi sezinso bangase badinge ezinye izindlela zokuguqula i-anesthesia.

Udokotela wakho we-anesthesiologist uzobuyekeza umlando wakho wezokwelapha ophelele ngaphambi kokuhlinzwa ukuze abone noma yiziphi izimo ezingase zithinte ukukhethwa kwemithi. Izimo ezidinga ukuqapha okwengeziwe zihlanganisa i-myasthenia gravis, isifuba esikhulu, noma ukusabela okwedlule komzimba emithini efanayo.

Ukukhulelwa nokuncelisa kufuna ukucatshangelwa ngokucophelela, nakuba umuthi ungasetshenziswa lapho izinzuzo zidlula izingozi ezingaba khona. Ithimba lakho lezokwelapha lizoxoxa ngalezi zinto nawe ngesikhathi sokubonisana kwakho ngaphambi kokuhlinzwa uma zisebenza esimweni sakho.

Ezimweni ezingavamile, abantu abanokushoda kwamanye ama-enzyme e-genetic bangase bakwazi ukucubungula lo muthi ngendlela ehlukile. Nokho, lezi zimo zivame ukubonwa ngomlando womndeni noma okuhlangenwe nakho kwezokwelapha kwangaphambilini, futhi ithimba lakho lezokwelapha lingahlela ngokufanele.

Amagama Omkhiqizo we-Neostigmine Methylsulfate kanye ne-Glycopyrrolate

Le nhlanganisela iyatholakala ngaphansi kwegama lomkhiqizo elithi Bridion kwezinye izindlela zokulungiselela, nakuba inhlanganisela ethile ye-neostigmine ne-glycopyrrolate ingalungiswa ngamapharmacy esibhedlela. Izikhungo eziningi zezokwelapha zisebenzisa inhlanganisela ejwayelekile elungiswe ngokuvumelana nemithetho ejwayelekile.

Ungase futhi uzwe abahlinzeki bezempilo bebhekisa kuyo kalula ngokuthi "ama-ejenti okubuyisela emuva" noma "ama-antagonists" ngesikhathi sokuhlinzwa kwakho. Igama lomkhiqizo elithile libaluleke kancane kuneqiniso lokuthi uthola inhlanganisela efakazelwe, ephephile yokubuyisela i-anesthesia.

Ezinye izindlela ze-Neostigmine Methylsulfate ne-Glycopyrrolate

Ezinye izindlela ziyatholakala zokubuyisela ama-muscle relaxants, ne-sugammadex iyindlela entsha esebenza ngendlela ehlukile kune-neostigmine. I-Sugammadex iqondana ngqo nama-muscle relaxants athile kunokuvimba ama-enzyme, okungenzeka ukuthi inikeze ukubuyiselwa emuva okusheshayo kwezinye izimo.

Udokotela wakho we-anesthesiologist angase akhethe i-edrophonium ene-atropine njengenye inketho yenhlanganisela, nakuba lokhu kungasetshenziswa kakhulu namuhla. Ukukhetha kuncike ekutheni yiluphi uhlobo lwe-muscle relaxant olusetshenziswe ngesikhathi sokuhlinzwa kwakho kanye nezici zakho zezokwelapha.

Kwezinye izimo, ukuvumela isikhathi sokuthi imetabolism yemvelo yenzeke kungase kufaneleke, ikakhulukazi ngama-muscle relaxants asebenza ngesikhathi esifushane. Kodwa-ke, le ndlela idinga ukuhlala isikhathi eside ekamelweni lokululama kanye nokuqhubeka nokungenisa umoya ngomshini, okwenza ukubuyiselwa emuva okusebenzayo kuvame ukukhethwa.

Ingabe i-Neostigmine Methylsulfate ne-Glycopyrrolate ingcono kune-Sugammadex?

Zombili lezi zithako zibuyisela ngempumelelo ama-muscle relaxants, kodwa zisebenza ngezindlela ezihlukene futhi zinezinzuzo ezihlukile. I-Neostigmine ene-glycopyrrolate ineminyaka eminingi yokuphepha okufakazelwe futhi isebenza nazo zonke izinhlobo zama-muscle relaxants, kuyilapho i-sugammadex inikeza ukubuyiselwa emuva okusheshayo kuma-muscle relaxants athile amasha.

Ukukhetha "okungcono" kuncike esimweni sakho sokuhlinzwa esithile, umlando wakho wezokwelapha, kanye nohlobo lwe-muscle relaxant olusetshenziswayo. Izinhlanganisela ze-Neostigmine ngokuvamile azibizi kakhulu futhi zitholakala kabanzi, okuzenza zibe yizinqumo ezingokoqobo ezinqubweni eziningi.

Udokotela wakho we-anesthesiologist uzocabangela izinto ezinjengomsebenzi wakho wezinso, impilo yenhliziyo, kanye nokuphuthuma kokuguqulwa lapho ekhetha phakathi kwezinketho. Yomibili imithi inamaphrofayili okuphepha amahle kakhulu uma isetshenziswa ngendlela efanele ezindaweni zezokwelapha.

Imibuzo Evame Ukubuzwa Mayelana ne-Neostigmine Methylsulfate kanye ne-Glycopyrrolate

Ingabe i-Neostigmine Methylsulfate kanye ne-Glycopyrrolate iphephile ezigulini ezinokugula kwenhliziyo?

Lo muthi ungasetshenziswa ngokuphepha kubantu abaningi abanokugula kwenhliziyo, kodwa udinga ukuqapha ngokucophelela futhi ngezinye izikhathi ukulungiswa kwemithamo. Ingxenye ye-glycopyrrolate empeleni isiza ukuvikela inhliziyo yakho ngokuvimbela izinga lenhliziyo elihamba kancane elingase libangelwe yi-neostigmine yodwa.

Udokotela wakho we-anesthesiologist uzobuyekeza isimo sakho senhliziyo esithile kanye nemithi yamanje ngaphambi kokuhlinzwa. Bangase bakhethe ukulinganisa okuguquliwe noma ezinye izindlela uma unezinkinga ezinzima zokushaya kwenhliziyo noma ukugula kwenhliziyo okungazinzile.

Ngingenzani uma ngiphuthelwa ukusebenzisa i-Neostigmine Methylsulfate kanye ne-Glycopyrrolate eningi kakhulu?

Awukwazi ukweqisa ngengozi ngalo muthi ngoba unikezwa kuphela ochwepheshe bezempilo ezindaweni zezokwelapha ezilawulwayo. Ukulinganisa kubalwa ngokucophelela futhi kulawulwa abahlinzeki be-anesthesia abaqeqeshiwe abaqapha impendulo yakho ngokuqhubekayo.

Uma othile engathola okuningi, izimpawu zingabandakanya ubuthakathaka bemisipha, izinguquko zokushaya kwenhliziyo, noma ubunzima bokuphefumula. Kodwa-ke, ithimba lakho lezokwelapha lihlome ukubona nokwelapha noma yiziphi izinkinga zokulinganisa ngokushesha ngokunakekelwa okufanele kokusekela kanye nama-antidotes uma kudingeka.

Ngingenzani uma ngiphuthelwa umthamo we-Neostigmine Methylsulfate kanye ne-Glycopyrrolate?

Lo mbuzo awusebenzi kulolu hlobo lomuthi ngoba awuthathwa ngesimiso esifana nemithi yansuku zonke. Uthola kanye kuphela ngesikhathi sokuhlinzwa kwakho njengengxenye yokuphathwa kwe-anesthesia.

Iqembu lakho le-anesthesia linquma isikhathi esiqondile ngokusekelwe ekuphenduleni komzimba wakho kuma-muscle relaxants kanye nezidingo zakho zokuhlinzwa. Akukho "isimo somthamo ongaphuthelwe" ngoba umuthi unikezwa njengengxenye yokunakekelwa kwakho kwezokwelapha ngesikhathi sokuhlinzwa.

Ngingayeka nini ukuthatha i-Neostigmine Methylsulfate ne-Glycopyrrolate?

Akudingeki ukhathazeke ngokuyeka lo muthi ngoba umjovo owodwa onikezwa ngesikhathi sokuhlinzwa kuphela. Imiphumela iyaphela ngokwemvelo phakathi kwemizuzu engama-30-60, futhi akukho ukwelashwa okuqhubekayo noma inqubo yokuhoxisa.

Uma usululame ku-anesthesia futhi amandla akho emisipha ebuyele esimweni esijwayelekile, umuthi usuqedele umsebenzi wawo. Ithimba lakho lezokwelapha lizoqinisekisa ukuthi uyaphefumula futhi unyakaza ngendlela ejwayelekile ngaphambi kokuthi ushiye indawo yokululama.

Ngingashayela ngemva kokuthola i-Neostigmine Methylsulfate ne-Glycopyrrolate?

Akufanele ushayele okungenani amahora angama-24 ngemva kokuthola lo muthi, kodwa lo mkhawulo ikakhulukazi ngenxa ye-anesthesia nokuhlinzwa kunokuba yi-ejenti yokuguqula uqobo lwayo. Umuthi ukusiza ukuthi ululame ku-anesthesia, kodwa usazodinga isikhathi sokuthi yonke imiphumela ye-anesthetic isule ngokuphelele uhlelo lwakho.

Ithimba lakho lezempilo lizohlinzeka ngemiyalelo ethile mayelana nokuthi ungasithatha nini ngokuphepha ukuqhuba ezinye izinto. Lezi ziqondiso zicabangela uhlobo lokuhlinzwa kwakho, isipiliyoni esiphelele se-anesthesia, kanye nentuthuko yokululama komuntu ngamunye.