Yini i-Oritavancin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Oritavancin iyikhambi elinamandla elinikezwa ngomugqa we-IV (intravenous) ukwelapha izifo ezinzima zesikhumba ezibangelwa amagciwane. Le mithi ingeyodidi olusha lwama-antibiotics olubizwa ngokuthi ama-lipoglycopeptides, asebenza ngendlela ehlukile kuma-antibiotics amaningi endabuko ongase uwajwayele.

Okuhlukanisa i-oritavancin ukuthi yakhelwe njengokwelashwa okukodwa. Esikhundleni sokuthatha imithamo eminingi ezinsukwini ezimbalwa, uthola ukumnika okukodwa nje okuqhubeka kusebenza emzimbeni wakho cishe isonto elilodwa. Le ndlela ingasiza ikakhulukazi uma ubhekene nezifo ezinzima ezingazange zisabele kahle kwezinye izindlela zokwelapha.

Isetshenziselwani i-Oritavancin?

I-Oritavancin iphatha izifo zesikhumba ezinzima ezibangelwa amagciwane kanye nezifo zesakhiwo sesikhumba (ABSSSI) kubantu abadala. Lezi yizifo ezinzima ezingena ngaphakathi kunendawo yesikhumba sakho futhi zingabandakanya izicubu, imisipha, noma amafutha angaphansi.

Udokotela wakho angase ancome i-oritavancin uma unezifo ezibangelwa amagciwane athile, okuhlanganisa i-methicillin-resistant Staphylococcus aureus (MRSA). I-MRSA wuhlobo lwebhaktheriya olungasabeli kuma-antibiotics amaningi avamile, okwenza kube yinselele ekwelapheni. I-Oritavancin iphinde isebenze kahle kwamanye amagciwane e-gram-positive angabangela izifo zesikhumba.

Umuthi ngokuvamile ugcinelwa izimo lapho amanye ama-antibiotics engasebenzi noma uma unesifo esibi esidinga ukwelashwa okunonya. Umhlinzeki wakho wezempilo uzoqaphela ukuthi i-oritavancin iyindlela efanele yini ngokusekelwe esifweni sakho esithile kanye nomlando wezokwelapha.

Isebenza Kanjani i-Oritavancin?

I-Oritavancin ithathwa njenge-antibiotic eqinile esebenza ngokuphazamisa indlela amagciwane akha ngayo izindonga zawo zamaseli. Cabanga ngezindonga zamaseli amagciwane njengengubo yokuzivikela egcina amagciwane ephila futhi esebenza kahle.

Lo muthi uhlasela amagciwane ngezindlela eziningi ngesikhathi esisodwa. Uvimbela amagciwane ukuthi angakhi izinto ezintsha zodonga lwamaselula futhi ulimala nezindonga zamaselula asevele enawo. Lesi senzo esiphindwe kabili senza kube nzima ngamagciwane ukuthi asinde futhi azale, okunikeza amasosha akho omzimba ithuba elingcono lokususa lesi sifo.

Umuthi uhlala usebenza emzimbeni wakho isikhathi eside ngemuva kokufakwa, uqhubeka nokulwa namagciwane cishe izinsuku eziyisikhombisa. Lesi senzo esiqhubekayo yingakho udinga umthamo owodwa kuphela kunokwelashwa okuningi ezinsukwini eziningana.

Kufanele Ngiyithathe Kanjani I-Oritavancin?

I-Oritavancin inikezwa kuphela ngomugqa we-IV esibhedlela noma endaweni yezokwelapha. Awukwazi ukuthatha lo muthi ekhaya noma ngomlomo. Umuthi uza njengempushana ochwepheshe bezempilo abayixuba namanzi ahlanzekile ukuze bakhe ukumnika.

Inqubo yokumnika ithatha cishe amahora amathathu. Ithimba lakho lezempilo lizokuqapha eduze ngalesi sikhathi ukuze libheke noma yiziphi izindlela zokuphendula. Uzoxhunywa emgqeni we-IV, futhi umuthi uzogeleza kancane ungene egazini lakho.

Ngaphambi kokumnika kwakho, awudingi ukugwema ukudla noma iziphuzo ngaphandle kwalapho udokotela wakho ekunikeza imiyalelo ethile. Kodwa-ke, kubalulekile ukutshela umhlinzeki wakho wezempilo ngayo yonke imithi oyithathayo njengamanje, njengoba eminye ingase ihlangane ne-oritavancin.

Ngesikhathi sokumnika, cishe uzodinga ukuhlala endaweni eyodwa yesibhedlela noma umtholampilo. Ngokuvamile ungafunda, usebenzise ifoni yakho, noma uhlanganyele emisebenzini ethule ngenkathi umuthi unikezwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Oritavancin?

I-Oritavancin yakhelwe njengokwelashwa komthamo owodwa. Uzothola ukumnika okukodwa nje, futhi lokho ngokuvamile konke okudingayo ngesifo sakho.

Umuthi uqhubeka usebenza emzimbeni wakho cishe izinsuku eziyisikhombisa ngemuva kokumnika. Lesi sikhathi esandisiwe sokusebenza sakhelwe endleleni umuthi osebenza ngayo, ngakho awudingi imithamo eyengeziwe njengoba ungathola ngamanye ama-antibiotics amaningi.

Udktela wakho uzoqapha intuthuko yakho ezinsukwini nasemavikini alandelayo ukuqinisekisa ukuthi ukutheleleka kuyanyamalala kahle. Ezimweni ezingavamile, uma ukutheleleka kungaphenduli ngendlela efanele, umhlinzeki wakho wezempilo angase acabangele ukwelashwa okwengeziwe, kodwa lokhu kungabandakanya indlela ehlukile kunokuthi kuthathwe i-oritavancin eyengeziwe.

Yiziphi Imiphumela Eceleni Ye-Oritavancin?

Njengayo yonke imithi, i-oritavancin ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Abantu abaningi bayayibekezelela kahle imithi, kodwa kubalulekile ukwazi ukuthi yini okufanele uyibheke.

Nawa amanye imiphumela emibi evamile ongase uyithole:

• Ukucabeka kwekhanda
• Isicanucanu
• Ubuhlungu engalweni noma emlenzeni
• Ukuqunjelwa
• Ukusabela endaweni ye-IV (ububomvu, ukuvuvukala, noma ubuhlungu)

Le miphumela ivame ukuba mncane futhi ivame ukuzixazulula yona ngaphakathi kwezinsuku ezimbalwa. Ithimba lakho lezempilo lingasiza ekuphatheni noma yikuphi ukungakhululeki okutholayo.

Imiphumela emibi kakhulu ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Lokhu kungabandakanya ukusabela okukhulu komzimba, okungabangela ubunzima bokuphefumula, ukuvuvukala kobuso bakho noma umphimbo, noma ukuqubuka okubanzi. Uma uthola noma yiziphi zalezi zimpawu, funa ukunakekelwa kwezempilo eziphuthumayo ngokushesha.

Abanye abantu bangase bathuthukise ukutheleleka kwamathumbu okukhulu okuthiwa i-C. difficile-associated diarrhea (CDAD) ngesikhathi noma ngemva kokwelashwa. Lokhu kungenzeka emasontweni ngemva kokuthola umuthi. Xhumana nodokotela wakho uma uthola ukuqunjelwa okuqhubekayo, ikakhulukazi uma kunegazi noma kunamafinyila.

Ubani Ongafanele Athole I-Oritavancin?

I-Oritavancin ayifanele wonke umuntu. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuncoma lokhu kwelashwa.

Akufanele uthole i-oritavancin uma wake waba nokusabela komzimba kuyo esikhathini esidlule noma kuma-antibiotics afanayo njenge-vancomycin noma i-telavancin. Xhumana nomhlinzeki wakho wezempilo mayelana nanoma yikuphi ukungezwani komzimba okwenzeka ngaphambili kuma-antibiotics, ngisho noma kubonakala kuncane.

Abantu abanezimo ezithile zenhliziyo badinga ukucatshangelwa okukhethekile. I-Oritavancin ingathinta ukuhlolwa kokujiya kwegazi kuze kube amahora angu-120 (izinsuku ezinhlanu) ngemva kokwelashwa. Uma usebenzisa izinciphisi zegazi njenge-warfarin, udokotela wakho uzodinga ukukuqapha eduze futhi angase adinge ukulungisa imithi yakho.

Umuthi awukahlolisiswa kakhulu kubantu besifazane abakhulelwe, ngakho udokotela wakho uzolinganisela izinzuzo nezingozi ezingaba khona uma ukhulelwe noma uhlela ukukhulelwa. Ngokufanayo, akwaziwa ukuthi i-oritavancin idlulela emanzini obisi, ngakho omama abancelisa izingane badinga isiqondiso esenziwe ngabanye.

Igama Lomkhiqizo le-Oritavancin

I-Oritavancin ithengiswa ngaphansi kwegama lomkhiqizo elithi Orbactiv e-United States. Leli igama lezentengiso ozolibona kumashadi esibhedlela kanye nemibhalo yezokwelapha.

Umuthi ukhiqizwa yi-Melinta Therapeutics futhi wagunyazwa yi-FDA ngonyaka ka-2014. Uma abahlinzeki bezempilo bekhuluma ngalolu hlobo lokwelashwa, bangase basebenzise igama elivamile (oritavancin) noma igama lomkhiqizo (Orbactiv).

Ezinye izindlela ze-Oritavancin

Ezinye izinhlobo eziningi zama-antibiotics zingelapha izifo ezifanayo, nakuba udokotela wakho ezokhetha ngokusekelwe esimweni sakho esithile kanye namagciwane abangela ukutheleleka kwakho.

I-Vancomycin iyindlela esetshenziswa kakhulu, ikakhulukazi ezifweni ze-MRSA. Kodwa-ke, idinga imithamo eminingi ezinsukwini eziningana kunokusebenzisa umthamo owodwa we-oritavancin. I-Linezolid ingenye inketho engathathwa nge-IV noma ngomlomo.

Kwezinye izifo, i-daptomycin ingase ifaneleke. Leli antibiotic linikezwa kanye ngosuku nge-IV futhi lisebenza kahle ngokumelene namagciwane amaningi afana ne-oritavancin. I-Telavancin elinye i-antibiotic le-lipoglycopeptide elifana ne-oritavancin kodwa ngokuvamile lidinga ukuthathwa nsuku zonke.

Umhlinzeki wakho wezempilo uzocabangela izinto ezinjengamagciwane athintekayo, ukusebenza kwezinso zakho, eminye imithi oyithathayo, nempilo yakho yonke lapho ekhetha i-antibiotic engcono kakhulu ngesimo sakho.

Ingabe i-Oritavancin ingcono kune-Vancomycin?

Kokubili i-oritavancin ne-vancomycin ziyizibulala-magciwane eziphumelelayo zokutheleleka okungathi sína kwamagciwane, kodwa ngamunye unamathuba ahlukile ngokuya ngesimo sakho.

Inzuzo enkulu ye-Oritavancin ukulula. Uthola ukumnika okukodwa nje esikhundleni semithamo eminingi ezinsukwini ezimbalwa. Lokhu kungaba usizo ikakhulukazi uma unzima ukufinyelela i-IV noma uma ufuna ukunciphisa isikhathi esibhedlela.

I-Vancomycin isetshenziswe amashumi eminyaka futhi ineprofayili yokuphepha esungulwe kahle. Ivame ukungabizi kakhulu kune-oritavancin futhi itholakala ezindaweni eziningi zokunakekelwa kwezempilo. Kodwa-ke, idinga ukuqapha amazinga egazi nokusebenza kwezinso ngesikhathi sokwelashwa.

Izifundo zibonisa ukuthi yomibili imithi iphumelela ngokufanayo ekwelapheni izifo zesikhumba nezicubu ezithambile. Udokotela wakho uzocabangela izinto ezinjengokusebenza kwezinso zakho, eminye imithi, umshwalense, nezintandokazi zomuntu siqu lapho enquma ukuthi iyiphi i-antibiotic engcono kakhulu kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Oritavancin

Ingabe i-Oritavancin iphephile kubantu abanezifo zezinso?

I-Oritavancin ibonakala iphephe kakhulu kubantu abanezinkinga zezinso uma iqhathaniswa namanye ama-antibiotics. Umuthi awudingi ukulungiswa komthamo ngokuya ngokusebenza kwezinso, okuyinzuzo ngaphezu kwama-antibiotics afana ne-vancomycin.

Kodwa-ke, udokotela wakho usazoqapha ukusebenza kwezinso zakho ngaphambi nangemva kokwelashwa. Uma unezifo ezinzima zezinso noma use-dialysis, umhlinzeki wakho wezempilo uzohlola ngokucophelela ukuthi i-oritavancin iyisinqumo esifanele yini kuwe.

Ngingenzani uma ngiba nokusabela komzimba ku-Oritavancin?

Uma ubona izimpawu zokungezwani komzimba ngesikhathi noma ngemuva kokufakwa kwakho, funa usizo lwezokwelapha ngokushesha. Izimpawu zihlanganisa ukuba nobunzima bokuphefumula, ukuvuvukala kobuso bakho noma umphimbo, ukuqubuka okusabalalele, noma isiyezi esikhulu.

Njengoba uthola i-oritavancin endaweni yezokwelapha, ochwepheshe bezempilo bazotholakala ngokushesha ukwelapha noma yiziphi izindlela zokuphendula. Banemithi nemishini elungele ukubhekana nezindlela zokungezwani komzimba ngokushesha nangempumelelo.

Uma uba nokusabela okubambezelekile kokungezwani komzimba ngemva kokuphuma esibhedlela, iya egumbini eliseduze eliphuthumayo noma ushayele ku-911. Ungalindi ukubona ukuthi izimpawu ziyathuthuka yini zodwa.

Ngingenzani uma ngiphuthelwa umthamo we-Oritavancin?

Lo mbuzo awusebenzi ku-oritavancin ngoba unikezwa njengomthamo owodwa endaweni yezokwelapha. Awukwazi ukuphuthelwa umthamo njengoba uthola lonke ukwelashwa ngesikhathi sokuvakasha okukodwa esibhedlela.

Uma ngasizathu simbe ukufakwa kwakho kuphazamiseka noma kumiswa ngaphambi kwesikhathi, ithimba lakho lezempilo lizothola indlela engcono kakhulu yokwenza. Bangase baqede ukufakwa uma kuphephile ukwenza kanjalo noma bacabange ezinye izindlela zokwelapha.

Ngingayeka nini ukuthatha i-Oritavancin?

Akudingeki uyeke ukuthatha i-oritavancin ngoba ukwelashwa okukodwa. Ngemva kokufakwa kwakho okukodwa, umuthi uqhubeka usebenza emzimbeni wakho cishe isonto elilodwa ngaphandle kweminye imithamo eyengeziwe.

Udokotela wakho uzohlela ama-aphoyintimenti okulandelayo ukuze aqaphe ukululama kwakho futhi aqinisekise ukuthi ukutheleleka kuyacaca kahle. Qhubeka nokuthatha eminye imithi njengoba kunqunyiwe ngaphandle kokuthi udokotela wakho ekutshela ngenye indlela.

Ngingashayela ngemva kokuthola i-Oritavancin?

Kufanele ugweme ukushayela ngemva nje kokufakwa kwakho kwe-oritavancin, ikakhulukazi uma uzizwa unesiyezi, ukhathele, noma ungazizwa kahle. Inqubo yokufakwa ithatha amahora amaningana, futhi ungase uzizwe ukhathele ngemva kwalokho.

Cela othile ukuthi akuqhubele ekhaya ngemva kokwelashwa kwakho, noma lungiselela ezinye izindlela zokuhamba. Abantu abaningi bazizwa bejwayelekile ngosuku olulodwa noma ezimbili, kodwa lalela umzimba wakho futhi ungaqhubi uma ungazizwa uqaphile ngokuphelele futhi uzinzile.