Yini i-Rilpivirine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Rilpivirine iyikhambi le-HIV elisiza ukulawula igciwane emzimbeni wakho. Ingaphansi kohlobo lwemithi ebizwa ngokuthi ama-non-nucleoside reverse transcriptase inhibitors (NNRTIs), asebenza ngokuvimba i-HIV ukuthi ingaphindaphani emangqamuzaneni akho.

Le mithi isetshenziswa njalo njengengxenye yokwelashwa okuhlanganisiwe neminye imithi ye-HIV. Ngeke nanini uthathe i-rilpivirine uwedwa ngoba i-HIV ingakwazi ukuthuthukisa ngokushesha ukumelana nemithi eyodwa.

Yini i-Rilpivirine Esetshenziselwa Yona?

I-Rilpivirine iphatha ukutheleleka nge-HIV-1 kubantu abadala kanye nezingane ezinobunzima obungama-kilogramu angama-35 (cishe amakhilogremu angama-77). Yenzelwe ngokuqondile abantu abaqala ukwelashwa nge-HIV okokuqala futhi abanenani legciwane elingaphansi kwama-100,000 copies per milliliter.

Udokotela wakho uzokunika le mithi njengengxenye yohlelo olugcwele lokwelashwa nge-HIV. Umgomo ukunciphisa izinga lakho legciwane liye emazingeni angatholakali, okuvikela amasosha akho omzimba futhi kuvimbele ukudluliselwa kwabanye.

Le mithi ayikwelaphi i-HIV, kodwa ingakusiza ukuthi uphile impilo ende, enempilo uma ithathwa njalo. Abantu abaningi abathola ukwelashwa okuphumelelayo kwe-HIV baneminyaka yokuphila ejwayelekile futhi bangavimbela ukudlulisela igciwane kozakwabo.

Isebenza Kanjani i-Rilpivirine?

I-Rilpivirine ivimba i-enzyme ebizwa ngokuthi i-reverse transcriptase edingwa yi-HIV ukuze izikopishe yona. Cabanga ngayo njengokuvimba umshini wokukopisha wegciwane ukuze lingakwazi ukwenza amakhophi amasha awo emangqamuzaneni akho.

Lokhu kuthathwa njengemithi ye-HIV enamandla amancane. Isebenza kahle kodwa inesithiyo esiphansi sokumelana uma iqhathaniswa neminye imithi ye-HIV entsha, yingakho ngokuvamile igcinelwa abantu abanenani legciwane eliphansi.

Umuthi usebenza kahle kakhulu uma uhlanganiswe neminye imithi ye-HIV ehlasela igciwane ezigabeni ezihlukene. Le ndlela yokuhlanganisa yenza kube nzima kakhulu ukuthi i-HIV ithuthukise ukumelana nokwelashwa kwakho.

Kufanele Ngiyithathe Kanjani i-Rilpivirine?

Thatha i-rilpivirine ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngokudla. Ukudla kubalulekile ngoba kusiza umzimba wakho ukuba umunce imithi kahle.

Kufanele udle okungenani ama-calories angu-390 ngaphambi kokuthatha umthamo wakho. Lokhu kungaba ukudla okuvamile noma ukudla okulukhuni okufana nesemishi noma isitsha se-cereal nobisi.

Thatha imithi yakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo egazini lakho. Abantu abaningi bakuthola kuwusizo ukuxhumanisa umthamo wabo nomsebenzi wansuku zonke njengekusasa noma isidlo sakusihlwa.

Gwinya ithebhulethi yonke ngamanzi. Ungayichobozi, uyihlukanise, noma uyihlafune ithebhulethi ngoba lokhu kungathinta indlela imithi emuncwa ngayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Rilpivirine?

Uzodinga ukuthatha i-rilpivirine impilo yakho yonke njengengxenye yokwelashwa kwakho i-HIV. Imithi ye-HIV ayikwelaphi ukutheleleka, kodwa igcina igciwane licindezelwe uma nje uyithatha ngokuqhubekayo.

Ukuyeka imithi yakho, ngisho nesikhashana, kuvumela i-HIV ukuba iphindaphindeke ngokushesha futhi kungaholela ekumelaneni nemithi. Lokhu kwenza ukwelashwa okuzayo kube yinselele enkulu futhi kungalimaza amasosha akho omzimba.

Udokotela wakho uzoqapha inqubekela phambili yakho ngezivivinyo zegazi ezivamile ukuze ahlolisise umthwalo wakho wegciwane kanye nenani le-CD4. Lezi zivivinyo zisiza ekuqinisekiseni ukuthi ukwelashwa kwakho kusebenza ngempumelelo nokuthi amasosha akho omzimba ahlala eqinile.

Yiziphi Imiphumela Eceleni Ye-Rilpivirine?

Abantu abaningi bayayibekezelela i-rilpivirine kahle, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathi sína ayivamile, futhi imiphumela eminingi emincane iyathuthuka ngokuhamba kwesikhathi.

Nansi imiphumela emibi evame kakhulu ongase uyithole:

• Ukucabuka kwekhanda
• Ukuhluleka ukulala noma amaphupho angavamile
• Isiyezi
• Isicanucanu
• Ukukhathala
• Ukuqubuka
• Ushintsho lwemizwa noma ukucindezeleka

Lezi zimpawu zivame ukuba mnene futhi zivame ukuba ngcono njengoba umzimba wakho ujwayela imithi. Uma ziqhubeka noma zikuphazamisa kakhulu, khuluma nomhlinzeki wakho wezempilo mayelana namasu okuphatha.

Abanye abantu bahlangabezana nemiphumela emibi engathi sína kodwa engavamile edinga ukunakekelwa kwezempilo ngokushesha:

• Ukucindezeleka okukhulu noma imicabango yokuzilimaza
• Ukuphendula kwesikhumba okukhulu ngamabhamuza noma ukuxebuka
• Izimpawu zezinkinga zesibindi njengokuphuzi kwesikhumba noma amehlo
• Ukuphendula okukhulu komzimba okunzima ngokuphefumula

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína. Bangakwazi ukukusiza ukuthi uthole ukuthi udinga ukulungisa ukwelashwa kwakho noma ufune ukunakekelwa okuphuthumayo.

Ubani Ongafanele Athathe i-Rilpivirine?

I-Rilpivirine ayifanele wonke umuntu. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha kanye nesimo sakho sempilo yamanje ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-rilpivirine uma unomthwalo omkhulu wegciwane (ngaphezu kwama-100,000 amakhophi nge-milliliter) lapho uqala ukwelashwa. Umuthi kungenzeka awuqini ngokwanele ukulawula amazinga aphezulu e-virus ngempumelelo.

Abantu abanezimo ezithile zezokwelapha bangase badinge imithi ehlukene ye-HIV:

• Isifo sesibindi esibi noma i-hepatitis B noma C
• Umlando wokucindezeleka okukhulu noma izimo zempilo yengqondo
• Izinkinga zezinso
• Ukuphazamiseka kwesigqi senhliziyo

Imithi eminingi ingaphazamisa ukusebenza kahle kwe-rilpivirine. Lokhu kuhlanganisa ama-antibiotics athile, ama-antifungals, imithi yokuhlaselwa yisithuthwane, kanye nezithiyo ze-proton pump ze-acid reflux.

Njalo tshela udokotela wakho ngayo yonke imithi, izithasiselo, kanye nemikhiqizo yamakhambi oyithathayo. Bangakwazi ukukusiza ukuthi ugweme ukuxhumana okuyingozi noma ulungise uhlelo lwakho lokwelapha ngokufanele.

Amagama Omkhiqizo we-Rilpivirine

I-Rilpivirine itholakala ngaphansi kwamagama amaningi omkhiqizo ngokuya ngokuthi ihlanganiswe kanjani neminye imithi ye-HIV. Amafomula avamile afaka i-Edurant, equkethe i-rilpivirine yodwa.

Ungase futhi uthole amaphilisi ahlanganisiwe afana ne-Complera (rilpivirine, emtricitabine, kanye ne-tenofovir) noma i-Odefsey (rilpivirine, emtricitabine, kanye ne-tenofovir alafenamide). Lawa maphilisi ahlanganisiwe anciphisa inani lamaphilisi okudingeka uwathathe nsuku zonke.

Udokotela wakho uzokhetha ifomula engcono kakhulu ngokusekelwe ezidingweni zakho ezithile, ezinye izimo zempilo, kanye nokusebenzisana okungase kube khona kwemithi. Zonke izinhlobo ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efanayo emzimbeni wakho.

Ezinye izindlela ze-Rilpivirine

Eminye imithi eminingi ye-HIV ingasebenza njengezinye izindlela ze-rilpivirine uma ingakulungele. Udokotela wakho angase acabangele ezinye izinto ze-NNRTIs njenge-efavirenz noma izithiyo ze-integrase ezifana ne-dolutegravir.

Izithiyo ze-Integrase ezifana ne-bictegravir noma i-raltegravir zivame ukukhethwa kubantu abanezinhlobo eziphezulu zamagciwane noma labo abadinga inketho yokwelashwa eqinile. Le mithi ngokuvamile inokusebenzisana okuncane kwemithi kanye nezithiyo eziphakeme zokumelana.

Ukukhethwa kwenye indlela kuncike enanini lakho lamagciwane, imiphumela yokuhlolwa kokumelana, eminye imithi oyithathayo, kanye nezintandokazi zakho mayelana nemiphumela emibi kanye nezimiso zokulinganisa.

Ingabe i-Rilpivirine ingcono kune-Efavirenz?

I-Rilpivirine ne-efavirenz yomibili imithi ye-HIV esebenzayo, kodwa inamandla ahlukene kanye nokucatshangelwa. Akukho noyedwa ongcono kunomunye - ukukhetha okungcono kuncike esimweni sakho.

I-Rilpivirine ivame ukubangela imiphumela emibi embalwa ye-neuropsychiatric efana namaphupho acacile, isiyezi, kanye nezinguquko zemizwa uma iqhathaniswa ne-efavirenz. Abantu abaningi bakuthola kulula ukukubekezelela, ikakhulukazi mayelana nokulala nokuphila kahle kwengqondo.

Kodwa-ke, i-efavirenz inamandla kakhulu futhi isebenza kangcono kubantu abane-viral loads ephezulu. Futhi inokuxhumana okuncane kwemithi futhi ayidingi ukudla ukuze imuncwe kahle.

Udokotela wakho uzocabangela izinto ezinjenge-viral load yakho, eminye imithi, indlela yokuphila, nezintandokazi zomuntu siqu lapho ekhetha phakathi kwalezi zinketho. Zombili zingasebenza kahle kakhulu uma zisetshenziswa ngendlela efanele.

Imibuzo Evame Ukubuzwa Mayelana ne-Rilpivirine

Ingabe i-Rilpivirine iphephile kubantu abane-Hepatitis B noma C?

I-Rilpivirine ingasetshenziswa kubantu abane-hepatitis B noma C, kodwa idinga ukuqapha ngokucophelela. Udokotela wakho uzodinga ukuhlola ukusebenza kwesibindi sakho njalo ngoba kokubili i-HIV ne-hepatitis kungathinta isibindi sakho.

Abantu abane-hepatitis bangase babe sengozini enkulu yezinkinga ezihlobene nesibindi. Umhlinzeki wakho wezempilo angase alungise isimiso sakho sokuqapha noma akhethe imithi ehlukile ye-HIV uma ukusebenza kwesibindi sakho kuphazamiseke kakhulu.

Ngingenzani uma ngiphuthelwa ngengozi ukuthatha i-Rilpivirine eningi kakhulu?

Uma ngengozi uthatha okungaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha i-rilpivirine eningi kakhulu kungakhuphula ingozi yakho yemiphumela emibi efana nezinkinga zesigqi senhliziyo.

Ungazami ukwenza umthamo owengeziwe ngokuqaqa umthamo wakho olandelayo ohleliwe. Kunalokho, landela isiqondiso sikadokotela wakho sokuthi ubuyele kanjani esimisweni sakho somthamo esivamile ngokuphepha.

Ngingenzani uma ngiphuthelwa umthamo we-Rilpivirine?

Uma uphuthelwa umthamo futhi sekudlule amahora angaphansi kwangu-12 kusukela ngesikhathi sakho esivamile, thatha umthamo ophuthelwe nokudla ngokushesha lapho ukhumbula. Uma sekudlule amahora angaphezu kwangu-12, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esivamile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe. Lokhu kungakhuphula ingozi yakho yemiphumela emibi ngaphandle kokuhlinzeka ngenzuzo eyengeziwe.

Ngingayeka nini ukuthatha i-Rilpivirine?

Akufanele uyeke ukuthatha i-rilpivirine ngaphandle kokukhuluma nodokotela wakho kuqala. Imithi ye-HIV idinga ukuthathwa njalo impilo yonke ukuze igcine igciwane licindezelwe futhi ivimbele ukumelana.

Uma uhlangabezana nemiphumela emibi noma ufuna ukushintsha ukwelashwa kwakho, udokotela wakho angakusiza ukuthi ushintshele emuthini ohlukile we-HIV ngokuphepha. Ukuyeka kungazelelwe kungaholela ekubuyeni kwegciwane kanye nokumelana okungenzeka ekwelashweni okuzayo.

Ngingayithatha i-Rilpivirine Ngesikhathi Ngikhulelwe?

I-Rilpivirine ngokuvamile ithathwa njengephephile ngesikhathi sokukhulelwa futhi ifakwe eziqondisweni zokwelashwa kwe-HIV ezinconywayo zabesifazane abakhulelwe. Ukwelapha i-HIV ngesikhathi sokukhulelwa kubalulekile ekuvikeleni ukudluliselwa enganeni yakho.

Udokotela wakho uzokuqapha ngokucophelela ngesikhathi sokukhulelwa futhi angashintsha uhlelo lwakho lokwelashwa ngokusekelwe emthwalweni wakho wegciwane kanye nempilo yakho yonke. Abesifazane abaningi bangaqhubeka nemithi yabo ye-HIV ngokuphepha ngenkathi bekhulelwe futhi bencelisa.