Yini i-Selexipag: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Selexipag iyimithi kadokotela eyenzelwe ngqo ukwelapha i-pulmonary arterial hypertension (PAH), isimo esibucayi lapho umfutho wegazi emithanjeni yamaphaphu akho uba phezulu ngendlela eyingozi. Le mithi isebenza ngokusiza ukuphumuza nokwandisa imithambo yegazi emaphapheni akho, okwenza kube lula ukuthi inhliziyo yakho ipompele igazi ngayo. Cabanga ngayo njengokunikeza inhliziyo namaphaphu akho usizo oludingeka kakhulu lapho esebenza ngokweqile ngenxa yalesi simo esiyinselele.

Yini i-Selexipag?

I-Selexipag iyimithi yomlomo eyisigaba semithi ebizwa ngokuthi ama-prostacyclin receptor agonists. Empeleni iyinguqulo yokwenziwa yento yemvelo umzimba wakho oyikhiqizayo ebizwa ngokuthi i-prostacyclin, esiza ukugcina imithambo yakho yegazi iphumule futhi ivulekile. Uma une-pulmonary arterial hypertension, umzimba wakho awukhiqizi okwanele kwalento ewusizo, ngakho i-selexipag ingena ukuzogcwalisa leyo gebe.

Le mithi ithathwa ngomlomo ngamaphilisi, okwenza kube lula kunezinye izindlela zokwelapha i-PAH ezidinga imijovo noma ukumnika okuqhubekayo. Le mithi yakhiwe ngqo ukuhlinzeka ngokuphumula okuhlala isikhathi eside ezimpawini ze-PAH ngenkathi kulula ukuyiphatha emsebenzini wakho wansuku zonke.

Isetshenziselwani i-Selexipag?

I-Selexipag ikakhulukazi inikezwa ukwelapha i-pulmonary arterial hypertension kubantu abadala. I-PAH yisimo esiqhubekayo lapho imithambo emincane emaphapheni akho iba mncane, ivaleke, noma ibhujiswe, okwenza inhliziyo yakho isebenze kanzima kakhulu ukumpompa igazi ngamaphaphu akho. Lo msebenzi owengeziwe ungaholela ekuhlulekeni kwenhliziyo uma ungalashwa.

Udktela wakho angase akunikeze i-selexipag uma uhlangabezana nezimpawu ezinjengokuphelelwa umoya, ukukhathala, ubuhlungu besifuba, noma ukuvuvukala emilenzeni yakho nasezingxenyeni zezinyawo. Umuthi uvame ukusetshenziswa lapho ezinye izindlela zokwelapha zinganikezanga ukukhululeka okwanele noma njengengxenye yendlela yokwelapha ehlanganisiwe. Lusizo ikakhulukazi kubantu abadinga ukunciphisa ukuqhubeka kwe-PAH yabo futhi bathuthukise ikhono labo lokuzivocavoca nokwenza imisebenzi yansuku zonke.

Isebenza Kanjani I-Selexipag?

I-Selexipag isebenza ngokulingisa i-prostacyclin, into yemvelo esebenza njengomqaphi omuhle wemithambo yakho yegazi. Uma uthatha i-selexipag, ibopha kuma-receptors athile emithanjeni yegazi yamaphaphu akho, ithumela amasignali asiza ukuba aphumule futhi ande. Le nqubo inciphisa ukumelana inhliziyo yakho ebhekana nakho lapho ipompa igazi ngamaphaphu akho.

Umuthi futhi usiza ukuvimbela ukwakheka kwamahlule egazi emithanjeni yakho yamaphaphu, okungaba yinkinga enkulu ye-PAH. Ngaphezu kwalokho, i-selexipag ingasiza ukunciphisa ukuvuvukala ezicutshini zamaphaphu akho futhi ivimbele ukulungiswa okuyingozi kwezindonga zemithambo yegazi okwenzeka ku-PAH. Lokhu kuthathwa njengomuthi onamandla ngokulinganisela odinga ukuqashwa ngokucophelela, kodwa ngokuvamile uyabekezeleleka kahle uma usetshenziswa ngendlela efanele.

Kufanele Ngiyithathe Kanjani I-Selexipag?

Kufanele uthathe i-selexipag ngendlela eqondile njengoba unqunyelwe udokotela wakho, ngokuvamile kabili ngosuku ngokudla. Ukuyithatha ngokudla kusiza ukunciphisa isisu esicasulayo futhi kuthuthukisa ukuthi umzimba wakho uyimunca kahle kangakanani imithi. Kungcono ukuthatha imithamo yakho cishe ngesikhathi esifanayo nsuku zonke, cishe amahora angu-12 ngaphandle, ukuze ugcine amazinga aqhubekayo ohlelweni lwakho.

Udktela wakho cishe uzoqala ngomthamo ophansi futhi awunyuse kancane kancane emasontweni ambalwa. Le ndlela yokunyuka isiza umzimba wakho ukuthi ujwayele umuthi futhi inciphisa imiphumela emibi. Ungathatha i-selexipag ngamanzi, ubisi, noma ijusi, kodwa gwema ijusi le-grapefruit njengoba lingaphazamisa indlela umzimba wakho oyiqhubula ngayo imithi.

Ungacindezeli, uhlafune, noma uphule amaphilisi. Gwinya wonke ukuze uqinisekise ukuthi umuthi ukhululwa kahle emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nomphathi wakho wemithi mayelana namanye amasu noma uxoxe ngezinketho nodokotela wakho.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Selexipag?

I-Selexipag ngokuvamile iyindlela yokwelapha yesikhathi eside ye-pulmonary arterial hypertension, okusho ukuthi cishe uzodinga ukuyithatha izinyanga noma iminyaka. I-PAH yisimo esingapheli esidinga ukuphathwa okuqhubekayo, futhi ukuyeka ukwelashwa kungazelelwe kungaholela ekubhebhethekeni okuyingozi kwezimpawu zakho.

Udokotela wakho uzoqapha ukusabela kwakho emuthini ngokuhlolwa okuvamile, ukuhlolwa kwegazi, kanye nokuhlolwa komsebenzi wenhliziyo. Ubude bokwelashwa busekelwe ekutheni usabela kahle kangakanani emuthini, ukuthi isimo sakho siqhubeka kanjani, nokuthi ngabe uhlangabezana nanoma yiziphi izimo ezingezinhle ezibalulekile. Abanye abantu bangase badinge ukuthatha i-selexipag impilo yabo yonke, kanti abanye bangase bashintshe baye kokunye ukwelashwa njengoba isimo sabo sishintsha.

Yiziphi Izimo Ezingezinhle Ze-Selexipag?

Njengayo yonke imithi, i-selexipag ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa:

• Ikhanda, elivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi
• Isicanucanu nokuhlanza, ikakhulukazi lapho uqala ukwelashwa
• Ukuphuma kwendle noma izitulo ezixekile
• Ubuhlungu bomhlathi noma izinhlungu zemisipha
• Ukubomvu noma ukuzwa ufudumele
• Ukulahlekelwa isifiso sokudla
• Ukukhathala noma ukuzizwa ukhathele

Le miphumela emibi ejwayelekile ivame ukuba milde kuya esimweni esiphakathi nendawo futhi ivame ukuba ngaphansi kokukhathaza njengoba umzimba wakho ujwayela umuthi. Udokotela wakho angase alungise umthamo wakho noma aphakamise izindlela zokulawula lezi zimpawu.

Imiphumela engavamile kodwa ebucayi edinga ukunakekelwa kwezempilo ngokushesha ihlanganisa:

• Ubuhlungu obukhulu besifuba noma ukushaya kwenhliziyo okusheshayo
• Ubunzima bokuphefumula noma ukushoda komoya okwanda
• Ubuhlungu obukhulu besisu
• Izimpawu zokuphuma igazi, njengokulimala okungavamile noma igazi esitulweni
• Isiyezi esikhulu noma ukuquleka
• Ukuvuvukala ebusweni bakho, izindebe, ulimi, noma umphimbo

Uma uhlangabezana nanoma yimiphi yale miphumela emibi, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezempilo eziphuthumayo. Khumbula, ithimba lakho lezempilo lanikeza lo muthi ngoba likholelwa ukuthi izinzuzo zidlula izingozi esimweni sakho esithile.

Ubani Ongafanele Athathe I-Selexipag?

I-Selexipag ayifanele wonke umuntu, futhi izimo ezithile noma izimo zikwenza kungaphephile ukuyisebenzisa. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuchazela lo muthi ukuze aqinisekise ukuthi uphephile kuwe.

Akufanele uthathe i-selexipag uma une:

• Ukungezwani okwaziwayo ne-selexipag noma yiziphi izithako zayo
• Isifo sesibindi esibi noma ukwehluleka kwesibindi
• Izifo zokuphuma igazi ezisebenzayo
• Izimo zenhliziyo ezinzima ezenza i-vasodilation ibe yingozi

Ngaphezu kwalokho, ukuqapha okukhethekile kuyadingeka uma une:

• Isifo sezinso noma ukusebenza kwezinso okuncishisiwe
• Umfutho wegazi ophansi
• Umlando wokushaywa unhlangothi noma ukuphuma igazi ebuchosheni
• Ukuhlinzwa okuzayo okuhleliwe
• Ukukhulelwa noma izinhlelo zokukhulelwa

Udokotela wakho uzokala lezi zici ngokucophelela futhi kungase kudingeke ukuthi alungise umthamo wakho noma akhethe ezinye izindlela zokwelapha uma i-selexipag ingafaneleki esimweni sakho.

Amagama Omkhiqizo we-Selexipag

I-Selexipag iyatholakala ngaphansi kwegama lomkhiqizo elithi Uptravi emazweni amaningi, okuhlanganisa i-United States, Canada, kanye ne-Europe. Leli igama lomkhiqizo langempela lapho umuthi waqala ukugunyazwa futhi wathengiswa yi-Actelion Pharmaceuticals.

Ezinye izizwe zingase zibe namagama omkhiqizo engeziwe noma izinhlobo ezivamile ezitholakalayo, kodwa i-Uptravi ihlala iyigama elaziwa kakhulu le-selexipag. Uma ukhuluma ngemithi yakho nabanakekeli bezempilo noma osokhemisi, ungangabaza ukuyibiza ngegama layo elivamile (selexipag) noma ngegama lomkhiqizo wayo (Uptravi).

Ezinye Izindlela Zokwelapha I-Selexipag

Uma i-selexipag ingakulungele noma inganikezi ukukhululeka okwanele kwezimpawu, kunezindlela eziningi zokwelapha ezingenye ezitholakalayo ze-pulmonary arterial hypertension. Udokotela wakho angase acabange ngeminye imithi yomgwaqo we-prostacyclin, ngalinye linenzuzo yalo eyingqayizivele nezindlela zokuletha.

Ezinye izindlela zokwelapha zihlanganisa:

• Epoprostenol (Flolan), enikezwa ngokufakwa kwe-IV okuqhubekayo
• Treprostinil (Remodulin), etholakala njengomjovo, ukuhogela, noma izinhlobo zomlomo
• Iloprost (Ventavis), enikezwa ngokuhogela
• Bosentan (Tracleer), i-endothelin receptor antagonist yomlomo
• Sildenafil (Revatio), i-phosphodiesterase-5 inhibitor
• Riociguat (Adempas), i-soluble guanylate cyclase stimulator

Ngayinye yalezi ezinye izindlela isebenza ngendlela ehlukile futhi ingase ilungele kakhulu kuye ngezimpawu zakho ezithile, indlela yokuphila, kanye nemigomo yokwelashwa. Udokotela wakho uzosiza ekunqumeni ukuthi iyiphi inketho engasebenza kahle esimweni sakho.

Ingabe i-Selexipag Ingcono Kune-Treprostinil?

Kokubili i-selexipag ne-treprostinil kuyizindlela zokwelapha eziphumelelayo ze-pulmonary arterial hypertension, kodwa zinezinzuzo ezihlukene kuye ngezidingo zakho. I-Selexipag inikeza lula lokuphathwa ngomlomo kabili ngosuku, kuyilapho i-treprostinil iza ngezinhlobo eziningi ezihlanganisa imijovo, ukuhogela, namathebulethi omlomo.

Inzuzo enkulu ye-selexipag ukusetshenziswa kwayo okulula kanye neqiniso lokuthi ayidingi imijovo noma ukufakwa okuqhubekayo njengezinye izinhlobo ze-treprostinil. Kodwa-ke, i-treprostinil itholakale isikhathi eside futhi inemininingwane eminingi yocwaningo esekela ukusetshenziswa kwayo. Ezinye iziguli zingase zisabele kangcono emuthini owodwa kunomunye.

Udokotela wakho uzocabangela izinto ezinjengezimpawu zakho zamanje, izintandokazi zokuphila, eminye imithi oyithathayo, nokuthi ukubekezelela kanjani ukwelashwa ngakunye lapho enquma ukuthi yikuphi okungcono kuwe. Kwesinye isikhathi, ukwelashwa okuhlanganisiwe kusetshenziswa yomibili imithi kungase kunconywe ukuze kutholakale imiphumela emihle.

Imibuzo Evame Ukubuzwa Mayelana ne-Selexipag

Ingabe i-Selexipag iphephile kubantu abanezifo zenhliziyo?

I-Selexipag idinga ukuqapha ngokucophelela kubantu abanezifo zenhliziyo, njengoba ingathinta umfutho wegazi nesilinganiso senhliziyo. Udokotela wakho wenhliziyo uzodinga ukuhlola isimo sakho senhliziyo esithile ukuze anqume ukuthi i-selexipag iphephile yini kuwe. Ezimweni eziningi, abantu abane-PAH nabo banezinkinga zenhliziyo, ngakho-ke udokotela wakho uzolinganisela ngokucophelela izinzuzo zokwelapha i-PAH yakho ngokumelene nanoma yiziphi izingozi ezingaba khona enhliziyweni yakho.

Ukuqapha njalo ngokusebenzisa ama-electrocardiograms, ama-echocardiograms, nokuhlolwa komfutho wegazi kusiza ukuqinisekisa ukuthi umuthi usebenza ngokuphepha enhliziyweni yakho. Uma unenhliziyo ehlulekayo enzima noma izinhlobo ezithile zezinkinga zesigqi senhliziyo, udokotela wakho angase akhethe ezinye izindlela zokwelapha noma alungise umthamo wakho we-selexipag ngokufanele.

Ngingenzani uma ngiphuthelwa ngithatha i-Selexipag eningi kakhulu?

Uma ngengozi uthatha i-selexipag eningi kakhulu kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuthatha i-selexipag eningi kakhulu kungabangela umfutho wegazi ophansi ngokuyingozi, ikhanda elibuhlungu elibuhlungu, isicanucanu, ukuhlanza, nokukhanya.

Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini, ngoba ukweqisa umthamo kungaba yingozi. Uma uhlangabezana nezimpawu ezinzima njengokuphefumula kanzima, ubuhlungu besifuba, noma ukuquleka, shayela izinsiza eziphuthumayo ngokushesha. Gcina ibhodlela lemithi nawe ukuze abahlinzeki bezempilo bakwazi ukubona kahle ukuthi uthatheni ini nokuthi uthathe kangakanani.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Selexipag?

Uma uphuthelwa umthamo we-selexipag, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma kungaphakathi kwamahora angu-6 esikhathi sakho esihleliwe. Uma kudlule amahora angaphezu kwangu-6, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kubangele izinkinga ezinkulu, kodwa zama ukugcina ukuthatha imithi njalo ukuze uthole imiphumela engcono kakhulu. Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi ukukusiza ukhumbule. Xhumana nomkhemisi wakho mayelana nezinhlelo zesikhumbuzi uma uqhubeka nokuba nenkinga yokukhumbula imithi yakho.

Ngingayeka nini ukuthatha i-Selexipag?

Akufanele uyeke ukuthatha i-selexipag ngokuzumayo ngaphandle kokuxoxa ngayo nodokotela wakho kuqala. Ukuyeka ngokuphazima kweso kungabangela ukuthi izimpawu zakho ze-PAH zibe zimbi ngokushesha futhi kungaholela ezinxushunxushwini eziyingozi. Udokotela wakho uzodinga ukunciphisa kancane kancane umthamo wakho ngokuhamba kwesikhathi uma ukuyeka kudingekile.

Isinqumo sokuyeka i-selexipag sincike ezintweni ezihlukahlukene, okuhlanganisa ukuthi usabela kahle kangakanani ekwelashweni, imiphumela emibi oyitholayo, nokuthi ngabe ezinye izindlela zokwelapha zingase zifaneleke yini. Udokotela wakho uzoqapha isimo sakho ngokucophelela futhi asebenze nawe ukuthola isu elingcono kakhulu lokwelapha isikhathi eside lokuphatha i-PAH yakho.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Selexipag?

Kungcono ukunciphisa noma ukugwema utshwala ngenkathi uthatha i-selexipag, njengoba kokubili kunganciphisa umfutho wegazi lakho. Ukuhlanganisa kokubili kungase kubangele ukwehla ngokweqile komfutho wegazi, okuholela ekuzizweni unesiyezi, ukuquleka, noma ukuwa. Uma ukhetha ukuphuza utshwala, kwenze ngokulinganisela futhi unake indlela ozizwa ngayo.

Qala ngezilinganiso ezincane ukuze ubone ukuthi umzimba wakho usabela kanjani, futhi gwema ukuphuza utshwala uma uwedwa noma ezimweni lapho ukuwa kungaba yingozi. Njalo xoxa ngokusebenzisa kwakho utshwala nodokotela wakho, njengoba bengakunikeza isiqondiso esiqondene nawe esisekelwe empilweni yakho yonke neminye imithi oyithathayo.