Yini i-Sofosbuvir ne-Velpatasvir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Sofosbuvir ne-velpatasvir kuyinhlanganisela yemithi elapha i-hepatitis C, ukutheleleka ngegciwane okuthinta isibindi sakho. Le nhlanganisela enamandla isebenza ndawonye ukumisa igciwane le-hepatitis C ukuthi lingaphindaphindi emzimbeni wakho, inikeze isibindi sakho ithuba lokuphola nokululama eminyakeni yokulimala.

Cabanga ngale mithi njengokwelashwa okuqondiwe okuqondiswe ngqo egciwaneni elibangela izimpawu zakho. Abantu abaningi bathola impumuzo bazi ukuthi kukhona inketho esebenzayo engasusa ukutheleleka ngokuphelele uma ithathwa njengoba kunqunywe.

Yini i-Sofosbuvir ne-Velpatasvir?

I-Sofosbuvir ne-velpatasvir ihlanganisa imithi emibili elwa namagciwane ibe ithebhulethi eyodwa elula. I-Sofosbuvir ivimba i-enzyme igciwane le-hepatitis C eliyidingayo ukuze lizikopishe, kuyilapho i-velpatasvir ivimbela igciwane ukuthi lingahlanganisi amakhophi amasha.

Le nhlanganisela iqondise izinyathelo ezihlukene emjikelezweni wokuphila wegciwane, okwenza kube nzima kakhulu ukuthi i-hepatitis C iphile futhi isabalale emzimbeni wakho. Umuthi ungowesigaba esibizwa ngokuthi ama-antivirals aqondile, okusho ukuthi uhlasela igciwane ngokuqondile kunokuthi limane likhulise amasosha akho omzimba.

Udokotela wakho unqume le nhlanganisela ethile ngoba kufakazelwe ukuthi isebenza kahle kakhulu ezinhlotsheni eziningi zegciwane le-hepatitis C. Abantu abaningi abaqeda inkambo ephelele yokwelashwa bangalindela ukuthi basuse igciwane ngokuphelele ohlelweni lwabo.

Isetshenziselwani i-Sofosbuvir ne-Velpatasvir?

Le mithi ilapha ukutheleleka okungamahlalakhona kwe-hepatitis C kubantu abadala kanye nezingane ezineminyaka emi-3 nangaphezulu. Isebenza ngokumelene nazo zonke izinhlobo eziyisithupha eziyinhloko zegciwane le-hepatitis C, okusho ukuthi udokotela wakho akudingeki ukuthi athole uhlobo lwakho oluthile lwegciwane ngaphambi kokuqala ukwelashwa.

Umhlinzeki wakho wezempilo angase ancome le nhlanganisela uma une-hepatitis C enezinhlobo ezithile noma ngaphandle kwe-cirrhosis (ukulimala kwesibindi). Isetshenziswa futhi kubantu abangazange basabele kahle kwezinye izindlela zokwelashwa i-hepatitis C esikhathini esidlule.

Umuthi ungaphatha i-hepatitis C ngisho noma unezinye izimo zempilo ezinjenge-HIV noma izinkinga zezinso. Kodwa-ke, udokotela wakho uzohlola ngokucophelela impilo yakho yonke ngaphambi kokukuchazela lo muthi ukuze aqinisekise ukuthi uphephile esimweni sakho esithile.

Isebenza Kanjani I-Sofosbuvir ne-Velpatasvir?

Le nhlanganisela isebenza ngokuvimba izinqubo ezimbili ezibalulekile ezidingwa yi-hepatitis C virus ukuze iphile futhi yande. I-Sofosbuvir isebenza njengokuthi “isakhiwo esingamanga” esifakwa ezintweni zofuzo zegciwane, okwenza ukuthi liyeke ukuzikopisha.

I-Velpatasvir iqondise ingxenye ehlukile yomjikelezo wokuphila wegciwane ngokuvimba iphrotheni ebizwa nge-NS5A, okudingwa yigciwane ukuhlanganisa nokukhipha amakhophi amasha awo. Ngokuhlangene, lezi zindlela zenza ukuthi kube khona ukushaya okunamandla okubili ngokumelene nokutheleleka.

Lokhu kuthathwa njengomuthi onamandla onamazinga aphezulu okuphulukisa, ngokuvamile ususa igciwane kubantu abangaphezu kuka-95% abaqeda inkambo ephelele yokwelashwa. Indlela yokuhlanganisa yenza kube nzima kakhulu ukuthi igciwane likwazi ukumelana uma kuqhathaniswa nokwelashwa ngomuthi owodwa.

Kufanele Ngiyithathe Kanjani I-Sofosbuvir ne-Velpatasvir?

Thatha ithebhulethi eyodwa kanye ngosuku ngaphandle kokudla noma ngaphandle kokudla, okungcono ngesikhathi esifanayo nsuku zonke. Gwinya ithebhulethi yonke ngamanzi - ungagxobi, uhlafune, noma uyiphule, ngoba lokhu kungathinta indlela umuthi osebenza ngayo.

Ungawuthatha lo muthi ngokudla noma esiswini esingenalutho, noma yikuphi okuzizwa kukukhululekile. Abanye abantu bathola ukuthi ukuwuthatha ngokudla kusiza ukunciphisa noma yikuphi ukuphazamiseka kwesisu, kanti abanye bakhetha ukuwuthatha esiswini esingenalutho ukuze kumuncwe ngokuqhubekayo.

Setha isikhumbuzi sansuku zonke ocingweni lwakho noma xhuma ukuthatha umuthi wakho emsebenzini ojwayelekile njengokuxubha amazinyo akho. Ukweqa imithamo kunganciphisa ukusebenza kokwelashwa futhi kungenzeka kuvumele igciwane ukuthi likwazi ukumelana.

Uma usebenzisa eminye imithi, yihlukanise ngesikhathi njengoba udokotela wakho encoma. Eminye imithi ingaphazamisa ukuthi i-sofosbuvir ne-velpatasvir zisebenza kahle kangakanani, ngakho ukuhlela isikhathi kungabaluleka empumelelweni yakho yokwelashwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Sofosbuvir ne-Velpatasvir?

Abantu abaningi bathatha lo muthi amasonto angu-12 (izinsuku ezingu-84), nakuba ubude bokwelashwa kwakho buxhomeke esimweni sakho esithile. Udokotela wakho unquma ubude besikhathi ngokusekelwe ezintweni ezinjengokuthi ngabe unesifo sesibindi, umlando wokwelashwa wangaphambilini, nempilo yakho yonke.

Abanye abantu abanesifo sesibindi esithuthuke kakhulu noma izinkinga ezithile kungenzeka badinga ukwelashwa amasonto angu-24. Umhlinzeki wakho wezempilo uzochaza uhlelo lwakho oluthile lokwelashwa nokuthi kungani lobo bude bufanele wena.

Kubalulekile ukuqeda inkambo yonke ngisho noma uqala ukuzizwa ungcono ngaphambi kokuqeda wonke amaphilisi. Ukuyeka ngaphambi kwesikhathi kungavumela igciwane ukuthi libuye futhi mhlawumbe likwazi ukumelana nomuthi.

Udokotela wakho uzoqapha ukuqhubeka kwakho ngezivivinyo zegazi ngesikhathi nangemva kokwelashwa ukuze aqinisekise ukuthi igciwane liyaphendula njengoba kulindelekile. Lezi zivivinyo zisiza ukuqinisekisa ukuthi umuthi uyasebenza nokuthi igciwane lihlala licinyiwe ngemva kokuphela kokwelashwa.

Yiziphi Izimo Ezingezinhle Ze-Sofosbuvir ne-Velpatasvir?

Abantu abaningi bawuthatha kahle lo muthi, nezimo ezingezinhle ngokuvamile zithambile futhi zongozeka. Izimo ezingezinhle ezivame kakhulu zihlanganisa ikhanda, ukukhathala, nokucasuka, okuthuthuka ngokuvamile njengoba umzimba wakho uzivumela ekwelashweni.

Nawa ama-side effects avamile ongase uwathole, uqonda ukuthi akubona bonke abantu abazoba nalezi zimo:

• Ikhanda nokukhathala okuncane
• Ukuquleka noma ukungakhululeki kwesisu
• Ukuhluleka ukulala noma ukuzizwa ukhathele emini
• Ukuqunjelwa okuncane
• Ukucasuka noma izinguquko zemizwa

Lezi zimpawu ngokuvamile ziba zesikhashana futhi zivame ukuncipha njengoba ukwelashwa kwakho kuqhubeka. Abantu abaningi bathola ukuthi ukuhlala unamanzi ngokwanele nokuthola ukuphumula okwanele kuyasiza ekuphatheni le miphumela.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Lezi zinkinga ezingavamile zingabandakanya ukusabela okukhulu kwesikhumba, izinguquko ezinkulu zemizwa, noma izimpawu zezinkinga zesibindi.

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína:

• Ukuqubuka okukhulu kwesikhumba, ukuvela kwamabhamuza, noma ukuxebuka
• Ukuphuzi kwesikhumba noma amehlo (i-jaundice)
• Ukucindezeleka okukhulu noma imicabango yokuzilimaza
• Ukulimala noma ukopha okungavamile
• Ubuhlungu obukhulu besisu noma ukuhlanza okuqhubekayo

Ngenkathi lezi zindlela ezingathi sína zivamile, ukuzazi kuzokusiza ukuthi ufune ukunakekelwa ngokushesha uma kudingeka. Ithimba lakho lezempilo likhona ukukusekela kunoma yimiphumela emibi ongase uyithole.

Ubani Ongafanele Athathe i-Sofosbuvir ne-Velpatasvir?

Abantu abathile kufanele bagweme lo muthi ngenxa yezingozi ezingaba khona noma ukusebenzisana. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha kanye nemithi yamanje ngaphambi kokunquma lo muthi.

Akufanele uthathe lo muthi uma unokungezwani komzimba ne-sofosbuvir, velpatasvir, noma yiziphi izithako eziqukethwe ithebhulethi. Xhumana nodokotela wakho mayelana nanoma yiziphi izindlela ezedlule zokuphendula emithini elwa namagciwane noma ezinye izifo ezingezwani nemithi.

Abantu abathatha imithi ethile badinga ukucatshangelwa okukhethekile ngenxa yokusebenzisana okungenzeka. Eminye imithi inganciphisa ukusebenza kwe-sofosbuvir ne-velpatasvir noma ikhulise ingozi yemiphumela emibi.

Udokotela wakho uzocophelela ikakhulukazi uma unanoma yiziphi zalezi zimo noma izimo:

• Ukusetshenziswa kwamanje kwe-rifampin noma i-St. John's wort
• Ukuthatha imithi ethile yokulwa nokuhlaselwa njenge-phenytoin noma i-carbamazepine
• Isifo esibi sezinso esidinga i-dialysis
• Ukukhulelwa noma ukuhlela ukukhulelwa
• Ukuthatha imithi ethile ye-HIV

Ukuba nesinye salezi zimo akusho ngokuzenzakalelayo ukuthi awukwazi ukuthatha lo muthi, kodwa udokotela wakho angase adinge ukulungisa uhlelo lwakho lokwelapha noma akuqaphele eduze.

Amagama Omkhiqizo we-Sofosbuvir kanye ne-Velpatasvir

Lo muthi ohlanganisiwe utholakala ngaphansi kwegama lomkhiqizo elithi Epclusa. I-Epclusa iqukethe kokubili i-sofosbuvir kanye ne-velpatasvir kuthebhulethi eyodwa, okwenza kube lula ukuyithatha nsuku zonke.

Inguqulo yegama lomkhiqizo kanye nanoma iyiphi inguqulo ejwayelekile iqukethe izithako ezifanayo ezisebenzayo futhi zisebenza ngendlela efanayo. Ikhemisi lakho noma uhlelo lomshuwalense lungase lukhethe enye inguqulo kunenye, kodwa zombili zisebenza ngendlela efanayo.

Njalo hlola nekhemisi lakho uma ubona noma yikuphi ukungafani ekubukekeni kwethebhulethi yakho phakathi kokugcwaliswa kabusha. Lokhu kuqinisekisa ukuthi uthola umuthi ofanele kanye nomthamo odokotela bakho abaku-oda.

Ezinye Izindlela ze-Sofosbuvir kanye ne-Velpatasvir

Ezinye izindlela zokwelapha i-hepatitis C ziyatholakala uma i-sofosbuvir kanye ne-velpatasvir kungakulungele. Lezi ezinye izindlela zisebenza ngezindlela ezifanayo kodwa zingase zibe nemiphumela ehlukile noma amashejuli okulinganisa.

Ezinye izinhlanganisela zama-antiviral aqondile zihlanganisa i-glecaprevir/pibrentasvir (Mavyret) kanye ne-sofosbuvir/velpatasvir/voxilaprevir (Vosevi). Udokotela wakho angase acabangele lokhu uma unezinkinga ezithile zemithi noma umlando wokwelashwa.

Ukukhetha phakathi kokwelashwa kuncike ezintweni ezinjengohlobo lwakho lwe-hepatitis C, ulwazi lwangaphambilini lokwelashwa, ezinye izimo zempilo, kanye nokusebenzisana okungenzeka kwemithi. Umhlinzeki wakho wezempilo uzosiza ekunqumeni ukuthi iyiphi inketho enikeza ibhalansi engcono kakhulu yokusebenza kahle nokuphepha esimweni sakho.

Ingabe i-Sofosbuvir kanye ne-Velpatasvir Ingcono Kune-Harvoni?

Kokubili i-sofosbuvir/velpatasvir (Epclusa) kanye ne-ledipasvir/sofosbuvir (Harvoni) kuyizindlela zokwelapha i-hepatitis C eziphumelela kakhulu ezinamazinga okuphulukisa afanayo. Inzuzo enkulu ye-sofosbuvir/velpatasvir ukuthi isebenza ngokumelene nazo zonke izinhlobo ze-hepatitis C, kuyilapho i-Harvoni isetshenziswa ikakhulukazi ezinhlotsheni 1, 4, 5, kanye no-6.

Ukukhetha kukadokotela wakho phakathi kwale mithi kuncike ohlotsheni lwakho oluthile lwe-hepatitis C, umlando wokwelashwa, nezinye izinto zezempilo. Zombili zinezinhlobo ezifanayo zemiphumela emibi kanye namashejuli okulinganisa, okwenza kube lula ngokulinganayo kubantu abaningi.

Uma ungakaze uhlolwe uhlobo noma une-genotype okunzima ukuyelapha, udokotela wakho angase akhethe i-sofosbuvir/velpatasvir ngenxa yokuthi ihlanganisa izinhlobo eziningi. Kodwa-ke, zombili le mithi ziyizinqumo ezinhle ezinamazinga aphumelelayo aphezulu uma zisetshenziswa ngendlela efanele.

Imibuzo Evame Ukubuzwa Mayelana ne-Sofosbuvir kanye ne-Velpatasvir

Ingabe i-Sofosbuvir kanye ne-Velpatasvir iphephile kubantu abanezifo zezinso?

Abantu abanezifo zezinso ezingamakhulu kuya kweziphakathi ngokuvamile bangayithatha le mithi ngokuphepha, nakuba udokotela wakho angase akuqaphele kakhulu. Kodwa-ke, uma unezifo zezinso ezinzima noma use-dialysis, le mithi ingase ingakulungele.

Udokotela wakho uzohlola ukusebenza kwezinso zakho ngezivivinyo zegazi ngaphambi kokuqala ukwelashwa futhi angase alungise isimiso sakho sokuqapha ngokuya ngempilo yakho yezinso. Qiniseka ukuthi usho noma yiziphi izinkinga zezinso noma imithi oyithathayo ngezifo zezinso.

Ngingenzani uma ngiphuthelwa ngithatha i-Sofosbuvir kanye ne-Velpatasvir eningi kakhulu?

Uma ngengozi uthatha amaphilisi angaphezu kwelilodwa ngosuku, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Nakuba ukweqisa ngale mithi kungavamile, kubalulekile ukuthola iseluleko sezokwelapha mayelana nokuthi yini okufanele uyenze ngokulandelayo.

Ungazami "ukulungisa" umthamo owengeziwe ngokususa umthamo wakho olandelayo ohleliwe. Kunalokho, qhubeka nohlelo lwakho olujwayelekile lokuthatha imithi njengoba uqondiswe umhlinzeki wakho wokunakekelwa kwezempilo. Gcina ukupakishwa kwemithi unawe lapho ufuna usizo lwezokwelapha ukuze abahlinzeki bezempilo bazi kahle ukuthi uthatheni.

Ngingenzani Uma Ngeqe Umthamo We-Sofosbuvir kanye ne-Velpatasvir?

Uma weqa umthamo futhi sekudlule amahora angaphansi kwama-18 kusukela ngesikhathi sakho esihleliwe, thatha umthamo owuqegile ngokushesha lapho ukhumbula. Uma sekudlule amahora angaphezu kwama-18, weqa umthamo owuqegile bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuqegile, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Setha izikhumbuzi ocingweni lwakho noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule umthamo wakho wansuku zonke.

Ngingayeka nini Ukuthatha i-Sofosbuvir kanye ne-Velpatasvir?

Yeka kuphela ukuthatha lo muthi uma udokotela wakho ekutshela ukuthi wenze njalo, ngokuvamile ngemva kokuqeda inkambo ephelele ebekiwe. Abantu abaningi bayawuthatha amasonto angu-12, futhi ukuyeka ngaphambi kwesikhathi kungavumela igciwane ukuthi libuye noma likwazi ukumelana.

Udokotela wakho uzoqhuba izivivinyo zegazi ngesikhathi nangemva kokwelashwa ukuze aqinisekise ukuthi igciwane lisusiwe. Noma ngabe uzizwa ungcono ngokuphelele ngaphambi kokuqeda wonke amaphilisi akho, kubalulekile ukuqeda yonke inkambo ukuze uthole ithuba elingcono lokususa unomphela ukutheleleka.

Ngingakwazi Ukuphuza Utywala Ngenkathi Ngithatha i-Sofosbuvir kanye ne-Velpatasvir?

Kungcono ukugwema utshwala ngokuphelele ngenkathi uthatha lo muthi kanye nangezinyanga eziningana ngemva kokuphela kokwelashwa. Utshwala bungalimaza isibindi sakho, esivele sisebenza ukuze silulame ekuthelelekeni nge-hepatitis C.

Ngisho namanani amancane otshwala angaphazamisa inqubo yokwelapha yesibindi sakho futhi anganciphisa ukusebenza kahle komuthi. Khuluma nodokotela wakho mayelana nokusetshenziswa kotshwala - bangakunikeza isiqondiso esiqondene nawe esisekelwe empilweni yesibindi sakho kanye nemigomo yokwelashwa.