Yini i-Tecovirimat: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Tecovirimat iyimithi elwa namagciwane eyenzelwe ngqo ukwelapha izifo ze-smallpox kanye ne-monkeypox. Ngenkathi i-smallpox iqediwe emhlabeni wonke, le mithi isebenza njengenketho yokwelapha ebalulekile futhi njengamanje isetshenziselwa amacala e-monkeypox lapho ezinye izindlela zokwelapha zingafaneleki.

Ungase uzibuze ngale mithi uma udokotela wakho eyikhulumile njengenketho yokwelapha yokutheleleka nge-poxvirus. Ake sihambe kukho konke okudingeka ukwazi nge-tecovirimat ngamagama alula, acacile.

Yini i-Tecovirimat?

I-Tecovirimat iyidakamizwa elwa namagciwane eliqondise ngqo ama-poxviruses afana ne-smallpox ne-monkeypox. Isebenza ngokuvimba iphrotheni leli gciwane elidinga ukusabalala lisuka kwelinye iseli liye kwelinye emzimbeni wakho.

Le mithi yaqala ukuthuthukiswa njengesinyathelo sokulwa ne-smallpox, yize lesi sifo saqedwa emashumini eminyaka edlule. Namuhla, isetshenziswa ikakhulukazi ukwelapha izifo ze-monkeypox, ikakhulukazi kubantu abanezimpawu ezinzima noma abasengozini enkulu yezinkinga.

Le mithi imisha uma iqhathaniswa neminye imithi elwa namagciwane, ngoba ithole imvume evela e-FDA ngo-2018. Ithathwa njengokwelashwa okukhethekile okugcinelwe izimo ezithile kunokusebenzisa okuvamile.

Isetshenziselwani i-Tecovirimat?

I-Tecovirimat ivunyelwe ukwelapha isifo se-smallpox kubantu abadala nezingane ezinobunzima obungama-kilogramu amathathu (cishe amaphawundi angu-6.6). Isetshenziswa futhi ngaphandle kwethekhi ukwelapha izifo ze-monkeypox, ikakhulukazi ezimweni ezithile eziyingozi.

Udokotela wakho angase ancome i-tecovirimat uma une-monkeypox futhi ungena kwenye yalezi zigaba: unesistimu yokuzivikela ebuthakathaka, ukhulelwe, uncelisa, noma unezimpawu ezinzima. Imithi ingase futhi icatshangelwe kubantu abanezimo zesikhumba ezinjenge-eczema, njengoba bengase babhekane nobungozi obukhulu bezinkinga.

Ngenkathi i-tecovirimat ingasetshenziselwa ezinye izifo ze-poxvirus, lezi zimo zivame kakhulu. Abantu abaningi abane-monkeypox bayalulama ngaphandle kokudinga ukwelashwa nge-antiviral, ngakho lo muthi uvame ukugcinelwa amacala lapho kudingeka khona ukwesekwa okwengeziwe.

Isebenza Kanjani I-Tecovirimat?

I-Tecovirimat isebenza ngokugxila kuphrotheni ethile ebizwa nge-VP37 edingwa ama-poxvirus ukuze asakazeke emzimbeni wakho wonke. Cabanga ngayo njengokuvimba ukhiye ovirasi owusebenzisayo ukuvula iminyango phakathi kwamaseli.

Uma uthatha i-tecovirimat, ivimbela igciwane ekuzifakeni kahle futhi lisuke kumaseli anegciwane liye kwalawo anempilo. Lokhu akubulali ngqo igciwane, kodwa kunciphisa kakhulu ikhono lalo lokusabalala nokubanga umonakalo owengeziwe.

Lo muthi ubhekwa njengonamandla ngokulinganisela njengoba imithi ye-antiviral ihamba. Yenzelwe ngqo ama-poxvirus, okwenza iqondiswe kakhulu kodwa futhi kusho ukuthi ngeke isebenze ezinhlotsheni ezinye zezifo ezibangelwa amagciwane njengomkhuhlane noma umkhuhlane ojwayelekile.

Kufanele Ngiyithathe Kanjani I-Tecovirimat?

Thatha i-tecovirimat ngendlela eqondile udokotela wakho ayichazayo, ngokuvamile kabili ngosuku ngokudla. Umuthi usebenza kahle uma uthathwa nokudla okuqukethe amafutha athile, ngoba lokhu kusiza umzimba wakho ukuba uwamunce ngempumelelo.

Kufanele uthathe umthamo ngamunye cishe ngamahora ayi-12 ahlukene, ngakho-ke uma uthatha umthamo wakho wokuqala ngo-8 AM ngesidlo sasekuseni, thatha umthamo wakho wesibili ngo-8 PM ngesidlo sakusihlwa. Zama ukudla okuthile okukhulu ngomthamo ngamunye kunokuba nje isidlo esilula.

Gwinya amaphilisi wonke ngamanzi. Ungawachobozi, uwahlafune, noma uwaqhekeze, ngoba lokhu kungathinta ukuthi umuthi usebenza kanjani. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho ngezinketho ezinye.

Qhubeka nokuthatha umuthi isikhathi esiphelele udokotela wakho akuchazayo, ngisho noma uqala ukuzizwa ungcono. Ukuyeka ngaphambi kwesikhathi kungavumela igciwane ukuthi libe semsebenzini futhi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Tecovirimat?

Inkambo ejwayelekile ye-tecovirimat ihlala izinsuku eziyi-14, nakuba udokotela wakho engase alungise lokhu ngokuya ngesimo sakho esithile. Abantu abaningi bayayithatha amasonto amabili ngqo, bethatha amaphilisi amabili nsuku zonke.

Udokotela wakho uzoqoka ubude obufanele ngokuya ngezinto eziningana: ukuthi ukutheleleka kwakho kubi kangakanani, ukuthi isimiso sakho somzimba sokuzivikela siyasebenza kanjani, nokuthi usabela kanjani emuthini. Abanye abantu bangase badinge inkambo emfushane, kanti abanye bangase badinge ukwelashwa okude kancane.

Ungayeki ukuthatha i-tecovirimat ngaphambi kwesikhathi, ngisho noma izimpawu zakho zithuthuka. Ukutheleleka nge-Poxvirus kungaba yinkimbinkimbi, futhi ukuyeka ukwelashwa ngokushesha kungaholela ekutheni ukutheleleka kubuye noma kube kubi kakhulu.

Ziyini Imiphumela Eceleni ye-Tecovirimat?

Abantu abaningi bayayibekezelela kahle i-tecovirimat, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathí sina ayivamile, futhi abantu abaningi bathola kuphela izimpawu ezilula uma zikhona.

Nawa amanye imiphumela emibi evame kakhulu ongase uyithole ngenkathi uthatha i-tecovirimat:

• Ukucabuka kwekhanda
• Ukucasuka kwesisu noma isisu
• Ubuhlungu besisu
• Ukuphalaza
• Ukukhathala noma ukuzizwa ukhathele
• Isiyezi

Lezi zimpawu zivame ukuba lula futhi zivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Ukuthatha umuthi nokudla kungasiza ekunciphiseni imiphumela emibi ehlobene nesisu.

Imiphumela emibi engavamile kodwa engathi sína ingabandakanya ukusabela okukhulu komzimba, nakuba lokhu kungavamile. Xhumana nodokotela wakho ngokushesha uma uba nobunzima bokuphefumula, ukuqubuka okukhulu, noma ukuvuvukala kobuso bakho, izindebe, ulimi, noma umphimbo.

Abanye abantu bangase bathole izinguquko emiphumeleni yabo yokuhlolwa kwegazi, ikakhulukazi ehlobene nokusebenza kwesibindi. Udokotela wakho angase aqaphele lawa mazinga uma uthatha umuthi isikhathi eside.

Ubani Ongafanele Athatha i-Tecovirimat?

I-Tecovirimat ngokuvamile iphephile kubantu abaningi, kodwa zikhona izimo lapho kungenzeka ingabi yindlela efanele. Udokotela wakho uzocabangela ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela.

Akufanele uthathe i-tecovirimat uma unokungezwani nayo noma nganoma yiziphi izithako zayo. Xhumana nodokotela wakho mayelana nanoma yiziphi izindlela zokungezwani komzimba emithini, ikakhulukazi uma uke waba nokusabela okukhulu esikhathini esidlule.

Abantu abanezifo zesibindi ezinzima bangase badinge ukuqashwa okukhethekile noma indlela ehlukile yokwelapha. Umuthi ucutshungulwa yisibindi sakho, ngakho izinkinga ezinkulu zesibindi zingase zithinte ukuthi usebenza kahle kangakanani noma zikhuphule ingozi yemiphumela emibi.

Uma ukhulelwe noma uncelisa, udokotela wakho uzolinganisela izinzuzo nezingozi ezingaba khona. Nakuba i-tecovirimat ingasetshenziswa ngesikhathi sokukhulelwa ngezifo ezinzima, lesi sinqumo sidinga ukucatshangelwa ngokucophelela kwesimo sakho esithile.

Igama Lomkhiqizo le-Tecovirimat

I-Tecovirimat ithengiswa ngaphansi kwegama lomkhiqizo elithi TPOXX e-United States. Leli okwamanje yilo kuphela igama lomkhiqizo elitholakalayo lalo muthi, njengoba ukhiqizwa yinkampani eyodwa.

Ungase ukubone kubhekiselwa kulo njenge-ST-246 kwezinye izincwadi zezokwelapha, okuyigama lalo locwaningo ngaphambi kokuthi litholakale ngokuthengisa. Nokho, uma uthola umuthi wakho, uzolebula njenge-TPOXX.

Umuthi uza ngama-capsule angu-200-milligram, futhi okwamanje akukho okuhlukile okutholakalayo. Lokhu kusho ukuthi yonke imiyalelo ye-tecovirimat izoba ngegama lomkhiqizo elithi TPOXX.

Ezinye Izindlela ze-Tecovirimat

Njengamanje, zikhona ezinye izindlela eziqondile ze-tecovirimat zokwelapha izifo ze-poxvirus. Enye indlela enkulu yi-cidofovir, umuthi omdala wokulwa namagciwane ongasetshenziswa ezimweni ezinzima ze-monkeypox.

I-Cidofovir inikezwa ngomjovo (nge-IV) futhi idinga ukulaliswa esibhedlela ukuze inikezwe. Ngokuvamile kucatshangelwa uma i-tecovirimat ingatholakali noma ingafaneleki, kodwa inemiphumela emibi kakhulu futhi idinga ukuqashwa ngokucophelela.

I-Brincidofovir enye indlela engase ibe khona ehlolwayo yezifo ze-poxvirus. Ihlobene ne-cidofovir kodwa ingathathwa ngomlomo, nakuba ingakatholakali kabanzi ngale njongo.

Kubantu abaningi abane-monkeypox, ukunakekelwa okusekelayo ngaphandle kwemithi elwa namagciwane kuvame ukwanele. Lokhu kuhlanganisa ukuphathwa kobuhlungu, ukunakekelwa kwamanxeba, nokuqapha izinkinga.

Ingabe i-Tecovirimat Ingcono Kune-Cidofovir?

I-Tecovirimat ngokuvamile ithathwa njengcono kune-cidofovir kubantu abaningi abadinga ukwelashwa ngemithi elwa namagciwane yezifo ze-poxvirus. Inzuzo enkulu ukuthi i-tecovirimat ingathathwa ekhaya njengamaphilisi omlomo, kuyilapho i-cidofovir idinga ukulaliswa esibhedlela ukuze inikezwe nge-IV.

I-Tecovirimat nayo inemiphumela emibi embalwa uma iqhathaniswa ne-cidofovir. I-Cidofovir ingabangela ukulimala kwezinso nezinye izinkinga ezinkulu, idinga ukuhlolwa kwegazi njalo nokuqashwa ngokucophelela ngesikhathi sokwelashwa.

Nokho, i-cidofovir isetshenziswe isikhathi eside futhi inemininingwane ebanzi ngempumelelo yayo. Kwezinye izimo ezinzima kakhulu, odokotela bangase bakhethe i-cidofovir naphezu kwezinkinga zayo, ikakhulukazi uma umuntu engasabeli kahle ku-tecovirimat.

Udokotela wakho uzokhetha inketho engcono kakhulu ngokusekelwe esimweni sakho esithile, ecabangela izinto ezinjengokuthi isifo sakho sinzima kangakanani, impilo yakho yonke, nokuthi ungakwazi yini ukuthatha imithi yomlomo.

Imibuzo Evame Ukubuzwa Mayelana ne-Tecovirimat

Q1. Ingabe i-Tecovirimat Iphephile Kwabesifazane Abakhulelwe?

I-Tecovirimat ingasetshenziswa ngesikhathi sokukhulelwa lapho izinzuzo zidlula izingozi, ikakhulukazi ezifweni ezinzima ze-poxvirus. Izifundo zezilwane azizange zikhombise imiphumela eyingozi ekukhulelweni, kodwa idatha yabantu ilinganiselwe njengoba imithi isencane.

Uma ukhulelwe futhi unokutheleleka nge-poxvirus, udokotela wakho uzohlola ngokucophelela izingozi zokutheleleka uma ziqhathaniswa nanoma yiziphi izingozi ezingase zibe khona emuthini. Ukutheleleka okukhulu nge-poxvirus kungaba yingozi ngesikhathi sokukhulelwa, ngakho-ke ukwelashwa kuvame ukunconywa.

Udokotela wakho uzokugada eduze ngesikhathi sokwelashwa uma ukhulelwe. Isinqumo sokusebenzisa i-tecovirimat ngesikhathi sokukhulelwa senziwa njalo ngesisekelo ngasinye, kucatshangelwa izimo zakho ezithile.

Q2. Kufanele Ngenzeni Uma Ngithatha I-Tecovirimat Eningi Ngengozi?

Uma ngengozi uthatha i-tecovirimat eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi uzizwa ugula, ngoba kungcono ukuthola iseluleko ngokushesha.

Ukuthatha i-tecovirimat eningi kungase kwandise ingozi yakho yemiphumela emibi, ikakhulukazi isicanucanu, ukuhlanza, nobuhlungu besisu. Kwezinye izimo, kungase kuthinte ukusebenza kwesibindi sakho, nakuba lokhu kungenzeka kakhulu ngemithamo ephezulu kakhulu.

Uma ushayela ucingo ukuze uthole usizo, lungisa ibhodlela lakho lemithi ukuze ukwazi ukubatshela ngqo ukuthi uthathe malini nokuthi nini. Bazokuqondisa ukuthi ngabe udinga ukunakekelwa kwezokwelapha ngokushesha noma ungaqashwa ekhaya.

Q3. Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Tecovirimat?

Uma uphuthelwa umthamo we-tecovirimat, yithathe ngokushesha lapho ukhumbula, uma nje kungasondeli isikhathi somthamo wakho olandelayo. Uma sekudlule amahora angaphezu kwayi-6 kusukela kumthamo wakho ophuthelwe futhi usondela kumthamo wakho olandelayo ohleliwe, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Kungcono ukugcina ishejuli yakho ejwayelekile futhi ungaphindi umuthi.

Zama ukusetha izikhumbuzi ocingweni lwakho noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule imithamo yakho. Ukulinganisa okuqhubekayo kubalulekile ekugcineni imithi emazingeni asebenzayo emzimbeni wakho.

Q4. Ngingayeka Nini Ukuthatha I-Tecovirimat?

Kufanele uyeke kuphela ukuthatha i-tecovirimat uma udokotela wakho ekutshela ukuthi wenze njalo, ngokuvamile ngemva kokuqeda inkambo yezinsuku eziyi-14. Ungayeki ngaphambi kwesikhathi ngisho noma uzizwa ungcono ngokuphelele, ngoba lokhu kungavumela igciwane ukuthi libe semsebenzini futhi.

Udokotela wakho angase ancome ukuyeka imithi ngaphambi kwesikhathi uma uhlangabezana nemiphumela emibi kakhulu noma uma ukutheleleka kwakho kululama ngokushesha okungajwayelekile. Nokho, lesi sinqumo kufanele senziwe ngumhlinzeki wakho wezempilo, hhayi ngokuqondile.

Uma unenkinga yokubekezelela imithi, khuluma nodokotela wakho mayelana nezimpawu zakho kunokuyeka ngokwakho. Bangase bakwazi ukulungisa ukwelashwa kwakho noma banikeze ukunakekelwa okusekelayo ukukusiza ukuthi uqede inkambo.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Tecovirimat?

Ngokuvamile kungcono ukugwema utshwala ngenkathi uthatha i-tecovirimat, ikakhulukazi uma uhlangabezana nanoma yikuphi ukuphazamiseka kwesisu noma isicanucanu esivela emithini. Utshwala bungenza le miphumela emibi ibe yimbi futhi ingase iphazamise ukululama kwakho.

Ngenkathi kungekho ukusebenzisana okuthile okuyingozi phakathi kwe-tecovirimat notshwala, ukuphuza kungabeka ingcindezi eyengeziwe esibindini sakho, esivele sicubungula imithi. Lokhu kubaluleke kakhulu uma unezinkinga zesibindi.

Gxila ekuhlaliseni kahle ngamanzi nezinye iziphuzo ezingezona utshwala ngenkathi ululama ekuthelelekeni kwakho. Umzimba wakho udinga zonke izinsiza zawo ukulwa negciwane futhi ululame kahle.