Yini i-Tegaserod: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Tegaserod iyimithi kadokotela esiza ukwelapha izinkinga ezithile zokugaya ukudla, ikakhulukazi i-irritable bowel syndrome enokuqunjelwa (IBS-C) kwabesifazane. Le mithi isebenza ngokusiza amathumbu akho ukuthi ahambise ukudla ngempumelelo ngohlelo lwakho lokugaya ukudla, okunganciphisa izimpawu ezingakhululeki ongase uzizwe.

Uma ubhekene nokuqunjelwa okungapheli nokungakhululeki esiswini, awuwedwa. Abantu abaningi bathola impumuzo nge-tegaserod lapho ezinye izindlela zokwelapha zingasebenzi kahle ngokwanele. Ake sihambe kukho konke okudingeka ukwazi ngale mithi ngendlela ezizwakala ilawuleka futhi icacile.

Yini i-Tegaserod?

I-Tegaserod iyimithi eyingxenye yeqembu elibizwa ngokuthi ama-serotonin receptor agonists. Yenzelwe ngqo ukusiza uhlelo lwakho lokugaya ukudla ukuthi lusebenze kahle uma une-irritable bowel syndrome enokuqunjelwa.

Le mithi empeleni yasuswa emakethe iminyaka eminingana ngenxa yokukhathazeka ngokuphepha, kodwa yabuyela ngo-2019 ngemihlahlandlela eqinile yokuthi ubani ongayisebenzisa ngokuphepha. Udokotela wakho uzohlola ngokucophelela ukuthi i-tegaserod ilungile yini esimweni sakho esithile.

Imithi iza ngamaphilisi owathatha ngomlomo, futhi itholakala kuphela ngemvume kadokotela ovela kumhlinzeki wakho wezempilo. Kubalulekile ukwazi ukuthi i-tegaserod okwamanje ivunyelwe kuphela kwabesifazane abangaphansi kweminyaka engama-65 abahlangabezana nemibandela ethile yezempilo.

Yini i-Tegaserod Esizwa Ngayo?

I-Tegaserod isetshenziswa ikakhulukazi ukwelapha i-irritable bowel syndrome enokuqunjelwa (IBS-C) kwabesifazane. Lesi simo sibangela inhlanganisela yezinhlungu zesisu, ukuqunjelwa, nobunzima bokuba nokunyakaza kwamathumbu okuvamile.

Udokotela wakho angase acabangele i-tegaserod uma uzamile ezinye izindlela zokwelapha njengokushintsha ukudla, izithasiselo ze-fiber, noma eminye imithi ngaphandle kokuthola impumuzo eyanele. Imithi yenzelwe ngqo amacala lapho ukuqunjelwa kuyinkinga enkulu kunokuhuda.

Kufanelekile ukuqaphela ukuthi i-tegaserod ayisetshenziselwa ukuqunjelwa okuvamile noma ezinye izinkinga zokugaya ukudla. Umhlinzeki wakho wezempilo uzoqinisekisa ukuthi izimpawu zakho zihambisana nephethini ethile ephendula kahle kakhulu kulo muthi.

Isebenza Kanjani I-Tegaserod?

I-Tegaserod isebenza ngokwenza kusebenze ama-receptors athile emathunjini akho asiza ukuxhumanisa ukuncipha kwemisipha. Cabanga ngakho njengokusiza uhlelo lwakho lokugaya ukudla ukuthi lukhumbule ukuthi lungahambisa kanjani ukudla ngesivinini esivamile.

Lo muthi uqondise ngqo ama-serotonin receptors emathunjini akho, adlala indima ebalulekile ekutheni amathumbu akho anciphane futhi aphumule kanjani. Lapho la ma-receptors esebenza kahle, ukudla kanye nodoti kuhamba ngohlelo lwakho ngempumelelo enkulu.

Lo muthi awunamandla kakhulu uma uqhathaniswa nokunye ukwelashwa kokugaya ukudla, kodwa kungasebenza kumuntu ofanele. Abantu abaningi abazuza ku-tegaserod baqaphela ukuthuthuka kancane kancane ezimpawini zabo emasontweni amaningana kunokuthi bathole ukukhululeka ngokushesha.

Kufanele Ngiyithathe Kanjani I-Tegaserod?

Kufanele uthathe i-tegaserod ngendlela eqondile udokotela wakho ayiyalayo, ngokuvamile kabili ngosuku ngaphambi kokudla. Ukuyithatha esiswini esingenalutho kusiza umzimba wakho ukuthi umunce umuthi ngempumelelo enkulu.

Umthamo ovamile ungama-6 mg kabili ngosuku, uthathwa cishe imizuzu engama-30 ngaphambi kwasekuseni nakusihlwa. Ungayithathi nokudla noma ngemva nje kokudla, ngoba lokhu kunganciphisa ukuthi umuthi usebenza kahle kangakanani.

Ungayithatha i-tegaserod ngamanzi, futhi akudingeki ukuthi ugweme noma yikuphi ukudla ngaphandle kwalapho udokotela wakho ekutshela ngenye indlela. Nokho, ukugcina ukudla okunempilo okunefayibha eyanele kungasiza ukusekela ukusebenza komuthi.

Uma ukhohlwa umthamo, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma okungenani amahora ama-2 ngaphambi komthamo wakho olandelayo ohleliwe. Ungaphindi imithamo ukuze ulungise leyo oyiphuthelwe.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Tegaserod?

Abantu abaningi bathatha i-tegaserod amasonto angu-4 kuya kwangu-6 ekuqaleni ukuze babone ukuthi iyasiza yini ngezimpawu zabo. Udokotela wakho uzoqapha ukuthi usabela kanjani ngalesi sikhathi futhi anqume ukuthi uzoqhubeka yini nokwelashwa.

Uma i-tegaserod ikusebenzela kahle, udokotela wakho angase ancome ukuyisebenzisa isikhathi eside, kodwa lokhu kudinga ukuhlolwa njalo ukuze kuqinisekiswe ukuthi imithi ihlala iphephile futhi isebenza kahle. Abanye abantu bayayisebenzisa izinyanga eziningana noma isikhathi eside ngaphansi kokuqondiswa kwezokwelapha okucophelelayo.

Okubalulekile ukusebenzisana eduze nomhlinzeki wakho wezempilo ukuze uthole isikhathi esifanele sesimo sakho esithile. Ungayeki ukuthatha i-tegaserod ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala, njengoba bengase bafune ukulungisa uhlelo lwakho lokwelashwa kancane kancane.

Yiziphi Imiphumela Eceleni Ye-Tegaserod?

Njengemithi eminingi, i-tegaserod ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ivamise ukuba mncane futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi.

Nansi imiphumela emibi ongase uyithole, ihlelwe kusukela kokuvame kakhulu kuya kokungavamile:

Imiphumela emibi ejwayelekile abantu abaningi abayitholayo ihlanganisa:

• Ikhanda
• Ubuhlungu besisu noma ukungakhululeki
• Ukuqunjelwa
• Isicanucanu
• Isiyezi
• I-Flatulence (igesi)

Le miphumela emibi ejwayelekile ngokuvamile ayibi futhi ivame ukuba ngcono njengoba umzimba wakho ujwayela imithi. Uma ziqhubeka noma zikuphazamisa kakhulu, yazisa udokotela wakho.

Imiphumela emibi engavamile kodwa engase ibe yingozi ihlanganisa:

• Ukuqunjelwa okukhulu okungathuthuki
• Ubuhlungu obukhulu besisu
• Ukuphuma kwegazi ngemuva
• Ubuhlungu besifuba
• Ukuphefumula kanzima
• Ukuquleka noma isiyezi esikhulu

Uma uthola noma iyiphi yale miphumela emibi ebucayi, xhumana nomhlinzeki wakho wezempilo ngokushesha. Bangasiza ekunqumeni ukuthi kufanele uqhubeke yini nokuthatha i-tegaserod noma uzame indlela yokwelashwa ehlukile.

Imiphumela emibi engavamile kodwa ebucayi edinga ukunakekelwa kwezokwelapha ngokushesha:

• Izimpawu zezinkinga zenhliziyo (ubuhlungu besifuba, ukushaya kwenhliziyo okungajwayelekile, ukuphefumula kanzima)
• Ukuphendula okukhulu komzimba (ukuqubuka, ukuvuvukala, ubunzima bokuphefumula)
• Izimpawu zokuvaleka kwamathumbu (ubuhlungu obukhulu besisu, ukuhlanza, ukungakwazi ukukhipha igesi)
• Izimpawu ezinjenges stroke (ubuthakathaka obuzumayo, ukudideka, ubunzima bokukhuluma)

Le miphumela emibi engavamile yingakho i-tegaserod idinga ukuqashwa ngokucophelela futhi inikezwa kuphela iziguli ezithile eziqeda izindlela zempilo ezithile. Udokotela wakho ulinganise izinzuzo ngokumelene nalezi zingozi esimweni sakho esithile.

Ubani Ongafanele Athathe I-Tegaserod?

I-Tegaserod ayiphephile kuwo wonke umuntu, futhi kunezinqamulelo ezibalulekile zokuthi ubani ongathatha lo muthi. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwunikeza.

Akufanele uthathe i-tegaserod uma unezinkinga ezithile zenhliziyo noma zemithambo yegazi, okuhlanganisa umlando wokuhlaselwa yinhliziyo, i-stroke, noma izinhlobo ezithile zobuhlungu besifuba. Umuthi ungase ukwandise ingozi yezigameko ezinzima zenhliziyo nemithambo yegazi kwabanye abantu.

Izimo ezithile ezenza i-tegaserod ingaphephile zihlanganisa:

• Umlando wokuhlaselwa yinhliziyo, i-stroke, noma i-mini-stroke
• Izinhlobo ezithile zobuhlungu besifuba (i-angina engazinzile)
• Isifo semithambo yegazi esingaphandle
• Isifo sezinso esibi kakhulu
• Isifo sesibindi esibi kakhulu
• Umlando wokuvaleka kwamathumbu
• Isifo samathumbu esivuvukalayo (isifo sikaCrohn noma i-ulcerative colitis)

Ngaphezu kwalokho, i-tegaserod njengamanje ivunyelwe kuphela abesifazane abangaphansi kweminyaka engama-65 ubudala abasengozini ephansi yezinkinga zenhliziyo nemithambo yegazi. Amadoda nabesifazane abaneminyaka engaphezu kwengama-65 akufanele bathathe lo muthi ngenxa yezingozi ezengeziwe zokuphepha.

Kufanele futhi utshele udokotela wakho uma une:

• Umfutho wegazi ophezulu
• Isifo sikashukela
• I-cholesterol ephezulu
• Umlando womndeni wesifo senhliziyo
• Umlando wokubhema
• Noma yiziphi ezinye izimo zenhliziyo noma zemithambo yegazi

Umhlinzeki wakho wezempilo uzocabangela zonke lezi zinto ndawonye ukuze anqume ukuthi i-tegaserod iyindlela ephephile yini kuwe. Kungase kube nezinye izindlela zokwelapha ezisebenzayo uma i-tegaserod ingafaneleki esimweni sakho.

Igama Lomkhiqizo le-Tegaserod

I-Tegaserod itholakala ngaphansi kwegama lomkhiqizo elithi Zelnorm. Leli yigama eliyinhloko lomkhiqizo ozolibona lapho udokotela wakho ekunikeza lo muthi.

Njengamanje, akukho inguqulo ejwayelekile ye-tegaserod etholakalayo e-United States. Lokhu kusho ukuthi uzodinga ukuthola i-Zelnorm yegama lomkhiqizo ekhemisi lakho.

Umuthi uza ngamaphilisi angu-6 mg, futhi ukumbozwa komshuwalense wakho kungahluka ngemithi yegama lomkhiqizo. Kufanelekile ukuhlola nomhlinzeki wakho womshuwalense mayelana nokumbozwa kanye nanoma yiziphi izidingo zokugunyazwa kwangaphambilini.

Ezinye Izindlela ze-Tegaserod

Uma i-tegaserod ingakulungele noma ingasebenzi kahle ngokwanele, kunezinketho eziningana zokwelapha ze-IBS-C ezinganconywa udokotela wakho. Ngayinye inezinzuzo zayo kanye nokucatshangelwa kwayo.

Eminye imithi kadokotela ye-IBS-C ihlanganisa:

• Lubiprostone (Amitiza) - isiza ukwandisa uketshezi emathunjini
• Linaclotide (Linzess) - isebenza kuma-receptors ahlukene ukuze ithuthukise ukunyakaza kwamathumbu
• Plecanatide (Trulance) - ifana ne-linaclotide kodwa inomehluko othile
• Eluxadoline (Viberzi) - ye-IBS enezimpawu ezixubile

Udokotela wakho angase futhi asikisele izindlela ezingezona zemithi ezinjengokushintsha ukudla, ama-probiotics, noma amasu okulawula ukucindezeleka. Abantu abaningi bathola ukuthi ukuhlanganisa amasu ahlukene kusebenza kangcono kunokuncika emithini kuphela.

Izinketho ezingezona zemithi ezingasiza zihlanganisa:

• Ukwandisa ukudla kwe-fiber kancane kancane
• Ukuvivinya umzimba njalo
• Amaqhinga okunciphisa ukucindezeleka
• Ama-Probiotics
• Ukwagwema ukudla okubangela izimpawu
• Ukugcina izikhathi zokudla ezijwayelekile

Indlela engcono kakhulu ngawe incike ezimpawini zakho ezithile, umlando wakho wezokwelapha, nokuthi usabela kanjani ekwelashweni okuhlukene. Umhlinzeki wakho wezempilo angakusiza ukuthi uhlole lezi zinketho ngendlela ehlelekile.

Ingabe i-Tegaserod ingcono kune-Lubiprostone?

Kokubili i-tegaserod ne-lubiprostone kungasebenza kahle ku-IBS-C, kodwa zisebenza ngezindlela ezihlukene futhi zingase zibe ngcono kubantu abahlukene. Akukho ophumelele ngokusobala phakathi kwabo - kuncike esimweni sakho somuntu ngamunye.

I-Tegaserod isebenza ngokuthinta ama-serotonin receptors emathunjini akho, kuyilapho i-lubiprostone yandisa ukukhishwa kwamanzi emathunjini akho. Abanye abantu basabela kangcono kwenye indlela kunenye.

I-Lubiprostone ingase ibe yinketho kubantu abangakwazi ukuthatha i-tegaserod ngenxa yezimo zenhliziyo noma ezinye izinto ezivinjelayo. Iphinde yamukelwe kokubili amadoda nabesifazane, kuyilapho i-tegaserod okwamanje yamukelwe kuphela abesifazane abangaphansi kweminyaka engama-65.

Udokotela wakho uzocabangela izinto ezinjengomlando wakho wezokwelapha, eminye imithi oyithathayo, nezimpawu zakho ezithile lapho enquma ukuthi iyiphi imithi engasebenza kahle kuwe. Ngezinye izikhathi kuthatha ukuzama izinketho ezihlukene ukuze uthole okukulungele.

Imibuzo Evame Ukubuzwa Mayelana ne-Tegaserod

Ingabe i-Tegaserod iphephile kubantu abanezifo zenhliziyo?

Cha, i-tegaserod ayiphephile kubantu abanezifo zenhliziyo noma umlando wezinkinga zenhliziyo nemithambo yegazi. Umuthi ungase ukwandise ingozi yezigameko ezinzima zenhliziyo nemithambo yegazi.

Yingakho i-tegaserod yasuswa emakethe iminyaka eminingana futhi yabuyiselwa nemihlahlandlela eqinile mayelana nokuthi ubani ongayisebenzisa ngokuphepha. Udokotela wakho uzobuyekeza ngokucophelela impilo yakho yenhliziyo ngaphambi kokukuyalela lo muthi.

Uma unezinkinga zenhliziyo, umfutho wegazi ophezulu, noma ezinye izinto eziyingozi zenhliziyo nemithambo yegazi, qiniseka ukuthi udokotela wakho uyazi ngazo. Kukhona ezinye izindlela zokwelapha ezisebenzayo ze-IBS-C ezingase ziphephe kubantu abanezinkinga zenhliziyo.

Kufanele Ngenzeni Uma Ngisebenzisa I-Tegaserod Eningi Ngengozi?

Uma ngengozi uthatha i-tegaserod eningi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi, ikakhulu izinkinga ezihlobene nenhliziyo.

Ungazami ukuzenza uhlanze ngaphandle uma utshelwe ngqo ukuthi wenze kanjalo ngumhlinzeki wezempilo. Gcina umkhondo wokuthi ungakanani umuthi owengeziwe owuthathile nokuthi uwuthathile nini, ngoba lolu lwazi luzosiza ochwepheshe bezokwelapha ukukunikeza iseluleko esingcono kakhulu.

Qaphela izimpawu ezinjengokuhuda okukhulu, ubuhlungu besifuba, isiyezi, noma ubunzima bokuphefumula, futhi funa ukunakekelwa kwezempilo ngokushesha uma kwenzeka noma yikuphi kwalokhu. Kuhlale kungcono ukuqapha futhi uthole isiqondiso esichwepheshile ngemuva kokweqisa.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Tegaserod?

Uma uphuthelwa umthamo we-tegaserod, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma okungenani kungamahora ama-2 ngaphambi komthamo wakho olandelayo ohleliwe. Ungathathi imithamo emibili eduze ukuze ulungise lowo ophuthelwe.

Uma sekuyisikhathi somthamo wakho olandelayo, vele weqe umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile. Ukuthatha imithi eyengeziwe ngeke kukusize uzizwe ungcono ngokushesha futhi kungakhuphula ingozi yakho yemiphumela emibi.

Zama ukusungula isimiso esikusiza ukuthi ukhumbule imithamo yakho, njengokuyithatha ngezikhathi ezifanayo nsuku zonke noma ukusetha izikhumbuzi zocingo. Isikhathi esiqhubekayo sisiza umuthi ukuthi usebenze ngempumelelo.

Ngingayeka Nini Ukuthatha I-Tegaserod?

Kufanele uyeke kuphela ukuthatha i-tegaserod ngaphansi kwesiqondiso sikadokotela wakho. Abantu abaningi bazama umuthi amasonto ama-4 kuya kwangu-6 ekuqaleni ukuze babone ukuthi uyawasiza yini amasignali abo.

Uma i-tegaserod ingasizi izimpawu zakho ngemva kwalesi sikhathi sokuhlola, udokotela wakho cishe uzoncoma ukuyeka ukuyithatha bese ezama enye indlela. Uma isiza, bangase bancomise ukuqhubeka isikhathi eside ngokubheka njalo.

Ungayeki ukuthatha i-tegaserod kungazelelwe ngenxa yokuthi uzizwa ungcono. Udokotela wakho udinga ukuhlola ukuthi ngabe ukuthuthuka kwakho kungenzeka yini kuqhubeke nokuthi ngabe ukwelashwa okuqhubekayo kuyindlela engcono kakhulu yempilo yakho yesikhathi eside.

Ngingayithatha i-Tegaserod neminye imithi?

I-Tegaserod ingasebenzisana neminye imithi, ngakho-ke kubalulekile ukutshela udokotela wakho ngakho konke okuthathayo, okuhlanganisa imithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo.

Eminye imithi engasebenzisana ne-tegaserod ihlanganisa ama-antibiotics athile, imithi elwa nesikhunta, kanye nemithi ethinta ukushaya kwenhliziyo. Udokotela wakho uzobuyekeza yonke imithi yakho ukuze ahlole ukuthi kukhona yini ukusebenzisana okungenzeka.

Ungaqali noma iyiphi imithi emisha noma izithasiselo ngenkathi uthatha i-tegaserod ngaphandle kokubheka kuqala nomhlinzeki wakho wezempilo. Lokhu kufaka phakathi imithi yezitshalo kanye nokwelashwa okungaphandle kwemvume kadokotela, ngoba lezi ngezinye izikhathi zingasebenzisana nemithi kadokotela ngezindlela ezingalindelekile.