Yini i-Telaprevir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Telaprevir iyimithi elwa namagciwane eyenzelwe ngqo ukwelapha ukutheleleka okungamahlalakhona ngegciwane le-hepatitis C (HCV). Le mithi ingeyeqembu lezidakamizwa ezibizwa ngokuthi ama-protease inhibitors, asebenza ngokuvimba i-enzyme ebalulekile edingwa yigciwane le-hepatitis C ukuze liphindaphindeke emzimbeni wakho.

Ngenkathi i-telaprevir yayike yaba yindlela ebalulekile yokwelapha, kufanelekile ukuqaphela ukuthi imithi emisha, esebenza kahle kakhulu ye-hepatitis C isiyithathe indawo enkulu ekusebenzeni komtholampilo. Udokotela wakho uzosiza ekunqumeni indlela engcono kakhulu yokwelapha isimo sakho esithile.

Yini i-Telaprevir Esetshenziselwa Yona?

I-Telaprevir isetshenziselwa ikakhulukazi ukwelapha ukutheleleka okungamahlalakhona nge-hepatitis C, ikakhulukazi i-genotype 1 yegciwane. Le genotype ingenye yezinhlobo ezivame kakhulu ze-hepatitis C ezitholakala e-United States naseYurophu.

Le mithi ihlala isetshenziswa ngokuhlangana neminye imithi elwa namagciwane, ngokuvamile i-peginterferon alfa kanye ne-ribavirin. Le ndlela yokuhlanganisa isiza ukwandisa amathuba okususa igciwane ohlelweni lwakho ngokuphelele.

Kubalulekile ukuqonda ukuthi i-telaprevir ayisetshenziswa yodwa. Igciwane le-hepatitis C liqinile impela, ngakho ukuhlanganisa imithi ehlukene eyilihlasela ngezindlela ezihlukahlukene kukunika ithuba elingcono kakhulu lokuphumelela ekwelashweni.

Isebenza Kanjani I-Telaprevir?

I-Telaprevir isebenza ngokugxila kuphrotheni ethile ebizwa nge-NS3/4A protease esetshenziswa yigciwane le-hepatitis C ukuziphindaphinda. Cabanga ngale phrotheni njengebhangqa lezikele ze-molecular elidingwa yigciwane ukusika amaprotheni amakhulu abe yizingcezu ezincane, ezisebenzayo.

Lapho i-telaprevir ivimba le enzyme ye-protease, igciwane alikwazi ukuhlanganisa kahle amakhophi amasha awo. Lokhu kuphazamisa umjikelezo wempilo wegciwane kusiza ukunciphisa inani legciwane egazini lakho ngokuhamba kwesikhathi.

Njengomuthi oqeda amagciwane, i-telaprevir ithathwa njengemuthi onamandla ngokulinganiselwe. Isebenza kahle ngokumelene ne-hepatitis C, kodwa iza nemiphumela emibi ebalulekile edinga ukuqashwa ngokucophelela yithimba lakho lezempilo.

Kufanele Ngiyithathe Kanjani I-Telaprevir?

I-Telaprevir kufanele ithathwe ngendlela eqondile njengoba inqatshelwe udokotela wakho, ngokuvamile kathathu ngosuku ngokudla. Ukuyithatha ngokudla kubalulekile ngoba kusiza umzimba wakho ukuba umunce umuthi ngempumelelo enkulu.

Kufanele uzame ukuthatha umthamo ngamunye cishe ngamahora angu-7 kuya kwangu-9 ukwahlukana ukuze ugcine amazinga aqhubekayo omuthi emzimbeni wakho. Zama ukusungula umkhuba, njengokuyithatha nge-breakfast, isidlo sasemini, nesidlo sakusihlwa, ukukusiza ukuthi ukhumbule.

Ukudla okudlayo nge-telaprevir akudingeki kube yinto ekhethekile, kodwa kufanele kube namafutha athile ukusiza ukumuncwa. Ukudla noma ukudla okulula okukhulu kusebenza kahle. Gwema ukuyithatha esiswini esingenalutho, ngoba lokhu kunganciphisa ukuthi umzimba wakho usebenzisa kangakanani umuthi.

Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho noma usokhemisi. Ungawachobozi noma uwaphule amaphilisi ngaphandle uma uqondiswe ngqo, ngoba lokhu kungathinta indlela umuthi okhululwa ngayo emzimbeni wakho.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Telaprevir?

Isikhathi esijwayelekile sokwelashwa nge-telaprevir amasonto angu-12, nakuba lokhu kungahluka ngokuya ngesimo sakho esithile nokuthi usabela kanjani ekwelashweni. Udokotela wakho uzoqapha inqubekela phambili yakho ngokuhlolwa kwegazi okuvamile ukuze alandele amazinga e-virus emzimbeni wakho.

Ngemuva kokuyeka ukuthatha i-telaprevir, cishe uzoqhubeka nokuthatha eminye imithi ohlelweni lwakho lokwelashwa izinyanga eziningi. Isikhathi sokwelashwa esiphelele se-hepatitis C sivame ukusuka emasontweni angu-24 kuya kwangu-48, kuye ngezinto ezihlukahlukene.

Kubalulekile ngokuphelele ukuqeda inkambo ephelele yokwelashwa, ngisho noma uqala ukuzizwa ungcono. Ukuyeka ngaphambi kwesikhathi kungavumela i-virus ukuthi ibuye futhi kungenzeka ukuthi ikhule ukumelana nemithi.

Ziyini Imiphumela Eceleni ye-Telaprevir?

I-Telaprevir ingabangela imiphumela eminingi eceleni, futhi kubalulekile ukwazi okulindelekile ukuze ukwazi ukusebenza nethimba lakho lokunakekelwa kwezempilo ukuze uyiphatha ngempumelelo. Abantu abaningi bahlangabezana nemiphumela ethile eceleni, kodwa abaningi bayithola iphatheka ngosizo olufanele.

Imiphumela ejwayelekile eceleni ongase uyithole ihlanganisa:

• Ukuqubuka kwesikhumba, okungahluka kusuka kokulula kuya kokukhulu
• Ukukhathala nokuzizwa ukhathele kunokujwayelekile
• Isicanucanu nokungahambi kahle kokugaya ukudla
• Ukucindezeleka kwekhanda
• Ukuqina noma ukungakhululeki kwangasese
• Ushintsho ekunambithekeni
• Ukuqunjelwa

Le miphumela ejwayelekile eceleni ivamise ukuba yesikhashana futhi ingase ithuthuke njengoba umzimba wakho ujwayela imithi. Ithimba lakho lokunakekelwa kwezempilo linganikeza amasu okusiza ukuphatha lezi zimpawu.

Kukhona nemiphumela ethile eceleni engathi sína edinga ukunakekelwa kwezempilo ngokushesha, nakuba ingavamile:

• Ukuphendula kwesikhumba okukhulu, okuhlanganisa i-Stevens-Johnson syndrome noma i-toxic epidermal necrolysis
• I-anemia enkulu (ukwehla kwamaseli abomvu egazi)
• Izimpawu zezinkinga zesibindi, njengokuphuzi kwesikhumba noma amehlo
• Ukuphefumula kanzima noma ubuhlungu besifuba
• Ushintsho olukhulu lwemizwa noma ukucindezeleka

Uma uhlangabezana nanoma iyiphi yale miphumela emibi, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezempilo okuphuthumayo. Ukuphepha kwakho yikho konke okubalulekile, futhi lezi zimpawu, nakuba zingavamile, zidinga ukunakekelwa okusheshayo.

Ubani Ongafanele Athathwe I-Telaprevir?

I-Telaprevir ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Zikhona izimo eziningi lapho le mithi kufanele igwenywe noma isetshenziswe ngokucophelela okukhulu.

Akufanele uthathe i-telaprevir uma unezimo ezithile zezokwelapha noma uthatha imithi ethile:

• Isifo sesibindi esibi noma i-cirrhosis (ukulimala okuthuthukile kwesibindi)
• Ukukhulelwa noma ukuhlela ukukhulelwa
• Ukuncelisa
• Umlando wokucindezeleka okukhulu noma imicabango yokuzibulala
• Izinkinga ezithile zokushaya kwenhliziyo
• Ukuphuza imithi exhumana ngendlela eyingozi ne-telaprevir

Ngaphezu kwalokho, i-telaprevir ingaxhumana neminye imithi eminingi, okuhlanganisa nemithi evamile efana nemithi ethile yokunciphisa igazi, imithi yenhliziyo, kanye nemithi yokulwa nokuvuvukala. Njalo nikeza udokotela wakho uhlu olugcwele lwazo zonke izidakamizwa, izithasiselo, kanye nemikhiqizo yezitshalo oyithathayo.

Ubudala nabo bungaba yisici. Abantu abadala bangase bazwe imiphumela emibi kakhulu futhi bangase badinge ukuqapha njalo ngesikhathi sokwelashwa.

Amagama Omkhiqizo we-Telaprevir

I-Telaprevir itholakala ngaphansi kwegama lomkhiqizo elithi Incivek e-United States. Kodwa-ke, kubalulekile ukuqaphela ukuthi lo muthi awusathuthukiswa ngumkhiqizi kusukela ngo-2014.

Isinqumo sokuyeka ukuthengisa senziwe ngoba imithi emisha, esebenza kahle ye-hepatitis C yatholakala enemiphumela emibi embalwa kanye namazinga angcono okuphulukisa. Udokotela wakho cishe uzoncoma lezi zinketho ezintsha esikhundleni salokho.

Ezinye izindlela ze-Telaprevir

Imithi eminingi emisha ye-hepatitis C ishintshe kakhulu i-telaprevir emsebenzini wezempilo. Lezi zindlela ezingezinye zivame ukunikeza ukusebenza kahle okungcono ngemiphumela emibi embalwa kanye nobude bokwelashwa obufushane.

Izinketho zokwelashwa zamanje udokotela wakho angazicabangela zihlanganisa:

• Izindlela zokwelapha ezisekelwe ku-Sofosbuvir (njenge-Harvoni noma i-Epclusa)
• Izinhlanganisela ze-Glecaprevir/pibrentasvir (njenge-Mavyret)
• Ukwelashwa okuqukethe i-Velpatasvir
• Ezinye izinhlanganisela ze-antiviral (DAA) eziqondile

Le mithi emisha ngokuvamile iphulukisa i-hepatitis C emasontweni angu-8 kuya kwangu-12 ngamazinga okuphulukisa angaphezu kwama-95%. Futhi ngokuvamile banemiphumela emibi embalwa uma iqhathaniswa nezindlela ezindala ezazihlanganisa i-telaprevir.

Udktela wakho uzocabangela izinto ezinjengohlobo lwakho oluthile lwe-hepatitis C, noma yikuphi ukwelashwa okwenzile ngaphambili, ezinye izimo zezokwelapha, kanye nokusebenzisana okungenzeka kwemithi lapho ekhetha ukwelashwa okungcono kakhulu kuwe.

Ingabe i-Telaprevir ingcono kune-Sofosbuvir?

Ukwelashwa okusekelwe ku-Sofosbuvir kuvame ukuthathwa njengokungcono kune-telaprevir ekwelapheni i-hepatitis C. Izindlela zokwelapha ezintsha ze-sofosbuvir zinikeza izinzuzo eziningi ezibalulekile ezenza zibe yindlela ekhethwa abantu abaningi.

Ukwelashwa okusekelwe ku-Sofosbuvir ngokuvamile kunamazinga aphezulu okuphulukisa, ngokuvamile adlula ngaphezu kuka-95% uma kuqhathaniswa namazinga aphansi empumelelo e-telaprevir. Futhi bavame ukubangela imiphumela emibi embalwa futhi badinga izikhathi zokwelashwa ezimfushane, ngokuvamile amasonto angu-8 kuya kwangu-12 esikhundleni sezifundo ezinde ezidingekayo nge-telaprevir.

Ngaphezu kwalokho, i-sofosbuvir isebenza ngokumelene nezinhlobo eziningi ze-hepatitis C, okuyenza ibe nezinto eziningi kune-telaprevir, ehloselwe ikakhulukazi uhlobo 1. Yingakho odokotela abaningi manje bencoma izindlela zokwelapha ezisekelwe ku-sofosbuvir njengokwelashwa komugqa wokuqala.

Imibuzo Evame Ukubuzwa Mayelana ne-Telaprevir

Ingabe i-Telaprevir iphephile kubantu abanezifo zezinso?

I-Telaprevir ingasetshenziswa kubantu abanezifo zezinso ezilula kuya kweziphakathi, kodwa idinga ukuqapha ngokucophelela nokulungiswa kwemithamo okungenzeka. Udokotela wakho uzodinga ukuhlola ukusebenza kwezinso zakho ngokusebenzisa ukuhlolwa kwegazi ngaphambi kokuqala ukwelashwa.

Uma unezifo zezinso ezinzima noma use-dialysis, i-telaprevir kungenzeka ingabi yindlela engcono kakhulu kuwe. Ithimba lakho lezempilo cishe lizokuncoma ezinye izindlela zokwelapha i-hepatitis C eziphephe kakhulu kubantu abanezinkinga zezinso ezithuthukile.

Ngingenzani uma ngiphuthelwa ngengozi ngisebenzisa i-Telaprevir eningi kakhulu?

Uma ngengozi uthatha i-telaprevir eningi kakhulu kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini, njengoba ukuthola iseluleko sezokwelapha ngokushesha kubalulekile.

Ukunatha i-telaprevir eningi kungakhuphula ingozi yakho yemiphumela emibi, ikakhulukazi ukusabela kwesikhumba okukhulu noma izinkinga zesibindi. Umhlinzeki wakho wezempilo angase afune ukukuqapha eduze futhi angase ancome ukwelashwa okuthile ukusiza umzimba wakho ukucubungula imithi eyengeziwe.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Telaprevir?

Uma uphuthelwa umthamo we-telaprevir, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma kungaphakathi kwamahora angu-4 esikhathini sakho somthamo esihleliwe. Uma sekudlule amahora angaphezu kwangu-4, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Zama ukusungula isimiso noma ukusetha izikhumbuzi zokukusiza ukuthi ukhumbule imithamo yakho, njengoba ukunikeza imithamo okuqhubekayo kubalulekile empumelelweni yokwelashwa.

Ngingayeka nini ukuthatha i-Telaprevir?

Kufanele uyeke kuphela ukuthatha i-telaprevir uma udokotela wakho ekutshela ukuthi wenze njalo, ngokuvamile ngemva kokuqeda inkambo yakho yamasonto angu-12 ebekiwe. Ukuyeka ngaphambi kwesikhathi kungavumela igciwane le-hepatitis C ukuthi libuye futhi libe nethuba lokuthuthukisa ukumelana nomuthi.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokuhlolwa kwegazi okuvamile ukuze ahlolisise amazinga egciwane lakho. Noma ngabe lezi zivivinyo zikhombisa ukuthi igciwane alitholakali, kubalulekile ukuqeda inkambo ephelele yokwelashwa ukuze kuqinisekiswe ithuba elingcono kakhulu lokwelashwa unomphela.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Telaprevir?

Kufanele ugweme utshwala ngokuphelele ngenkathi uthatha i-telaprevir neminye imithi ye-hepatitis C. Utshwala bungakwandisa ukulimala kwesibindi futhi buphazamise ukusebenza kokwelashwa kwakho.

Njengoba welapha i-hepatitis C, esivele ithinta isibindi sakho, ukwengeza utshwala emxube kungabangela ukucindezeleka okwengeziwe kuleli lungu elibalulekile. Isibindi sakho sidinga konke ukusekelwa esingakuthola ngesikhathi sokwelashwa ukuze silulame futhi silulame kahle.