Yini i-Tetrabenazine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Tetrabenazine iyimithi kadokotela esiza ukulawula ukunyakaza okungafuneki, okweqile kubantu abanezimo ezithile zemizwa. Isebenza ngokunciphisa inani le-dopamine, ikhemikhali yobuchopho ethinta ukunyakaza, ezindaweni ezithile zobuchopho bakho.

Uma wena noma othile omkhathalelayo enikezwe lo muthi, kungenzeka ukuthi unemibuzo mayelana nokuthi usebenza kanjani nokuthi yini ongayilindela. Lo mhlahlandlela uzokuhambisa kukho konke okudingeka ukwazi nge-tetrabenazine ngamagama acacile, aqondile.

Yini i-Tetrabenazine?

I-Tetrabenazine ingeyodwa yezinhlobo zemithi ebizwa ngokuthi i-vesicular monoamine transporter 2 (VMAT2) inhibitors. Cabanga ngayo njengomuthi osiza ukuthi "uthulise" izimpawu zokunyakaza ezingaphezu kwamandla ebuchosheni bakho.

Lo muthi wenzelwe ngqo ukwelapha izifo zokunyakaza lapho abantu behlangabezana nokunyakaza okungazithandeli abakwazi ukukulawula. Ithathwa njengomuthi okhethekile odinga ukuqashwa ngokucophelela ngabahlinzeki bezempilo abaqonda izimo zemizwa.

Ngokungafani neminye imithi esebenza emzimbeni wakho wonke, i-tetrabenazine iqondisa izindlela ezithile ebuchosheni bakho ezilawula ukunyakaza. Le ndlela egxile isiza ukunciphisa ukunyakaza okungafuneki ngenkathi kunciphisa imiphumela kwezinye izinhlelo zomzimba.

Yini i-Tetrabenazine Esizwa Ngayo?

I-Tetrabenazine ikakhulukazi inikezwa ukwelapha i-chorea ehambisana nesifo sikaHuntington. I-Chorea ibhekisela ekunyakazeni okungazithandeli, okungazinzile okungathinta izingalo zakho, imilenze, ubuso, nezinye izingxenye zomzimba wakho.

Isifo sikaHuntington yisimo semvelo esithinta kancane kancane ukunyakaza, ukucabanga, nemizwa. Ukunyakaza kwe-chorea kungaba okucindezelayo futhi kuphazamise imisebenzi yansuku zonke efana nokudla, ukuhamba, noma ukukhuluma ngokucacile.

Udokotela wakho angase futhi acabangele i-tetrabenazine kwezinye izifo zokunyakaza, nakuba lokhu kungaba okubizwa ngokuthi ukusetshenziswa "ngaphandle kwelebula". Lezi zimo zingabandakanya:

• I-Tardive dyskinesia (ukuhamba okungahleliwe okubangelwa imithi ethile yezifo zengqondo)
• Ama-tics ku-Tourette syndrome angaphendulanga kwezinye izindlela zokwelapha
• Ezinye izinhlobo ze-chorea ezingahlobene nesifo sikaHuntington
• Ezinye izimo ze-dystonia (ukuqina kwemisipha okubangela ukuma okungajwayelekile)

Isimo somuntu ngamunye sihlukile, futhi udokotela wakho uzohlola ngokucophelela ukuthi i-tetrabenazine ilungile yini ngesimo sakho esithile nezimpawu zakho.

Isebenza Kanjani I-Tetrabenazine?

I-Tetrabenazine isebenza ngokuvimba ukugcinwa nokukhululwa kwe-dopamine ezingxenyeni ezithile zobuchopho ezilawula ukunyakaza. Ithathwa njengomuthi onamandla aphakathi nendawo odinga ukulungiswa komthamo kancane kancane.

Ukuze uqonde ukuthi isebenza kanjani, cabanga nge-dopamine njengomthunywa othwala izimpawu zokunyakaza ebuchosheni bakho. Ezimweni ezinjengesifo sikaHuntington, lezi zimpawu ziba namandla ngokweqile, okuholela ekunyakazeni okungafuneki.

Umuthi ngokuyisisekelo "uvula ivolumu" kulezi zimpawu ze-dopamine ezinamandla ngokweqile. Lokhu ukwenza ngokuvimbela i-dopamine ukuthi ingagcinwa kahle futhi ikhishwe eziphethweni zemizwa, okusiza ukunciphisa izimpawu zokunyakaza okweqile.

Imiphumela ye-tetrabenazine iyabuyiseka, okusho ukuthi uma uyeka ukuthatha umuthi, amazinga akho e-dopamine azobuyela kancane kancane esimweni sawo sangaphambilini. Lokhu kwehluka kweminye imithi ebangela izinguquko ezingapheli.

Ngingayithatha Kanjani I-Tetrabenazine?

Thatha i-tetrabenazine ngendlela udokotela wakho ayala ngayo, ngokuvamile ngokudla ukusiza ukunciphisa isisu esibuhlungu. Umuthi uza ngesimo samaphilisi futhi kufanele ugwinywe wonke ngamanzi.

Udokotela wakho uzoqala ngomthamo ophansi futhi awunyuse kancane kancane phakathi namasonto amaningana. Le ndlela ehamba kancane isiza umzimba wakho ukuba ujwayele umuthi futhi inciphisa ingozi yemiphumela emibi.

Nakhu okufanele ukwazi mayelana nokuthatha i-tetrabenazine ngendlela efanele:

• Yithathe ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho
• Ungazigayi, ungazihlafuni, noma ungaziphuli amaphilisi
• Yithathe nokudla noma ubisi ukuze unciphise ukucasuka kwesisu
• Uma uyithatha izikhathi eziningi ngosuku, hlukanisa imithamo ngokulinganayo
• Ungayeki ukuyithatha kungazelelwe ngaphandle kokukhuluma nodokotela wakho kuqala

Udokotela wakho uzokugada eduze, ikakhulukazi ezinyangeni ezimbalwa zokuqala zokwelashwa. Bangase balungise umthamo wakho ngokusekelwe ekutheni umuthi usebenza kahle kangakanani kanye nanoma yimaphi imiphumela emibi oyitholayo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Tetrabenazine?

Ubude bokwelashwa nge-tetrabenazine busekelwe esimweni sakho esithile nokuthi usabela kahle kangakanani emuthini. Ngesifo sikaHuntington, ukwelashwa kuvame ukuba isikhathi eside ngoba kuyisimo esiqhubekayo.

Udokotela wakho uzohlola njalo ukuthi umuthi usakusiza yini nokuthi izinzuzo zisaqhubeka yini ukwedlula noma yimiphi imiphumela emibi. Abanye abantu bangase badinge ukuyithatha iminyaka eminingi, kanti abanye bangase bayisebenzise isikhathi esifushane.

Isinqumo sokuqhubeka noma ukuyeka ukwelashwa kufanele senziwe njalo nomhlinzeki wakho wezempilo. Bazocabangela izinto ezinjengokuthi umuthi usiza kangakanani izimpawu zakho, noma yimiphi imiphumela emibi oyitholayo, kanye nezinguquko esimweni sakho esiphelele.

Uma udinga ukuyeka ukuthatha i-tetrabenazine, udokotela wakho ngokuvamile uzonciphisa umthamo wakho kancane kancane kunokuyeka konke ngesikhathi esisodwa. Lokhu kusiza ekuvikeleni noma yimiphi imiphumela yokuhoxiswa okungenzeka noma ukwanda okungazelelwe kwezimpawu.

Yiziphi Imiphumela Emibi ye-Tetrabenazine?

Njengayo yonke imithi, i-tetrabenazine ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ivame ukuba milde kuya esimweni esiphakathi nendawo futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi.

Ukuqonda okulindelekile kungakusiza ukuthi uzizwe ulungile futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo. Ake sibheke izinhlobo ezahlukene zemiphumela engemihle ongase uyithole.

Imiphumela Evamile Engemihle

Le miphumela engemihle yenzeka kubantu abaningi abathatha i-tetrabenazine futhi ngokuvamile iyalawuleka:

• Ukozela noma ukukhathala (ukuzizwa ukhathele kunokujwayelekile)
• Ukucindezeleka noma izinguquko zemizwa
• Ukungazinzi noma ukukhathazeka
• Ubunzima bokulala (ukuqwasha)
• Isicanucanu noma isisu esibuhlungu
• Isiyezi, ikakhulukazi lapho usukuma
• Ubunzima bokugxilisa ingqondo

Iningi lale miphumela libonakala kakhulu uma uqala ukuthatha umuthi noma lapho umthamo wakho ukhuphuka. Ngokuvamile iba ngaphansi kokukhathaza njengoba umzimba wakho ujwayela ukwelashwa.

Imiphumela Engemihle Engathi Sína

Ngenkathi ingavamile, eminye imiphumela engemihle idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nodokotela wakho ngokushesha uma uhlangabezana:

• Ukucindezeleka okukhulu noma imicabango yokuzibulala
• Ubunzima bokugwinya noma ukuphefumula
• Umkhuhlane omkhulu onokuqina kwemisipha
• Ukushaya kwenhliziyo okungajwayelekile noma ubuhlungu besifuba
• Ukungazinzi okukhulu noma ukucasuka
• Ukunyakaza kwemisipha okungalawuleki ebusweni bakho noma emzimbeni wakho

Le miphumela engemihle engathi sína ayivamile, kodwa kubalulekile ukuyazi futhi ufune usizo lwezokwelapha ngokushesha uma zenzeka.

Imiphumela Engavamile Engemihle

Abanye abantu bangase bahlangabezane nemiphumela engemihle engavamile esadinga ukunakekelwa:

• I-Neuroleptic malignant syndrome (isimo esingavamile kodwa esingathi sína esinomkhuhlane omkhulu, ukuqina kwemisipha, nokudideka)
• I-Prolonged QT interval (ushintsho lwesigqi senhliziyo oluvela ku-EKG)
• Ukwehla okukhulu kwengcindezi yegazi
• I-Parkinsonism (ukuthuthumela, ukuqina, nokunyakaza okuhamba kancane)
• I-Akathisia (ukungazinzi okukhulu nesidingo sokunyakaza njalo)

Udktela wakho uzokuhlola ngale miphumela engavamile kodwa ebucayi, ikakhulukazi ezigabeni zokuqala zokwelashwa.

Ubani Ongafanele Athathe I-Tetrabenazine?

I-Tetrabenazine ayifanele wonke umuntu, futhi izimo ezithile noma izimo ziyenza ingaphephile ukuyisebenzisa. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyala lo muthi.

Akufanele uthathe i-tetrabenazine uma unokucindezeleka okukhulu noma unemicabango yokuzibulala. Umuthi ungakwenza kube kubi ukucindezeleka, ngakho-ke kubalulekile ukubhekana nanoma yiziphi izinkinga zempilo yengqondo ngaphambi kokuqala ukwelashwa.

Ezinye izinto ezibalulekile ezingafanele zithathwe zihlanganisa:

• Ukucindezeleka okungelashwanga noma okungelashwanga ngokwanele
• Imicabango yokuzibulala esebenzayo noma imizamo yokuzibulala yamuva
• Ukuthatha ama-monoamine oxidase inhibitors (MAOIs) noma uwathathe ezinsukwini eziyi-14 ezedlule
• Izinkinga zesibindi ezinzima
• Ukungezwani okwaziwayo ne-tetrabenazine noma izingxenye zayo

Izimo ezithile zidinga ukuqapha okwengeziwe nokuqapha okuseduze uma uthatha i-tetrabenazine:

• Umlando wokucindezeleka noma ezinye izimo zempilo yengqondo
• Izinkinga zenhliziyo noma ukushaya kwenhliziyo okungajwayelekile
• Isifo sesibindi
• Izinkinga zezinso
• Isifo sikaParkinson
• Ubunzima bokugwinya

Njalo tshela udokotela wakho ngazo zonke izimo zakho zezokwelapha, okuhlanganisa nomlando wanoma yiziphi izinkinga zempilo yengqondo, ngisho noma zibonakala zingahlobene nesifo sakho sokunyakaza.

Amagama Omkhiqizo we-Tetrabenazine

I-Tetrabenazine iyatholakala ngaphansi kwegama lomkhiqizo elithi Xenazine e-United States. Le yindlela evame kakhulu yokuyala umuthi.

Kukhona nomuthi omusha, ohlobene obizwa ngokuthi i-deutetrabenazine, othengiswa ngaphansi kwegama lomkhiqizo elithi Austedo. Lena inguqulo eguquliwe ye-tetrabenazine engase ibe nezinzuzo ezithile mayelana nemvamisa yokulinganisa nemiphumela emibi.

Udktela wakho uzoqoka ukuthi yiluphi uhlobo lomuthi olufaneleka kakhulu esimweni sakho esithile. Yomibili imithi isebenza ngendlela efanayo, kodwa kungase kube khona umehluko ekutheni kufanele uyithathe kaningi kangakanani nokuthi imiphumela yayo emibi injani.

Njalo sebenzisa uhlobo oluqondile kanye nokwakheka okubhalwe udokotela wakho, njengoba ukushintsha phakathi kwezinhlobo ezahlukene kufanele kwenziwe ngaphansi kokuqondiswa kwezokwelapha kuphela.

Ezinye izindlela zokwelapha i-Tetrabenazine

Uma i-tetrabenazine ingakulungele noma ingasebenzi kahle, udokotela wakho angase acabangele ezinye izindlela zokwelapha. Ukukhetha ezinye izindlela zokwelapha kuncike esimweni sakho esithile nezimpawu.

Ngokuqondene ne-Huntington's disease chorea, ezinye izindlela zokwelapha zingabandakanya:

• Deutetrabenazine (Austedo) - umuthi omusha, ofanayo
• Imithi ye-Antipsychotic efana ne-haloperidol noma i-olanzapine
• Ama-Benzodiazepines okukhathazeka kanye nezinye izimpawu zokunyakaza
• Imithi elwa nokuhlaselwa njenge-valproic acid

Ngezinye izifo zokunyakaza, udokotela wakho angase acabangele:

• Ukujovwa kwe-Botulinum toxin ngezinkinga zemisipha yasendaweni
• Ukukhuthazwa kobuchopho obujulile ezimweni ezithile
• Eminye imithi evimbela i-dopamine
• Ukwelashwa ngokomzimba nokwelashwa komsebenzi

Indlela engcono kakhulu yokwelapha ivame ukubandakanya ukuhlanganisa imithi nokunye ukwelashwa okufana nokwelashwa ngokomzimba, ukwelashwa kwenkulumo, noma ukwelulekwa ukuze kubhekwane nezici ezihlukahlukene zezifo zokunyakaza.

Ingabe i-Tetrabenazine ingcono kune-Deutetrabenazine?

Kokubili i-tetrabenazine ne-deutetrabenazine yimithi esebenzayo yokwelapha izifo zokunyakaza, kodwa inomehluko obalulekile ongase wenze enye ifaneleke kakhulu kuwe kunenye.

I-Deutetrabenazine (Austedo) ngumuthi omusha owenzelwe ukuthuthukisa i-tetrabenazine. Izinzuzo eziyinhloko ze-deutetrabenazine zihlanganisa:

• Ukuphakelwa ngemithi okungavamile (ngokuvamile kabili ngosuku esikhundleni sokuthathu ngosuku)
• Amazinga aqagulekayo emzimbeni wakho
• Imiphumela emibi embalwa
• Ukungasebenzi kahle nezici ezithile zofuzo ezithinta ukugayeka kwemithi

Kodwa-ke, i-tetrabenazine isetshenziswe isikhathi eside futhi inocwaningo oluningi oluyisekelayo. Abanye abantu bangase basabele kangcono emuthini owodwa kunomunye, futhi izindleko nazo zingase zidlale indima ekwenzeni isinqumo.

Udokotela wakho uzocabangela izinto ezinjengezimpawu zakho ezithile, eminye imithi oyithathayo, isimiso sakho sansuku zonke, kanye nomshwalense lapho enquma ukuthi imuphi umuthi ongcono kuwe. Akukho muthi ongcono ngokujwayelekile - ukukhetha kuncike ezimweni zakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Tetrabenazine

Ingabe i-Tetrabenazine iphephile kubantu abanezifo zenhliziyo?

I-Tetrabenazine idinga ukucatshangelwa ngokucophelela uma unezinkinga zenhliziyo. Umuthi ungase uthinte ukushaya kwenhliziyo yakho, ikakhulukazi into ebizwa ngokuthi i-QT interval ku-EKG.

Ngaphambi kokuqala i-tetrabenazine, udokotela wakho cishe uzo-oda i-EKG ukuhlola ukushaya kwenhliziyo yakho. Uma unezimo ezithile zenhliziyo noma uthatha imithi ethinta ukushaya kwenhliziyo, ungase udinge ukuqapha kaningi noma indlela ehlukile yokwelapha.

Abantu abanezifo zenhliziyo ngezinye izikhathi bangathatha i-tetrabenazine ngokuphepha, kodwa kudinga ukubambisana eduze phakathi kwe-neurologist yakho kanye ne-cardiologist ukuqinisekisa ukuthi inhliziyo yakho ihlala iphilile ngesikhathi sokwelashwa.

Ngingenzani uma ngiphuzile i-Tetrabenazine eningi ngengozi?

Uma uthatha i-tetrabenazine eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa kahle. Ukweqisa kungase kubangele imiphumela emibi engase ingaveli ngokushesha.

Izimpawu zokuthatha i-tetrabenazine eningi zingabandakanya ukozela okukhulu, ukudideka, ubunzima bokuphefumula, ukuqina kwemisipha okukhulu, noma ukulahlekelwa ukwazi. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, funa ukunakekelwa kwezempilo eziphuthumayo ngokushesha.

Ukuvimbela ukweqisa ngengozi, gcina imithi yakho esitsheni sayo sokuqala, setha izikhumbuzi zokuthi uyithathe nini, futhi ungalokothi uphinde izilinganiso uma uphuthelwa yinye. Cabangela ukusebenzisa umhleli wamaphilisi uma uthatha imithi eminingi.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Tetrabenazine?

Uma uphuthelwa umthamo we-tetrabenazine, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, khuluma nodokotela wakho ngamasu okukusiza ukuthi ukhumbule, njengokusetha ama-alamu ocingweni noma ukusebenzisa uhlelo lokusebenza lokukhumbuza imithi.

Uma uphuthelwa imithamo njalo, izimpawu zakho zingase zibe zimbi, ngakho-ke kubalulekile ukuthola inqubo ekusebenzelayo. Abanye abantu bakuthola kuwusizo ukuthatha imithi yabo ngesikhathi esifanayo neminye imisebenzi yansuku zonke, njengokudla.

Ngingayeka nini ukuthatha i-Tetrabenazine?

Isinqumo sokuyeka ukuthatha i-tetrabenazine kufanele senziwe nodokotela wakho njalo. Ungayeki ukuyithatha ngokuzumayo wedwa, ngoba lokhu kungabangela ukuthi izimpawu zakho zibuye ngokushesha noma zibe zimbi okwesikhashana.

Udokotela wakho angase ancome ukuyeka noma ukunciphisa i-tetrabenazine uma imiphumela emibi iba yinkinga kakhulu, uma isimo sakho sishintsha, noma uma ezinye izindlela zokwelapha ziba zifaneleka kakhulu esimweni sakho.

Uma sekuyisikhathi sokuyeka, udokotela wakho ngokuvamile uzonciphisa umthamo wakho kancane kancane phakathi namasonto amaningana. Lokhu kusiza ukunciphisa noma yimiphi imiphumela yokuhoxisa futhi kuvumela umzimba wakho ukuthi ujwayele kancane ukusebenza ngaphandle komuthi.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Tetrabenazine?

Kungcono ukugwema utshwala ngenkathi uthatha i-tetrabenazine, njengoba kokubili kungabangela ukozela futhi kuthinte ukusebenzisana kwakho. Ukukuhlanganisa kungakhuphula le miphumela futhi kukwenze uzizwe uthule kakhulu kunokujwayelekile.

Utshwala bungase futhi buqhubekise ukucindezeleka, okuyinto esivele ikhathaza nge-tetrabenazine. Uma ukhetha ukuphuza ngezikhathi ezithile, khuluma nodokotela wakho ngobuningi obungase buphephe kuwe, futhi ungalokothi uphuze uma uzizwa ucindezelekile noma unoshintsho lwemizwa.

Qaphela ukuthi utshwala bukukuthinta kanjani ngenkathi usebenzisa lo muthi, njengoba ungase uthole ukuthi uzwela kakhulu emiphumeleni yawo kunangaphambi kokuqala ukwelashwa.