He aha te Eluxadoline: Ngā Whakamahinga, Te Inenga, Ngā Pānga Taha me Ētahi Atu

He rongoā whakahau a Eluxadoline i hangaia hei rongoā i te mate puku riri me te korere (IBS-D) i roto i ngā pakeke. E mahi ana tēnei rongoā whaiwhakaaro mā te whakatikatika i ngā nekehanga o te whekau me te whakaiti i te kōpū me te ohorere ka uaua ai te oranga o ia rā mō ngā tāngata e mate ana i te IBS-D.

Mēnā kei te raru koe i te korere auau, te mamae o te puku, me te āhua ohorere o ngā tohumate IBS, he huarahi hou a eluxadoline ki te whakahaere i ēnei āwangawanga. He wāhanga tēnei o te rōpū rongoā e mahi tika ana i runga i tō pūnaha whekau hei āwhina i te whakahoki mai i te mahi whekau noa.

He aha te Eluxadoline?

He rongoā mahi-rua a Eluxadoline e whai ana i ngā kaiwhakawhiwhi motuhake i roto i tō ara whekau hei whakahaere i ngā tohumate IBS-D. No te rōpū rongoā e kīia nei ko ngā kaiwhakawāhiwhi opioid receptor whakauru, ko te tikanga e mahi ana i runga i ngā ara kotahi e whakahaere ana i te mamae me te mahi whekau, engari i roto i te huarahi whaiwhakaaro.

Kāore i rite ki ētahi rongoā IBS tawhito e mahi ana puta noa i tō tinana katoa, i hangaia a eluxadoline kia mahi tuatahi i roto i tō pūnaha kūnatu. E āwhina ana tēnei huarahi whaiwhakaaro ki te whakaiti i ngā pānga ki ētahi atu wāhanga o tō tinana i te wā e whakatika ana i ngā tikanga pūtake e pā ana ki ngā tohumate IBS-D.

I whakawhiwhia te rongoā ki te whakaaetanga FDA i te tau 2015, e waiho ana hei kōwhiringa hou mō ngā tāngata kāore anō ngā tohumate IBS-D i pai ki ngā huringa kai, ki ētahi atu rongoā rānei.

He aha te Eluxadoline e whakamahia ana mō?

Ka whakahaua motuhake a Eluxadoline mō ngā pakeke e mate ana i te mate puku riri me te korere (IBS-D). E pā ana tēnei āhuatanga ki te miriona tāngata, ā, e whai ana i te huinga o te mamae o te puku, te kōpū, me te tūtae wewete, wai rānei e auau ana, ka pā kaha ki tō kounga oranga.

Ka whakaarohia pea e tō tākuta te eluxadoline mēnā ka pā koe i ngā wā o te pāhoro e hoki mai ana me te mamae o te puku e roa ana mō te ono marama. He tino whai hua te rongoā mō te hunga e toru, neke atu rānei ngā tūtae wewete i te rā, me te hiahia nui ki te whai i ngā nekehanga whekau.

He mea nui kia mōhio kāore te eluxadoline e whakamahia mō ētahi atu momo IBS, pēnei i te IBS me te pāpā (IBS-C) rānei, ngā tauira IBS whakauru. Kāore hoki te rongoā e tika ana mō te rongoā i te pāhoro koi mai i ngā mate, te paitini kai, ētahi atu take rānei mō te wā poto.

Me pēhea te mahi a Eluxadoline?

Ka mahi a Eluxadoline mā te pāhekoheko ki ngā momo momo kaiwhiwhi opioid e toru i roto i tō ara whekau, e whai wāhi ana ki te whakahaere i te mahi whekau. Koinei te mea e kīia ana e ngā tākuta he "whakawhitiwhiti kaiwhiwhi opioid whakauru" - ka taea e ia te whakahohe me te aukati i ngā kaiwhiwhi rerekē i runga i te hiahia o tō tinana.

Ka whakahohehia e te rongoā ngā kaiwhiwhi mu-opioid me te delta-opioid, e āwhina ana ki te whakaiti i te nekehanga o ngā mea mā roto i ō whekau me te whakaiti i te huna o ngā wai. I te wā ano, ka aukati i ngā kaiwhiwhi kappa-opioid, e āwhina ana ki te ārai i ētahi o ngā pānga taha ka pā ki a koe me ngā rongoā opioid tuku iho.

Ko tēnei huarahi taurite te tikanga ka taea e te eluxadoline te āwhina i te whakatō i ō tūtae me te whakaiti i te auau o ngā nekehanga whekau me te kore e pā te pāpā, ngā take whakawhirinaki rānei e pā ana ki ngā rongoā opioid kaha ake. E whakaarohia ana he whai hua te rongoā, kaua i te tino kaha, e āhei ana kia noho haumaru mō te whakamahi wā roa ki te whakahaere i te IBS-D mau tonu.

Me pēhea taku tango i te Eluxadoline?

Me tango te Eluxadoline i te mea i whakaritea e tō tākuta, te tikanga e rua ngā wā i te rā me te kai. He mea nui te tango me ngā kai nā te mea ka āwhina te kai i tō tinana ki te tango i te rongoā tika, ā, ka taea te whakaiti i te tūponotanga o ētahi pānga taha.

Ko te horopeta timatanga paerewa ko te tikanga 100 mg e rua nga wa i te ra, engari tera pea ka tohua e to taakuta he horopeta iti ake o te 75 mg e rua nga wa i te ra mena he etahi mea morearea kei a koe. Kei roto i enei ko te hitori o nga raruraru o te pukupuku, nga take ate, mena kei te tango koe i etahi atu rongoa ka pa mai ki te eluxadoline.

Me tango e koe ia horopeta me te kai nui, kaua ki te paramanawa noa. Ko te tikanga tenei me tango te rongoa me te parakuihi me te tina, te tina me te tina ranei, i runga i to waarangi kai. Kaore te kai e tika kia nui te ngako, kia taumaha ranei, engari me kai i te kai rahi noa hei awhina i to tinana ki te tukatuka i te rongoa.

Mena ka wareware koe ki te horopeta, kaua e rua i runga i to horopeta e whai ake nei. Me tango noa to horopeta e whai ake nei me te kai i nga wa katoa. Ko te tango i etahi atu rongoa e kore e pai ake te mahi, ka piki ake pea to tupono ki nga paanga taha.

Kia Pehea Te Roa E Tango Ai Au i te Eluxadoline?

He rereke te roa o te maimoatanga eluxadoline mai i te tangata ki te tangata, a ka whakawhirinaki ki te pai o to urupare ki te rongoa me te pehea e uru ai ki roto i to mahere whakahaere IBS. He maha nga tangata e tango ana mo etahi marama ki nga tau hei waahanga o ta raatau rautaki whakahaere IBS-D mo te wa roa.

Tera pea ka hiahia to taakuta ki te tirotiro me koe i muri i nga wiki tuatahi kia kite me pehea koe e urupare ana ki te rongoa. Ka kite etahi tangata i nga whakapainga i roto i o raatau tohu i roto i te wiki tuatahi, engari ko etahi atu ka hiahia etahi wiki ki te wheako i nga painga katoa.

Na te mea he mate mau tonu te IBS-D, i hangaia te eluxadoline mo te whakamahi mo te wa roa, kaua ki te awhina mo te wa poto. Heoi, tera pea ka tohutohu to taakuta kia okioki i nga wa katoa mai i te rongoa kia arotakehia mena kua pai ake o tohu i a raatau ake, mena kei te hiahia tonu koe ki te maimoatanga.

Kaua e mutu te tango eluxadoline ohorere me te kore e kōrero tuatahi ki tō tākuta, ina koa kua roa koe e tango ana i te rongoā nei mō ngā marama. Ahakoa kāore i te hanga i te waranga i te tikanga tuku iho, ko te whakamutu ohorere ka hoki mai pea ō tohumate IBS-D me te kaha ake.

He aha ngā pānga taha o Eluxadoline?

Pērā i ngā rongoā katoa, ka pānga taha te eluxadoline, ahakoa kāore katoa e pā ana. Mā te māramatanga ki ngā mea e tūmanakohia ana ka āwhina koe ki te whai wāhi atu, me te mōhio ki te wā ki te whakapā atu ki tō kaiwhakarato hauora.

Ko ngā pānga taha noa he ngawari tonu, ā, ka pai ake i te wā e urutau ana tō tinana ki te rongoā i ngā wiki tuatahi o te maimoatanga.

Ngā pānga taha noa ka pā ki a koe:

• Te pāhohe (te pānga taha auau, e pā ana ki te 8% o te iwi)
• Te whakapairuaki, e pai ake ana i te wā e tangohia ana me te kai
• Te mamae o te puku, te kōpū rānei, he ngawari ake i ō tohumate IBS taketake
• Ngā mate o te ara rāhaua o runga pērā i te makariri
• Te ruaki, ina koa i ngā rā tuatahi o te maimoatanga
• Te hau, te piki rānei o te hau

Ko ēnei pānga taha noa he mea whakahaere, ā, ka heke iho i te wā e waia ana tō tinana ki te rongoā. Ko te nuinga o te iwi e kite ana ko te tango eluxadoline me te kai e tika ana ka āwhina i te whakaiti i te whakapairuaki me te puku raru.

He onge ngā pānga taha nui ake, engari me whai wāhi tonu te rongoā:

• Te mamae nui o te puku kāore e pai ake, e kino ake rānei
• Te pancreatitis (te mumura o te pancreas), e pā ana te mamae nui o te puku ka horapa pea ki tō tuara
• Te pāhohe nui e roa ana i ngā rā maha
• Te kōpiko o te Sphincter of Oddi, e pā ana te mamae nui o te puku o runga
• Ngā tohu o te urupare pānga pērā i te pūwhero, te uaua ki te hā, te pūhi rānei

Mēnā ka pā koe ki te mamae nui o te puku, ina koa ki te mea e haere tahi ana me te whakapairuaki, te ruaki, te kirika rānei, whakapā atu ki tō tākuta tonu. He tohu pea tēnei o te pancreatitis, he raruraru nui engari he onge, e hiahia ana kia atawhai hauora wawe.

Ko wai kāore e tika kia tango Eluxadoline?

Kāore i te haumaru a Eluxadoline mō te katoa, ā, he maha ngā āhuatanga me ngā wāhi nui e kore ai tō tākuta e whakahau i tēnei rongoā. Mā te pono mō tō hītori hauora e āwhina ana kia whiwhi koe i te rongoā haumaru me te whai hua.

Kāore koe e tika kia tango eluxadoline mēnā he āhuatanga kōpū, ate rānei ōna e mōrearea ai te rongoā mō koe.

Ngā aukati tino nui ko:

• Kāore he pūpū (cholecystectomy) - ka nui ake te mōrearea o te pancreatitis
• Te aukati i te ara biliary e mōhiotia ana, e whakapaehia ana rānei
• Te mahi kino, te kōpiko rānei o te Sphincter of Oddi
• Ngā raruraru ate nui (te ngoikore o te ate)
• Hītori o te pancreatitis
• Te mate tākihi nui
• Te pāhohe nui, te pāhohe rānei
• Te aukati i te kōpū e mōhiotia ana

Ka tūpato anō tō tākuta ki te whakahau eluxadoline mēnā he hītori tō te whakamahi waipiro, nā te mea ka nui ake te mōrearea o te pancreatitis. I tua atu, mēnā kei te tango koe i ētahi rongoā e pā ana ki ngā enzyme ate kotahi e tukatuka ana i te eluxadoline, ka kōwhiri pea tō tākuta i tētahi atu whiringa rongoā.

He whakaaro motuhake e pā ana ki:

• Ngā tāngata neke atu i te 65 tau, he nui ake pea te tairongo ki ngā pānga taha
• Te hunga he raruraru ate ngawari ki te āhua
• Ko te hunga e tango ana i ngā rongoā e pā ana ki te eluxadoline
• Ngā tāngata he hītori tō te whakamahi matū
• Te hunga e hapū ana, e whāngai u ana rānei

Mena kei te hapu koe, kei te whakamahere ranei koe kia hapu, kōrerohia tēnei ki tō tākuta. Ahakoa kāore anō a eluxadoline i te tino rangahaua i roto i ngā wahine hapu, kāore i te nuinga o te wā e tūtohutia ana i te wā e hapu ana, ki te kore e nui ake ngā painga i ngā tūponotanga.

Ngā Ingoa Waitohu o Eluxadoline

Kei te wātea a Eluxadoline i raro i te ingoa waitohu Viberzi i te United States. Koinei anake te putanga ingoa waitohu e wātea ana i tēnei wā, i te mea he rānei te rongoā nei, ā, kāore anō ngā putanga whānui i te wātea whānui.

Ināianei ka tohua e tō tākuta a eluxadoline, ka tuhia e rātou te rongoā mō Viberzi, e rua ngā kaha: 75 mg me te 100 mg papa. He papa āhua ōwa ngā kaha e rua e horomia ana e koe mā te waha me te kai.

Mēnā kei te rapu koe i tō rongoā i te whare rongoā, e kōrero ana rānei koe ki tō rōpū hauora, ka rongo pea koe i ngā ingoa e rua e whakamahia ana i te wā kotahi. Ka rārangi pea ētahi mahere inihua i raro i te ingoa whānui eluxadoline, i te mea e whakamahi ana ētahi atu i te ingoa waitohu Viberzi i roto i ā rātou puka.

Ngā Kōwhiringa kē mō Eluxadoline

Mēnā kāore a eluxadoline i te tika mōu, kāore rānei e whai hua ana te whakaiti i ngā tohu, he maha ētahi atu kōwhiringa maimoatanga e wātea ana mō te whakahaere i te IBS-D. Ka āwhina tō tākuta i a koe ki te tūhura i ēnei kōwhiringa kē i runga i ō tohu motuhake me te hītori hauora.

Ko ētahi atu rongoā rongoā mō te IBS-D ko te alosetron (Lotronex), he mea motuhake mō ngā wāhine e tino kaha ana te IBS-D, me te rifaximin (Xifaxan), he paturopi ka āwhina i te tautuhi anō i ō huakita puku. He loperamide (Imodium) anō hoki, he kōwhiringa i runga i te kaute e whakamātau ana te nuinga o te tangata i mua i te neke ki ngā maimoatanga rongoā.

Ngā huarahi kāore i te rongoā ka taea te whakakī, i ētahi wā ka whakakapi i te eluxadoline ko:

• Ngā whakarerekētanga kai pēnei i te kai iti-FODMAP
• Ngā rongoā probiotic hei tautoko i ngā huakita puku hauora
• Ngā tikanga whakahaere ahotea tae atu ki te rongoā, te whakaaroaro rānei
• Te whakakori tinana i ngā wā katoa me te akuaku moe
• Ngā tāpiringa muka wairewa
• Ngā rongoā antispasmodic mō te pāhoahoa

He tokomaha ngā tāngata e kite ana ko te whakakotahi i te rongoā me ngā huringa oranga te mea e pai ai ngā hua i te wā roa. Ka tohutohu pea tō tākuta kia tīmata koe ki te eluxadoline i te wā e mahi ana koe i ngā mea e pā ana ki te kai me ngā tikanga whakahaere ahotea.

He pai ake te Eluxadoline i te Loperamide?

He rerekē te mahi a Eluxadoline me te loperamide (Imodium) me te whai wāhi rerekē ki te rongoā IBS-D, nō reira ehara i te mea tika te whakataurite i a rāua. Ko te kōwhiringa "pai ake" kei runga i ō tohumate motuhake, te kaha, me te pai o tō urupare ki ia rongoā.

He rongoā e hokona ana i te tatau a te rōpū loperamide e whakaiti ana i te nekehanga o te puku hei whakaiti i te korere. Koinei te rongoā tuatahi e whakamātauhia ana e te tangata nā te mea e wātea ana, he iti hoki te utu. Heoi, ko te nuinga e aro ana ki te wāhanga korere o te IBS-D me te kore e aro ki te mamae o te puku me te pāhoahoa e pā ana ki te tokomaha o te tangata.

Ko te Eluxadoline, i tērā taha, i hangaia hei aro ki te korere me ngā āhuatanga mamae o te puku o te IBS-D. Mā tēnei mahi rua ka whai hua ake mō te hunga e nui ana te pāhoahoa me te kore e pai me ō rātou tohumate whekau.

He tokomaha ngā tākuta e tohutohu ana kia whakamātau tuatahi i te loperamide, ina koa mō ngā mura tohumate i ia wā, i mua i te neke ki ngā kōwhiringa rongoā pēnei i te eluxadoline. Ki te kore te loperamide e whai oranga tika, ki te hiahia rānei koe ki te rongoā i ia rā hei whakahaere i ō tohumate, he pai ake pea te eluxadoline hei rongoā mō te wā roa.

E kitea ana e ētahi tāngata ka taea e rātou te whakamahi i ngā rongoā e rua i runga i te rautaki – te eluxadoline mō te whakahaere i ia rā, me te loperamide mō ngā tohumate pakaru, ngā rā uaua rānei. Me kōrero tonu tēnei huarahi ki tō tākuta i mua i te whakakotahi i ngā rongoā.

Ngā Pātai e Pānga ana ki te Eluxadoline

He Haumaru te Eluxadoline mō te Tāngata e mate huka ana?

Ka taea te whakamahi i te eluxadoline e te tāngata e mate huka ana, engari he mea nui hei kōrero ki tō tākuta. Kāore te rongoā e pā tika ana ki ngā taumata huka toto, engari ka pā pea ngā tohumate kōpū me ngā huringa i ngā tikanga kōpū ki te āhua e ngāwari ai tō tinana ki te tango i ngā matūkai me ngā rongoā.

Mēnā he mate huka tōu, ka hiahia tō tākuta ki te aroturuki i a koe i te wā e tīmata ana koe i te eluxadoline, ina koa kei a koe ētahi raruraru e pā ana ki tō mate huka e pā ana ki tō pūnaha kōpū. Ko te tāngata e mate gastroparesis diabetic, ētahi atu raruraru kōpū rānei, ka hiahia pea ki te whakaaro motuhake.

He mea tika anō kia mōhio ko te pai ake o te whakahaere IBS-D ka āwhina i te whakapūmautanga o tō hauora whānui, tae atu ki te māmā ake o te pupuri i ngā tauira kai e tautoko ana i te whakahaere pai i te mate huka.

Me pēhea ahau ki te tango i te nui rawa o te Eluxadoline?

Mēnā ka tango koe i te nui rawa o te eluxadoline i te mea i whakaritea, whakapā atu ki tō tākuta, ki te pūtau whakahaere paitini rānei, ahakoa kāore koe e rongo i ngā tohumate i te wā tonu. Ko te tango i te nui rawa o te eluxadoline ka piki ake te tūponotanga o ngā pānga taha kino, ina koa te kōroke nui, te mamae puku rānei.

Kaua e ngana ki te

Mēnā kei te pā ana koe ki te mamae nui o te puku, te uaua ki te manawa, ētahi atu tohumate rānei i muri i te tango i te rongoā nui rawa atu, rapua he āwhina hauora ohorere tonu. Mauria mai te pounamu rongoā ki a koe kia mōhio ngā tākuta ki te aha me te nui i tangohia e koe.

He aha taku mahi mēnā ka ngaro i ahau tētahi horopeta o Eluxadoline?

Mēnā ka ngaro i a koe tētahi horopeta o eluxadoline, tangohia i te wā e mahara ana koe, engari mēnā ka taea e koe te tango me te kai. Mēnā kua tata te wā mō tō horopeta e whai ake nei, waiho te horopeta i ngaro, ka haere tonu ki tō hōtaka horopeta auau.

Kaua rawa e tango i ngā horopeta e rua i te wā kotahi hei utu mō te horopeta i ngaro. Ka piki ake tēnei i tō tūponotanga ki ngā pānga taha me te kore e whai hua atu. He pai te mahi a Eluxadoline ina tangohia tonu, engari ko te ngaro i tētahi horopeta i ia wā ka kore e whara i a koe, e pā nui rānei ki tō rongoā.

Mēnā he maha ngā wā e wareware ana koe i ngā horopeta, whakaarohia te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i tētahi kaiwhakarite pire hei āwhina i a koe kia noho i runga i te ara. Ka āwhina te horopeta tonu ki te pupuri i ngā taumata pumau o te rongoā i roto i tō pūnaha mō te whakahaere tohumate pai.

Āhea ka taea e au te whakamutu i te tango i te Eluxadoline?

Ko te whakatau ki te whakamutu i te tango i te eluxadoline me mahi tonu i te kōrero tahi me tō tākuta, kaua i runga i a koe anō. I te mea he āhuatanga mau tonu te IBS-D, he maha ngā tāngata e hiahia ana ki te rongoā tonu hei pupuri i te whakahaere tohumate.

Ka whakaaro pea tō tākuta ki te whakamutu, ki te whakaiti rānei i te eluxadoline mēnā kua pai te whakahaere i ō tohumate mō tētahi wā roa, mēnā kua huri nui koe i te oranga e whakahaere ana i tō IBS-D, mēnā rānei kei te pā ana koe ki ngā pānga taha e nui ake ana i ngā hua.

E kite ana ētahi tāngata ka taea e rātou te okioki mai i te eluxadoline i ngā wā e iti ake ana ngā tohumate IBS-D. Heoi, me whakamahere tēnei me tō kaiwhakarato hauora kia mōhio kei a koe ngā rautaki i te wāhi mēnā ka hoki mai ngā tohumate.

I te whakamutu i te eluxadoline, ka tohutohu tō tākuta kia whakaheke haere, kaua e whakamutu ohorere, ina koa kua maha ngā marama e tango ana koe. Mā tēnei e ārai te hokinga ohorere mai o ngā tohumate, he kaha ake pea i tō IBS-D taketake.

Ka taea e au te inu waipiro i te wā e tango ana i te Eluxadoline?

E tohutohu ana kia karo, kia whakawhāiti rānei i te waipiro i te wā e tango ana i te eluxadoline, ina koa he hītori tō ki te waipiro. Ka taea e te waipiro te whakanui i tō tūponotanga ki te whakawhanake i te pancreatitis, he pānga taha onge engari he nui te eluxadoline.

Mēnā ka whiriwhiri koe ki te inu waipiro i ētahi wā, kōrerohia tēnei ki tō tākuta i te tuatahi. Ka taea e rātou te āwhina i a koe ki te mārama ki ō āhuatanga tūpono takitahi me te whakarato tohutohu mō ngā rohe haumaru. Ko ngā tāngata he hītori tō te whakamahi waipiro kia karo katoa i te waipiro i te wā e tango ana i te eluxadoline.

Kia mahara ka taea hoki e te waipiro te whakaoho i ngā tohumate IBS-D i roto i te tini tāngata, nō reira ko te whakawhāiti i te inu waipiro ka āwhina pea ki te whakapai ake i tō mana whakahaere tohumate whānui i tua atu i ngā whakaaro haumaru rongoā.