He aha te Metyrosine: Ngā Whakamahinga, Inenga, Ngā Pānga Taha me Ētahi Atu

He rongoā motuhake te Metyrosine e aukati ana i te kaha o tō tinana ki te whakaputa i ētahi homoni ahotea e kiia nei ko te catecholamines. Ko tēnei rongoā i runga i te whakahaunga e whakamahia ana ki te rongoā i tētahi āhuatanga onge engari he nui te kino e kiia nei ko te pheochromocytoma, kei reira ngā puku e pā ana ki te pikinga kino o te toto mā te tuku i te nui rawa o te adrenaline me ngā homoni rite.

Ahakoa ehara te metyrosine i te ingoa rongonui pēnei i ētahi atu rongoā, he whiringa rongoā nui mō te hunga e pā ana ki ngā puku e whakaputa homoni. Whakaarohia he pēnei i te whakatakoto i ngā pūmua ki runga i te pūnaha whakautu ahotea o roto o tō tinana ina mahi nui ana i te taha o ēnei puku.

He aha te Metyrosine?

He rongoā waihanga te Metyrosine e mahi ana mā te aukati i tētahi enzyme e kiia nei ko te tyrosine hydroxylase. Ko tēnei enzyme te kawenga mō te wāhanga tuatahi i te hanga i ngā homoni ahotea pēnei i te dopamine, norepinephrine, me te epinephrine (adrenaline) i tō tinana.

Mā te aukati i tēnei enzyme kia kore e mahi tika, ka whakaiti te metyrosine i te whakaputanga o ēnei homoni kaha. Ka whai hua nui tēnei ina pā ana ki ngā puku e whakaputa ana i te nui rawa o ēnei matū, e āwhina ana ki te whakahaere i ngā tohu kino ka puta i a rātou.

No tētahi rōpū rongoā e kiia nei ko te enzyme inhibitors te rongoā, ā, e kiia ana he rongoā motuhake e hiahia ana kia tino mātakitaki te rongoā. Ko te tikanga ka whakahaunga tō tākuta i te metyrosine i muri noa i te whakapūmau kua pā koe i tētahi āhuatanga e pā ana ki te whakaputanga nui o te catecholamine.

He aha te Metyrosine e Whakamahia Ana?

Ko te tikanga ka whakahaunga te Metyrosine ki te rongoā i te pheochromocytoma, tētahi puku onge e puta ana i ngā repe adrenal me te whakaputa i te nui rawa o ngā homoni ahotea. Ka pā ēnei puku ki te pikinga kino o te toto, te tere o te ngākau, me ētahi atu tohu kino.

Ko te rongoā nei te mea e whakamahia nuitia ana hei rongoā whakarite i mua i te tango pokanga o ēnei puku. Mā te whakaiti i te hanga homoni i mua, ka āwhina te metyrosine ki te whakanui i te haumaru me te ngawari o te pokanga mō koe me tō rōpū pokanga.

I ētahi wā, ka whakamahia pea te metyrosine mō te whakahaere wā-roa i te wā e kore e taea te pokanga i te wā tonu, e kore rānei e tika. Ka pēnei pea mehemea he maha ngā puku kei a koe, mehemea kei tētahi wāhi te puku e tino mōrearea ai te pokanga, mehemea rānei e hiahia ana koe ki te wā ki te whakapai ake i tō hauora whānui i mua i te tikanga.

I te nuinga o te wā, ka tohutohu pea ngā tākuta i te metyrosine mō te paraganglioma, he puku e hanga homoni ana e rite ana, ka puta i ētahi atu wāhi o tō tinana i waho o ngā repe adrenal. Ka puta pea ēnei puku i ngā tohu e rite ana, ā, ka whai hua mai i te huarahi aukati homoni kotahi.

Me pēhea te mahi a te Metyrosine?

Ka mahi te Metyrosine mā te aukati i te mahi tuatahi rawa atu i te hanga homoni ahotea o tō tinana. E whāia ana e ia tētahi enzyme e kīia ana ko te tyrosine hydroxylase, e huri ana i te waikawa amino tyrosine ki tētahi pūhui e kīia ana ko L-DOPA.

Ki te kore tēnei huringa, e kore e taea e tō tinana te haere tonu ki te hanga dopamine, norepinephrine, epinephrine rānei. He mea nui tēnei ina mahi ana ki ngā puku e hanga homoni ana, i te mea ka hanga pea ēnei tipu i ngā rahinga mōrearea o ēnei mea e kore e taea e tō tinana te whakahaere i te haumaru.

E whakaarohia ana he kaha ngawari te rongoā nei i ōna pānga, e whakaiti ana i te hanga catecholamine mā te 50-80% i te wā e whakamahia ana i ngā horopeta rongoā. Mā tēnei whakaitinga nui e āwhina ana ki te whakahaere i ngā tohu kino e pā ana ki te hanga homoni nui, pērā i te toto tiketike rawa atu, te tere o te ngākau, me te nui o te werawera.

He mea huri te pānga o te metyrosine, te tikanga, ka mutu ana te tango i te rongoā, ka hoki haere tō tinana ki ōna tauira whakaputa homoni noa. Koinei te mea he taputapu whai hua mō te whakahaere wā poto i te wā e whakarite ana mō te rongoā pumau pēnei i te pokanga.

Me pēhea taku tango i te Metyrosine?

Me tango te Metyrosine i te mea i whakaritea e tō tākuta, te tikanga ka tīmata me te horopeta iti ka piki haere i roto i ngā rā maha. Ko te nuinga o te tangata ka tīmata me te 250 mg e whā ngā wā i te rā, me te whakatakoto i ngā horopeta kia ōrite puta noa i te rā kia mau tonu ngā taumata i roto i tō toto.

Ka taea e koe te tango metyrosine me te kore kai rānei, engari ko te tango me ngā kai ka āwhina i te whakaiti i te puku puku ki te pā ana koe i te raruraru keri. Ki te kitea e koe te rongoā e pōuri ana i tō puku, ngana ki te tango me te paramanawa māmā, te karaihe miraka rānei.

He mea nui kia mau tonu te nui o te wai i te wā e tango ana i te metyrosine, nā te mea ka pā te rongoā ki te matewai i ētahi wā. Ko te inu nui i te wai puta noa i te rā ka āwhina i tō tinana ki te tukatuka i te rongoā i te whai hua me te whakaiti i te tūponotanga o ngā pānga taha.

Ngana ki te tango i ō horopeta i ngā wā kotahi i ia rā kia āwhina i te mau tonu i ngā taumata rite o te rongoā i roto i tō pūnaha. Ko te whakatakoto i ngā whakamaharatanga waea, te whakamahi rānei i te kaiwhakarite pire ka āwhina i a koe kia noho i runga i te ara me tō hōtaka horopeta.

Kia Pēhea te Roa e Tango Ana ahau i te Metyrosine?

He rerekē te roa o te rongoā metyrosine i runga i tō āhuatanga me ngā whāinga rongoā. Ki te whakarite ana koe mō te pokanga ki te tango i te puku whakaputa homoni, ka tango koe i te rongoā mō te 5-7 rā i mua i te tikanga.

I te wā o mua i te pokanga, ka āta tirotiro tō tākuta i tō toto me ngā tohu kia mōhio ai kei te whai hua te rongoā. Ko te whāinga kia tutuki te toto pūmau me te whakaiti i ngā tohu i mua i te haere tonu ki te pokanga.

Mō ētahi tāngata e kore e taea te pokanga tonu, ka whakamahia pea te metyrosine mō ngā wā roa ake hei rongoā piriti. Ka roa pea tēnei mō ētahi wiki, mō ētahi marama rānei i a koe e haere ana i ngā whakamātautau anō, e whakapai ana i tō hauora, e tatari ana rānei mō te wā tika mō tō tikanga.

I ngā wā onge e kore e taea te pokanga nā te wāhi o te puku, te tūnga rānei o tō hauora whānui, ka whakamahia pea te metyrosine hei rautaki whakahaere wā roa. Heoi anō, me mātakitaki tonu tēnei e te tākuta, me te aroturuki i ngā wā katoa kia mōhio ai kei te whai hua tonu te rongoā, me te haumaru hoki.

He aha ngā pānga taha o te Metyrosine?

Pērā i te maha o ngā rongoā e pā ana ki te hanga taiaki, ka pā mai pea ngā pānga taha o te metyrosine i te wā e whakatikatika ana tō tinana ki ngā huringa o ngā taumata catecholamine. Mā te māramatanga ki ēnei pānga ka taea e koe te mōhio wawe, me te mahi tahi me tō rōpū hauora ki te whakahaere i ēnei pānga.

Ko ngā pānga taha tino noa ka pā mai pea ko te moe, te ngenge, me te āhua whānui o te kore e mataara ana i te tikanga. Ka puta ēnei pānga nā te mea ka whakaiti te metyrosine i te hanga dopamine, he mea nui tēnei ki te pupuri i te mataara me te mārama o te hinengaro.

Ko ēnei ngā pānga taha ka pā mai pea ki a koe:

• Te moe me te ngenge ka mau tonu i te rā katoa
• Te korere, i ētahi wā ka raru rawa
• Te uaua ki te kōrero, tae atu ki ngā kupu e kōrerohia ana, te uaua rānei ki te kimi i ngā kupu tika
• Te wiri, te rūrū rānei, ina koa i ō ringa
• Te pōrearea o te ihu e rite ana ki te makariri
• Te iti o te hiahia me te ngaronga taumaha
• Ngā huringa o te ngākau, tae atu ki te kore e whai whakaaro, te pōuri rānei

Ko ēnei pānga noa ka taea te whakahaere, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā i ngā rā tuatahi o te rongoā.

He iti noa iho engari he kino ake pea nga pānga taha, ahakoa he iti noa te hunga e tango ana i te metyrosine. Akene me tino aro turuki enei pānga, me whakatika rānei i tō mahere maimoatanga.

Anei ngā pānga taha e mōhiotia ana:

• Crystalluria, e hanga ana ngā tioata i roto i tō mimi, ka raru pea i ō tākihi
• Te pōuri nui, te āwangawanga rānei e raru ana i ngā mahi o ia rā
• Te raruraru nui, te ngaro rānei o te wāhi
• Te mārō o ngā uaua, te uaua rānei ki te whakatikatika
• Te whānui o ngā u, i roto i ngā tāne (gynecomastia)
• Ngā wā hē o te wāhine
• Te mamae nui o te puku, te whakapairuaki tonu rānei

Mēnā ka pā tētahi o ēnei pānga kino ki a koe, he mea nui kia whakapā atu ki tō tākuta kia kōrero mō te whakatikatika i tō maimoatanga.

Ko wai kāore e tika kia tango i te Metyrosine?

Kāore te Metyrosine e tika ana mō te katoa, ā, ko ētahi āhuatanga hauora, āhuatanga rānei e mea nui ana kia karo i tēnei rongoā. Ka āta arotake tō tākuta i tō hītori hauora i mua i te whakahau i te metyrosine kia mōhio ai he haumaru mō tō āhuatanga motuhake.

Kāore koe e tango i te metyrosine mēnā he mōhiotia tō mate pāwera ki te rongoā, ki ētahi o ōna kai rānei. Ko ngā tohu o te pānga pāwera ko te pāwera, te mōmiti, te pūhi, te whanoke nui, te uaua rānei ki te hā.

Ko ngā tāngata e pā ana ki ētahi āhuatanga hauora me tino tūpato, me karo rānei i te metyrosine. Me mōhio tō kaiwhakarato hauora ki ō raru hauora i mua i te tīmatanga o tēnei rongoā.

Anei ngā āhuatanga e kore ai e tika te metyrosine, e hiahia ana rānei kia tūpato:

• Te mate tākihi nui, nā te mea ka pēhi te rongoā i te mahi o te tākihi
• Te mate ate kaha, te ngoikoretanga ate nui rānei
• Te pōuri nui, te hītori rānei o ngā whakaaro whakamomori
• Te mate o Parkinson, ētahi atu mate rānei e pā ana ki te neke
• Te mate ngākau nui, te whakaeke ngākau tata rānei
• Ngā mate toto kaha, te toto nui tata rānei
• Te hapū, te whāngai ū rānei (me tino āta aromatawai i ngā tūponotanga me ngā painga)

I tua atu, ka taea e te metyrosine te pā ki ētahi atu rongoā, nō reira me mōhio tō tākuta ki ngā rongoā katoa i runga i te whakahaunga, ngā rongoā ka taea te hoko, me ngā tāpiringa e whakamahia ana e koe.

Ngā Ingoa Waitohu o te Metyrosine

Kei te wātea te Metyrosine i raro i te ingoa waitohu Demser i te United States. Koinei te hanganga waitohu tuatahi e mau ana i te nuinga o ngā whare rongoā, ā, e mōhio ana te nuinga o ngā tākuta ki te whakahau.

Ka wātea pea te rongoā hei hanganga whānui i ētahi rohe, ahakoa ka rerekē te wātea i runga i tō wāhi me te whare rongoā. Kei roto i ngā putanga whānui te whakauru kaha kotahi, ā, ka mahi i te ara kotahi me te putanga waitohu.

I te wa e whakakī ana i tō whakahaunga, he mea nui kia piri ki te putanga o te kaihanga kotahi puta noa i tō wā maimoatanga ki te taea. Ka āwhina tēnei ki te whakarite i te inenga rite, me te whakaiti i te tūponotanga o ngā huringa ohorere i te pānga o te rongoā ki a koe.

Ngā Kōwhiringa kē mō te Metyrosine

Ahakoa ko te metyrosine te rongoā e pai ana mō te whakahaere i ngā puku e whakaputa ana i te homoni, he ētahi atu kōwhiringa maimoatanga e wātea ana i runga i tō āhuatanga motuhake. Ka whakaaro pea tō tākuta ki ētahi atu kōwhiringa mēnā kāore te metyrosine e tika ana mōu, mēnā rānei e hiahiatia ana te whakahaere i ngā tohu atu.

He maha ngā rongoā aukati-ā-alpha pērā i te phenoxybenzamine e whakamahia ana i te taha, i te wāhi rānei o te metyrosine hei āwhina i te whakahaere i te pēhanga toto mō te hunga e mate ana i te pheochromocytoma. E mahi ana ēnei rongoā mā te aukati i ngā pānga o ngā homoni nui atu, kaua mā te aukati i tō rātou hanga.

Ka whakamahia pea ngā rongoā aukati-ā-beta pērā i te propranolol hei āwhina i te whakahaere i te tere o te ngākau me te whakaiti i ētahi atu tohumate i puta mai i te nui o te catecholamines. Heoi, ka whakamahia ēnei i te taha o ngā rongoā aukati-ā-alpha, kaua hei rongoā motuhake.

Mō ētahi tāngata, ka whai hua pea ngā rongoā aukati i te hongere konupūmā pērā i te nifedipine, i te amlodipine rānei ki te whakahaere i ngā tohumate pēhanga toto. E mahi ana ēnei mā te āwhina i ngā oko toto kia whakangā, ā, ka whai hua pea mō te hunga kāore e pai ana ki ētahi atu huarahi.

He Pai Anei te Metyrosine i te Phenoxybenzamine?

E mahi ana te Metyrosine me te phenoxybenzamine i ngā huarahi rerekē, e hanga ana i a rāua hei rongoā whakakapi, kaua hei rongoā whakataetae. Ka whakaiti te Metyrosine i te hanga o ngā homoni nui atu, i te wā e aukati ana te phenoxybenzamine i ngā pānga o ngā homoni e noho ana.

He maha ngā tākuta e pai ana ki te whakamahi i ngā rongoā e rua i te taha, kaua ki te kōwhiri i tētahi i runga i tētahi. Ka taea e tēnei huarahi whakakotahi te whakarato i te whakahaere tohumate tino pai, me te whakarite i ngā tūroro mō te pokanga mā te whakatika i te raruraru mai i ngā koki maha.

Ka pai pea te Metyrosine ina hiahia koe ki te whakaiti i te hanga homoni whānui i te wā, mō te whakahaere wā roa i mua i te pokanga. Ka whai hua pea ina hanga ana ngā puku i ngā taumata tino tiketike o te catecholamines e uaua ana ki te whakahaere mā ngā rongoā aukati anake.

Ka kōwhiria pea te Phenoxybenzamine hei rongoā tuatahi ina hiahiatia te whakahaere tere i te pēhanga toto, i te wā rānei kāore e taea e tētahi te aro ki ngā pānga taha neurological e puta ana i ētahi wā ki te metyrosine. He maha ngā wā ka whakawhirinaki te kōwhiringa ki ō tohumate takitahi, te aro, me te wā-ā-rongoā.

Ngā Pātai Auau mō Metyrosine

He Haumaru te Metyrosine mō te hunga mate huka?

Ka taea te whakamahi haumaru te Metyrosine mō te hunga mate huka, engari me tino mātakitaki i ngā taumata huka toto. I ētahi wā ka pā te rongoā ki te āhua o te urupare a tō tinana ki ngā huringa o te huka toto, ina koa i ngā wā o te pēhanga, te mate rānei.

Tērā pea ka hiahia tō tākuta ki te mātakitaki i tō huka toto i te wā e tīmata ana te tango metyrosine, ina koa kei te tango koe i te insulin, i ētahi atu rongoā mate huka rānei. E kite ana ētahi tāngata he paku huringa o ā rātou tauira huka toto i te wā e tango ana i te metyrosine, nō reira he mea nui kia noho tata koe ki tō rōpū hauora.

Me aha au mēnā ka tango au i te nui rawa o te Metyrosine?

Mēnā ka tango koe i te nui rawa o te metyrosine i te mea i whakaritea, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini tonu. Ko te tango i te nui rawa ka pā mai te moe nui, te rangirua, te uaua ki te manawa, te hekenga kino rānei o te pēhanga toto.

Kaua e ngana ki te rongoā i te nui rawa o te horopeta mā te tango i ētahi atu rongoā, i ngā whakaohooho rānei. Engari, rapua te āwhina hauora ngaio tonu. Ki te taea, mauria mai te pounamu rongoā hei āwhina i ngā kaiwhakarato hauora ki te mārama ki te aha me te nui i tango koe.

I ngā tūāhua o te nui rawa o te horopeta, tērā pea me haere koe ki te rūma ohorere mō te mātakitaki me te manaaki tautoko kia ngaro rawa te rongoā nui atu i tō pūnaha.

Me aha au mēnā ka ngaro au i tētahi horopeta o Metyrosine?

Mēnā ka ngaro koe i tētahi horopeta o metyrosine, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua wā, waiho te horopeta i ngaro, ka haere tonu ki tō hōtaka horopeta auau.

Kaua rawa e tango i te horopeta rua hei utu mō tētahi i ngaro, nā te mea ka piki ake tō tūponotanga ki ngā pānga taha. Mēnā he auau tō wareware i ngā horopeta, whakaarohia te whakatakoto i ngā whakaoho waea, te whakamahi rānei i tētahi kaiwhakarite pire hei āwhina i a koe kia noho i runga i te ara.

Mena ka ngaro koe i te maha o nga horopeta, he awangawanga ranei koe mo nga horopeta kua ngaro e pa ana ki to maimoatanga, whakapā atu ki tō tākuta mō te tohutohu me pēhea te haere haumaru.

Āhea ka taea e au te whakamutu i te tango Metyrosine?

Me whakamutu noa koe i te tango metyrosine i raro i te tirotiro hauora tika. Mena kei te tango koe i mua i te pokanga, ka mutu pea te tākuta i te rongoā i te rā o tō tikanga, i mua tata rānei.

Mō te hunga e whakamahi ana i te metyrosine mō te whakahaere wā roa, me mahi mā te āta haere me te aroturuki tupato te whakamutu i te rongoā. Ka hiahia tō tākuta ki te whakarite kia mau tonu tō toto me ō tohu i te wa e wehe ana te rongoā i tō pūnaha.

Kaua rawa e whakamutu ohorere i te tango metyrosine i runga i a koe anō, nā te mea ka puta he pānga rebound mōrearea ka hoki tere mai ō tohu, ā, ka kaha ake pea i mua.

Ka taea e au te taraiwa i te wa e tango ana i te Metyrosine?

He maha ngā wā ka pā te hiamoe, te ngenge, me te whakaheke i te mataara ki te metyrosine, ka tino pā ki tō kaha ki te taraiwa haumaru. He maha ngā tāngata e kite ana he puhoi ake te wā urupare me te whakaheke i te aro i te wa e tango ana i tēnei rongoā.

E taunaki ana kia kaua e taraiwa, ina koa i te wā tuatahi ka tīmata koe ki te tango metyrosine, i te wā rānei e piki ana tō horopeta. Kia mārama koe ki te pānga o te rongoā ki a koe ake, ka taea e koe me tō tākuta te kōrero mō te haumaru o te taraiwa.

Mena me taraiwa koe, me mahi anake i ngā wā e tino mataara ana koe, karo i ngā haerenga roa, me whai tonu he mahere tārua mō te hoki haumaru ki te kāinga mēnā ka tīmata koe ki te hiamoe rawa, ki te rangirua rānei.