He aha te Mexiletine: Ngā Whakamahinga, te Inenga, Ngā Pānga Taha me Ētahi Atu

Ko te Mexiletine he rongoā whakahau e āwhina ana ki te whakahaere i ngā pōkae o te ngākau e kore e rite ana mā te whakapūmau i te mahi hiko o tō ngākau. Ko tēnei rongoā waha nō te kāwai rongoā e kīia ana ko te antiarrhythmics, e mahi ana pērā i ngā kaiwhakahaere hiko ngawari kia tō ngākau e patu ana i te manawataki tū tonu, hauora.

Ka pōrangi pea koe i te rongonga mō ngā rongoā manawataki ngākau, engari kua whakamahia marie te mexiletine mō ngā tekau tau ki te āwhina i te tangata ki te noho i ngā oranga whakamarie ake. Whakaarohia he hoa tautoko mō tō ngākau, e āwhina ana i a ia ki te pupuri i tōna manawataki tūturu ina raruraru ana ngā mea.

He aha te Mexiletine?

Ko te Mexiletine he aukati hongere konutai e aro ana ki ngā ara hiko i roto i tō uaua ngākau. Koinei te mea e kīia ana e ngā tākuta he rongoā antiarrhythmic Class IB, ko te tikanga e mahi ana mā te whakaroa i ētahi tohu hiko ka taea te whakapōkae i tō ngākau.

Ka tae mai tēnei rongoā i roto i te puka pūtau, ā, ka tangohia e te waha e rua ki te toru ngā wā ia rā. Ka whakahau tō tākuta i te mexiletine ina kāore anō ētahi atu rongoā i whai hua, i te wā rānei e pai ana tō raruraru manawataki ngākau ki tēnei rongoā motuhake.

Kua noho te rongoā nei mai i ngā tau 1970, ā, he pūkete haumaru kua whakatūria pai ina whakamahia ana i raro i te tirotiro hauora tika. E whakaarohia ana he rongoā ngākau kaha ngawari e hiahia ana kia āta aroturukihia, engari ka whai hua rawa mō ngā tūroro tika.

He aha te Mexiletine e Whakamahia Ana?

Ko te Mexiletine te mea nui e whakahaua ana ki te rongoā i ngā ventricular arrhythmias, arā, ngā pōkae ngākau e kore e rite ana ka tīmata i ngā ruma o raro o tō ngākau. Ko ēnei momo raruraru manawataki ka pērā te āhua kei te peke tō ngākau i ngā patu, kei te tere, kei te patu rānei i te kaha rawa.

Ka tohutohu pea tō tākuta i te mexiletine mēnā he maha ngā kōpiko o te ventricular premature (PVCs) e pā ana ki ngā tohumate e raruraru ana. Ko te PVC he pōwhiti ngakau anō ka waiho koe kia pērā te āhua o tō ngakau e rere ana, e pōkeke ana rānei, inā koa i te wā e ngana ana koe ki te okioki, ki te moe rānei.

Ka whakamahia hoki te rongoā hei ārai i ngā arrhythmias ventricular nui ake, tae atu ki te ventricular tachycardia, arā, ka tere rawa tō ngakau. I ētahi wā, ka tohutohu ngā tākuta i tēnei rongoā mō ngā tūroro i ora i ētahi momo whakaeke ngakau, me te hiahia kia haere tonu te tiaki i ngā raru o te manawataki.

I te nuinga o te wā, ka whakamahia te mexiletine i waho o te tapanga mō ētahi āhuatanga mamae io, raru uaua rānei, ahakoa e hiahia ana tēnei ki te tirotiro hauora tino motuhake. Ka whakaaro noa tō tākuta ki ēnei whakamahinga mēnā kāore anō ngā rongoā paerewa i whai hua.

Me pēhea te mahi a te Mexiletine?

Ka mahi te Mexiletine mā te aukati i ngā hongere konutai i roto i ngā pūtau uaua o tō ngakau, e āwhina ana ki te whakaroa i ngā tohu hiko ka puta ai ngā pōwhiti ngakau kōaro. Whakaarohia me te whakauru i ngā pūpū tere i runga i ngā huarahi hiko o tō ngakau kia kore ai ngā tohu e tere rawa.

I te wā e whiwhi ana ō pūtau ngakau i ngā tohu hiko, ka whakatuwherahia e rātou ngā hongere e tuku ana i te konutai kia rere mai, e whakaoho ana i te pōwhiti ngakau. Ka aukati wāhanga te Mexiletine i ēnei hongere, e uaua ai te whakaoho i ngā pōwhiti kōaro e ngā tohu hiko kōaro, i te wā e tuku tonu ana i te manawataki ngakau noa kia haere tonu.

E kiia ana he kaha te rongoā nei i waenga i ngā rongoā manawataki ngakau. Kāore i te kaha pērā i ētahi antiarrhythmics Class I, engari he kaha ake i ngā beta-blockers noa, e whai hua ana mō ngā raru manawataki uaua kāore e aro ki ngā rongoā ngawari ake.

Ka tīmata te rongoā ki te mahi i roto i ngā hāora ruarua i muri i te tangohanga, engari kāore pea koe e rongo i ngā painga katoa mō ētahi rā, wiki rānei. Me wā te ngākau ki te whakatika ki ngā pānga o te rongoā, ā, ka āta mātakitaki tō tākuta i tō urupare i tēnei wā.

Me pēhea taku tango i te Mexiletine?

Tangohia te mexiletine i runga i te tohutohu a tō tākuta, te nuinga e rua ki te toru ngā wā ia rā me te kai, te miraka rānei. Mā te tango me te kai ka āwhina i te whakaiti i te puku, ā, ka pai ake te āhua o tō tinana ki te tango i te rongoā.

Horomia ngā kāpene katoa me te karaihe wai katoa, ā, ngana ki te tango i ō horopeta i ngā wā kotahi i ia rā. Mā tēnei ka āwhina i te pupuri i ngā taumata riterite o te rongoā i roto i ō toto, he mea nui tēnei mō te whakahaere i te manawataki ngākau.

Ka taea e koe te tango mexiletine me te nuinga o ngā kai, engari karo i te nui o ngā kai waikawa, inu rānei i ngā wā horopeta, nā te mea ka pā tēnei ki te āhua o te tukatuka o tō tinana i te rongoā. He pai te kai i ngā kai auau, ā, kāore he take ki te whai i tētahi kai motuhake ki te kore tō tākuta e tohutohu.

Mēnā he raruraru tō te mahara ki ngā horopeta, whakaarohia te whakatakoto i ngā whakaoho waea, te whakamahi rānei i tētahi kaiwhakarite pire. Mā te wā tika ka āwhina i te rongoā ki te mahi i te tino whai hua, nō reira he mea nui te whakawhanake i tētahi tikanga e mahi ana me tō hōtaka o ia rā.

Kaua rawa e kuru, e whakatuwhera rānei i ngā kāpene, nā te mea ka pā tēnei ki te āhua o te tuku o te rongoā i roto i tō tinana. Mēnā he uaua ki a koe te horomia i ngā kāpene, kōrero ki tō tākuta mō ngā momo rongoā kē, ngā tikanga rānei ka āwhina.

Kia Pēhea te Roa o taku tango i te Mexiletine?

He rerekē te roa o te maimoatanga mexiletine i runga i tō āhuatanga motuhake me te pai o tō urupare ki te rongoā. E hiahia ana ētahi tāngata mō ētahi marama noa iho, i te wā e tango ana ētahi atu mō ngā tau, mō te wā roa rānei ki te pupuri i te pumau o te manawataki ngākau.

Ka tīmata te tākuta ki te wā whakamātau mō ētahi wiki hei kite i te urupare o tō ngākau, me te kite hoki i ngā pānga taha e pōraru ana. I tēnei wā, ka whai koe i ngā tātari auau, me te aroturuki i te manawataki o te ngākau hei whai i tō haere.

Mō te hunga e raru ana i te manawataki ngākau mō te wā roa, ka waiho pea te mexiletine hei rongoā mō te wā roa, pērā i te tangata e tango ana i ngā rongoā toto tiketike mō te ora. Ko te whāinga he kimi i te taurite tika i waenga i te whakahaere i ō tohumate me te whakaiti i ngā pānga taha.

Kaua rawa e mutu te tango mexiletine ohorere me te kore kōrero ki tō tākuta tuatahi. Ko te whakamutu ohorere ka puta pea te hokinga mai o ō raru manawataki ngākau i te kaha ake i mua, he āhuatanga e kīia ana ko te rebound arrhythmias.

Ka arotake auau tō tākuta mēnā kei te hiahia tonu koe i te rongoā, ā, ka whakatika pea i tō horopeta, ka tūtohu rānei kia whakamātau i te okiokinga mai i te rongoā mēnā kua pūmau tō manawataki ngākau mō te wā roa.

He aha ngā pānga taha o Mexiletine?

Pērā i te nuinga o ngā rongoā ngākau, ka puta pea ngā pānga taha o mexiletine, ahakoa he maha ngā tāngata e pai ana ki te tango i te rongoā i te wā e urutau ana tō rātou tinana ki te rongoā. Ko ngā pānga taha tino noa he ngawari tonu, ā, he pai ake i muri i ngā wiki tuatahi o te rongoā.

Koinei ngā pānga taha ka pā ki a koe, ka tīmata mai i ngā mea tino noa, kāore i te tino kino:

• Te whakapairuaki, te pōraru puku rānei, ina koa i te tīmatanga o te rongoā
• Te whanoke, te māmā rānei o te mahunga, ina koa i te tū ohorere
• Te wiri, te rūrū rānei o ō ringa
• Te ngenge, te ngenge rānei i te nuinga o te wā
• Te ngākau pāwera, te korenga rānei
• Ngā raruraru tūhono, te korenga rānei
• Ngā raruraru moe, ngā moemoeā rānei

Ko ēnei pānga taha noa ka memeha i te wā e urutau ana tō tinana ki te rongoā, engari whakamōhio atu ki tō tākuta mēnā ka mau tonu, ka pōraru rānei i a koe.

Ko ētahi tāngata ka pā atu ki ngā pānga taha e mōrearea ana, e hiahia ana kia āwhina hauora. Ahakoa he iti noa iho ēnei, he mea nui kia mōhio:

• Ngā raruraru manawa hou, e kino haere ana rānei
• Te whanoke nui, te ngaro rānei
• Te mamae o te uma, te uaua rānei ki te hā
• Te whakapairuaki, te ruaki rānei e mau tonu ana
• Ngā wiri nui, ngā raruraru rānei ki te ruruku
• Ngā huringa o te ngākau, te rangirua rānei

I te wā onge, ka pā atu ngā pānga taha nui ake ki te mexiletine, e hiahia ana kia āwhina hauora tonu. Kei roto i ēnei ko ngā tauhohenga mate pāwera nui, ngā raruraru ate, ngā mate toto rānei, ahakoa ka puta ēnei i roto i te iti iho i te 1% o ngā tāngata e tango ana i te rongoā.

Whakapā atu ki tō tākuta tonu mēnā ka puta he pūhi, te kōwhai o tō kiri, o ō kanohi rānei, ngā pānga kikorangi rerekē, te kirika rānei e mau tonu ana i te wā e tango ana koe i te mexiletine. He mea rerekē ēnei tohu, engari ka tohu pea i te tauhohenga nui e hiahia ana kia āwhina tonu.

Ko wai kāore e tika kia tango i te Mexiletine?

Kāore te Mexiletine i te pai mō te katoa, ā, ka āta arotake tō tākuta i tō hītori hauora i mua i te whakahau i te rongoā. Ko ētahi āhuatanga o te manawa ka kore e haumaru, ka mōrearea rānei te whakamahi i te mexiletine.

Kāore koe e tika kia tango i te mexiletine mēnā he momo aukati manawa tō, he ngoikore manawa nui rānei, nā te mea ka kino ake te rongoā i ēnei āhuatanga. Ka mahi tō tākuta i te electrocardiogram (ECG) hei tirotiro i te mahi hiko o tō manawa i mua i te tīmatanga o te rongoā.

Kāore pea ngā tāngata e pā ana ki ngā raruraru ate e kaha ki te tango i te mexiletine, nā te mea ka tukatukahia tēnei rongoā e te ate. Mēnā he hītori tō ki te mate ate, ki te tango rānei i ētahi atu rongoā e pā ana ki te mahi ate, me āta aroturuki tō tākuta i a koe.

Me karo ngā wāhine hapū i te mexiletine, ki te kore te painga e nui ake i ngā mōrearea, nā te mea kāore i te tino māramahia ōna pānga ki ngā pēpi e whanake ana. Mēnā kei te whāngai ū koe, ka taea e te mexiletine te uru ki roto i te waiu ū, ā, ka pā pea ki tō pēpi.

Korero atu ki tō tākuta mō ngā rongoā katoa e inu ana koe, tae atu ki ngā rongoā ka taea te hoko me ngā taapiringa. Ka taea e te Mexiletine te pā ki te maha o ētahi atu rongoā, ina koa ētahi atu rongoā manawa, ētahi paturopi, me ētahi rongoā anti-depressant.

Mēnā he raruraru tāu tākihi, he mate hopu, he hītori rānei mō ngā āhuatanga hinengaro, me āta whakatau tō tākuta i ngā painga me ngā tūponotanga i mua i te whakahau i te mexiletine.

Ngā Ingoa Waitohu Mexiletine

Kei te wātea te Mexiletine i raro i ētahi ingoa waitohu, ko Mexitil te mea e mōhiotia ana. Heoi, kei te nuinga o ngā whare rongoā ngā putanga generic o te mexiletine, he rite tonu te whai hua ki ngā putanga waitohu.

Kua wātea te mexiletine generic mō ngā tau maha, ā, e tutuki ana ngā paerewa kounga rite tonu ki ngā rongoā waitohu. Ka pai pea tō inihua ki te putanga generic, ā, he iti ake te utu, kāore he rerekētanga o te whai huatanga.

Ko ētahi atu ingoa waitohu ka kitea e koe ko Mexitil me ngā momo generic mai i ngā kaihanga rerekē. Ko te mea nui ko te whakauru kaha, ko te mexiletine hydrochloride, he rite tonu ahakoa te waitohu.

Mēnā kei te huri koe i waenga i ngā kaihanga rerekē o te mexiletine generic, whakamōhio atu ki tō tākuta, nā te mea he rerekētanga iti kei te āhua o te ngongo o ngā momo rerekē e tō tinana.

Ngā Kōwhiringa Mexiletine

Mēnā kāore te mexiletine i te tika mōu, kāore rānei e whakahaere i tō manawa i te whai hua, he maha ētahi atu rongoā ka taea te rongoā i ngā āhuatanga rite. Ka whakaaro pea tō tākuta ki ētahi atu rongoā antiarrhythmic pēnei i te flecainide, propafenone, amiodarone rānei.

Ko te Flecainide tētahi atu Class I antiarrhythmic e mahi ana i te rite ki te mexiletine engari he pai ake pea te whakamanawanui e ētahi tāngata. He maha ngā wā e whakamahia ana mō ngā momo raruraru manawa rite, ā, he kōwhiringa pea mēnā he nui rawa ngā pānga taha o te mexiletine.

Ko ngā aukati-pēta pēnei i te metoprolol, i te atenolol rānei, he rongoā ngawari ake pea e pai ana mō ngā raruraru manawa e kore e tino kaha. Ka whakaiti ēnei rongoā i tō reiti manawa, ā, ka whai hua mō ētahi momo o te manawa kōaro, kāore he pānga taha kaha ake i te mexiletine.

Mō ngā raruraru manawa nui ake, ka whakaaro pea tō tākuta ki te amiodarone, he rongoā antiarrhythmic tino kaha. Heoi anō, he rārangi pānga taha anō tō te amiodarone, ā, me mātakitaki pū.

Ko ngā rongoā kore-rongoā pēnei i te katita ablation, i ngā pūrere whakauru rānei, he kōwhiringa kē pea mō ētahi tāngata, ina koa kāore ngā rongoā e whakahaere i ō rātou tohumate.

He Pai Ake Anei te Mexiletine i te Flecainide?

E whakawhirinaki ana te pai ake o te mexiletine i te flecainide ki tō āhuatanga manawa motuhake me te pēhea te urupare o tō tinana ki ia rongoā. E mahi ana ngā rongoā e rua i ngā raruraru manawa, engari he rerekē ō rātou kaha me ō rātou rārangi pānga taha.

He maha ngā wā ka kōwhiria te Mexiletine mō ngā tāngata kua pā i te whakaeke manawa, i ētahi raruraru manawa hanganga rānei, nā te mea he haumaru ake i ngā wāhanga pēnei i te flecainide. E pai ana hoki ina he kino ngā urupare a ngā tāngata ki ētahi atu rongoā antiarrhythmic.

Ka pai pea te flecainide mō ngā tāngata he ngākau hanganga noa ō rātou, he fibrillation atrial rānei, ētahi momo rānei o te tachycardia supraventricular. He maha ngā wā ka pai ake te aro ki a ia, ā, he iti ake pea te horopeta i te mexiletine.

Ka whakaaro tō tākuta ki ngā āhuatanga pēnei i tō momo arrhythmia motuhake, tō hauora manawa whānui, ētahi atu āhuatanga hauora kei a koe, me ō urupare o mua ki ngā rongoā manawa i te wā e kōwhiri ana i waenga i ēnei kōwhiringa.

I ētahi wā ka whakamātau ngā tākuta i tētahi rongoā i te tuatahi, ā, ka huri ki tērā atu mēnā kāore te kōwhiringa tuatahi e pai ana, e pā ana rānei ngā pānga taha whakararuraru. He mea noa tēnei huarahi whakamātau-me-he, ā, he mea noa i te whakahaere manawa.

Ngā Pātai Auau mō te Mexiletine

He Haumaru te Mexiletine mō te hunga mate huka?

He haumaru te Mexiletine mō te hunga mate huka, engari me tino mātakitaki mai i te mea ka pā te mate huka ki tō ngākau me ō uaua toto. Me whakaaro tō tākuta ki te pai o te whakahaere i tō mate huka me te mea he raruraru ngākau tō te mate huka.

Kāore te rongoā e pā tika ana ki ngā taumata huka toto, nō reira kāore e whakararu i ō rongoā mate huka, i te whakahaere rānei i te huka toto. Heoi, ki te pā mai te whakapairuaki, te puku rānei i te mexiletine, ka pā tēnei ki ō tauira kai me te whakahaere huka toto.

Ko te hunga mate huka e raru ana i te manawataki ngākau, he maha ngā wā e hiahia ana ki te mexiletine nā te mea ka whakanui te mate huka i te tūponotanga ki te whanake i ngā arrhythmias. Ka mahi tō tākuta ki a koe kia mōhio ai ka whakahaere ngātahi ngā āhuatanga e rua.

Me aha au ki te inu au i te nui rawa o te Mexiletine?

Ki te inu koe i te nui rawa o te mexiletine i te mea i whakaritea, whakapā atu ki tō tākuta, ki te pūtau whakahaere paitini rānei i te wā tonu, ahakoa kei te pai koe. Ko te inu i te nui rawa ka pā mai ngā raruraru manawataki ngākau nui, kāore pea i te kitea tonu.

Kaua e ngana ki te whakapairuaki i a koe, ki te tango rānei i ētahi atu rongoā hei whakakore i te nui rawa. Engari, rapua te āwhina hauora i te wā tonu, ina koa ki te mārō koe, he mamae tō uma, ka kite rānei i tō ngākau e patupatu ana i te kore tika.

Kawea mai te pounamu rongoā ki a koe ki te ruma ohorere kia kite ai ngā kaimahi hauora i te mea i inu koe me te nui. He mea nui te wā ki ngā nui rawa o ngā rongoā ngākau, nō reira kaua e tatari kia kite i te whanake o ngā tohu.

Hei aukati i ngā nui rawa ohorere, whakaarohia te whakamahi i te kaiwhakarite pire me te whakatakoto i ngā whakamaharatanga i tō waea. Ki te noho koe me ētahi atu, whakamōhio atu ki a rātou mō tō hōtaka rongoā kia taea ai e rātou te āwhina ki te whai.

Me aha au ki te ngaro au i te horopeta o te Mexiletine?

Mena ka ngaro koe i te horopeta o te mexiletine, tangohia i te wa e mahara ana koe, ki te kore e tata ana te wa mo to horopeta e whai ake nei. I tera keehi, pekehia te horopeta i ngaro, ka haere tonu ki to waarangi horopeta.

Kaua rawa e tango e rua nga horopeta i te wa kotahi hei utu mo te horopeta i ngaro, na te mea ka raru pea nga raru o te manawa. He pai ake te ngaro i te horopeta kotahi i te tupono ki te tango i te nui rawa o te rongoa i te wa kotahi.

Mena ka wareware koe i nga horopeta, korero ki to taakuta mo nga rautaki hei awhina i a koe ki te mahara. He mea nui te horopeta rite tonu kia pai ai te mahi a te mexiletine, no reira he mea tino nui te kimi i tetahi tikanga e pai ana ki a koe.

Ko te ngaro i nga horopeta i etahi wa karekau he morearea, engari ko te ngaro i nga horopeta i nga wa katoa ka taea e nga raru o te manawa te hoki mai, ka kino pea i te wa.

Ahea Ka Taea e Au te Kati te Tango Mexiletine?

Me mutu noa koe te tango mexiletine i raro i te tirotiro a to taakuta, ahakoa kei te pai koe. Ko te whakamutu ohorere i nga rongoa manawa i etahi wa ka hoki mai ano o manawataki koretake i mua atu.

Ko te tikanga ka whakaiti to taakuta i to horopeta i roto i nga ra, i nga wiki ranei, kaua ki te whakamutu i te wa kotahi. Ma tenei ka whai wa to ngakau ki te whakatika me te whakaiti i te tupono o te arrhythmias rebound.

Ko te whakatau ki te whakamutu i te mexiletine kei runga i te roa o to tango, te take i hiahia ai koe i te tuatahi, me te pai ake o to mate ngakau. Ko etahi tangata e hiahia ana ki te rongoa mo te wa roa, ko etahi ka mutu te rongoa.

Ko nga huihuinga whai muri i nga wa katoa me to taakuta ka awhina ki te whakatau i te wa tika ki te whakaaro ki te whakamutu i te mexiletine. Ka hiahia pea to taakuta ki te aro turuki i to manawataki mo tetahi wa i muri i te whakamutu kia mohio kei te kore e hoki mai o arrhythmias.

Ka Taea e Au te Inu waipiro i te wa e tango ana i te Mexiletine?

He pai ake te whakaiti i te inu waipiro i te wa e tango ana i te mexiletine, na te mea ka nui ake te waipiro i etahi paanga taha penei i te whanoke me nga raruraru ruruku. Ka taea e te mexiletine me te waipiro te pa ki to punaha io, no reira ko te whakakotahi i a raua ka nui ake te kore e pumau, te rangirua ranei.

Ka taea hoki e te waipiro te whakaoho i nga raruraru o te manawa i roto i etahi tangata, ka taea te mahi ki nga mea e ngana ana a mexiletine ki te whakatutuki. Mena ka whiriwhiria e koe te inu i etahi wa, me mahi i runga i te whakaōrite me te aro ki te ahua o to ahua.

Korero ki to taakuta mo o tikanga inu waipiro kia taea e ratou te hoatu ki a koe he tohutohu whaiaro i runga i to ahuatanga motuhake. Ko etahi tangata me karo katoa i te waipiro, ko etahi atu ka taea te inu i etahi wa.

Mena ka kite koe ahakoa he iti noa te waipiro ka whanoke koe, kaore ranei i te pai i te wa e tango ana i te mexiletine, he pai ake te karo i te waipiro i te wa e tango ana koe i tenei rongoa.