He aha te Selexipag: Ngā Whakamahinga, te Inenga, ngā Pānga taha, me ētahi atu mea

Ko te Selexipag he rongoā ā-tautapa i hangaia hei rongoā i te pēhanga toto i roto i ngā uaua o te pūkahukahu (PAH), he āhua kino e piki ana te pēhanga toto i roto i ngā uaua o ō pūkahukahu. E mahi ana tēnei rongoā mā te āwhina i te whakangāwari me te whānui i ngā uaua toto i roto i ō pūkahukahu, e māmā ake ai te ngākau ki te papu toto mā roto i a rātou. Whakaarohia me te mea e hoatu ana e koe ki tō ngākau me ō pūkahukahu he ringa āwhina e tino hiahiatia ana i te wā e mahi nui ana rātou nā te āhua uaua nei.

He aha te Selexipag?

Ko te Selexipag he rongoā waha nō te rōpū rongoā e kīia ana ko ngā kaiwhakahohe i te kaiwhakawhiwhi prostacyclin. He putanga waihanga tēnei o te mea tūturu e hangaia ana e tō tinana e kīia ana ko te prostacyclin, e āwhina ana ki te pupuri i ō uaua toto kia whakangāwari me te tuwhera. Ki te whai koe i te pēhanga toto i roto i ngā uaua o te pūkahukahu, kāore tō tinana e hanga i te nui o tēnei mea āwhina, nō reira ka uru mai te selexipag ki te whakakī i tērā wāhi.

Ka tangohia tēnei rongoā mā te waha hei papa, e māmā ake ai i ētahi atu rongoā PAH e hiahia ana ki te werohanga, ki te whakawhiwhi tonu rānei. I hangaia te rongoā nei kia whai oranga roa mai i ngā tohumate PAH i te wā e māmā ake ana te whakahaere i roto i tō mahi o ia rā.

He aha te Selexipag e whakamahia ana?

Ko te Selexipag te mea tuatahi e tohua ana hei rongoā i te pēhanga toto i roto i ngā uaua o te pūkahukahu i roto i ngā pakeke. Ko te PAH he āhua haere tonu e whāiti ana, e aukati ana, e whakangaromia ana rānei ngā uaua iti i roto i ō pūkahukahu, e uaua ake ai te mahi a tō ngākau ki te papu toto mā roto i ō pūkahukahu. Ka taea e tēnei pōkai mahi nui te arahi ki te kore o te ngākau ki te kore e rongoatia.

Ka tohua pea e tō tākuta te selexipag mēnā kei te pā koe i ngā tohumate pēnei i te poto o te manawa, te ngenge, te mamae o te uma, te pūhi rānei i ō waewae me ō rekereke. He maha ngā wā e whakamahia ana te rongoā nei i te wā kāore anō ētahi atu rongoā i whai hua, hei wāhanga rānei o te rongoā whakakotahi. He tino whai hua mō te hunga e hiahia ana ki te whakaiti i te haere whakamua o tō rātou PAH me te whakapai ake i tō rātou kaha ki te whakakorikori tinana me te mahi i ngā mahi o ia rā.

Me pēhea te mahi a te Selexipag?

Ka mahi te selexipag mā te whai i te prostacyclin, he matū tūturu e mahi ana hei kaitiaki ngawari mō ō uaua toto. I te wā e tango ana koe i te selexipag, ka herea ki ngā kaiwhakawhiwhi motuhake i roto i ngā uaua toto o tō pūkahukahu, ka tuku tohu e āwhina ana i a rātou kia okioki me te whānui. Ka whakaiti tēnei tukanga i te aukati e pā ana ki tō ngākau i te wā e pōmpu ana i te toto mā ō pūkahukahu.

Ka āwhina hoki te rongoā nei ki te ārai i te hanganga o ngā kōpuku toto i roto i ō uaua pūkahukahu, he raruraru nui pea o te PAH. I tua atu, ka āwhina pea te selexipag ki te whakaiti i te mumura i roto i tō kiko pūkahukahu me te ārai i te whakatikatika kino o ngā pakitara uaua toto e puta ana i te PAH. E kiia ana he rongoā kaha tēnei e hiahia ana kia mātakitaki pū, engari he pai te tūāhua i te wā e whakamahia ana i te tika.

Me pēhea taku tango i te Selexipag?

Me tango e koe te selexipag i te tika i te mea i tohua e tō tākuta, te tikanga e rua ngā wā i te rā me te kai. Ko te tango me ngā kai ka āwhina ki te whakaiti i te pōhara o te puku me te whakapai ake i te pai o te tango a tō tinana i te rongoā. He pai ki te tango i ō horopeta i te wā kotahi i ia rā, tata ki te 12 hāora te wehenga, kia mau tonu ngā taumata i roto i tō pūnaha.

Ka tīmata pea tō tākuta i a koe i te horopeta iti me te whakanui haere i te wā o ngā wiki. Ka āwhina tēnei huarahi whakanui i tō tinana ki te urutau ki te rongoā me te whakaiti i ngā pānga taha. Ka taea e koe te tango i te selexipag me te wai, te miraka, te wai rānei, engari karohia te wai karepe nā te mea ka raru pea i te mahi a tō tinana i te rongoā.

Kaua e kuru, e ngaungau, e whati ranei i ngā papa. Horomia katoatia kia tika ai te tuku i te rongoā i roto i tō tinana. Ki te uaua ki a koe te horomi i ngā papa, kōrerohia ki tō kaiwhakawhāiti rongoā mō ētahi atu tikanga, kōrerohia rānei ngā kōwhiringa ki tō tākuta.

Kia Pēhea te Roa e Tango ana ahau i te Selexipag?

Ko te Selexipag te tikanga he rongoā wā-roa mō te pēhanga toto i roto i ngā pūkahukahu, te tikanga ka hiahia koe ki te tango mō ngā marama, tau rānei. He mate tūturu te PAH e hiahia ana ki te whakahaere tonu, ā, ko te whakamutu ohorere i te rongoā ka hua te kino o ō tohu.

Ka aroturukihia e tō tākuta tō urupare ki te rongoā mā ngā arowhai auau, ngā whakamātautau toto, me ngā aromatawai mahi ngākau. Ko te roa o te rongoā ka whakawhirinaki ki te pai o tō urupare ki te rongoā, te ahunga whakamua o tō āhua, me te mea ka pā ki a koe ētahi pānga taha nui. Ko ētahi tāngata ka hiahia ki te tango selexipag mō te toenga o ō rātou oranga, i te wā e huri ana ētahi ki ētahi atu rongoā i te huringa o tō rātou āhua.

He Aha ngā Pānga Taha o te Selexipag?

Pērā i ngā rongoā katoa, ka taea e te selexipag te pānga taha, ahakoa kāore te katoa e pā ana ki a rātou. Ko te māramatanga ki te aha e tūmanakohia ana ka āwhina i a koe ki te pūmau ake, me te mōhio ki te wā ki te whakapā atu ki tō kaiwhakarato hauora.

Ko ngā pānga taha tino noa ka pā ki a koe ko:

• Te ānini, he maha ngā wā ka pai ake i te wa e urutau ana tō tinana ki te rongoā
• Te whakapairuaki me te ruaki, ina koa i te tīmatanga o te rongoā
• Te pāhau, te tūtae rānei
• Te mamae kauae, te mamae uaua rānei
• Te whero, te mahana rānei
• Te ngaro o te hiahia
• Te ngenge, te pōuri rānei

Ko ēnei pānga taha noa te tikanga he ngawari ki te āhua, ā, he maha ngā wā ka iti ake te raruraru i te wa e waia ana tō tinana ki te rongoā. Ka taea e tō tākuta te whakatika i tō horopeta, te whakaaro rānei i ngā huarahi hei whakahaere i ēnei tohu.

Ko ngā pānga taha he iti noa iho engari he nui ake te kino, me whai wawe tonu te āwhina hauora:

• Te mamae nui i te uma, te tere o te ngākau rānei
• Te uaua ki te hā, te pōturi rānei o te manawa
• Te mamae nui i te puku
• Ngā tohu o te toto, pērā i te pānga kikorangi rerekē, te toto rānei i roto i te tūtae
• Te whanoke nui, te ngaro rānei o te mahara
• Te pūhi i tō mata, ngā ngutu, te arero, te korokoro rānei

Mēnā ka pā tētahi o ēnei pānga taha kino ki a koe, whakapā atu ki tō tākuta i te wā tonu, rapu rānei i te āwhina hauora ohorere. Kia mahara, i whakarite tō rōpū hauora i tēnei rongoā nā te mea e whakapono ana rātou he nui ake ngā painga i ngā tūponotanga mō tō āhuatanga motuhake.

Ko wai e kore e tango i te Selexipag?

Kāore te Selexipag i te pai mō te katoa, ā, ko ētahi āhuatanga, ngā wā rānei ka kore e haumaru te whakamahi. Ka āta arotake tō tākuta i tō hītori hauora i mua i te whakarite i tēnei rongoā kia mōhio ai he haumaru mō koe.

Kaua koe e tango i te selexipag mēnā kei a koe:

• He mate pāwera mō te selexipag, ētahi o ōna kai rānei
• He mate ate nui, he rahunga ate rānei
• Ngā mate toto kaha
• Ngā āhuatanga ngākau nui e mōrearea ai te whakawhānui i ngā oko toto

I tua atu, e hiahiatia ana te tūpato motuhake mēnā kei a koe:

• Te mate tākihi, te iti rānei o te mahi tākihi
• Te pēhanga toto iti
• He hītori o te whiu, te toto rānei i roto i te roro
• He pokanga kei te haere ake nei
• Te hapū, ngā mahere rānei kia hapū

Ka āta whakatau tō tākuta i ēnei āhuatanga, ā, me whakatika pea tō inenga, te kōwhiri rānei i ngā rongoā kē mēnā kāore te selexipag i te pai mō tō āhuatanga.

Ngā Ingoa Waitohu Selexipag

Kei te wātea te Selexipag i raro i te ingoa waitohu Uptravi i te nuinga o ngā whenua, tae atu ki te United States, Canada, me Europe. Koinei te ingoa waitohu taketake i raro i te whakaaetanga tuatahi me te hokohoko o te rongoā e Actelion Pharmaceuticals.

He maha pea ngā ingoa waitohu anō, ngā momo rānei, kei ētahi whenua, engari ko Uptravi tonu te ingoa e mōhiotia whānuitia ana mō te selexipag. I te wā e kōrero ana mō tō rongoā ki ngā kaiwhakarato hauora, ki ngā kaiwhakawhāiti rongoā rānei, ka taea e koe te kōrero mōna mā tōna ingoa whānui (selexipag) rānei, mā tōna ingoa waitohu (Uptravi) rānei.

Ngā Kōwhiringa kē mō te Selexipag

Mēnā kāore te selexipag i te pai mōu, kāore rānei e whai hua ana ki te whakaora i ō tohumate, he maha ngā rongoā kē e wātea ana mō te pēhanga toto i roto i ngā pūkahukahu. Ka whakaaro pea tō tākuta ki ētahi atu rongoā ara prostacyclin, he rerekē ngā painga me ngā tikanga tuku o ia rongoā.

Kei roto i ngā rongoā kē:

• Epoprostenol (Flolan), ka tukuna mā te rongoā IV tonu
• Treprostinil (Remodulin), e wātea ana hei werohanga, hei whakauru, hei momo waha rānei
• Iloprost (Ventavis), ka tukuna mā te whakauru
• Bosentan (Tracleer), he kaiwhakatūtū i te kaiwhakawhiwhi endothelin waha
• Sildenafil (Revatio), he kaiārai i te phosphodiesterase-5
• Riociguat (Adempas), he kaiwhakatūtū i te guanylate cyclase wairewa

He rerekē te mahi o ia rongoā, ā, he pai ake pea i runga i ō tohumate, tō oranga, me ō whāinga rongoā. Mā tō tākuta e āwhina ki te whakatau ko tēhea kōwhiringa e pai ana mō tō āhuatanga takitahi.

He Pai Ake te Selexipag i te Treprostinil?

He rongoā whai hua te selexipag me te treprostinil mō te pēhanga toto i roto i ngā pūkahukahu, engari he rerekē ngā painga i runga i ō hiahia takitahi. E whai wāhi ana te Selexipag ki te tango waha e rua ngā wā i te rā, i te wā e wātea ana te treprostinil i roto i ngā momo maha tae atu ki ngā werohanga, ngā whakauru, me ngā papa waha.

Ko te painga nui o te selexipag ko tōna ngāwari ki te whakamahi, me te mea karekau he werohanga, he whakawhitinga tonu rānei e hiahiatia ana, pērā i ētahi momo treprostinil. Heoi, kua roa kē te wā e wātea ana te treprostinil, ā, he nui ake ngā raraunga rangahau e tautoko ana i tōna whakamahinga. Akene he pai ake te urupare a ētahi tūroro ki tētahi rongoā i tērā atu.

Ka whakaaro tō tākuta ki ngā āhuatanga pēnei i ō tohumate o nāianei, ngā hiahia o te oranga, ētahi atu rongoā e tango ana koe, me te pai o tō whakamanawanui ki ia rongoā i te wā e whakatau ana ko tēhea te mea pai ake mōu. I ētahi wā, ka tūtohu pea te rongoā whakakotahi mā te whakamahi i ngā rongoā e rua mō ngā hua pai rawa atu.

Ngā Pātai Auau mō Selexipag

He Haumaru te Selexipag mō ngā Tāngata e Pā ana ki te Mate Ngākau?

Me mātakitaki tūpato te selexipag i ngā tāngata e pā ana ki te mate ngākau, nā te mea ka pā ki te pēhanga toto me te tere o te ngākau. Me arotake tō kairangahau ngākau i tō āhuatanga ngākau motuhake kia whakatau ai mehemea he haumaru te selexipag mōu. I te nuinga o ngā wā, he raruraru ngākau anō hoki ngā tāngata e pā ana ki te PAH, nō reira ka āta taurite tō tākuta i ngā painga o te rongoā i tō PAH ki ngā tūponotanga pea ki tō ngākau.

Ko te mātakitaki auau mā ngā electrocardiograms, echocardiograms, me ngā arowhai pēhanga toto ka āwhina i te whakarite kia haumaru te mahi a te rongoā mō tō ngākau. Mēnā he nui te ngoikore o te ngākau, ētahi momo raruraru rānei o te manawataki ngākau, ka kōwhiri pea tō tākuta i ētahi atu rongoā, ka whakatika rānei i tō horopeta selexipag.

Me Pēhea Taku Mahi Mēnā Ka Tango Au i te Nui Rawa o te Selexipag?

Mēnā ka tango koe i te nui rawa o te selexipag i te mea i whakaritea, whakapā atu ki tō tākuta, ki te pokapū whakahaere paitini rānei i te wā tonu, ahakoa kei te pai koe. Ko te tango i te nui rawa o te selexipag ka pā ki te pēhanga toto iti rawa, te mamae nui o te upoko, te whakapairuaki, te ruaki, me te whero.

Kaua e tatari kia kite mena ka puta mai nga tohu, na te mea he kino te horopeta nui. Mena kei te pa ki a koe nga tohu kino penei i te uaua ki te manawa, te mamae o te uma, te ngaro ranei, waea atu ki nga ratonga ohorere tonu. Puritia te pounamu rongoa ki a koe kia kite ai nga kaiwhakarato hauora i nga mea katoa me te nui i tangohia e koe.

Me aha ahau ki te ngaro i te horopeta o Selexipag?

Mena ka ngaro koe i te horopeta o te selexipag, tangohia i te wa e mahara ana koe, engari mena kei roto i te 6 haora o to wa i whakaritea. Mena kua pahemo i te 6 haora, waiho te horopeta i ngaro, ka tango i to horopeta e whai ake nei i te wa tika. Kaua rawa e tango i nga horopeta e rua i te wa kotahi hei utu mo te horopeta i ngaro.

Ko te ngaro i nga horopeta i etahi wa ka kore e raru nui, engari ngana ki te pupuri i te inenga rite tonu mo nga hua pai. Mena ka wareware koe i nga horopeta, whakaarohia te whakarite i nga whakaoho waea, te whakamahi ranei i te kaiwhakarite pire hei awhina i a koe ki te mahara. Korero ki to kaipatu rongoa mo nga punaha whakamahara mena kei te raru tonu koe ki te mahara ki o rongoa.

Ahea ka taea e au te whakamutu i te tango Selexipag?

Kaua rawa koe e whakamutu i te tango selexipag ohorere me te kore e korero ki to taakuta i te tuatahi. Ko te whakamutu ohorere ka raru ai o tohu PAH, ka arahi pea ki nga raruraru kino. Me whakaiti haere e to taakuta to horopeta i roto i te waa mena e tika ana te whakamutu.

Ko te whakatau ki te whakamutu i te selexipag kei runga i nga momo mea, tae atu ki te pai o to urupare ki te maimoatanga, nga paanga o te taha e pa ana ki a koe, mehemea he pai ake pea etahi atu maimoatanga. Ka ata tirotirohia e to taakuta to ahuatanga, ka mahi tahi me koe ki te whakatau i te rautaki maimoatanga mo te wa roa mo te whakahaere i to PAH.

Ka taea e au te inu waipiro i te wa e tango ana i te Selexipag?

He pai ake te whakaiti, te karo rānei i te waipiro i te wā e tango ana koe i te selexipag, nā te mea ka taea e rāua te whakaheke i tō toto. Ko te whakakotahi i a rāua ka tupu pea te hekenga nui o te toto, ka pā ki te whanoke, te ngaro o te mahara, te hinga rānei. Ki te whiriwhiri koe ki te inu waipiro, inu i te āhua tika, ā, kia mōhio ki te āhua o tō tinana.

Me tīmata ki ngā rahinga iti kia kite me pēhea te urupare o tō tinana, ā, karo i te inu waipiro i te wā e noho ana koe i te taha kotahi, i ngā wāhi rānei e mōrearea ai te hinga. Kōrerohia tō inu waipiro ki tō tākuta, nā te mea ka taea e rātou te tohutohu whaiaro i runga i tō hauora whānui me ētahi atu rongoā e tango ana koe.