He aha te Tetrabenazine: Ngā Whakamahinga, te Inenga, ngā Pānga taha, me ētahi atu mea

He rongoā tā te tākuta a Tetrabenazine e āwhina ana ki te whakahaere i ngā nekehanga kore e hiahiatia, e nui rawa ana i roto i ngā tāngata e pā ana ki ētahi āhuatanga neurological. E mahi ana mā te whakaiti i te nui o te dopamine, he matū roro e pā ana ki te nekehanga, i roto i ngā wāhi motuhake o tō roro.

Mēnā i tohua tēnei rongoā ki a koe, ki tētahi rānei e manaaki ana koe, tērā pea he pātai āu mō te āhua o tana mahi me te aha e tūmanakohia ana. Mā tēnei aratohu e ārahi i a koe i ngā mea katoa e hiahia ana koe ki te mōhio mō te tetrabenazine i roto i ngā kupu mārama, tika tonu.

He aha te Tetrabenazine?

E pā ana a Tetrabenazine ki tētahi rōpū rongoā e kiia ana ko te vesicular monoamine transporter 2 (VMAT2) inhibitors. Whakaarohia he rongoā e āwhina ana ki te "whakamārie" i ngā tohu nekehanga kaha rawa i tō roro.

I hangaia te rongoā mō te rongoā i ngā mate nekehanga e pā ana ki te hunga e pā ana ki ngā nekehanga kore e taea e rātou te whakahaere. E whakaarohia ana he rongoā motuhake e hiahia ana kia āta aroturukihia e ngā kaiwhakarato hauora e mōhio ana ki ngā āhuatanga neurological.

Kāore i rite ki ētahi rongoā e mahi ana puta noa i tō tinana katoa, e whai ana a tetrabenazine i ngā ara motuhake i tō roro e whakahaere ana i te nekehanga. Mā tēnei huarahi aro nui e āwhina ana ki te whakaiti i ngā nekehanga kore e hiahiatia i te wā e whakaiti ana i ngā pānga ki ētahi atu pūnaha tinana.

He aha te Tetrabenazine e whakamahia ana?

Ko te mea nui e tohua ana a Tetrabenazine hei rongoā i te chorea e pā ana ki te mate o Huntington. E pā ana te Chorea ki ngā nekehanga kore e hiahiatia, e wiri ana, e pā ana ki ō ringaringa, waewae, mata, me ētahi atu wāhi o tō tinana.

Ko te mate o Huntington he āhuatanga ira e pā ana ki te nekehanga, te whakaaro, me ngā kare-ā-roto. Ka raru pea ngā nekehanga chorea, ka raru pea i ngā mahi o ia rā pēnei i te kai, te hikoi, te kōrero mārama rānei.

Ka whakaaro pea tō tākuta ki te tetrabenazine mō ētahi atu mate nekehanga, ahakoa koinei te mea e kiia ana ko te whakamahi "off-label". Ko ēnei āhuatanga pea:

• Te dyskinesia tardive (ngā nekehanga kore i puta mai i ētahi rongoā hinengaro)
• Ngā tics i roto i te mate o Tourette kāore i aro ki ētahi atu rongoā
• Ētahi atu momo chorea kāore i te hono ki te mate o Huntington
• Ētahi keehi o te dystonia (ngā kirimoko uaua e pā ana ki ngā tūnga rereke)

He ahurei te āhuatanga o ia tangata, ā, ka āta arotake tō tākuta mēnā he tika te tetrabenazine mō tō āhuatanga me ō tohumate.

Me pēhea te mahi a Tetrabenazine?

Ka mahi a Tetrabenazine mā te aukati i te pūrua me te tuku o te dopamine i roto i ngā wāhi roro motuhake e whakahaere ana i te nekehanga. E whakaarohia ana he rongoā kaha ngawari e hiahia ana ki ngā whakatikatika horopeta haere.

Hei māramatanga ki te pēhea te mahi, whakaarohia te dopamine hei karere e kawe ana i ngā tohu nekehanga i roto i tō roro. I roto i ngā āhuatanga pēnei i te mate o Huntington, ka kaha rawa ēnei tohu, ka puta ki ngā nekehanga e kore e hiahiatia.

Ko te rongoā te mea e "whakaheke ana i te rōrahi" i runga i ēnei tohu dopamine kaha rawa. Ka mahia tēnei mā te aukati i te dopamine mai i te pūrua tika me te tuku i ngā pito io, e āwhina ana ki te whakaiti i ngā tohu nekehanga nui.

He huri ngā pānga o te tetrabenazine, te tikanga ki te whakamutu koe i te tango i te rongoā, ka hoki haere ō taumata dopamine ki tō rātou āhua o mua. He rerekē tēnei i ētahi atu rongoā e pā ana ki ngā huringa tūturu.

Me pēhea taku tango i te Tetrabenazine?

Tangohia te tetrabenazine kia rite ki tā tō tākuta i whakarite ai, te tikanga me te kai hei āwhina i te whakaiti i te pōpō o te puku. Ka tae mai te rongoā i roto i te āhua papa, ā, me horomia katoa ki te wai.

Ka tīmata tō tākuta i a koe i runga i te horopeta iti, ā, ka piki haere i roto i ngā wiki maha. Ko tēnei huarahi puhoi e āwhina ana i tō tinana ki te whakatika ki te rongoā me te whakaiti i te tūponotanga o ngā pānga taha.

Anei te mea me mōhio koe mō te tango tika i te tetrabenazine:

• Me inu i ngā wā rite tonu i ia rā kia mau tonu ai ngā taumata i tō tinana
• Kaua e kuru, e ngaungau, e whati rānei i ngā papa
• Me inu me te kai, te miraka rānei hei whakaiti i te riri o te puku
• Mēnā he maha ngā wā e inu ana koe i te rā, me whakatakoto ō horopeta kia ōrite
• Kaua e mutu te inu ohorere me te kore e kōrero tuatahi ki tō tākuta

Ka mātakitaki pū tō tākuta i a koe, ina koa i ngā marama tuatahi o te rongoā. Ka whakatika pea rātou i tō horopeta i runga i te pai o te mahi a te rongoā me ngā pānga taha e pā ana ki a koe.

Kia Pēhea te Roa e Inu ai au i te Tetrabenazine?

Ko te roa o te rongoā me te tetrabenazine e whakawhirinaki ana ki tō āhuatanga motuhake me te pai o tō urupare ki te rongoā. Mō te mate o Huntington, he rongoā wā-roa te tikanga, nā te mea he āhuatanga haere tonu.

Ka arotakehia e tō tākuta i ngā wā katoa mēnā kei te āwhina tonu te rongoā i a koe, me te mea kei te nui tonu ngā painga i ngā pānga taha. Ko ētahi tāngata ka hiahia ki te inu mō ngā tau maha, ēngari ko ētahi ka whakamahi mō ngā wā poto ake.

Ko te whakatau ki te haere tonu, ki te whakamutu rānei i te rongoā me mahi tonu me tō kaiwhakarato hauora. Ka whakaarohia e rātou ngā āhuatanga pēnei i te nui o te āwhina o te rongoā i ō tohumate, ngā pānga taha e pā ana ki a koe, me ngā huringa i tō āhuatanga whānui.

Mēnā ka hiahia koe ki te whakamutu i te inu tetrabenazine, ka whakaiti te tikanga a tō tākuta i tō horopeta i te wā, kaua ki te whakamutu ohorere. Mā tēnei e ārai ngā pānga tangohanga, te pōraruraru ohorere rānei o ngā tohumate.

He Aha ngā Pānga Taha o te Tetrabenazine?

Pērā i ngā rongoā katoa, ka taea e te tetrabenazine te pānga taha, ahakoa kāore katoa e pā ana ki a rātou. Ko ngā pānga taha tino noa he ngawari ki te āhua, ā, he maha ngā wā ka pai ake i te wā e urutau ana tō tinana ki te rongoā.

Ka taea e te māramatanga ki ngā mea e tūmanakohia ana te āwhina i a koe kia rite ake, kia mōhio hoki ki te wā hei whakapā atu ki tō tākuta. Me titiro tātou ki ngā momo pānga taha ka pā ki a koe.

Ngā Pānga Taha Auau

Ka puta ēnei pānga taha i roto i te nuinga o te hunga e tango ana i te tetrabenazine, ā, he pai te whakahaere:

• Te moe nui, te ngenge rānei (te ngenge ake i te tikanga)
• Te pōuri, te huringa rānei o te ngākau
• Te noho tūkinotia, te āwangawanga rānei
• Te uaua ki te moe (te kore moe)
• Te whakapairuaki, te pōpō rānei o te puku
• Te whanoke, ina koa ka tū ake
• Te uaua ki te arotahi

Ko te nuinga o ēnei pānga ka kitea i te wā tuatahi ka tīmata koe ki te tango i te rongoā, i te wā rānei ka whakanuia tō horopeta. He maha ngā wā ka iti ake te raruraru i te wā e urutau ana tō tinana ki te rongoā.

Ngā Pānga Taha Kaha

Ahakoa he iti noa iho, ko ētahi pānga taha e hiahia ana kia tere te rongoā. Whakapā atu ki tō tākuta i te wā tonu mēnā ka pā ki a koe:

• Te pōuri nui, ngā whakaaro rānei mō te whakamomori
• Te uaua ki te horo, ki te hā rānei
• Te kirika nui me te mārō o te uaua
• Te ngākau pōrearea, te mamae rānei o te uma
• Te noho tūkinotia nui, te ohooho rānei
• Ngā nekehanga uaua e kore e taea te whakahaere i tō kanohi, i tō tinana rānei

He onge ēnei pānga taha kaha, engari he mea nui kia mōhio koe ki a rātou, kia rapu rongoā tonu mēnā ka puta.

Ngā Pānga Taha Kāore i te Auau

Ka pā pea ki ētahi tāngata ngā pānga taha kāore i te auau, engari e tika ana kia aro:

• Te mate kino o te neuroleptic (he mate onge engari he kino me te kirika nui, te mārō o te uaua, me te rangirua)
• Te wā QT roa (he huringa manawataki ngākau e puta ana i runga i te EKG)
• Te hekenga nui o te pēhanga toto
• Parkinsonism (te wiri, te mārō, me te nekehanga puhoi)
• Akathisia (te noho tūkinotia nui me te hiahia ki te neke tonu)

Ka aroturukihia koe e tō tākuta mō ēnei pānga onge engari tino nui, ina koa i ngā wā tuatahi o te rongoā.

Ko wai kāore e tika kia tango Tetrabenazine?

Kāore te Tetrabenazine e tika mō te katoa, ā, nā ētahi āhuatanga ka kore e haumaru te whakamahi. Ka āta arotakehia e tō tākuta tō hītori hauora i mua i te whakahau i tēnei rongoā.

Kāore koe e tika kia tango tetrabenazine mēnā he tino pōuri koe, kei te whakaaro rānei koe ki te whakamomori. Ka taea e te rongoā te whakapōuri ake i te pōuri, nō reira he mea nui kia whakatika i ngā āwangawanga hauora hinengaro i mua i te tīmatanga o te rongoā.

Ko ētahi atu aukatinga nui ko:

• Te pōuri kāore i rongoatia, i te kore rānei i rongoatia tika
• Ngā whakaaro whakamomori kaha, ngā nganatanga whakamomori rānei i ngā wā tata
• Te tango i ngā aukati monoamine oxidase (MAOIs) kua tango rānei i roto i ngā rā 14 kua pahure
• Ngā raruraru ate nui
• Te mate pāwera ki te tetrabenazine, ki ōna wāhanga rānei

Me mātua tūpato me te āta aroturuki i ētahi āhuatanga mēnā ka tango koe i te tetrabenazine:

• Hītori o te pōuri, ētahi atu āhuatanga hauora hinengaro rānei
• Ngā raruraru ngākau, ngā manawataki ngākau rerekē rānei
• Te mate ate
• Ngā raruraru tākihi
• Te mate o Parkinson
• Ngā uaua ki te horo

Me kōrero tonu ki tō tākuta mō ō āhuatanga hauora katoa, tae atu ki ngā hītori o ngā take hauora hinengaro, ahakoa kāore e pātahi ana ki tō raruraru nekehanga.

Ngā Ingoa Waitohu Tetrabenazine

Kei te wātea te Tetrabenazine i raro i te ingoa waitohu Xenazine i te United States. Koinei te momo rongoā e tino whakahaua ana.

He rongoā hou, e pā ana ki tēnei, e kiia ana ko te deutetrabenazine, e hokona ana i raro i te ingoa waitohu Austedo. He putanga whakarerekē tēnei o te tetrabenazine, ā, he painga pea ki te auau inenga me ngā pānga taha.

Ma te tākuta e whakatau te momo rongoā e tika ana mō tō āhuatanga. E mahi ana ngā rongoā e rua i te ara rite, engari he rerekētanga pea i te auau o te tango me ō rātou pūtake pānga.

Me whakamahi tonu i te waitohu me te hanganga tika i whakaritea e tō tākuta, nā te mea me huri anake i waenga i ngā momo rerekē i raro i te tirotiro hauora.

Ngā Kōwhiringa kē mō te Tetrabenazine

Mēnā kāore te tetrabenazine e tika ana mōu, kāore rānei e pai te mahi, ka whakaaro pea tō tākuta ki ētahi atu kōwhiringa maimoatanga. Ko te kōwhiringa o te kōwhiringa kē e whakawhirinaki ana ki tō āhuatanga me ō tohumate.

Mō te mate a Huntington's chorea, ko ngā kōwhiringa kē pea:

• Deutetrabenazine (Austedo) - he rongoā hou, rite tonu
• Ngā rongoā antipsychotic pēnei i te haloperidol, olanzapine rānei
• Ngā benzodiazepines mō te āwangawanga me ētahi tohumate nekehanga
• Ngā rongoā anti-seizure pēnei i te waikawa valproic

Mō ētahi atu mate nekehanga, ka whakaaro pea tō tākuta:

• Ngā werohanga paitini botulinum mō ngā raruraru uaua ā-rohe
• Te whakaihiihi roro hōhonu mō ētahi āhuatanga
• Ētahi atu rongoā aukati dopamine
• Te rongoā tinana me te rongoā mahi

Ko te huarahi maimoatanga pai rawa atu he whakakotahi i te rongoā me ētahi atu rongoā pēnei i te rongoā tinana, te rongoā kōrero, te tohutohu rānei hei whakatika i ngā āhuatanga rerekē o ngā mate nekehanga.

He Pai Anei te Tetrabenazine i te Deutetrabenazine?

He rongoā whai hua te tetrabenazine me te deutetrabenazine mō te rongoā i ngā mate nekehanga, engari he rerekētanga nui ō rātou e pai ai tētahi mōu i tētahi atu.

He rongoā hou te Deutetrabenazine (Austedo) i whakawhanakehia hei whakapai ake i te tetrabenazine. Ko ngā painga nui o te deutetrabenazine ko:

• He iti ake te horopeta (e rua nga wa ia ra, kaua e toru nga wa ia ra)
• He pai ake te matapae i nga taumata i roto i to tinana
• He iti ake pea nga paanga taha
• He iti ake te taunekeneke ki etahi mea ira e pa ana ki te whakawhitiwhiti rongoa

Heoi, kua roa te whakamahi i te tetrabenazine, he nui ake hoki nga rangahau i muri. Ko etahi tangata ka pai ake te urupare ki tetahi rongoa i tetahi atu, a tera pea ka whai waahi ano nga whakaaro utu ki te whakatau.

Ka whakaarohia e to taakuta nga mea penei i o tohu motuhake, etahi atu rongoa e tango ana koe, to waarangi o ia ra, me te inihua inihua i te wa e whakatau ana ko wai te rongoa pai mo koe. Karekau he rongoa e tino pai ana - kei runga i o ahuatanga takitahi te whiriwhiri.

Nga Pātai e Pātai pinepine ana mō Tetrabenazine

He Haumaru te Tetrabenazine mō te hunga e mate ana i te ngakau?

Me tino tupato te Tetrabenazine mena he raruraru to ngakau. Ka taea e te rongoa te pa ki te manawataki o to ngakau, ina koa ko tetahi mea e kiia nei ko te wa QT i runga i te EKG.

I mua i te tiimata i te tetrabenazine, ka tono pea to taakuta i te EKG hei tirotiro i to manawataki ngakau. Mena he mate ngakau koe, he rongoa ranei e pa ana ki te manawataki ngakau, tera pea ka hiahia koe ki te aroturuki i nga wa maha, ki tetahi atu huarahi maimoatanga ranei.

Ka taea e te hunga e mate ana i te ngakau te tango i te tetrabenazine i etahi wa, engari me mahi tahi te tohunga neurologist me te tohunga ngakau kia pai ai to ngakau i te wa e rongoatia ana.

Me aha ahau ki te tango pohehe au i te nui rawa o te Tetrabenazine?

Mena ka nui ake te tetrabenazine i te mea i tohua, whakapaa atu ki to taakuta, ki te pokapū whakahaere paihana ranei, ahakoa kei te pai koe. Ka taea e te horopeta nui te whakaputa i nga paanga taha nui kaore pea e puta tonu.

Ko ngā tohu o te nui rawa o te tetrabenazine ka uru pea ki te moe nui, te rangirua, te uaua ki te manawa, te mārō nui o ngā uaua, te ngaro rānei o te māramatanga. Ki te pā mai ētahi o ēnei tohu, rapua tonu te āwhina hauora ohorere.

Hei ārai i te horopeta nui ohorere, waiho tō rongoā ki roto i tōna ipu taketake, whakatakotoria ngā whakamaharatanga mō te wā hei tango, kaua rawa e rua ngā horopeta ki te ngaro i tētahi. Whakaarohia te whakamahi i tētahi kaiwhakarite pire ki te tango koe i te maha o ngā rongoā.

Me Pēhea Taku Mahi Ki Te Ngaro Au i Tētahi Horopeta o Tetrabenazine?

Ki te ngaro koe i tētahi horopeta o te tetrabenazine, tangohia i te wā e mahara ana koe, ki te kore e tata ana te wā mō tō horopeta e whai ake nei. I taua wā, pekehia te horopeta i ngaro, ka tango i tō horopeta e whai ake nei i te wā tika.

Kaua rawa e tango e rua ngā horopeta i te wā kotahi hei utu mō te horopeta i ngaro, nā te mea ka piki ake tō tūponotanga ki ngā pānga taha. Ki te wareware pinepine koe i ngā horopeta, kōrerohia ki tō tākuta mō ngā rautaki hei āwhina i a koe ki te mahara, pērā i te whakatakoto i ngā whakaoho waea, te whakamahi rānei i tētahi taupānga whakamahara rongoā.

Ki te ngaro koe i ngā horopeta i ngā wā katoa, ka kino pea ō tohu, nō reira he mea nui kia kitea tētahi tikanga e pai ana mōu. E kitea ana e ētahi tāngata he āwhina ki te tango i tā rātou rongoā i te wā kotahi me ētahi atu mahi o ia rā, pērā i ngā kai.

Āhea Āhei Ai Au ki te Kati i te Tango Tetrabenazine?

Ko te whakatau ki te kati i te tango tetrabenazine me mahi tonu me tō tākuta. Kaua e kati i te tango ohorere i runga i a koe anō, nā te mea ka hoki tere mai ō tohu, ka kino rānei mō te wā poto.

Ka tūtohu pea tō tākuta ki te kati, ki te whakaiti rānei i te tetrabenazine ki te nui rawa ngā pānga taha, ki te huri tō āhuatanga, ki te pai ake rānei ētahi atu maimoatanga mō tō āhuatanga.

Ka tae ki te wā ki te kati, ka whakaiti te tikanga a tō tākuta i tō horopeta i te wā roa i roto i ngā wiki maha. Ka āwhina tēnei ki te whakaiti i ngā pānga tangohanga, ka āhei tō tinana ki te whakatika pōturi ki te mahi me te kore te rongoā.

Ka Āhei Au ki te Inu Waipiro i te Wā e Tango Ana i te Tetrabenazine?

He pai ake te karo i te waipiro i te wa e tango ana i te tetrabenazine, na te mea ka puta te hiamoe me te pa ki to ruruku. Ko te whakakotahi i a raua ka nui ake enei paanga, ka nui ake to ngenge i te tikanga.

Ka taea hoki e te waipiro te whakapōrearea i te pouri, he mea e pā ana ki te tetrabenazine. Mena ka whiriwhiria e koe te inu i etahi wa, korero ki to taakuta mo te nui pea e pai ana ki a koe, kaua rawa e inu mena kei te pouri koe, kei te huri ranei to ngakau.

Kia tūpato ki te pānga o te waipiro ki a koe i te wa e tango ana koe i tenei rongoa, na te mea ka kitea e koe he nui ake to tairongo ki ona paanga i mua i te tīmatanga o te maimoatanga.